Here we present an unusual case of isolated IgG-deficiency presenting with an excruciating back pain. DESIGN/METHODS: Case Report RESULTS: A 39 year-old male with a history of multiple episodes of pneumonia and meningitis had recurrent back pain. [n.neurology.org]

The amount of the different IgG subclasses present in the bloodstream varies with age. [primaryimmune.org]

[…] among others present on phagocytic cells. [ncbi.nlm.nih.gov]

The presence of anti-GQ1b antibody was reported in patients presenting with acute isolated post-infectious ophthalmoparesis (4 ,7,14 ). [functionalneurology.com]

• Sepsis

  Two relapses of group B streptococcal sepsis and transient hypogammaglobulinemia. Pediatr Infect Dis J. 1989;8(10):729–730. [PubMed] [Google Scholar] 48. Hsueh KC, Chiu HH, Lin HC, Hsu CH, Tsai FJ. [ncbi.nlm.nih.gov]

• Recurrent Infection

  These circumstances include: IgA deficient patients with recurrent infections to determine if there is an associated IgG2 and IgG4 subclass deficiency Wiskott-Aldrich and Ataxia-Telangiectasia patients at the onset of recurrent infections Specific Antibody [primaryimmune.org]

• Recurrent Respiratory Infection

  Clinical Presentations of IgG Subclass Deficiency Patients with any form of IgG subclass deficiency occasionally suffer from recurrent respiratory infections similar to the ones seen in other antibody deficiency syndromes, chiefly infections with encapsulated [primaryimmune.org]

  IgG subclasses in children with recurrent respiratory tract infections in an allergy practice. Acta Paediatr Jpn. 1996 Apr. 38(2):124-7. [Medline]. Shackelford PG, Granoff DM, Madassery JV, et al. [emedicine.medscape.com]

• Recurrent Sinusitis

  IgG3 subclass deficiency, either isolated or combined with other IgG subclass deficiency, was found in 85.5% of 55 children, most of whom were first evaluated for recurrent sinusitis. [5] Melamed IR, Heffron M, McGee S, Ulltate Sanz L, Testori A. [emedicine.medscape.com]

• Anemia

  These authors suggested a possible connection with induction of systemic inflammation and discuss the possible impact of anemia. In addition, levels of plasmatic citrulline were suggested as an indicator of intestinal damage. [ghrnet.org]

• Blood in Stool

  vomiting, sensitivity to foods, difficulty swallowing, and blood in stool or vomit. [frontiersin.org]

• Seizure

  Immunoglobulin subgroups in children with febrile seizures. Pediatr Int. 2001 Feb. 43(1):58-60. [Medline]. Ojuawo A, Milla PJ, Lindley KJ. Serum immunoglobulin and immunoglobulin G subclasses in children with allergic colitis. [emedicine.medscape.com]

  In addition, participants with seizure disorder, genetic disorders, or other chronic diseases and/or infections were also excluded. [frontiersin.org]

• Hypogammaglobulinemia

  Causes of deficiency in the production of immunoglobulins, the so-called hypogammaglobulinemia, include primary and secondary immunodeficiency. [ncbi.nlm.nih.gov]

• Streptococcus Pneumoniae

  In contrast, IgG2 antibodies are predominantly against the polysaccharide (complex sugar) coating (capsule) of certain disease-producing bacteria (such as, Streptococcus pneumoniae and Haemophilus influenzae ). [primaryimmune.org]

Treatment of IgG Subclass Deficiency Recurrent or chronic infections of the ears, sinuses and lungs need comprehensive treatment to prevent permanent damage that might result in hearing loss or chronic lung disease. [primaryimmune.org]

[…] elimination of stress and additional side effects of cancer treatment. [ghrnet.org]

None received immunotherapy for at least 2 months prior to treatment with IVIG. [jamanetwork.com]

Mortality/Morbidity Early diagnosis and treatment of IgG deficiency is essential to prevent and control both morbidity and mortality. [emedicine.medscape.com]

Treatment with acyclovir continued which, along with the fluid removal, led to the patient’s discharge at an acceptable pain level. Lumbar drain was planned. [n.neurology.org]

Therefore, through both decreased galactosylation and decreased sialylation, IgG in CRC patients with poorer prognosis had significantly greater pro-inflammatory properties (decreased galactosylation and sialylation) than CRC patients with better prognosis [nature.com]

It was suggested that in patients with elevated levels of specific anti-cancer antibodies have a better prognosis of survival [9]. [ghrnet.org]

Generally this syndrome has a benign prognosis and the most appropriate treatment is yet to be established. [functionalneurology.com]

This raises questions as to whether dysbiosis is present very early in life in ASD and may be involved in the etiology of ASD that need further investigation. [frontiersin.org]

Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus. Stroke 1989 ; 20 : 583 –91. 24 Asherson RA, Khamashta MA, Gil A et al. [academic.oup.com]

Epidemiology Frequency Although the frequency of isolated IgG deficiency is not known with certainty, deficiencies in specific IgG antibody or IgG subclass is probably more common and occurs in families with common variable immunodeficiency (CVID). [emedicine.medscape.com]

The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect. (2006) 114:1119–25. doi: 10.1289/ehp.8483 PubMed Abstract | CrossRef Full Text | Google Scholar 38. [frontiersin.org]

Moreover, the biological features of anti-GQ1b IgG antibody may not only explain the variability, but also indicate a different pathophysiology of the clinical signs. [functionalneurology.com]

Effects of β-glucan supplementation on cancer growth, allergy, autoimmune diseases, gastrointestinal tract problems, infections and other pathophysiological problems were repeatedly demonstrated [13-16] (for review see Vetvicka [17], Vannucci [18]. [ghrnet.org]

Pathophysiology B and T cells are responsible for specific immunity, otherwise known as adaptive immunity. [emedicine.medscape.com]

Pathophysiologically, it is unlikely that the occurrence of APLAs in stroke patients is merely an epiphenomenon. [academic.oup.com]

Treatment of IgG Subclass Deficiency Recurrent or chronic infections of the ears, sinuses and lungs need comprehensive treatment to prevent permanent damage that might result in hearing loss or chronic lung disease. [primaryimmune.org]

Mortality/Morbidity Early diagnosis and treatment of IgG deficiency is essential to prevent and control both morbidity and mortality. [emedicine.medscape.com]

Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus. Stroke 1989 ; 20 : 583 –91. 24 Asherson RA, Khamashta MA, Gil A et al. [academic.oup.com]