Symptomatic voiding dysfunction was present in 27 of the 30 patients (90 %). [ncbi.nlm.nih.gov]

• Unconsciousness

  After a short period of time, she became unconscious and experienced hypotension and refractory arrhythmia, finally being diagnosed with imipramine poisoning. [ncbi.nlm.nih.gov]

• Family History of Suicide

  family history of suicide, bipolar disorder, depression) prior to initiating therapy. j Cardiovascular Effects Possible conduction defects, arrhythmias, CHF, MI, strokes, and tachycardia, particularly at higher dosages. a b Patients with preexisting [drugs.com]

• Nausea

  Common side effects include nausea, weakness and dry mouth. Imipramine can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you. [rxwiki.com]

  Do not suddenly stop taking this medication: you may get side effects like ( nausea, headaches, and fatigue ). Missed Dose: If you are taking more than 1 a day and miss a dose do not take it if it is almost time for the next dose. [psyweb.com]

  Secondary Outcome Measures : Individual dyspeptic symptom scores [ Time Frame: 12 weeks ] 8-item dyspepsia symptom score questionnaire assessing epigastric pain, epigastric burning, postprandial fullness, early satiety, belching, bloating, nausea, and [clinicaltrials.gov]

  If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away. [nlm.nih.gov]

• Tachycardia

  Electrocardiography (ECG) showed tachycardia and widened QRS. He was immediately treated with bicarbonate infusion and made an uneventful recovery. This is the youngest and only reported case of symptomatic imipramine ingestion in our locality. [ncbi.nlm.nih.gov]

  CV: orthostatic hypotension, tachycardia, ECG changes, hypertension, MI, arrhythmias, heart block, precipitation of heart failure. EENT: blurred vision, tinnitus, mydriasis. [glowm.com]

  Cardiac abnormalities may include arrhythmia, tachycardia (fast or irregular heartbeat), ECG evidence of impaired conduction, and signs of congestive failure. [healthyplace.com]

  […] drowsiness, confusion, seizures, headache, anxiety, tremors, stimulation, weakness, insomnia, nightmares, extrapyramidal symptoms in geriatric patients, increased psychiatric symptoms, paresthesia Cardiovascular: orthostatic hypotension, ECG changes, tachycardia [en.wikipedia.org]

• Acrocyanosis

  An 11 year old girl who was being treated for enuresis with imipramine developed acrocyanosis of the hands and feet. All biochemical and haematological investigations gave normal results. [ncbi.nlm.nih.gov]

• Sweating

  I sweat ALOT and VERY easily since I started this as well. Report [everydayhealth.com]

  […] difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating [generalhlthnews.org]

  Sweating a lot. Flushing. Feeling tired or weak. Headache. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. [drugs.com]

  • Patient may develop Serotonin Syndrome with the following symptoms: increased heart rate, shivering, sweating, dilated pupils. • Heart : Low/high blood pressure, fast heart rate, palpitations, heart attack, abnormal heart rhythm, heart block, ECG [medindia.net]

• Pruritus

  […] increased appetite, cramps, epigastric distress, jaundice, hepatitis, stomatitis, constipation, taste change Genitourinary: urinary retention Hematological: agranulocytosis, thrombocytopenia, eosinophilia, leukopenia Skin: rash, urticaria, diaphoresis, pruritus [en.wikipedia.org]

  Skin: diaphoresis, rash, urticaria, photosensitivity, pruritus. Other: gynecomastia, galactorrhea and breast enlargement, altered libido, SIADH, hypersensitivity reaction. [glowm.com]

• Tinnitus

  A chart review of 475 patients treated with tricyclic antidepressants indicated that tinnitus occurred in about 1% of the patients. The case vignettes of 5 patients who developed tinnitus in the course of imipramine therapy are presented. [ncbi.nlm.nih.gov]

  […] nightmares, extrapyramidal symptoms in geriatric patients, increased psychiatric symptoms, paresthesia Cardiovascular: orthostatic hypotension, ECG changes, tachycardia, hypertension, palpitations, dysrhythmias Eyes, ears, nose and throat: blurred vision, tinnitus [en.wikipedia.org]

  EENT: blurred vision, tinnitus, mydriasis. GI: dry mouth, constipation, nausea, vomiting, anorexia, paralytic ileus, abdominal cramps. GU: urine retention, testicular swelling, impotence. [glowm.com]

  Neurological: Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus. [healthyplace.com]

• Loss of Libido

  Naunyn-Schmiedeberg’s Arch Pharmacol 374:215–222 CrossRef Google Scholar Pierce JR Jr (1983) Cimetidine-associated depression and loss of libido in a woman. [doi.org]

• Insomnia

  In addition, this child experienced initial insomnia and nocturnal enuresis, problems not previously reported with fragile X. [ncbi.nlm.nih.gov]

  A tricyclic drug, C 19 H 24 N 2, used in the form of its salts to treat depression and enuresis. imipramine Neuropharmacology A dibenzazepine class tricyclic antidepressant used for depression, enuresis Adverse effects Insomnia, numbness, tingling, tremors [medical-dictionary.thefreedictionary.com]

  Physical Symptoms of Depression in Pictures Depression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Learn the signs of depression... [medicinenet.com]

  Less effective for insomnia † and associated with more serious adverse reactions than conventional hypnotics. c Imipramine Hydrochloride Dosage and Administration General Major Depressive Disorder Allow at least 2 weeks to elapse between discontinuance [drugs.com]

• Paresthesia

  Central nervous system: dizziness, drowsiness, confusion, seizures, headache, anxiety, tremors, stimulation, weakness, insomnia, nightmares, extrapyramidal symptoms in geriatric patients, increased psychiatric symptoms, paresthesia Cardiovascular: orthostatic [en.wikipedia.org]

  Adverse reactions CNS: drowsiness, dizziness, excitation, tremor, confusion, hallucinations, anxiety, ataxia, paresthesia, nervousness, EEG changes, seizures, extrapyramidal reactions, CVA. [glowm.com]

  Neurological: Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus. [healthyplace.com]

  Not Defined Fatigue Lethargy Sedation Weakness Constipation Dry mouth Blurred vision Agitation Anxiety Headache Insomnia Nausea Vomiting Sweating ECG changes, orthostatic hypotension, tachycardia Confusion, extrapyramidal symptoms (EPS), dizziness, paresthesia [reference.medscape.com]

• Vertigo

  Nervous side effects: disorientation, vertigo, tiredness, weakness, headache, difficulty concentrating, confusion, agitation, mood changes, aggressiveness, difficulty sleeping, hallucinations, anxiety, restlessness, pricking sensation, tremor, muscle [medizzine.com]

• Hot Flushes

  The most commonly reported side effects when taking Tofranil tablets 25mg include: weight gain, anorexia, tremor, tachycardia (rapid heart beat), vasodilation (hot flushes), orthostatic hypotension or dizzy spell (low blood pressure when standing up), [inhousepharmacy.vu]

  Anticholinergic side effects: Dry mouth, blurred vision or double vision, constipation, sweating, hot flushes, difficulty urinating or urinary retention, pupil dilation, glaucoma and intestinal paralysis. [medizzine.com]

• QTc Interval Prolonged

  To report QTc interval prolongation associated with combination therapy including levofloxacin, imipramine, and fluoxetine. A 49-year-old white female presented to the emergency department with fever, aches, and pains for the past 3 days. [ncbi.nlm.nih.gov]

• Torsades De Pointes

  Risk of QT Prolongation and Torsades de Pointes with Psychotropic Drugs, Acquired Long QT Syndrome, (102-120), (2007). [doi.org]

• Electrocardiogram Change

  Common side effects of imipramine include dry mouth, drowsiness, dizziness, low blood pressure, rapid heart rate, urinary retention, and electrocardiogram changes. Overdose can result in death. [en.wikipedia.org]

Finally, imipramine was used for the treatment. The patient had a good response to the treatment by imipramine. Before the treatment was started, he had both diurnal and nocturnal enuresis almost every day. [ncbi.nlm.nih.gov]

Despite a good prognosis and the beneficial effect of reassurance for many patients, most continue to have chest pain that may result in visits to the emergency room, admission to the coronary care unit, and even repeat cardiac catheterization 1-5,7-9 [nejm.org]

The rapid resolution of intraventricular conduction delay and normalization of the QRS-T complexes after gastric lavage, installation of activated charcoal and alkalinization of the blood strongly implicates imipramine intoxication in the etiology of [ncbi.nlm.nih.gov]

Within the group of depressions, few etiologic principles have been substantiated and little agreement exists on subgroups. Consequently, differential drug responses are not clearly understood. [pharmrev.aspetjournals.org]

Genitourinary: urinary retention Hematological: agranulocytosis, thrombocytopenia, eosinophilia, leukopenia Skin: rash, urticaria, diaphoresis, pruritus, photosensitivity Imipramine affects numerous neurotransmitter systems known to be involved in the etiology [en.wikipedia.org]

The literature pertaining to etiology, epidemiology, pathophysiology and management of TCA-induced lung injury has been reviewed. In one series of severe TCA overdose, an ARDS rate of 9% was reported. [ncbi.nlm.nih.gov]

Epidemiology 3: 434–440. View Article Google Scholar 56. Lanevskij K, Japertas P, Didziapetris R, Petrauskas A (2009) Ionization-specific prediction of blood-brain permeability. J Pharm Sci 98: 122–134. View Article Google Scholar 57. [doi.org]

Both the clinical features and the pathophysiology of the serotonin syndrome are discussed. [ncbi.nlm.nih.gov]

The pathophysiology of functional dyspepsia is not fully understood and the correlation of those proposed mechanisms with the clinical characteristics and treatment response is poor. [clinicaltrials.gov]

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160, 1554–1565 (2003). 60. Gourley, S. L. et al. [doi.org]

To try to prevent this complication, early intubation should be considered to avoid aspiration, and cautious volume loading, plus judicious use of alpha-adrenergic agonists, is indicated to prevent protracted hypotension. [ncbi.nlm.nih.gov]