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Immune Complex Disease


Presentation

  • Clinical and serologic data are summarized and representative cases are presented.[ncbi.nlm.nih.gov]
  • In the present study, we purified and characterized IgM from plasma of WAIHA patients and from healthy controls using FPLC-based protocols and optical biosensor technology, and investigated IgG present within the IgM fractions.[ncbi.nlm.nih.gov]
  • In the Review the present concepts concerning the pathogenesis of inflammatory injury associated with immune deposits resulting from a local deposition of circulating immune complexes or formed 'in situ' are discussed.[ncbi.nlm.nih.gov]
  • The clinical history and biological investigations of a patient presenting an immune complex disease induced by Peroben are reported. Biological signs were those of a drug-induced lupus syndrome.[ncbi.nlm.nih.gov]
  • It seems likely that acquired complement deficiencies, possibly present at the time of initiation of the disease, may be important in many of the other cases.[ncbi.nlm.nih.gov]
Purpura
  • A man with ocular myasthenia gravis had rapidly progressing pulmonary hemorrhage, acute renal failure, arthralgias, and palpable purpura.[ncbi.nlm.nih.gov]
  • Red blood cells leak into the tissue producing purpura and the inflammatory infiltrate accounts for the palpability.[ncbi.nlm.nih.gov]
  • IVGG given to one patient with Henoch-Schönlein purpura resulted in the onset of gross hematuria. In sum, IVGG may be useful in treating specific IC renal diseases by solubilization of circulating or in situ ICs but definitive proof is lacking.[ncbi.nlm.nih.gov]
  • Disease Clinicopathologic Manifestations Autoimmune hemolytic anemia Erythrocyte membrane proteins (Rh blood group antigens, I antigen) Opsonization and phagocytosis of erythrocytes, complement-mediated lysis Hemolysis, anemia Autoimmune thrombocytopenic purpura[arthritisresearch.us]
  • When the immune complexes contain immunoglobulin class A (IgA) and when there is systemic involvement, the disease has been referred to as Henoch Schönlein purpura.[clinicaltrials.gov]
Cutaneous Manifestation
  • The physician can now recognize clinically and histopathologically the cutaneous manifestations of immune complex disease. The usual clinical environment in which this type of reaction occurs has been very specifically delineated.[ncbi.nlm.nih.gov]
Arthralgia
  • A man with ocular myasthenia gravis had rapidly progressing pulmonary hemorrhage, acute renal failure, arthralgias, and palpable purpura.[ncbi.nlm.nih.gov]
  • […] antigen excess, No Ab response yet Ab production begins to increase, exponentially Complexes form that are large enough to induce complement but not large enough (yet) to be cleared by RES (reticuloendothelial system) leads to fever, malasise, rash, arthralgia[brainscape.com]
  • Vasculitis manifests in types II and III cryoglobulinemic patients with a triad of arthralgias, myalgias, and palpable purpura. Involvement of medium-sized vessels results in cutaneous ulcers, digital ischemia, and fixed livedo reticularis.[ime.acponline.org]
  • Serum sickness, a constellation of symptoms that includes arthralgias, arthritis, lymph-adenopathy, fever, and urticarial, petechial, or macular skin lesions, results from widespread deposition of immune complexes in various organs.[rheumaknowledgy.com]
Suggestibility
  • This case, therefore, provides a unique haplotype and may be of importance in mapping the C2(0) locus, as it suggests that the gene order on chromosome 6 is HLA-D, C2(0), HLA-B, HLA-A.[ncbi.nlm.nih.gov]
  • The data suggest that self-immunoglobulin is the original autoantigen underlying WAIHA. The molecular characterization of IgM-IgG immune complexes may define new targets for therapeutic intervention in WAIHA.[ncbi.nlm.nih.gov]
  • Pretreatment of the cells with cytochalasin B decreased these activities but increased release of lysosomal beta-glucuronidase, suggesting that degranulation and the burst of oxygen metabolism that characterizes phagocytes are independently regulated[ncbi.nlm.nih.gov]
  • The level of antibody activity to HbsAg was higher in the eluate than the serum, suggesting immunopathogenic specificity of the antibody.[ncbi.nlm.nih.gov]
  • These results suggest that PPP may be an immune complex disease, and that it may be closely associated with the tonsil as a focus for the release of antigens or immune complexes.[ncbi.nlm.nih.gov]
Microscopic Hematuria
  • Abstract To the editor: During an episode of typhoid fever, a patient developed transient proteinuria, microscopic hematuria, as well as urinary hyaline and granular casts and pericarditis.[annals.org]

Workup

Borrelia Burgdorferi
  • The most frequently used assays are those based on antibodies to Borrelia burgdorferi or its variants, the causative agent of LD. However, an antibody test at a single time point only measures exposure, not necessarily an active infection.[dl.begellhouse.com]
HLA-Dw2
  • However, the two chromosomes differed at the HLA-D locus, as one coded for HLA-DW2 whilst the other did not.[ncbi.nlm.nih.gov]

Treatment

  • We report upon a 46-year-old woman, who developed immune complex disease after treatment with clonidine for one year.[ncbi.nlm.nih.gov]
  • Immune complexes were detected in 5 of these 28 patients before CP treatment.[ncbi.nlm.nih.gov]
  • The limited value of plasmapheresis alone without cytostatic treatment is stressed as regards hyperviscosity. Another indication is removal of noxious protein components.[ncbi.nlm.nih.gov]
  • There are both specific and non-specific forms of treatment for immune complex disease.[smartlivingnetwork.com]
  • Treatment is symptomatic and in most cases this condition resolves spontaneously within two weeks.[unboundmedicine.com]

Prognosis

  • As each of these clinical presentations involves specific treatment and prognosis, it is important to be able to distinguish between them. Publisher Full Text Rituximab Hypersensitivity: Evaluation, Desensitization, and Potential Mechanisms.[unboundmedicine.com]
  • The development of nephritis carries a poor prognosis and high risk of developing end-stage renal failure despite recent therapeutic advances.[dovepress.com]

Etiology

  • The characterization of the autoantigen in WAIHA has not yet led to definitive results, and the etiology of RBC autoantibodies remains unclear.[ncbi.nlm.nih.gov]
  • Autoimmune thyroid disease is often associated with other conditions that are believed to have an autoimmune etiology, like diabetes and inflammatory bowel disease. Thanks for your feedback![verywell.com]
  • Particular emphasis will be given to the etiology, pathogenesis and description of gross and microscopic pathologic patterns occurring during the progress and outcome of major human diseases and conditions.[pathmicro.med.sc.edu]
  • Comment: Immune complex assays are seldom used in clinical practice because they are expensive, etiologically nonspecific, poorly correlated with each other, and slow because many are performed primarily in reference laboratories.[rheumaknowledgy.com]

Epidemiology

  • Infectious agents are discussed in relation to their morphology, biology, epidemiology and pathogenesis.[pathmicro.med.sc.edu]
Sex distribution
Age distribution

Pathophysiology

  • An altered control of self-reactive IgG by autologous IgM has been proposed as the underlying mechanism of disease in WAIHA, suggesting that IgM-IgG immune complexes contribute to the pathophysiology of the disease.[ncbi.nlm.nih.gov]
  • Nydegger UE (2007) Immune complex pathophysiology. Annals of the New York Academy of Sciences 1109: 66–83. Rich RR (1992) Immune complex diseases.[els.net]
  • Last reviewed: 2014 DOI: Content Hide Pathophysiology Human immune complex disease Diagnosis Treatment Links to Primary Literature Additional Readings Local or systemic tissue injury caused by the vascular deposition of products of antigen-antibody interaction[accessscience.com]
  • Our understanding of the molecular mechanisms that underlie the pathophysiology of IC-triggered diseases has focused attention on the central role of the IgG Fc receptors and the secondary role of complement in these in vivo reactions.[jci.org]
  • It is tested for by adding the patient's serum to IgG coated microbeads, where IgM anti-IgG will agglutinate the beads Post-Streptococcal Glomerulonephritis Briefly describe the pathophysiology Outline procedure to diagnose it, and what pattern you would[brainscape.com]

Prevention

  • Thus, the factors that regulate this ratio will be central to defining the homeostatic mechanisms that function to direct the inflammatory response to protect the host and prevent inappropriate activation and unbridled inflammatory states.[jci.org]
  • Early therapy for subclinical thyroid disease may prevent its progression, but this has not been validated. A Word From Verywell Usually, autoimmune disease affects one or a few organs in the body.[verywell.com]
  • Well, whenever an invader enters our body, such as a virus, bacteria, and so on, our antibodies, namely IgG and IgM in type III hypersensitivity, love to gang up on these guys - to neutralize them, get rid of them, and prevent them from hurting our body[study.com]
  • Control mechanisms to prevent unregulated activity (and tissue damage) are present in each pathway.[primaryimmune.org]
  • Presumably this would lower virus load and prevent deposition of immune complexes," he added.[cidrap.umn.edu]

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