Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune disease affecting thrombocytes.
The most common presentations observed are bleeding and prolonged bleeding time leading to thrombocytopenia and anemia. Common signs are bleeding spots (purpura) and petechiae mostly on extremities, bleeding gums, epistaxis and menorrhagia. Complications occur due to extremely low blood cell counts (< 5,000 per ul). These include subarachnoid hemorrhage hematomas and lower gastrointestinal bleeding. Care should be taken as ITP patients are at a risk for internal bleeding with slightest trauma. This is unlikely if the platelet count is more than 20,000 per ul. .
Clinical examination revealed mucosal hemorrhages and splenomegaly. The initial diagnosis was immune thrombocytopenic purpura (ITP) and he received intravenous gamma globulins and steroids with good hematologic and clinical response. [ncbi.nlm.nih.gov]
There is no evidence of splenomegaly on abdominal exam. A complete blood count is significant for a platelet count of 24,000/μL and peripheral blood smear demonstrates enlarged platelets. He is started on corticosteroids. [medbullets.com]
[…] the platelet membrane, not the bone marrow. 03:55 Treatment maybe IVIg and if counts are less than 50,000. 04:01 Remember, normal, lower limit, is at least 150,000, so that's pretty significant drop. 04:06 And you may have the spleen which may undergo splenomegaly [lecturio.com]
Keywords polycythemia vera, immune thrombocytopenic purpura, treatment method Polycythemia Vera (PV) is a chronic, clonal and progressive myeloproliferative disease generally characterized by leukocytosis, thrombocytosis, splenomegaly accompanied by an [oatext.com]
Splenomegaly is also a typical finding in ALPS and leukemia. The combination of thrombocytopenia and splenomegaly would also suggest hypersplenism from liver disease and/or portal hypertension. Atypical Laboratory Findings: See below. [clinicaladvisor.com]
Entire Body System
All 10 patients received rituximab 2-18 days after diagnosis, and corticosteroids combined with rituximab within MeSH terms, Substances, Grant support MeSH terms Adolescent Adrenal Cortex Hormones/therapeutic use Adult Aged Anemia, Hemolytic, Autoimmune [ncbi.nlm.nih.gov]
Here, we describe a previously healthy adolescent who presented with fever, influenza-like symptoms and acute onset of generalized petechiae and active oral mucosa bleeding on the third day of his illness. [ncbi.nlm.nih.gov]
Common side effects may include fever, chills, headache, light-headedness, flushing, itching, and a change in blood pressure. Anti-D IgG or WinRho, given intravenously. [cincinnatichildrens.org]
Symptoms to ask about include: gingival bleeding gastrointestinal bleeding menorrhagia neurological symptoms (intracerebral bleeding) a relapsing-remitting course mild fevers left upper quadrant discomfort due to splenic enlargement bleeding following [sharinginhealth.ca]
- Easy Bruising
An 11-year-old boy presented with epistaxis, petechial hemorrhages, easy bruising, and purpuric rash. He was diagnosed to have immune thrombocytopenic purpura and evidence of concomitant parvovirus B19 and dengue viral infection. [ncbi.nlm.nih.gov]
The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs. Also called idiopathic thrombocytopenic purpura, immune thrombocytopenia, and ITP. [cancer.gov]
Symptoms can include any of the following: abnormally heavy menstruation, bleeding into the skin, often around the shins, causing a skin rash that looks like pinpoint red spots (petechial rash), easy bruising, nosebleed or bleeding in the mouth. « Back [aarda.org]
The result of this is easy bruising or bleeding with no apparent injury. Every year, there is one new case of ITP per 100,000 people. It most often develops in women between the ages of 20 and 40, but it can occur at any age. There is no known cure. [uihc.org]
- Prolonged Bleeding
The most common presentations observed are bleeding and prolonged bleeding time leading to thrombocytopenia and anemia. Common signs are bleeding spots (purpura) and petechiae mostly on extremities, bleeding gums, epistaxis and menorrhagia. [symptoma.com]
Symptoms Excessive bruising Fatigue Superficial bleeding on the skin Prolonged bleeding Spontaneous bleeding Bleeding Gums Blood in urine or stool Unusually heavy menstrual flow Diagnosis Physical Exam Complete blood count Blood smear Biopsy- Biopsies [raredr.com]
bleeding from the cuts, we talk about increase in bleeding time, spontaneous bleeding from the gums, bleeding in to the urine or stool, and if it's a lady, when she's then having her menses, she may have increase menstrual flow. 02:38 So now you should [lecturio.com]
The following symptoms require prompt attention: Bleeding symptoms easy bruising bleeding for no apparent reason unusually heavy or prolonged bleeding petechiae, or tiny areas of pinpoint bleeding on the skin of the arms or legs blood in the urine or [uihc.org]
Jaw & Teeth
- Bleeding Gums
Platelets help stop bleeding. So, a decrease in platelets can result in easy bruising, bleeding gums, and bleeding inside the body. The lower the platelet count, the greater the risk of bleeding. [stlouischildrens.org]
Tiny red dots under the skin that are due to very small bleeds. Nosebleeds Bleeding in your mouth, or in and around your gums Heavy menstrual periods Blood in your vomit, urine, or stool Bleeding in your head. [cedars-sinai.org]
- Oral Bleeding
In some instances there is oral bleeding, epistaxis, rectal bleeding or haematuria. Morbidity in ITP is usually minimal and parents need to be reassured of this. [rch.org.au]
Oral bleeding (“wet purpura”) has historically been considered to be a risk factor for more serious bleeding such as intracranial hemorrhage, although there are insufficient data to prove this. [clinicaladvisor.com]
We use ϵ-aminocaproic acid or tranexamic acid swish and swallow to help control oral bleeding, topical thrombin, collagen, and fibrin glue to manage dental extractions, and progestational agents to manage menorrhagia. Figure 1. [doi.org]
(itp) Idiopathic thrombocytopenic purpura Idiopathic thrombocytopenic purpura, (itp), chronic Idiopathic thrombocytopenic purpura, chronic Purpura, idiopathic thrombocytopenia Purpura, idiopathic thrombocytopenia, acute Purpura, idiopathic thrombocytopenia [icd9data.com]
Background Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of [emedicine.com]
Bierling, Purpura thrombopénique auto-immun, EMC - Hématologie, 10.1016/S1155-1984(08)46631-1, 3, 2, (1-13), (2008). [doi.org]
Bleeding into the skin takes the form of purpura or petechiae. Purpura is a purplish or reddish-brown rash or discoloration of the skin; petechiae are small round pinpoint hemorrhages. [medical-dictionary.thefreedictionary.com]
Petechiae, purpura, vesicles, bullae, target lesions, desquamation). ITP is one of those entities that we often consider when we are evaluating a rash. [pedemmorsels.com]
BACKGROUND: Idiopathic thrombocytopenic purpura is characterized by extravasation of blood into the subcutaneous tissue, mucous membranes or skin; it generates bleeding manifestations as ecchymotic lesions, petechiae of sudden onset, epistaxis, bleeding [ncbi.nlm.nih.gov]
Face, Head & Neck
- Intracranial Hemorrhage
Intracranial hemorrhage in immune thrombocytopenic purpura: a retrospective analysis. J Pediatr Hematol Oncol. 2003 ;25: 660 - 664. Google Scholar | Crossref | Medline | ISI Medeiros D, Buchanan GR. [doi.org]
Life-threatening hemorrhage (intracranial hemorrhage) complicates acute ITP 4. [slideshare.net]
This includes, but is not limited to, life threatening gastrointestinal bleeding and intracranial hemorrhage. [emdocs.net]
Diagnosis is partly made through a careful history and nature of symptoms. A complete blood count shows thrombocytopenia and low hemoglobin suggests anemia due to blood loss. Blood smear is mandatory to evaluate and rule out other causes of thrombocytopenia.
Congenital thrombocytopenia shows abnormal morphology in leucocytes and erythrocytes as well, suggesting an underlying bone marrow disease. A blood smear shows large number of schistocytes suggesting thrombocytopenia due to thrombotic purpura or hemolytic uremic syndrome.
A bone marrow examination is done in cases who do not respond to the primary treatment. The bone marrow biopsy may show reduced counts of megakaryocytes that help in diagnosis of ITP. Also, leukemia is ruled out. In cases where splenectomy is done, bone marrow examination is done to evaluate for fibrosis.
- Decreased Platelet Count
The resulting shortened life span of platelets in the circulation, together with incomplete compensation by increased platelet production by bone marrow megakaryocytes, results in a decreased platelet count. [emedicine.medscape.com]
Results The literature synthesis and themes from the focus group data suggest that decreased platelet counts, disease symptoms, and treatment side effects influence multiple domains of HRQoL for ITP patients. [hqlo.biomedcentral.com]
It should be noted that many hematological diseases have oral manifestations like ITP: aplastic anemia, Glanzman thrombasthenia, Hemophilias, Ehlers Danlos Syndrome, Hyperglobulinemia and von Willebrand disease [ 19 Nakhoul IN, Kozuch P, Varma M. [benthamopen.com]
- Hemoglobin Decreased
Response to Initial Anti-D Treatment: Platelet Increase and Hemoglobin Decrease Table 2. [bloodjournal.hematologylibrary.org]
Treatment aims at increasing the platelet level to a safe value of more than 30x 109/L and maintaining the count thereafter till remission. Corticosteroids comprise the first line of treatment that includes prednisone, dexamethasone and methylprednisolone. In case of bleeding tendencies, along with corticosteroids anti-RhD injections are also given to stimulate the platelet count. Studies show that the platelet value increases by > 50 × 109/L in a few days to several weeks after giving prednisolone. Patients requiring anti–RhD treatment are first screened direct antiglobulin test and the Rh type is determined before initiating the treatment. The standard dose is 50 nanogms/kg. The response is seen after 48- 72 hrs.
Prognosis of acute ITP in children is good. Studies showed that about 80% of children recovered completely. There might be a relapse after 6 weeks and only about a small percentage of children develop a chronic disease. Chronic disease is usually seen in adults. Patients gain a normal platelet count with prednisone treatment. If the prednisone is reduced chances of platelet reducing further increases.
The exact cause of the immune mediated antibodies that cause platelet destruction is unknown, however it is postulated that a reduction in suppressor T regulatory cells and increase in B cell activating factor may be responsible for the generation of these autoantibodies. Certain theories relate activation of self-reactive platelet antibodies after infections such as HIV, H pylori and hepatitis C. Here the antibodies cross reacts with the platelets leading to immune thrombocytopenic purpura .
The incidence of ITP is estimated to be 50-100 cases per million per year . It is accounted that most of the adult age group is affected with this disease, children being concerned 50% off the adult ratio. The mortality rate is higher in adults. It was concluded that over 90% deaths occurred in the age group of individuals over 45 years .
Dr. William Harrington had first experimented on himself, along with his other colleagues by injecting with the blood of patients with ITP. The experiment resulted into severe thrombocytopenia in their blood sample lasting for several days. Immune thrombocytopenic purpura involves both cellular and humoral immunity. There are certain autoantibodies found which are directed against the platelet surface glycoprotein (GP) complexes gp IIb-IIIa  .
The autoantibodies are mostly of IgG subtype and they attach to the targeted platelets on their surfaces. It was found that in ITP patients who were injected with in-labeled autologous platelets, the uptake is primarily from the spleen and liver. After platelets are attached to the antibodies’ surface, there is degradation and macrophages secrete cytokines that stimulate CD4 T cell clones. These CD4 T cells identifies distinct epitopes on gp IIb-IIIa, leading to a general autoimmune response and massive platelet destruction. The trigger for such a response is not known. Studies show that platelet associated auto antibodies are found in about 50-70% affected individuals.
B cells in ITP produce antibodies directed against the normal platelet antigens thereby initiating response from the CD4 T cells. A potent immunosuppressive cytokine called beta 1, is found to be elevated in patients with ITP in remission as compared to those with active ITP. The autoreactive T cells are found in healthy individuals, but the active form is only found in patients with autoimmune diseases. Also, along with destruction of platelets there is suppression of production of megakaryocytes leading to thrombocytopenia.
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder also referred to as primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, characterized by destruction of platelets and impairment of platelet production (thrombopoeisis) leading to a tendency to prolonged bleeding .
Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune mediated disorder wherein antibodies are directed to destroy or kill normal platelets leading to bleeding disorders. The cause is not known. Certain drugs and infections such as HIV and Helicobacter pylori infections are thought to be some of the causes for this disease. Signs and symptoms include bleeding from gums, nostrils, bruises on extremities, easy bleeding to slightest injury and there is a increased risk of intracranial hemorrhage which may prove fatal. Treatment is aimed in restoring the platelet values to normal levels by treating with corticosteroids. Chronic long standing patients are advised spleen removal (splenectomy) that has shown considerable results.
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