VCP, a member of the AAA-ATPase gene family, associates with a plethora of protein adaptors to perform a variety of cellular processes including Golgi assembly/disassembly and regulation of the ubiquitin-proteasome system. [ncbi.nlm.nih.gov]

Knee-Ankle-Foot Orthosis A KAFO is a long-leg orthosis that spans the knee, the ankle, and the foot in an effort to stabilize the joints and assist the muscles of the leg. [ibmmyositis.com]

The phenotype of this chromosome 7q22.3-31.2 linked autosomal dominant muscle disease includes the onset of symptoms between the ages of 30 and 50 years and a slowly progressive proximal limb and neck flexor muscle weakness that remains benign. [journals.plos.org]

Two family members also showed signs of early hearing impairment, which was confirmed to be sensorineural in one person, a symptom not yet described in the context of IBMPFD. [ncbi.nlm.nih.gov]

"Both of these processes have a role in the disease process but which one occurs first and which has the dominant role is still debated " ( Needham and Mastaglia 2007). sIBM is not considered a fatal disease (baring complications - mostly dysphasia, generally [ibmmyositis.com]