Presentation
Entire Body System
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Asymptomatic
Granuloma gluteale infantum is characterised by asymptomatic firm erythematous or violaceous nodules. The nodules are located in inguinal folds, on the convexities of the buttocks, and less commonly, in the scrotal area and medial thighs. [dermnetnz.org]
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Physician
Dermatology and Cutaneous Sciences, University of Alberta Faculty of Medicine and Dentistry, Canada Marlene T Dytoc, MD, PhD, FRCPC is a member of the following medical societies: Alberta Medical Association, American Academy of Dermatology, College of Physicians [emedicine.medscape.com]
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Inflammation
The disorder is believed to represent a unique cutaneous response to local inflammation, maceration, and secondary infection. [emedicine.medscape.com]
Skin
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Papule
Less common conditions that may require consideration include: Allergic contact dermatitis Tinea corporis Langerhans histiocytosis Mastocytoma Perianal pseudoverrucous (wart-like) papules Kaposi sarcom a Scabies nodules [7]. [dermnetnz.org]
Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum. [emedicine.medscape.com]
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Dermatitis
Granuloma gluteale infantum is a complication of irritant contact dermatitis ( napkin dermatitis ). The exact cause is unknown [5]. [dermnetnz.org]
Granuloma Glutaeale Infantum: A Re-emerging Complication of Diaper Dermatitis. Pediatrics. 2018 Feb. 141 (2): [Medline]. Van L, Harting M, Rosen T. Jacquet erosive diaper dermatitis: a complication of adult urinary incontinence. [emedicine.medscape.com]
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Cradle Cap
Infantile seborrhoeic dermatitis is a flexural rash that often involves the infant's eyebrows and scalp ( cradle cap ). [dermnetnz.org]
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Ulcer
Jacquet erosive dermatitis refers to tender punched out ulcers occurring in infants over 6 months old that are due to infrequent nappy changes and poor hygiene. [dermnetnz.org]
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Eruptions
A similar eruption may have been described in 1891, and, in 1962, as vegetating bromidism due to the application of bromide ointment. [emedicine.medscape.com]
Psychiatrical
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Suggestibility
This observation suggests a causative role for topical fluorinated steroids in this skin disorder. [emedicine.medscape.com]
Neurologic
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Irritability
Granuloma gluteale infantum is a complication of irritant contact dermatitis ( napkin dermatitis ). The exact cause is unknown [5]. [dermnetnz.org]
Together, urine and feces can irritate diapered skin, increasing its permeability and susceptibility to other irritants. [emedicine.medscape.com]
Urogenital
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Incontinence
Van et al reported a case related to adult urinary incontinence. [7, 8, 9] Epidemiology Frequency Granuloma gluteale infantum is rare; only approximately 30 cases have been reported worldwide. [emedicine.medscape.com]
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Overflow Incontinence
Recurrent Granuloma Gluteale Infantum Secondary to Fecal Overflow Incontinence. Case Rep Dermatol. 2018 May-Aug. 10 (2):203-207. [Medline]. De Zeeuw R, Van Praag MC, Oranje AP. Granuloma gluteale infantum: a case report. [emedicine.medscape.com]
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Urinary Incontinence
Van et al reported a case related to adult urinary incontinence. [7, 8, 9] Epidemiology Frequency Granuloma gluteale infantum is rare; only approximately 30 cases have been reported worldwide. [emedicine.medscape.com]
Workup
Microbiology
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Candida
Candida albicans should be treated with a topical antifungal agent. The nodules spontaneously regress within 1–2 months without any active treatment, often leaving an atrophic scar. See smartphone apps to check your skin. [dermnetnz.org]
Candida hyphae are detected in skin biopsy specimens obtained from some, but not all, patients. Intradermal testing to Candida albicans antigen does not elicit immediate or delayed hypersensitivity. [emedicine.medscape.com]
Treatment
What is the treatment and outcome for granuloma gluteale infantum? Granuloma gluteale infantum lesions are typically resistant to treatments with barrier creams, antifungal agents, and topical steroids. [dermnetnz.org]
Prognosis
Prognosis The lesions persist for 3-6 weeks, followed by spontaneous regression over 2-4 weeks. Residual, brown hyperpigmented macules and lax, atrophic scars are observed in some patients. [emedicine.medscape.com]
Etiology
Etiology The etiology of granuloma gluteale infantum is unclear. The disorder is believed to represent a unique cutaneous response to local inflammation, maceration, and secondary infection. [emedicine.medscape.com]
Epidemiology
Van et al reported a case related to adult urinary incontinence. [7, 8, 9] Epidemiology Frequency Granuloma gluteale infantum is rare; only approximately 30 cases have been reported worldwide. [emedicine.medscape.com]
Pathophysiology
Pathophysiology No systemic association is known. Etiology The etiology of granuloma gluteale infantum is unclear. The disorder is believed to represent a unique cutaneous response to local inflammation, maceration, and secondary infection. [emedicine.medscape.com]