difficulties Feeding problems Poor feeding [ more ] 0011968 Frontal bossing 0002007 Gait ataxia Inability to coordinate movements when walking 0002066 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Generalized muscle weakness [rarediseases.info.nih.gov]

We recommend that people with INAD or PLAN be started on an age or weight appropriate dose of DHA in the form of fish or other oil. Your doctor should recommend the dose and be part of the decision to begin this supplement. [nbiacure.org]

Many children experience delayed/difficulty walking, loss of neck control and low muscle tone in the trunk, which occurs early on. Eventually, muscle tightness and weakness in both arms and legs will follow. [inadcure.org]

This leads to nutritional problems such as Dysphagia (difficulty swallowing), difficulty chewing, choking on liquids and nasal regurgitation. Due to these challenges of eating and drinking, children are often put on feeding tubes. [inadcure.org]

[…] problems Dysarthria (poor articulation or slurring) Dysphonia (defective use of the voice) Dysphasia (difficulty in using or understanding words) Causes nutritional problems Dysphagia (difficulty swallowing) Difficulty with chewing Choking on liquids Nasal regurgitation [nbiacure.org]

[…] cranial nerve dysfunction: -Speech problems including poor articulation (dysarthria), poor use of voice (dysphonia) and poor understanding of words (dysphasia) -Difficulty swallowing and chewing (dysphagia) causing nutritional problems -Choking and nasal regurgitation [rarediseases.org]

Distinctive facial deformities may be present at birth, including a prominent forehead, crossed eyes, an unusually small nose or jaw, and large, low-set ears. [secure.ssa.gov]

There are signs of Infantile Neuroaxonal Dystrophy which can be noticed at birth in some cases, including facial deformities such as crossed eyes, a small nose, large ears, low set ears, a small jaw and a jutting forehead. [disabilitybenefitscenter.org]

There are signs of Infantile Neuroaxonal Dystrophy which can be noticed at birth in some cases, including facial deformities such as crossed eyes, a small nose, large ears, low set ears, a small jaw and a jutting forehead. [disabilitybenefitscenter.org]

The iPA 2 -VIA expression is strong in the optic nerve axons and in the cornea, moderately strong in the iris, ciliary body and lens, and very strong in the adult eye’s retinal pigment epithelium (Polster et al., 2010, p. 378). [breathepsychology.wordpress.com]

attention span Poor attention span Problem paying attention [ more ] 0000736 Short nose Decreased length of nose Shortened nose [ more ] 0003196 Spastic tetraplegia 0002510 Spasticity Involuntary muscle stiffness, contraction, or spasm 0001257 Strabismus [rarediseases.info.nih.gov]

[…] tightness and weakness in both arms and legs -Reduced joint mobility due to muscle tightness -Overactive reflexes developing early disease -Absent reflexes developing late in disease Common neuropsychiatric symptoms: -Poor attention span -Impulsivity -Hyperactivity [rarediseases.org]

The atypical form begins in early childhood with gait instability, ataxia, speech delay, autistic features with neurologic deterioration and extrapyramidal findings; neuropsychiatric disturbances including poor attention, hyperactivity and emotional lability [scielo.mec.pt]

[…] movements when walking 0002066 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Generalized muscle weakness 0003324 Gliosis 0002171 Global developmental delay 0001263 Hearing impairment Deafness Hearing defect [ more ] 0000365 Hyperactivity [rarediseases.info.nih.gov]

Due to an impairment of the function of cranial nerves (Bulbar dysfunction), children affected by INAD often have speech problems, Dysarthria (poor articulation or slurring), Dysphonia (defective use of the voice), Dysphasia (difficulty in using or understanding [inadcure.org]

[…] connects the eye to the brain) Seen later in the disease Bulbar dysfunction (impairment of the function of cranial nerves IX, X, XI and XII) Results in speech problems Dysarthria (poor articulation or slurring) Dysphonia (defective use of the voice) Dysphasia [nbiacure.org]

[…] the nerve that connects the eye to the brain (optic atrophy) seen later in disease Common symptoms of cranial nerve dysfunction: -Speech problems including poor articulation (dysarthria), poor use of voice (dysphonia) and poor understanding of words (dysphasia [rarediseases.org]

Infantile neuroaxonal dystrophy (INAD): Description, Causes and Risk Factors: A rare, familial disorder of early childhood manifested as progressive psychomotor deterioration, increased reflexes, Babinski sign, hypotonia and progressive blindness. [medigoo.com]

sign 0003487 Bradykinesia Slow movements Slowness of movements [ more ] 0002067 Cerebellar atrophy Degeneration of cerebellum 0001272 Cerebral atrophy Degeneration of cerebrum 0002059 Childhood onset Symptoms begin in childhood 0011463 Chorea 0002072 [rarediseases.info.nih.gov]

[…] development Poor language development Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Dysarthria Difficulty articulating speech 0001260 Dysdiadochokinesis Difficulty performing quick and alternating movements 0002075 Dysmetria [rarediseases.info.nih.gov]

drooling with transdermal scopolamine patch or other treatments (as needed) Early physical therapy and orthopedic management to prevent contractures Periodic testing of vision and hearing PROGRESSION The progression of INAD is usually rapid. [nbiacure.org]