Edit concept Question Editor Create issue ticket

Infective Dermatitis Associated with HTLV-1

IDH


Presentation

  • Comprehensive Approach to Infections in Dermatology is a guide to all types of skin infection, with detailed information on epidemiology, presentation, diagnosis and management.[books.google.de]
  • We draw attention to the possibility of co-presentation of adult-onset IDH in patients with a previous diagnosis of HAM/TSP, although IDH is a disease classically described in children.[ncbi.nlm.nih.gov]
  • The variable clinical presentation of IDH, in particular its chronicity, the morphology and distribution of the lesions, and its clinical resemblance to other cutaneous inflammatory conditions, make it necessary to distinguish it from other common dermatoses[ncbi.nlm.nih.gov]
  • Related Links: We present a male patient who presented peripheral blood leukocytosis. On the basis of his morphological appearances and molecular findings he was determined to have a diagnosis of chronic neutrophilic leukemia.[medworm.com]
  • It presents as an exudativeolving mainly the scalp, external ear and neck.[docslide.com.br]
Asymptomatic
  • A total of 193 individuals (73 HAM/TSP and 120 asymptomatic carriers) were evaluated, three of which were associated with adult-onset IDH and HAM/TSP.[ncbi.nlm.nih.gov]
  • Materials and methods RNA was extracted from PBMC of 31 patients with IDH and 8 adolescent asymptomatic carriers. The mRNA expression levels were quantified by real-time quantita- tive PCR.[documentslide.com]
  • Method: In a study of 14 cases with IDH from South Africa and their controls which included five AD patients, five asymptomatic carriers (ACs), and 18 healthy uninfected individuals, we conducted a clinical assessment.[omicsonline.org]
  • The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers.[ncbi.nlm.nih.gov]
  • A total of 193 HTLV-1 infected subjects were studied, including asymptomatic carriers and HAM/TSP patients. Of the subjects, 76% had an abnormal skin condition, with a high prevalence both among HTLV-1 asymptomatic carriers and HAM/TSP patients.[journals.plos.org]
Loss of Hair
  • It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed) Htlv-i Antibodies Antibodies reactive with the HTLV-I ANTIGENS.[bioportfolio.com]
Chills
  • Typical fever and chills were experienced two weeks after returning from one year duty in Congo, West-Central Africa. The diagnosis of ovale malaria was made by peripheral blood smear, and 35/250 parasites in small microscopic view was found.[medworm.com]
Eczema
  • This disease occurs primarily in children and should be differentiated from other eczemas, especially from atopic dermatitis. The largest series of IDH are from Jamaica and Brazil.[ncbi.nlm.nih.gov]
  • BACKGROUND: Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL).[ncbi.nlm.nih.gov]
  • Infective dermatitis associated with HTLV-1: differential diagnosis of atopic dermatitis. ( 28954118 ) Oliveira L.M.L....AraA_jo M.G. 2017 2 Infective dermatitis associated with HTLV-1 mimics common eczemas in children and may be a prelude to severe systemic[malacards.org]
  • Bittencourtb, or, Bahia, BrazilBahia, Brazillvador, Bahia, Brazilr, Bahia, Brazilr, Bahia, Brazil with HTLV-1 (IDH) is a severe childhood form of eczema thatphoma (ATL).cal and laboratoryparameters suggestiveofATLwasevaluated he patients were submitted[docslide.net]
Chronic Dermatitis
  • Abstract Infective dermatitis associated with human T-cell lymphotropic virus type 1 (HTLV-1) (IDH) is a chronic dermatitis that has been observed in a variable proportion of HTLV-1-infected children.[ncbi.nlm.nih.gov]
  • Show More Hide Infective dermatitis associated with human T-cell lymphotropic virus type 1 (HTLV-1) (IDH) is a chronic dermatitis that has been observed in a variable proportion of HTLV-1-infected children.[plu.mx]
  • Histological findings of IDH are those of spongiotic dermatitis or simple chronic dermatitis. Infrequently histology may mimic psoriasis or mycosis fungoides. In IDH, the inflammatory infiltrate is predominantly made up of CD8 T-cells.[jped.com.br]
Alopecia
  • This issue of the Dermatologic Clinics focuses on the most common skin and hair disorders seen in black skin, with articles focusing on acne scarring, alopecia, keloids, and skin pigmentation.[books.google.com]
  • Result: The clinical outcomes in this study revealed evidence of dry skin, scarring alopecia, significant visual disturbances but no asthma in IDH cases compared to controls.[omicsonline.org]
Dry Skin
  • Result: The clinical outcomes in this study revealed evidence of dry skin, scarring alopecia, significant visual disturbances but no asthma in IDH cases compared to controls.[omicsonline.org]
  • He consulted the Dermatology service for dry skin, markedly predominant in extremities, and generalized itching of 3-month duration.[ncbi.nlm.nih.gov]
Xanthoma
  • We report on a normolipemic patient with cutaneous xanthomas who was subsequently diagnosed with mycosis fungoides.[medworm.com]
Suggestibility
  • Studies suggest that IDH in children may be a marker for the development of T-cell leukemia/lymphoma (ATL) or myelopathy associated with HTLV-1/tropical spastic paraparesis (HAM / TSP) in adulthood.[ncbi.nlm.nih.gov]
  • OBJECTIVE: In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH.[ncbi.nlm.nih.gov]
  • Objectives The objective of this study was to evaluate the presence of clin-ical and laboratory parameters suggestive of ATL in a cohort of 30patients with IDH. see front matter 2010 Elsevier B.V.[docslide.net]
Withdrawn
  • The dis-ds to antibiotic therapy but relapses immediately onces withdrawn.2,3 n aggressive T-cell malignancy that generally occursfter vertically acquired HTLV-1 infection.4 It has beento ve clinical types: acute, chronic, lymphomatous, ding author at[docslide.net]
  • The dis-ds to antibiotic therapy but relapses immediately onces withdrawn.2,3n aggressive T-cell malignancy that generally occursfter vertically acquired HTLV-1 infection.4 It has beento ve clinical types: acute, chronic, lymphomatous,ding author at:[docslide.com.br]
  • Chronic relapsing dermatitis which responds immediately to antibiotic therapy and relapses immediately once treatment is withdrawn. 4. Early childhood onset. 5. HTLV-I seropositivity.[jped.com.br]
  • . • The relapsing nature of this disease with a prompt response to appropriate therapy and an equally rapid relapse if the drugs are withdrawn were present in all the patients and should be considered as an indispensable criterion for the diagnosis. •[oapublishinglondon.com]
Myelopathy
  • KEYWORDS: Clustering of HTLV-1-associated diseases; HTLV-1 associated myelopathy/tropical spastic paraparesis; HTLV-1 infection; HTLV-1 vertical transmission; Infective dermatitis associated with HTLV-1[ncbi.nlm.nih.gov]
  • Studies suggest that IDH in children may be a marker for the development of T-cell leukemia/lymphoma (ATL) or myelopathy associated with HTLV-1/tropical spastic paraparesis (HAM / TSP) in adulthood.[ncbi.nlm.nih.gov]
  • 28954118 ) Oliveira L.M.L....AraA_jo M.G. 2017 2 Infective dermatitis associated with HTLV-1 mimics common eczemas in children and may be a prelude to severe systemic diseases. ( 24680009 ) Hlela C....Bittencourt A. 2014 3 Clustering of HTLV-1 associated myelopathy[malacards.org]
  • Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), infective dermatitis associated with HTLV-1 (IDH), and various other[ncbi.nlm.nih.gov]

Workup

Lymphocytes Increased
  • Once these lymphocytes increase in number (e.g. in association with an inflammatory response) the HTLV viral load increases.[idmic.net]
Lymphocytic Infiltrate
  • We identified a strong lymphocytic infiltrate which did not confine itself to the dermis but extended into the epidermis.[omicsonline.org]
  • Dense dermal lymphocytic infiltrate with nuclear atypia. CD25 staining is positive. (C) Biopsy of an umbilicated papule in 2008, HE 200. Sub-epidermal dense lymphocytic infiltrate with significant epidermotropism (Pautrier’s abscess).[medicaljournals.se]
  • Dermis observation shows lymphocyte infiltrates of liquenoid or superficial perivascular type. A small number of cases could present lymphocytic epidermotropism, with or without atypical lymphocytes.[ncbi.nlm.nih.gov]
  • Yet a few cases have been reported, who were suspected of CNS GVHD from brain biopsy or autopsy, their CSF showed predominant T-lymphocyte infiltration of donor origin (Kamble et al. 2007 ).[springerplus.springeropen.com]
  • The rationale for this suggestion is the finding of a lymphocytic infiltrate together with epidermotropism in the same non-specific skin lesions in previous studies.[oapublishinglondon.com]

Treatment

  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.de]
  • Treatment might fail in a small proportion of the patients with WR during imatinib treatment, but close and careful monitoring and timely switching to 2GTKIs might translate into favorable outcomes.[medworm.com]
  • There are also articles addressing moisturizers for the skin and the effect of hair treatments on the hair and scalp. Also discussed is the sociohistoric issues that can cloud the scientific understanding of clinical entities.[books.google.com]
  • Anais brasileiros de dermatologia ISSN : 1806-4841 Pages : 573-574 Links PubMed Source: DOI: Medical and Biotech [MESH] Definitions Diagnosis-related Groups A system for classifying patient care by relating common characteristics such as diagnosis, treatment[bioportfolio.com]

Prognosis

  • Zidovudine ( AZT ) and alpha interferon have shown some response and improved the ATL prognosis.[canada.ca]
  • Despite medical science advancements, once diagnosed with adult T-cell leukemia/lymphoma the prognosis is not promising.[softschools.com]
  • J Cutan Pathol 24:286–291 PubMed CrossRef Google Scholar Van Doorn R, van Haselen CW, van Voorst Vader PC et al (2000) Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients.[link.springer.com]
  • Allo-HSCT is a promising treatment option to cure ATL because it may improve disease prognosis (Utsunomiya et al. 2001 ; Kami et al. 2003 ).[springerplus.springeropen.com]
  • The main differential diagnosis is atopic eczema, an important consideration, as treatment and prognosis are different.[oapublishinglondon.com]

Etiology

  • Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), infective dermatitis associated with HTLV-1 (IDH), and various other[ncbi.nlm.nih.gov]
  • Brief Summary: Doctors of the University of West Indies, the Caribbean Epidemiology Center (CAREC) and the National Cancer Institute have been studying the epidemiology of HTLV-I and its role in the etiology and pathogenesis of adult T-cell leukemia/lymphoma[clinicaltrials.gov]
  • Thus, it is important to stress that HTLV-1 infection may have an etiological link to skin disease.[journals.plos.org]
  • HTLV-1 is the etiological agent of mainly two severe diseases: a malignant T CD4 cell lymphoproliferation, of very poor prognosis, named Adult T cell Leukemia/Lymphoma (ATL), and a chronic neuro-myelopathy named Tropical spastic paraparesis/HTLV-1 Associated[medcraveonline.com]
  • Adult T-cell leukemia/lymphoma Introduction ATL is a severe and generally fatal form of leukemia/lymphoma that is etiologically linked with HTLV-I.[jped.com.br]

Epidemiology

  • Comprehensive Approach to Infections in Dermatology is a guide to all types of skin infection, with detailed information on epidemiology, presentation, diagnosis and management.[books.google.de]
  • Brief Summary: Doctors of the University of West Indies, the Caribbean Epidemiology Center (CAREC) and the National Cancer Institute have been studying the epidemiology of HTLV-I and its role in the etiology and pathogenesis of adult T-cell leukemia/lymphoma[clinicaltrials.gov]
  • The epidemiology and disease outcomes of human T-lymphotropic virus type II. AIDS Rev. 2004;6(3):144-54.[rarediseases.org]
  • Clinicians and other scientists employing traditional and molecular epidemiologic tools have been reasonably successful at defining important public health issues related to HTLV infections.[htlv.net]
  • Recently, a new work about epidemiology and world distribution of HTLV-1 estimated that are 5-10 million persons infected worldwide.[medcraveonline.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology is unknown and several hypotheses are proposed: direct toxicity, autoimmunity, and bystander damage (5).[medicaljournals.se]
  • […] although this is rare. 7 In the majority of cases, cytotoxic T-cells effectively control the virus by lysis of infected lymphocytes, which in turn results in the release of inflammatory cytokines that can be pathogenic. 6 On account of these various pathophysiological[sajhivmed.org.za]

Prevention

  • Avoiding early switch to 2GTKIs would prevent patients from experiencing potential toxicities.[medworm.com]
  • These discoveries have led to improved preventative measures to block mother to child transmission, better confirmatory test strategies for blood donor screening, and the prevention of HTLV-2 infection among injection drug users.[htlv.net]
  • In countries where HTLV-1 is prevalent, screening of blood is done to help prevent its spread. The most common method of transmission of HTLV-1 is through unsafe sex, blood contact, and breastfeeding.[softschools.com]
  • Use condoms to prevent sexual transmission. No, blood collection is performed using a sterile needle. You cannot get an HTLV infection from donating.[labtestsonline.org]
  • NCI_CTEP-SDC (Cancer Therapy Evaluation Program - Simple Disease Classification) 2015AB NCI_CareLex (Content Archive Resource Exchange Lexicon) 2015AB NCI_DCP (NCI Division of Cancer Prevention Program) 2015AB NCI_DICOM (Digital Imaging Communications[doctor.am]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!