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Infiltrative Basal Cell Carcinoma


Presentation

  • (See Presentation .) See the clinical images below of basal cell carcinoma. Basal cell carcinoma. A 68-year-old patient presenting with an advanced basal cell carcinoma (BCC) of the right periorbital region, frontal view.[emedicine.medscape.com]
Cyanosis
  • Rombo syndrome Rombo syndrome is an autosomal dominant condition distinguished by basal cell carcinoma and atrophoderma vermiculatum, trichoepitheliomas, hypotrichosis milia, and peripheral vasodilation with cyanosis. [40] Alcohol consumption A study[emedicine.medscape.com]
Corneal Opacity
Freckles
  • Those with type 1 skin are very fair and have red or blond hair and freckles; these individuals always burn and never tan. Those with type 2 skin are fair and burn easily while tanning minimally.[emedicine.medscape.com]
Papule
  • […] and symptoms Approximately 85% of BCCs occur on the face, head (scalp included), and neck; others appear on the trunk or extremities; rarely, they may occur on the hands. [4, 5] Other characteristic features of BCC tumors include the following: Waxy papules[emedicine.medscape.com]
Neglect
  • Neglected tumors can continue to grow and lead to significant local destruction and even disfigurement. Surgery, in almost all cases, is the recommended treatment, [6, 8] with treatments varying on the basis of cancer size, depth, and location.[emedicine.medscape.com]

Workup

  • (See Workup .) Neglected tumors can continue to grow and lead to significant local destruction and even disfigurement.[emedicine.medscape.com]

Treatment

  • Surgery, in almost all cases, is the recommended treatment, [6, 8] with treatments varying on the basis of cancer size, depth, and location. (See Treatment .)[emedicine.medscape.com]

Prognosis

  • The multivariate odds ratio for early-onset BCC in obese versus normal individuals was 0.43 for adult BMI and 0.54 for BMI at age 18. [47] Prognosis The prognosis for patients with BCC is excellent, with a 100% survival rate for cases that have not spread[emedicine.medscape.com]

Etiology

  • (See Etiology .) A skin biopsy (most often a shave biopsy is sufficient) may be necessary to confirm the diagnosis and is often required to determine the histologic subtype of BCC.[emedicine.medscape.com]

Epidemiology

  • HCTZ showed the strongest association with skin cancers on heavily sun-exposed sites such as the lower limbs (versus the trunk). [42] Epidemiology The American Cancer Society (ACS) reports skin cancer as being the most common cancer in the United States[emedicine.medscape.com]
Sex distribution
Age distribution

Prevention

  • Patient Education Adequate patient education is essential in the prevention of recurrence and spread of basal cell carcinoma.[emedicine.medscape.com]

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