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Inflammation

Inflammations


Presentation

  • The presentation is highly variable, ranging from an incidental finding to aortic dissection and rupture.[ncbi.nlm.nih.gov]
  • We describe the clinical presentation of uveitis in three patients with concomitant systemic melanoma treatment.[ncbi.nlm.nih.gov]
  • We report a case of granulomatous orbital inflammation due to high-pressure oil injury to the orbit presenting as an atypical orbital cellulitis. Here we review the presentation and treatment of orbital inflammation from oil.[ncbi.nlm.nih.gov]
  • CASE PRESENTATION: An 11-year-old boy presented with a minimal ocular foreign-body sensation and peripheral visual-field defect, as well as mild upper respiratory symptoms.[ncbi.nlm.nih.gov]
  • Intracranial high-resolution vessel wall magnetic resonance imaging evidence of vessel wall inflammation is present following stent retriever manipulation but absent following aspiration thrombectomy.[ncbi.nlm.nih.gov]
Fever
  • A 31-year-old Japanese woman suffered high fever and arthralgia lasting for 2 to 3 days after each menstrual period's start.[ncbi.nlm.nih.gov]
  • This is apparently the first successful case of surgical resection of G-CSF-producing lung cancer in a patient with severe anemia and uncontrollable fever.[ncbi.nlm.nih.gov]
  • BACKGROUND: Currently, it is not clear whether recurrent traumatic events lead to progression of rheumatic heart disease (RHD) after the incident of acute rheumatic fever or a persistent inflammatory state at the site of the valves.[ncbi.nlm.nih.gov]
  • In most instances they are attributable to prevertebral soft-tissue edema accompanied by inflammatory responses such as fever and an increase in the white blood cell count and in C-reactive protein.[ncbi.nlm.nih.gov]
  • If the rate of metabolism is higher due to a fever, more antibodies and cells of the immune system can be produced. Changes in the blood, such as an increased number of immune system cells.[ncbi.nlm.nih.gov]
Abdominal Mass
  • INTERVENTIONS: Both the orbital inflammation and abdominal mass infiltrating the mesentery were responsive to steroids and rituximab administered to treat IgG4-RD.[ncbi.nlm.nih.gov]
Dysphagia
  • CONCLUSIONS Severe dysphagia and odynophagia are post-ACDF complications.[ncbi.nlm.nih.gov]
Radiculopathy
  • OBJECTIVE Anterior cervical discectomy and fusion (ACDF) procedures are performed to treat patients with cervical myelopathy or radiculopathy. Dysphagia is a post-ACDF complication.[ncbi.nlm.nih.gov]

Workup

  • No orbital or systemic involvement was found on clinical examination, imaging, and laboratory workup. The serum IgG4 level was normal (87.1 mg/dL). The patient was free of recurrence at 6-month follow-up.[ncbi.nlm.nih.gov]
  • After extensive workup culminating in tissue sampling, she was found to have developed granulomatous inflammation surrounding microscopic embolization of hydrophilic polymer, which is used to coat many interventional devices such as wires and catheters[ncbi.nlm.nih.gov]
Myocardial Fibrosis
  • Postnatal cardiac MRI - using fast acquisition, free-breathing with feed-and-swaddle technique - was used to evaluate for myocardial fibrosis/inflammation.[ncbi.nlm.nih.gov]

Treatment

  • Thus, the PTA score has the potential as an objective criterion to identify patients with peritonsillar inflammation profiting from medical treatment.[ncbi.nlm.nih.gov]
  • While both clinical trials and standardized treatment guidelines are lacking in this domain, this case illustrates a potential role for TNF-α inhibitors in the treatment of inflammatory tracheitis, irrespective of the underlying etiology.[ncbi.nlm.nih.gov]
  • In contrast, apart from hypertension treatment, few therapeutic options exist in cerebral amyloid angiopathy.[ncbi.nlm.nih.gov]
  • We describe the clinical presentation of uveitis in three patients with concomitant systemic melanoma treatment.[ncbi.nlm.nih.gov]
  • Here, we report impact surveys conducted after that treatment. METHODS: We undertook population-based trachoma surveys in 18 evaluation units of the 8 treated districts, at least 6 months after the MDA.[ncbi.nlm.nih.gov]

Prognosis

  • Less than 1 % of all melanomas arise in the mucosal surfaces of the oral cavity, with purely in situ lesions being exceedingly rare tumors, but with a favorable prognosis compared with invasive lesions.[ncbi.nlm.nih.gov]
  • Hypoxia induces hypoxia-inducible factor and inducible nitric oxide synthase (iNOS), which increases the levels of intracellular RNS and ROS, resulting DNA damage in progression with poor prognosis.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The prognosis for extensive SAA is poor. Surgical interventions may improve radiologic findings and clinical presentation at least temporarily. Even extradural infection can lead to severe SAA.[ncbi.nlm.nih.gov]
  • Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J. Natl Cancer Inst. 86, 120–126 (1994). 29 Shacter, E. & Weitzman, S. A.[doi.org]
  • Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma. Free Radic Biol Med. 2012;52(8):1465–72. doi: 10.1016/j.freeradbiomed.2012.01.018.[doi.org]

Etiology

  • Regardless of the underlying etiology, tracheitis can, in its most severe form, be life-threatening, thus making its treatment an area of interest.[ncbi.nlm.nih.gov]
  • This review assesses the potential role of prenatal cytokine and complement elevations on the etiology of schizophrenia.[ncbi.nlm.nih.gov]
  • Therefore, the objective of the present study was to determine the antibacterial and anti-inflammatory activities of ES against P. acnes, the etiologic agent of skin inflammation.[ncbi.nlm.nih.gov]
  • The involvement of these lesions in the etiology of human diseases and aging was also investigated in the past several decades, suggesting that the oxidatively induced DNA adducts, especially bulky DNA lesions, may serve as biomarkers for exploring the[doi.org]
  • Future studies should concomitantly assess both muscle protein synthesis and muscle protein breakdown to delineate the exact temporal contribution each makes to the etiology of disuse atrophy.[doi.org]

Epidemiology

  • An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer.[ncbi.nlm.nih.gov]
  • However, the epidemiological evidence for the association of specific PM 2.5 sources with health outcomes is still limited.[ncbi.nlm.nih.gov]
  • Abstract In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child[ncbi.nlm.nih.gov]
  • Harvard Medical School, Boston, MA 02215, USA. 4 Center for Health and the Environment, University of California, Davis, Davis, CA 95616, USA. 5 Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA. 6 Department of Biostatistics, Epidemiology[ncbi.nlm.nih.gov]
  • Accumulating epidemiological evidence implicates thrombosis, as well as inflammation, as important factors in the development and causation of cerebral palsy.[dictionary.cambridge.org]
Sex distribution
Age distribution

Pathophysiology

  • Its precise pathophysiology remains uncertain and we currently have limited evidence on which immunosuppressive agents are the most effective in its treatment.[ncbi.nlm.nih.gov]
  • Abstract Vitamin D is known to have immunomodulatory effects, is involved in osteo-cartilaginous metabolism, and may have a role in human intervertebral disc pathophysiology.[ncbi.nlm.nih.gov]
  • Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ...[doi.org]
  • Inflammation is a biological process of central importance for biomedical research and is now believed to be a key underlying factor for the pathophysiology of a wide range of diseases, from “classical” inflammatory conditions (e.g.[olink.com]
  • Inflammatory mediators can also induce clinical depression, bolstering support for inflammation’s role in depression’s pathophysiology.[doi.org]

Prevention

  • Although antiretroviral therapy for HIV infection prevents AIDS-related complications and prolongs life, it does not fully restore health.[ncbi.nlm.nih.gov]
  • However, it is possible that intermittent colchicine therapy only during FMF attacks prevents the attacks completely in patients with FMF with expectable attacks.[ncbi.nlm.nih.gov]
  • Inhibition of mTORC2 either by silencing Rictor expression or inhibiting its association with mTOR notably prevents LPS induced Akt activation, scavenger receptors expression, and macrophage lipid accumulation.[ncbi.nlm.nih.gov]
  • High perivascular FAI values (cutoff -70·1 HU) are an indicator of increased cardiac mortality and, therefore, could guide early targeted primary prevention and intensive secondary prevention in patients.[ncbi.nlm.nih.gov]
  • Antibodies against NET-remodeled laminin prevented awakening of dormant cells. Therapies aimed at preventing dormant cell awakening could potentially prolong the survival of cancer patients.[ncbi.nlm.nih.gov]

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