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Influenza Virus


Presentation

  • Laboratory evidence of influenza A(H1N1) virus infection was present. Two children died as a result of their illness. The association of virus and gastrointestinal haemorrhage is explored.[ncbi.nlm.nih.gov]
  • With the benefit of hindsight, he presented with symptoms of SCLS 2 years prior the major acute episode.[ncbi.nlm.nih.gov]
  • The age distribution seen in the present study is compatible with the results of these serological studies.[doi.org]
  • Our previous studies have demonstrated that some individuals possess antibody responses that are narrowly focused on epitopes that were present in viral strains that they encountered during childhood.[ncbi.nlm.nih.gov]
  • We report a 4-year-old boy with hyperprolinaemia type II presenting acute encephalopathy associated with influenza virus type A infection. This case suggests that hyperprolinaemia may cause acute encephalopathy under certain conditions.[ncbi.nlm.nih.gov]
Hypoxemia
  • The illness was acute, with rapid onset, high fever, nonproductive cough, dyspnea, cyanosis, crepitations and rales over both lung bases, and associated arterial hypoxemia, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov]
  • The infection was characterized by respiratory symptoms, fever, rapid progression, and significant hypoxemia.[ncbi.nlm.nih.gov]
Limited Mobility
  • In contrast, the viruses in cyto-D-treated cells show much more limited mobility ( Fig. 3 a ). These results suggest that stage I movement is an actin-dependent active transport.[doi.org]
Tachypnea
  • The first woman had the symptoms of fever, cough, dyspnea and tachypnea lasting for four days. The second woman refused to take oseltamivir treatment.[ncbi.nlm.nih.gov]
Severe Clinical Course
  • The pathologic change induced by the direct viral invasion cannot be responsible for all of the symptoms, especially for the rapid and severe clinical course of the disease within 24-48 h after the initial respiratory symptoms.[ncbi.nlm.nih.gov]
  • Infection due to pandemic virus with the H275Y mutation can be associated with a severe clinical course, supporting the systematic monitoring of antiviral susceptibility in pandemic influenza-positive high-risk patients whose influenza is not resolved[ncbi.nlm.nih.gov]
Myopathy
  • It is postulated that the pathogenesis of Reye's syndrome may be related to the other influenzal eipiphenomena including influenzal pneumonia in previously healthy persons and influenza-associated myopathy, both of which, like Reye's syndrome, become[ncbi.nlm.nih.gov]
Muscle Weakness
  • All six cases suffered from myalgia or muscle weakness especially in the lower extremities and the serum creatine kinase (CK) values were elevated above 1,000 IU/l without MB isoenzymes or electrocardiogram abnormalities.[ncbi.nlm.nih.gov]
Myelopathy
  • To investigate the etiologic agent involved in myelopathy post influenza-like syndrome.[ncbi.nlm.nih.gov]
Excitement
  • DiD-labeled viruses were excited with a 633-nm helium–neon laser (Melles-Griot), whereas Cy3/Cypher5-labeled viruses were simultaneously excited with a 532-nm diode-pumped Nd:YAG laser (CrystaLaser, Reno, NV) and the helium–neon laser.[doi.org]

Workup

Pericardial Effusion
  • Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated.[ncbi.nlm.nih.gov]
  • Abstract We report, to our knowledge, the first successful treatment of novel Influenza A (H1N1)/2009 chronic pericardial effusion in an adult.[ncbi.nlm.nih.gov]
Atelectasis
  • These 3 children shared common clinical and radiologic features: rapid and progressive respiratory distress with whole lung atelectasis on chest radiograph.[ncbi.nlm.nih.gov]
  • Persistent radiographic abnormalities included peribronchial thickening, interstitial densities, bronchiectasis, obliterative bronchiolitis, and segmental atelectasis.[ncbi.nlm.nih.gov]
Penicillium
  • About this article Publication history Published 04 February 2009 DOI Further reading Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743 Manabu Yamasaki, Masayuki Igarashi, Ryuichi Sawa, Chisato[doi.org]
Brain Edema
  • The mild hypothermia suppressed the brain edema on computed tomography (CT) scanning and protected the brain from the subsequent irreversible neural cell damage.[ncbi.nlm.nih.gov]
  • Together with the rapid production of several inflammatory cytokines, the breakdown of the blood-brain barrier may induce severe brain edema and can be a major pathologic change for the disease.[ncbi.nlm.nih.gov]
Diffuse Encephalopathy
  • Focal reversible encephalopathy has rarely been reported in association with influenza virus infection, although it often provokes diffuse encephalopathies, with a poor prognosis.[ncbi.nlm.nih.gov]

Treatment

  • The use of hemodynamic support by extracorporeal membrane oxygenation emerges as a promising treatment.[ncbi.nlm.nih.gov]
  • Oseltamivir is considered the drug of choice for patients with pandemic influenza for whom drug treatment is recommended because adamantanes seem to be ineffective against pandemic A/H1N1 influenza virus and zanamivir is contraindicated in people with[ncbi.nlm.nih.gov]
  • The child had the 275Y mutation detected after being persistently A/H1N1 09 RT-PCR positive while receiving oseltamivir treatment. Resistance was not detected in 17 pre-treatment samples and 54 A/H1N1 09 RT-PCR positive outpatients.[ncbi.nlm.nih.gov]
  • Abstract We report, to our knowledge, the first successful treatment of novel Influenza A (H1N1)/2009 chronic pericardial effusion in an adult.[ncbi.nlm.nih.gov]
  • Early admission, prompt diagnosis and early recourse to antiviral treatment gives better results in H1N1 infected pregnant women (Fig. 2, Ref. 10).[ncbi.nlm.nih.gov]

Prognosis

  • Focal reversible encephalopathy has rarely been reported in association with influenza virus infection, although it often provokes diffuse encephalopathies, with a poor prognosis.[ncbi.nlm.nih.gov]
  • It also discusses aspects relevant to the treatment and prognosis of fulminant myocarditis. The patient was a female, 4 years and 8 months old, previously healthy and with a history of flu symptoms in the past two weeks.[ncbi.nlm.nih.gov]
  • Li Deng, Peng Pang, Ke Zheng, Jiao Nie, Huachong Xu, Sizhi Wu, Jia Chen and Xiaoyin Chen, Forsythoside A Controls Influenza A Virus Infection and Improves the Prognosis by Inhibiting Virus Replication in Mice, Molecules, 10.3390/molecules21050524, 21,[doi.org]

Etiology

  • The H1N1 influenza virus is an etiological agent associated with acute myocarditis, but there are few reported cases of fulminant myocarditis caused by the H1N1 virus.[ncbi.nlm.nih.gov]
  • Any other etiologies were discarded. Recidivating pericardial effusion after medical treatment, firstly with Oseltamivir, and afterwards, with colchicine and corticosteroids during six months, was solved with pericardiectomy.[ncbi.nlm.nih.gov]
  • To investigate the etiologic agent involved in myelopathy post influenza-like syndrome.[ncbi.nlm.nih.gov]
  • The etiology of this disorder has not been clarified due to its low incidence. We describe two patients with PPCM and elevated antibody titers to influenza virus in paired sera that were recovered by high doses of intravenous immune globulin.[ncbi.nlm.nih.gov]
  • Influenza viruses are the etiological agents of influenza. Although vaccines and drugs are available for the prophylaxis and treatment of influenza virus infections, the generation of escape mutants has been reported.[ncbi.nlm.nih.gov]

Epidemiology

  • Petersburg, Russia. 7 Pasteur Institute of Epidemiology and Microbiology, 14 Mira str, 197101, St. Petersburg, Russia. zarubaev@gmail.com. 8 School of Pharmacy, University of Nottingham, Malaysia Campus, 43500, Semenyih, Malaysia.[ncbi.nlm.nih.gov]
  • These laboratory data supported the epidemiologic findings that this human infection occurred by transmission of an enzootic swine influenza virus and that the virus showed no major genetic changes potentially related to increased pathogenesis.[ncbi.nlm.nih.gov]
  • Here, we primarily discuss the pathogenesis of influenza virus type A, its epidemiology, pandemic potential, current status of antiviral drugs and vaccines, and ways to effectively manage the disease during a crisis.[ncbi.nlm.nih.gov]
  • Even though co-infection with both influenza A and B viruses appears to be a rare event, it occurs naturally and may play a role in epidemiology and pathogenicity.[ncbi.nlm.nih.gov]
  • In this study, epidemiologic, clinical, and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • To establish a treatment strategy for acute encephalopathy and encephalitis associated with influenza virus infection, the pathophysiology of the disease was investigated through manifestations and laboratory findings of patients.[ncbi.nlm.nih.gov]
  • Minodier L, Charrel RN, Ceccaldi PE, van der Werf S, Blanchon T, Hanslik T, Falchi A (2015) Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what[doi.org]

Prevention

  • Author information 1 Changsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, China. 2 Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, China. 3 Changsha Center for Disease Control and Prevention, Changsha[ncbi.nlm.nih.gov]
  • Author information 1 College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. zhoupei@scau.edu.cn. 2 Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou 510642[ncbi.nlm.nih.gov]
  • Our case suggests that oseltamivir administration for influenza infection should be continued, at least until successful engraftment, to prevent virus reactivation.[ncbi.nlm.nih.gov]
  • Author information 1 Animal Infectious Disease Laboratory, School of Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China. 2 Jiangsu Co-innovation Center for Prevention and Control[ncbi.nlm.nih.gov]
  • Therefore, to prevent the H7N9 virus from causing further damage, developing a safe and effective vaccine is necessary.[ncbi.nlm.nih.gov]

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