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Influenza Virus Vaccine
Vaccine Influenza

Presentation

[…] between physical activity and the initial immune response to a specific antigenic challenge in the present sample of older adults. [ncbi.nlm.nih.gov]

Entire Body System

  • Fever

    Fever rates were numerically higher, but not statistically different, with IIV4 versus comparator IIV4. No new safety signals were reported. [ncbi.nlm.nih.gov]

    Aspirin also reduces fever. Rectal aspirin is used to reduce pain, inflammation, and fever. Aspirin is also used to treat the symptoms of arthritis and rheumatic fever. doxycycline (Vibramycin) Doxycycline is a tetracycline antibiotic. [emedicinehealth.com]

    If you have a severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine. [uwhealth.org]

  • Weakness

    […] analysis were days of work missed, days working but at reduced effectiveness, and days with a health care provider visit due to at least one of the following symptoms: fever, runny nose, sore throat, cough, headache, muscle aches, chills, or tiredness/weakness [ncbi.nlm.nih.gov]

    […] vaccine is safe for you, tell your doctor if you have ever had: a bleeding or blood clotting disorder such as hemophilia or easy bruising; a neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine); seizures; a weak [everydayhealth.com]

    Tell your doctor if you have ever had: bleeding problems; a neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine); seizures; a weak immune system caused by disease, bone marrow transplant, or by using certain [uwhealth.org]

  • Fatigue

    […] worldwide, from the "Spanish Flu" outbreak in the early 20th century, to the first "Avian Flu" outbreak in 2003, to the first "Swine Flu" outbreak in 2009. 1,2 The symptoms of influenza virus infection can vary and may include fever, cough, general fatigue [clinicaladvisor.com]

    In clinical trials, the most common adverse events in adults were headache, fatigue, injection site reaction (pain, mass, redness, and induration), and malaise. References: FLUVIRIN (package insert). Holly Springs, NC. Seqirus, Inc: 2016. [flu.seqirus.com]

    This can include systemic symptoms such as fever, headache or fatigue, which may mistakenly be assumed to be early signs of influenza but are the body responding to the vaccination. [influenza.org.nz]

    Side Effects Adverse events associated with the use of Flucelvax may include, but are mot limited to, the following: injection site pain injection site erythema headache fatigue myalgia malaise Mechanism of Action Flucelvax is an inactivated cell-culture-derived [centerwatch.com]

    It is usually associated with symptoms such as fever, chills, cough, runny or stuffy nose, sore throat, nasal congestion, watering and reddened eyes, head ache, body aches, petechial rash, and fatigue. [clinicaltrialsarena.com]

  • Asymptomatic

    On Friday, Chinese scientists reported in the medical journal JAMA an apparent case of asymptomatic spread of the virus, from a patient with a normal chest CT scan. [theatlantic.com]

    Influenza infection can vary from mild or even asymptomatic illness to severe community-acquired pneumonia (CAP). [network.bepress.com]

    […] information is available on the use of live attenuated influenza vaccine in HIV-infected people, but what is available suggests that this vaccine is safe in adults who are in the CDC class A1-2, and in children who are in the CDC class N1-2 or A1-2, i.e. asymptomatic [influenzareport.com]

  • Military Personnel

    However, frontline workers such as healthcare personnel, as well as police forces and military personnel, might be high priority targets. [influenzareport.com]

Respiratoric

  • Cough

    It is contagious and can spread from person to person by droplets of respiratory fluids released into the air from coughing, sneezing or talking. [clinicaltrialsarena.com]

    Text Size: Find the Information You Need to Make an Informed Vaccine Decision Influenza: The Disease Influenza is a viral infection that produces fever, chills, sore throat, muscle aches, and cough that lasts a week or more. [nvic.org]

    Influenza usually comes on suddenly and may include these symptoms: fever, headache, malaise (a feeling of being ill and without energy that can be extreme), cough, sore throat, nasal congestion and body aches. [fda.gov]

    The flu can spread when: Someone with the flu coughs, sneezes, or talks — and droplets from their mouth or nose get into the mouths or noses of people nearby Someone touches a surface that has flu virus on it and then touches their mouth, nose, or eyes [vaccines.gov]

  • Nasal Congestion

    Influenza usually comes on suddenly and may include these symptoms: fever, headache, malaise (a feeling of being ill and without energy that can be extreme), cough, sore throat, nasal congestion and body aches. [fda.gov]

    The infection is associated with symptoms such as fever, chills, cough, runny or stuffy nose, sore throat, nasal congestion, watering and reddened eyes, head ache and body aches. [clinicaltrialsarena.com]

    The incidence of rhinorrhea or nasal congestion, fever, and decreased activity after the first dose of vaccine or placebo is summarized in Table 2. [nejm.org]

  • Rhinitis

    (Bell's palsy), optic neuritis/neuropathy, brachial neuritis, syncope (shortly after vaccination), dizziness, paresthesia Vascular Disorders: Vasculitis, vasodilatation/flushing Respiratory, Thoracic and Mediastinal Disorders: Dyspnea, pharyngitis, rhinitis [rxlist.com]

    […] and last 1 to 2 days; incidence generally equal to placebo in adults; occurs more frequently than placebo in children) Respiratory: Bronchitis, cough, dyspnea, nasal congestion, nasopharyngitis, oropharyngeal pain, pharyngitis, pharyngolaryngeal pain, rhinitis [drugs.com]

    […] headache / Early / 1.0-24.7 fatigue / Early / 1.0-20.0 fever / Early / 0-16.0 ecchymosis / Delayed / 0.5-15.2 arthralgia / Delayed / 0.3-15.0 vomiting / Early / 1.4-14.8 shivering / Rapid / 2.6-12.1 nausea / Early / 0.4-12.0 diaphoresis / Early / 1.0-10.0 rhinitis [pdr.net]

  • Rhinorrhea

    The incidence of rhinorrhea or nasal congestion, fever, and decreased activity after the first dose of vaccine or placebo is summarized in Table 2. [nejm.org]

    […] to 2 days; incidence generally equal to placebo in adults; occurs more frequently than placebo in children) Respiratory: Bronchitis, cough, dyspnea, nasal congestion, nasopharyngitis, oropharyngeal pain, pharyngitis, pharyngolaryngeal pain, rhinitis, rhinorrhea [drugs.com]

    […] fever / Early / 0-16.0 ecchymosis / Delayed / 0.5-15.2 arthralgia / Delayed / 0.3-15.0 vomiting / Early / 1.4-14.8 shivering / Rapid / 2.6-12.1 nausea / Early / 0.4-12.0 diaphoresis / Early / 1.0-10.0 rhinitis / Early / 1.0-10.0 chills / Rapid / 2.0-7.3 rhinorrhea [pdr.net]

  • Dyspnea

    Pulmonary Histoplasmosis In A Patient With Cough, Dyspnea, Pulmonary Nodule And Rheumatologic Manifestations: Case Report And Review, Johnson Britto 2018 St. [network.bepress.com]

    […] myelitis), facial palsy (Bell's palsy), optic neuritis/neuropathy, brachial neuritis, syncope (shortly after vaccination), dizziness, paresthesia Vascular Disorders: Vasculitis, vasodilatation/flushing Respiratory, Thoracic and Mediastinal Disorders: Dyspnea [rxlist.com]

    […] injection site) Neuromuscular & skeletal: Arthralgia, back pain, myalgia (may start within 6 to 12 hours and last 1 to 2 days; incidence generally equal to placebo in adults; occurs more frequently than placebo in children) Respiratory: Bronchitis, cough, dyspnea [drugs.com]

    1.0 wheezing / Rapid / 1.0-1.0 neuropathic pain / Delayed / Incidence not known dysphonia / Delayed / Incidence not known encephalopathy / Delayed / Incidence not known confusion / Early / Incidence not known dysphagia / Delayed / Incidence not known dyspnea [pdr.net]

Gastrointestinal

  • Vomiting

    But influenza is usually associated with more severe illness and lasts longer than the common cold and, normally, influenza does not cause vomiting or diarrhea in adults. [nvic.org]

    The infection may also cause vomiting, diarrhoea, and abdominal pain in children. [clinicaltrialsarena.com]

    However, vomiting was reported in more children in the vaccine group than in the placebo group at some time on days 1 through 10 after the first dose (unadjusted P = 0.03). [nejm.org]

    Meclizine is used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness. [emedicinehealth.com]

  • Diarrhea

    But influenza is usually associated with more severe illness and lasts longer than the common cold and, normally, influenza does not cause vomiting or diarrhea in adults. [nvic.org]

    Common symptoms of the flu include: Fever and chills Cough Sore throat Runny or stuffy nose Muscle or body aches Headache Feeling very tired Some people with the flu may throw up or have diarrhea (watery poop) — this is more common in children than adults [vaccines.gov]

    People with the stomach flu — which is commonly caused by a virus called norovirus — have diarrhea, cramping and other gastrointestinal symptoms. Influenza does not cause such symptoms. Pass it on: Myths still exist regarding the flu vaccine. [livescience.com]

    • Patient may experience injection site pain or irritation, muscle pain, joint pain, loss of strength and energy, nausea (children), vomiting (children), diarrhea (children), lack of appetite (children), abdominal pain (children), fatigue (children), [drugs.com]

    All vaccines can be administered to persons with minor illnesses such as diarrhea, mild upper-respiratory infection with or without low-grade fever, or other low-grade febrile illness. [pdr.net]

  • Nausea

    Systemic adverse reactions such as myalgia (muscle ache), headache, malaise, nausea, chills, vomiting and fever were also seen. [clinicaltrialsarena.com]

    Meclizine is used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness. [emedicinehealth.com]

    • Patient may experience injection site pain or irritation, muscle pain, joint pain, loss of strength and energy, nausea (children), vomiting (children), diarrhea (children), lack of appetite (children), abdominal pain (children), fatigue (children), [drugs.com]

    […] syndrome General Disorders and Administration Site Conditions: Pruritus, asthenia/fatigue, pain in extremities, chest pain Gastrointestinal Disorders: Vomiting Other Events Reported During Post-Approval Use of Fluzone High-Dose Gastrointestinal Disorders: Nausea [rxlist.com]

  • Abdominal Pain

    The infection may also cause vomiting, diarrhoea, and abdominal pain in children. [clinicaltrialsarena.com]

    Evaluation of 59 COSTART codes identified abdominal pain as being significantly associated with the first dose of vaccine (occurring in 19 children), as compared with the first dose of placebo (1 child). [nejm.org]

    • Patient may experience injection site pain or irritation, muscle pain, joint pain, loss of strength and energy, nausea (children), vomiting (children), diarrhea (children), lack of appetite (children), abdominal pain (children), fatigue (children), [drugs.com]

    / Delayed / 1.5-1.5 abdominal pain / Early / 1.4-1.4 dysmenorrhea / Delayed / 1.3-1.3 cough / Delayed / 1.0 infection / Delayed / 1.0 pharyngitis / Delayed / 1.0 throat irritation / Early / Incidence not known urticaria / Rapid / Incidence not known [pdr.net]

Cardiovascular

  • Heart Disease

    Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. simvastatin (Zocor) Simvastatin is a cholesterol-lowering medication that blocks the production [emedicinehealth.com]

    Chronic heart disease Congenital heart disease. Hypertension with cardiac complications. Chronic heart failure. Individuals requiring regular medication and/or follow-up for coronary heart disease. Kidney disease Chronic kidney disease. [patient.info]

    Vaccination has been associated with lower rates of some cardiac events among people with heart disease, especially among those who had had a cardiac event in the past year. [cdc.gov]

  • Hypertension

    Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). It is also used to treat or prevent heart attack. acetaminophen oral/rectal (Tylenol) Acetaminophen is a pain reliever and a fever reducer. [emedicinehealth.com]

    Hypertension with cardiac complications. Chronic heart failure. Individuals requiring regular medication and/or follow-up for coronary heart disease. Kidney disease Chronic kidney disease. Nephrotic syndrome. Renal transplantation. [patient.info]

    […] therefore, may be at risk for developing Reye syndrome after influenza • Women who are or will be pregnant during the influenza season • Patients with chronic pulmonary disorders (including asthma) or cardiovascular systems disorders (except isolated hypertension [drugs.com]

  • Heart Failure

    A severe viral infection may lead to complications such as bacterial pneumonia, ear infections, dehydration, and chronic conditions such as congestive heart failure, asthma, and diabetes. [clinicaltrialsarena.com]

    It can also cause serious complications like: Pneumonia (lung infection) Worsening of long-term health problems, like asthma or heart failure Inflammation of the brain or heart Sepsis, a life-threatening inflammatory condition The flu is contagious, meaning [vaccines.gov]

    Chronic heart disease Congenital heart disease. Hypertension with cardiac complications. Chronic heart failure. Individuals requiring regular medication and/or follow-up for coronary heart disease. Kidney disease Chronic kidney disease. [patient.info]

Neurologic

  • Guillain-Barré Syndrome

    If Guillain-Barré syndrome has occurred within 6 weeks of receipt of prior influenza vaccine, the decision to give FLUVIRIN should be based on careful consideration of the potential benefits and risks. [flu.seqirus.com]

    The Guillain-Barré syndrome and the 1992-1993 and 1993-1994 influenza vaccines. N Engl J Med 1998;339:1797-802. 2.Baxter, R, et al. Lack of Association of Guillain-Barré Syndrome with Vaccinations. Clin Infect Dis 2013;57(2):197-204. [rxlist.com]

    It is not known whether the flu shot can increase the risk for recurrence of Guillain-Barré syndrome (GBS) in people with a history of the disease. [healthlinkbc.ca]

    […] using cultured animal cells instead of fertilized chicken eggs. 6 Common side effects with vaccination against influenza infection include fever, fatigue, headache, and joint pain, which usually resolve within a week; though cases are much more rare, Guillain-Barré [clinicaladvisor.com]

  • Confusion

    Symptoms of Reye's syndrome include drowsiness, confusion, seizures, coma. In severe cases, Reye's syndrome can result in death. [webmd.com]

    These illnesses should not be confused with influenza. How effective are the vaccines against influenza strains not included in the formulation? Effectiveness can be reduced by a difference between circulating virus strains and vaccine strains. [influenza.org.nz]

    Incidence not known Moderate erythema / Early / 1.0-76.4 migraine / Early / 1.0-1.0 wheezing / Rapid / 1.0-1.0 neuropathic pain / Delayed / Incidence not known dysphonia / Delayed / Incidence not known encephalopathy / Delayed / Incidence not known confusion [pdr.net]

  • Stroke

    Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. meclizine (Antivert, Bonine, Dramamine II, D-Vert) Meclizine is an antihistamine that reduces [emedicinehealth.com]

    There is also evidence to suggest that the flu vaccine can reduce your risk of having a stroke. Over time, protection from the injected flu vaccine gradually decreases and flu strains often change. [nhs.uk]

    Chronic neurological disease Stroke. Transient ischaemic attack (TIA). Diabetes Type 1 diabetes. Type 2 diabetes requiring insulin or oral hypoglycaemic drugs. Diet-controlled diabetes. Immunosuppression Immunosupression due to disease or treatment. [patient.info]

    In observational studies, immunization has been shown to reduce the number of physician visits, hospitalizations and deaths in high-risk persons 18 to 64 years of age Footnote 105, hospitalizations for cardiac disease and stroke in the elderly Footnote [canada.ca]

Workup

Microbiology

  • Human Herpesvirus 3

    herpesvirus 3 ( varicella-zoster virus ) administered subcutaneously for production of immunity to varicella and herpes zoster. yellow fever vaccine a preparation of attenuated yellow fever virus, used to immunize against yellow fever. influenza virus [medical-dictionary.thefreedictionary.com]

  • Bordetella Pertussis

    […] vaccine a preparation of killed Bordetella pertussis bacilli (whole-cell vaccine) or of purified antigenic components thereof (acellular vaccine), used to immunize against pertussis ; generally used in combination with diphtheria and tetanus toxoids [medical-dictionary.thefreedictionary.com]

Treatment

The medium of the 23-valent pneumococcal polysaccharide vaccine treatment group had a higher antimicrobial activity than the medium of the Haemophilus influenzae type b vaccine treatment group. [ncbi.nlm.nih.gov]

Suitable inactivation of the virus preparations with retention of full red cell agglutinating activity and immunizing potency in mice was achieved by treatment with minimal amounts of formaldehyde or ultraviolet light. [rupress.org]

A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. [webmd.com]

Prognosis

With so little data, prognosis is difficult. [theatlantic.com]

Etiology

Ramirez The University of Louisville Journal of Respiratory Infections Abstract Background: Transmissibility of several etiologies of lower respiratory tract infections (LRTI) may vary based on outdoor climate factors. [network.bepress.com]

Disease-related concerns: • Acute illness: The decision to administer or delay vaccination because of current or recent febrile illness depends on the severity of symptoms and the etiology of the disease. [drugs.com]

Fever, respiratory infection The decision to administer or to delay vaccination with the influenza virus vaccine because of current or recent febrile illness depends on the severity of symptoms and on the etiology of the disease. [pdr.net]

Epidemiology

Abstract As outlined in other chapters, the influenza virus, existing laboratory diagnostic abilities, and disease epidemiology have several peculiarities that impact on the timing and processes for the annual production of influenza vaccines. [ncbi.nlm.nih.gov]

3, January 2019 Publication Influenza virus characterisation, Summary Europe, December 2018 Data Weekly influenza update, week 2, January 2019 Publication Communicable disease threats report, 13-19 January 2019, week 3 Event ISIRV and ECDC influenza epidemiology [ecdc.europa.eu]

During this meeting, the advisory committee reviewed and evaluated the surveillance data related to epidemiology and antigenic characteristics of recent influenza isolates, serological responses to 2016-2017 vaccines, and the availability of candidate [fda.gov]

Network: ECDC European Antibiotic Awareness Day ESCAIDE - Scientific conference Eurosurveillance journal LOGIN CONTACT SUPPORT Europe's journal on infectious disease surveillance, epidemiology, prevention and control Home Current Archives Eurosurveillance [eurosurveillance.org]

Pathophysiology

Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. [annualreviews.org]

Prevention

S-IgA antibodies are highly effective at preventing virus infection. [ncbi.nlm.nih.gov]

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