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Infratentorial Tumor

Infratentorial Neoplasms


Presentation

  • Few reports have presented adequate hematologic data. Reëmphasis of the diagnostic problem presented by patients with polycythemia and papilledema appeared justified.[annals.org]
  • Presentation: The most common presentation of posterior fossa tumors in children is symptomatic elevated ICP secondary to obstructive hydrocephalus . Focal signs are less common.[ispn.guide]
  • Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer.[books.google.es]
  • Of 117 children with cerebellar-fourth ventricle tumors, 110 had hydrocephalus, whereas 11 of 34 with brain-stem tumors and all 21 with pineal tumors presented with hydrocephalus.[ncbi.nlm.nih.gov]
  • Better understand how problems present differently in infants, children, and adolescents with age-specific diagnoses.[books.google.com]
Hypertension
  • Patients with heart failure, pulmonary edema, electrolyte imbalance, chronic hypertension, coronary heart disease, and diabetes often have renal dysfunction without clinical manifestations.[trialsjournal.biomedcentral.com]
  • "Benign" intracranial hypertension. A survey of the clinical and radiological features, and long-term prognosis. Brain . 1974 Jun. 97(2):313-26. [Medline] . Chatrian GE, Shaw CM, Leffman H.[emedicine.medscape.com]
Cutaneous Manifestation
  • Manifestations of Cancer 2349 Colon Cancer 240 2352 Approach to the Patient with Paraneoplastic Neurologic Disease 2359 Gastrointestinal Cancers 664 2376 HepaticoBiliary System 713 2381 Summary 668 2384 Diagnosis 1237 2389 Treatment 2396 HOWLEY DON GANEM[books.google.es]
Nystagmus
  • The preoperative physical examinations showed dizziness and nystagmus on the bilateral lateral gaze.[e-arm.org]
  • Blurred vision, diplopia, and nystagmus also are associated with infratentorial tumors.[obgynkey.com]
  • […] by papilledema) - Change in personality or behavior Infratentorial Signs and Symptoms These signs and symptoms include: - Facial pain and weakness - Ataxia - Dysphagia: DECREASED GAG REFLEX - Hoarseness - Drooling - Hearing Loss (Acoustic Neuroma) - Nystagmus[quizlet.com]
  • Optic nerve or chiasmal defect: visual deficits, Marcus Gunn pupil (afferent pupillary defect), bitemporal hemianopsia (classic chiasmal tumor), unilateral or bilateral nystagmus with head tilt (chiasmal).[hawaii.edu]
  • Clinical signs and symptoms may include ataxia, nystagmus, spasticity long tract signs, headache, nausea, vomiting, papilledema, diplopia, spasticity, and weakness, etc.)[icd10data.com]
Vertigo
  • Focal symptoms reflect the intracranial location of the tumor and include seizures, hemiparesis, diplopia, aphasia, vertigo, incoordination, sensory abnormalities, and dysphagia ( Table 3-2 ).[clinicalgate.com]
  • […] benign tumor from cranial nerve 8 (s/t: 5,7,9,10) - These compress the brain tissue - Surgery is difficult and can cause permanent brain damage Acoustic Neuroma Signs and Symptoms These signs and symptoms include: - Hearing loss, tinnitus, dizziness, vertigo[quizlet.com]
  • Posterior fossa ependymoma presents in younger children and frequently includes symptoms and signs of increased intracranial pressure, such as headache, fatigue, diplopia, papilledema, nausea, vomiting, ataxia, vertigo, head tilt, or neck pain.[clinicaladvisor.com]
  • Characteristics Arises from cells that form a protective sheath around nerve fibers Typically grows around the eighth cranial nerve, but can be found around other cranial or spinal nerves Symptoms Hearing loss in one ear Dizziness or vertigo Tinnitus[braintumor.org]
  • It is quite rare that it actually produces vertigo because the slow growth permits ample time for compensation. These tumors are resectable, though larger tumors may leave residual deficit.[dartmouth.edu]
Hyperreflexia
  • He was found to have bilateral gaze-evoked nystagmus (with a rotatory component), and a right sixth nerve palsy with hyperreflexia and hyperesthesia on the left side of the body.[file.scirp.org]
  • ., hemiparesis, hyperreflexia, clonus). Supratentorial tumors are more commonly associated with focal disorders such as motor weaknesses, sensory changes, speech disorders, seizures, and reflex abnormalities.[obgynkey.com]
  • They may develop macrocephaly, hyperreflexia and cranial nerve palsies. Children with an intracranial tumour and neurofibromatosis: Reduced visual acuity, exophthalmia and optic atrophy.[patient.info]
  • Upper motor neuron signs: hemiparesis, hyperreflexia, clonus and sensory losses. Frontal or parietal-occipital, third ventricle: may have no focal deficits (present with increased ICP).[hawaii.edu]
Trigeminal Neuralgia
  • In other cases, compression of the ophthalmic division of the trigeminal nerve or involvement of the nerve by tumor results in the typical pain of trigeminal neuralgia.[clinicalgate.com]

Workup

  • 1859 Infectious Agents and Cancer 549 1860 Cancer of the Skin 1863 Melanoma 1889 Diagnostic Studies and Pretreatment Staging 1001 1908 Principles of Isolation Perfusion 701 1923 Intraocular Melanomas 1951 Invasion and Metastasis 117 1952 Metastatic WorkUp[books.google.es]
  • Despite being preventable and curable, this disease is still a diagnostic challenge using conventional workup.[file.scirp.org]
  • Any adult who has a recent onset of seizures, particularly focal seizures, is considered a tumor suspect until adequate neurologic workup proves otherwise. Specific Tumor Types There are many types of tumors that develop intracranially.[dartmouth.edu]

Treatment

  • Treatment Efficacy and Follow-Up All patients experienced good response in the early course of ATT treatment. Paradoxical responses were seen in 2 patients. The No 1 patient experienced worsen Figure 1 . MRI changes before and after treatment.[file.scirp.org]
  • Careful selection of layouts should enable an effective treatment of multi-focal disease with tumors located in both supratentorial and infratentorial regions simultaneously. The Author(s) 2017.[academic.oup.com]
  • Classification Histopathology and Molecular Genetics 1703 Cholangiocarcinomas 1157 1712 Natural History and Patterns of Failure 1000 1713 Emerging Therapeutic Options 1718 Incidence 1186 1720 Clinical Presentation 1001 1723 Anatomy of the Colon 1236 1724 Treatment[books.google.es]
  • Brem S, Panattil JG (2005) An era of rapid advancement: diagnosis and treatment of metastatic brain cancer. Neurosurgery 57 [suppl 5]: S5–S9; discussion S1–S4 Google Scholar 22.[link.springer.com]
  • The book is well-organized and clearly structured according to each entity and its neurosurgical treatment options.[books.google.es]

Prognosis

  • This volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs.[books.google.es]
  • Infratentorial GBM presents with limited surgical treatment options and a poorer prognosis. Computational studies have shown a strong connection between the array layout and the field distribution within the supratentorial region.[academic.oup.com]
  • EZH2 was recently suggested as the marker of a poor prognosis in children with infratentorial ependymoma.[journals.plos.org]
  • Prognosis” refers to the probable course and outcome of the disease. Physicians reference one or more clinical studies to obtain their prognosis statistics.[cern-foundation.org]
  • On the whole, the long term prognosis is better in children than adults. Incidence The incidence of pediatric brain tumors is roughly 3.3 cases per 100,000 children in North America.[pedsoncologyeducation.com]

Etiology

  • […] anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology[ncbi.nlm.nih.gov]
  • The possibilities exists that mycobacteria infection might act as a potential contributing or pathogenetic factor in some certain CNS diseases because of their unknown etiologies.[file.scirp.org]
  • Izbicki T, Mazur J, Izbicka E (2003) Epidemiology and etiology of neuroblastoma: an overview. Anticancer Res 23: 755–760 PubMed Google Scholar 43. Kushner BH (2004) Neuroblastoma: a disease requiring a multitude of imaging studies.[link.springer.com]
  • As with most tumors, the etiology of PBT is unknown. Mueller and Gurney have suggested that their etiology may be multi-factorial and includes both genetic and environmental factors (Mueller & Gurney 2005 ).[springerplus.springeropen.com]
  • Classification, epidemiology, and etiology of brain tumors. Samuels MA, Feske S, eds. Office Practice of Neurology . 2nd ed. Philadelphia, Pa: Churchill Livingstone; 2003. 1006-13. Van der Drift JHA, Magnus O. EEG and cerebral tumor.[emedicine.medscape.com]

Epidemiology

  • […] options Subheadings: analysis anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology[ncbi.nlm.nih.gov]
  • Incidence patterns for ependymoma: a surveillance, epidemiology, and end results study. J Neurosurg 2009;110(4):725–9. [ CrossRef ] [ Pubmed ] Louis DN, Ohgaki H, Wiestler OD, et al.[ijcasereportsandimages.com]
  • Carcinoma of the Vulva 1528 Cancer of the Uterine Body 1543 Chemoprevention 609 1545 Uterine Sarcomas 1557 Gestational Trophoblastic Diseases 1564 Colon Cancer 1232 1574 Epothilones 455 1586 Genetic Predisposition 1390 1595 Epidemiology 1232 1604 Malignant[books.google.es]
  • Epidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center. IJBC. 2011; 4 (1) :19-23 URL:[ijbc.ir]
  • Epidemiology of primary brain tumors in childhood and adolescence in Kuwait. Springerplus 2013;2:58. 18. Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification.[journal.sajc.org]
Sex distribution
Age distribution

Pathophysiology

  • Peripheral primitive neuroectodermal tumors are regarded as distinct entities. [ 2 ] Pathophysiology PNET of the CNS can be divided grossly into infratentorial tumors (medulloblastoma or iPNET) and supratentorial tumors (sPNET).[emedicine.medscape.com]
  • This not only provides a better pathophysiological understanding, but will help clinicians in their therapeutical choices, especially in cases of inoperable tumors. References [1] Albers MJ, Krieger MD, Gonzalez-Gomez I, et al.[em-consulte.com]

Prevention

  • Pagina 310 - A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. ‎[books.google.ro]
  • […] imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology genetics history immunology metabolism microbiology mortality nursing organization and administration parasitology pathology physiology physiopathology prevention[ncbi.nlm.nih.gov]
  • Additionally, the intraoperative monitoring (IOM) can help localize nerves and prevent nerve injury during surgery [ 1 , 2 , 3 ].[e-arm.org]
  • Position the patient to avoid extreme hip or neck flexion and maintain the head in midline, neutral position to prevent increased ICP.[quizlet.com]
  • This can be detrimental to the children as it might prevent a fast development of symptoms, which can lead to a delay in diagnosis.[steadyhealth.com]

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