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Inhalation of Nitric Oxide


Presentation

  • The objective of the present study was to review the result of 2 patients with donor right heart failure following heart transplantation treated with inhaled nitric oxide (NO).[ncbi.nlm.nih.gov]
  • Abstract A 27-year-old female with sickle cell disease (HbSS) was admitted presenting with severe bone pain and fever. She refused blood transfusions throughout her hospital stay for religious reasons.[ncbi.nlm.nih.gov]
  • The present study demonstrates that tcPO2 increases during nasal breathing compared with oral breathing in healthy subjects. Furthermore, in intubated patients, who are deprived of self-inhalation of endogenous NO.[ncbi.nlm.nih.gov]
  • Herein, two patients with massive pulmonary thromboembolism are presented whose condition improved only after they received nitric oxide as an adjunct to pulmonary suction thrombectomy.[ncbi.nlm.nih.gov]
  • Abstract A 57-year-old man with a history of prosthetic aortic valve and supracoronary ascending aortic replacement presented with a 9.8 cm Sinuses of Valsalvae aneurysm ruptured into the left upper pulmonary vein leading to massive pulmonary hemorrhage[ncbi.nlm.nih.gov]
Contusion
  • Twelve hours after the accident, haemodynamic status of the patient rapidly worsened because of right ventricular (RV) failure due to myocardial contusion, requiring increasing doses of catecholamine.[ncbi.nlm.nih.gov]
Withdrawn
  • No patient has been withdrawn as a result of a safety concern, and no patient has had a serious adverse event related to NO. CONCLUSIONS: We present methods and a protocol for the first double-blinded, randomized trial of inhaled NO to treat PE.[ncbi.nlm.nih.gov]

Workup

Reversible Airway Obstruction
  • One of these subjects had underlying reversible airway obstruction suggestive of chronic asthma and possible increased susceptibility to the side effects of NO.[thorax.bmj.com]

Treatment

  • OBJECTIVE: To investigate the effect of nitric oxide (NO) inhalation for the treatment of neonatal pulmonary hypertension.[ncbi.nlm.nih.gov]
  • Although the cause is multifactorial, treatment of primary organ failure remains difficult with dismal results.[ncbi.nlm.nih.gov]
  • Our report suggests that a clinical trial of NO treatment for severe right ventricular failure caused by myocardial infarction is warranted.[ncbi.nlm.nih.gov]
  • The cases in this group met the same criteria as those administered the iNO treatment.[ncbi.nlm.nih.gov]
  • Out of 104 patients, 79 responded to treatment with inhaled nitric oxide and other treatment changes by an increase in oxygen saturation of more than 5%. The 30-day mortality was 27% in the group transported with inhaled nitric oxide.[ncbi.nlm.nih.gov]

Prognosis

  • INTRODUCTION: Severe chronic obstructive pulmonary disease (COPD) is often associated with secondary pulmonary hypertension (PH), which worsens prognosis.[ncbi.nlm.nih.gov]
  • University Hospital Antwerp, Edegem, 2 FluidDA nv, Antwerp, Belgium; 3 Bellerophon Therapeutics, Warren, NJ, USA Introduction: Severe chronic obstructive pulmonary disease (COPD) is often associated with secondary pulmonary hypertension (PH), which worsens prognosis[dovepress.com]
  • […] chronic obstructive pulmonary disease (COPD), especially in the presence of pulmonary hypertension. 1 2 Onset of persistent pulmonary hypertension in patients with COPD presents a therapeutic challenge as it is associated with a significantly worse prognosis[thorax.bmj.com]

Etiology

  • ., Extramural MeSH terms Administration, Inhalation Bronchopulmonary Dysplasia/epidemiology Bronchopulmonary Dysplasia/etiology* Female Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases/mortality Infant, Premature, Diseases/therapy[ncbi.nlm.nih.gov]
  • Regardless of etiology of pulmonary hypertension, pulmonary vasoreactivity is frequently demonstrated with the use of NO. Right ventricular diastolic dysfunction may predict a poor vasodilator response.[onlinejacc.org]

Epidemiology

  • Electronic address: ballardr@peds.ucsf.edu. 2 Department of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA. 3 Department of Epidemiology and Biostatistics, University of California San Francisco[ncbi.nlm.nih.gov]
  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Pathophysiology and Epidemiology of ARDS and PARDS One of the hallmarks of ARDS is hypoxemia.[frontiersin.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of respiratory failure and the potential risks of iNO differ substantially in preterm infants, necessitating specific study in this population.[ncbi.nlm.nih.gov]
  • Pathophysiology and Epidemiology of ARDS and PARDS One of the hallmarks of ARDS is hypoxemia.[frontiersin.org]

Prevention

  • We successfully performed right ventricular thrombectomy to prevent further embolization from the right ventricular thrombus.[ncbi.nlm.nih.gov]
  • Early routine use of iNO in preterm infants with respiratory disease does not prevent serious brain injury or improve survival without BPD.[ncbi.nlm.nih.gov]
  • Abstract Inhaled nitric oxide is an agent known to reduce pulmonary vascular resistance and prevent right heart failure. Pulmonary embolism is frequently followed by right heart failure and cardiogenic shock.[ncbi.nlm.nih.gov]
  • The probability of early iNO being cost-effective was approximately 72%, based on a willingness to pay 100,000 or less to prevent ECMO therapy and/or death. In both deterministic sensitivity analyses, early iNO was cost-saving.[ncbi.nlm.nih.gov]
  • Breathing NO prevents PH induced by stored blood transfusions or sickle cell disease. Exploiting the anti-inflammatory properties of NO helps to treat malaria.[ncbi.nlm.nih.gov]

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