She has published over 100 peer-reviewed publications in the field of haemostasis, is an international expert on platelet testing and aspirin resistance, and has served on review panels from the National Institutes of Health (NIH), College of American Pathologists [books.google.com]

College of American Pathologists, January 2003 Survey of instruments [On-line information]. Available online at . Corcoran, G. and Kottke-Marchant, K. (2002 June). Chasing after the causes of platelet disorders. [labtestsonline.it]

We determined the necessary coverage level based on recommendations forwarded by the Royal College of Pathologists of Australasia [ 65 ] whose guidance is in compliance with National Pathology Accreditation Advisory Council (NPAAC) standards for testing [intechopen.com]

Chicago : American Society of Clinical Pathologists 1978. Powers L.W. Diagnostic Hematology Clinical and Technical Principles. St Louis : Mosby 1989. Rapaport S.I. Introduction to Hematology. 2nd ed. Philadelphia : JB Lippincott 1987. [doctorlib.info]

Most such patients have a bleeding disorder characterized by nosebleeds, gum bleeding, easy bruising (black and blue marks), heavy menstrual periods in women, and excessive bleeding after surgery or trauma. [clinicaltrials.gov]

As with Bernard-Soulier Syndrome, children experience easy bruising, nasal, mouth and gum bleeds and women are liable to heavy or prolonged bleeding (menorrhaegia) during childbirth. [haemophilia.org.uk]

This disorder causes easy bruising or bleeding. [medlineplus.gov]

The most common symptoms of a platelet disorder are easy bruising, nosebleeds, bleeding of the mouth or gums, heavy menstrual bleeding (periods), postpartum (after child birth) bleeding, and bleeding following dental work, surgical or invasive procedures [ihtc.org]

[…] syndrome Scurvy (vitamin C deficiency) Clinical features Symptoms: bleeding associated with surgery, trauma, dental extractions, postpartum, circumcision or umbilical stumps, GI bleeding, intracranial hemorrhage, hemarthrosis or soft tissue hematomas, easy [pathologyoutlines.com]

They also suggest that an alternative technique be used along with an aspirating syringe and a local anaesthetic with a vasoconstrictor to reduce bleeding tendency. [bsdht.org.uk]

[…] abnormalities: mixing studies, factor levels, Bethesda assay (to detect coagulation factor inhibitors); can confirm hereditary deficiency by determining factor levels in relatives For suspected platelet disorders: platelet aggregation studies, bone marrow aspirate [pathologyoutlines.com]

Aminophylline and some foods e.g. garlic) Investigation FBC § /- citrated sample Blood film § Platelet size Coagulation screen § VWD 2N Platelet adhesion testing PFA-100 § Aspirates whole blood under constant vacuum through a capillary and a microscopic [ihaematology.com]

One individual who had been previously misdiagnosed as having ITP and treated with steroids and splenectomized, exhibited a bone marrow aspirate and biopsy showing decreased cellularity and megakaryocyte counts, with 24% of the metaphases revealing monosomy [ojrd.biomedcentral.com]

A blood sample of 0.8 mL of citrated blood is placed in a cup and is aspirated through the aperture. The shear stress and the agonists in the membrane activate platelets, leading to platelet aggregation. [emedicine.medscape.com]

loss of teeth Chediak-Higashi syndrome (CHS) platelet dense granule deficiency severe immunologic deficiency increased vulnerability to severe gingivitis and periodontitis Premature loss of teeth Gray platelet syndrome defective retention of αgranule protein [bsdht.org.uk]

loss When patients suffering from an inherited platelet disorder require treatment anti-haemorrhagic agents may be used. [bsdht.org.uk]

The authors then propose the following management options for dental treatments: Oral health Previous studies have suggested that caries and periodontal disease incidence is higher in patients with bleeding disorders. [bsdht.org.uk]

Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care [books.google.com]

This has been felt to be related to the fear of bleeding when performing oral hygiene measures such as flossing and during professional dental treatments. [bsdht.org.uk]

Glembotsky, Alessandro Pecci, Marco Cattaneo, Nicole Schlegel, Paolo Gresele Haematologica July 2017 102: 1192-1203; doi: 10.3324/haematol.2016.160754 Abstract Excessive bleeding at surgery is a feared complication in patients with inherited platelet [haematologica.org]

[…] were the 7 patients presenting specific features characteristic of IPDs: 2 patients with hypopigmentation and giant granules in polymorphonuclear leukocytes characteristic of Chediak-Higashi syndrome (CHS), 1 patient with oculocutaneous albinism and nystagmus [ojrd.biomedcentral.com]

Mild adverse effects of desmopressin may include headache, nausea and hypotension, although sometimes more serious side effects, such as hyponatremia and renal dysfunction, may occur. [haematologica.org]

Other adverse effects occasionally include a hypertensive response and hyponatremia. [emedicine.medscape.com]

Platelet aggregation abnormalities are usually seen but vary, depending on the disorder. 2, 8, 41, 42 Storage pool diseases Platelet disorders of the storage pool type can be related to defects of the dense granules or defects of the α-granules. [doctorlib.info]

They include patients who have decreased platelet counts, abnormal platelet function or a combination of both, in general reflecting underlying abnormalities that culminate in defective platelet production and function. [link.springer.com]