Presentation
Diabetes mellitus is an independent risk factor for stroke, and the incidence of diabetes in patients presenting with stroke is 16% to 20%. [ncbi.nlm.nih.gov]
Entire Body System
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Noncompliance
Well-recognized reasons for this failure include issues related to patients' noncompliance with an injectable drug and the late stage at which insulin is prescribed, but less explicit reasons related to the nonphysiological way insulin is currently administered [ncbi.nlm.nih.gov]
At his establishing visit, he was taken off his insulin pump due to noncompliance with blood glucose checks and placed on basal-bolus therapy with insulin glargine and insulin aspart. [mdedge.com]
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Short Stature
In summary, we found that insulin administration in children with short stature decreases plasma leptin levels, equally in those with and without GHD. [ncbi.nlm.nih.gov]
Liver, Gall & Pancreas
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Hepatomegaly
We suggest that plasma be obtained for insulin determination in children with hypoglycemia, and that transient hepatomegaly may be a helpful sign in cases of insulin overdose. [ncbi.nlm.nih.gov]
Musculoskeletal
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Shoulder Pain
Abstract A case of gas gangrene that caused intractable shoulder pain refractory to narcotics in an immunocompromised host is presented. [ncbi.nlm.nih.gov]
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Fracture
Gas gangrene has been associated with severe trauma involving penetrating wounds, compound fractures, extensive soft-tissue injury, intramuscular injection of epinephrine, and interruption of arterial blood supply. [ncbi.nlm.nih.gov]
Psychiatrical
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Suggestibility
Indeed, evidence suggests that the increased acquisition cost of safety devices could be more than offset by savings resulting from the reduced incidence of needlestick injuries. [ncbi.nlm.nih.gov]
Neurologic
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Forgetful
The analysis included six domains: Forgetting, what people forgot; Reasons for forgetting; Realizing forgetting; Corrective actions; Consequences of forgetting; and Feelings about forgetting. [ncbi.nlm.nih.gov]
Do not forget to advise that a sharps container be included for disposal of the lancets and needles. At least a three-day supply of non-perishable food and bottled water is also recommended. [touchendocrinology.com]
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Memory Impairment
In contrast, memory-impaired epsilon4 subjects demonstrated a relative decline in verbal memory. [ncbi.nlm.nih.gov]
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Mononeuropathy
After an episode of diabetic mononeuropathy or poor glycemic control, they started human insulin therapy. [ncbi.nlm.nih.gov]
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Mild Cognitive Impairment
On separate mornings, 33 memory-impaired adults with AD or amnestic mild cognitive impairment and 59 normal adults each underwent five intranasal treatment conditions consisting of insulin (10, 20, 40, or 60 IU) or placebo. [ncbi.nlm.nih.gov]
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Cognitive Deficit
Abstract Aging is a major risk factor for cognitive deficits and neurodegenerative disorders, and impaired brain insulin receptor (IR) signaling is mechanistically linked to these abnormalities. [ncbi.nlm.nih.gov]
Workup
Serum
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Leptin Decreased
This effect was independent of GHD, and no difference in leptin decrease was found when comparing patients with ISS to those with GHD. [ncbi.nlm.nih.gov]
HLA Type
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HLA-DR3
All subjects who developed diabetes were positive for antibodies to GAD and expressed the HLA-DR3 or DR4 alleles, whereas only one of the non-progressors had these parameters (P 0.05). [ncbi.nlm.nih.gov]
Treatment
Additional treatment with caspofungin and G-CSF was associated because of poor initial result to treatment. Caspofungin was later continued as monotherapy when LAmB had to be interrupted because of renal toxicity. [ncbi.nlm.nih.gov]
Epidemiology
Richardson T, Kerr D (2003) Skin-related complications of insulin therapy: epidemiology and emerging management strategies. Am J Clin Dermatol 4:661–667 PubMed CrossRef Google Scholar 7. [link.springer.com]
Heidelberg, Melbourne, VIC, 3084, Australia (2) Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Trieste, Italy (3) Department of Pathology, Austin Health, Melbourne, VIC, Australia (4) Department of Epidemiology [annalsofintensivecare.springeropen.com]
Pathophysiology
Abstract Reduced insulin-mediated glucose transport in skeletal muscle is a hallmark of the pathophysiology of T2DM (Type II diabetes mellitus). Impaired intracellular insulin signalling is implicated as a key underlying mechanism. [ncbi.nlm.nih.gov]
Colorado State University, Pathophysiology of the Endocrine System [On-line Biomedical Hypertextbook]. Available online through . CSU (1999 June 15, Updated). Glucagon. [labtestsonline.it]
The hyperglycaemic response to surgery: pathophysiology, clinical implications and modification by the anaesthetic technique. Clin Intensive Care 1998;9:118–28 2. Lattermann R, Carli F, Wykes L, Schricker T. [journals.lww.com]
Accumulation of c-peptide in atherogenic plaques and chemotactic effects of c-peptide on monocytes may be involved in the pathophysiology of such complications [ 21 ]. [annalsofintensivecare.springeropen.com]
Prevention
Several anabolic agents have been utilized for retarding or preventing progressive wasting with limited success. [ncbi.nlm.nih.gov]