Edit concept Question Editor Create issue ticket

Insulin Antibody

Antibodies Insulin


Presentation

  • The patient presented with IAS, which worsened during treatment of hepatitis C. The patient was then discovered to have a monoclonal gammopathy that progressed to MM.[ncbi.nlm.nih.gov]
  • MATERIALS AND METHODS: To estimate C-peptide levels and autoantibody presentation, patients underwent a meal-stimulated C-peptide test 1, 6, and 12 months after diagnosis.[ncbi.nlm.nih.gov]
  • The present enzyme immunoassay does not require radioactive materials, is less expensive and is concluded to be practically useful.[ncbi.nlm.nih.gov]
  • Thus, present observations show that HLA-DR1- and HLA-DR3-linked genes do play opposite roles in the humoral immune response to an exogenous protein, i.e. injected insulin.[ncbi.nlm.nih.gov]
  • Insulin antibodies were evaluated by antibody-bound immunoreactive insulin (Abl) and by the labelled insulin binding capacity (IBC) which presented a significant correlation best fitted by a logarithmic curve.[ncbi.nlm.nih.gov]
Falling
  • […] after the commencement of this study, whereas insulin antibody levels began to fall significantly from a mean of 61.8% to 49.5% (p less than 0.01) 6 months after the start of the study.[ncbi.nlm.nih.gov]
  • Falling titres of antibodies on this regimen correlated with improved glycaemic control.[ncbi.nlm.nih.gov]
  • The level of these autoantibodies is generally low and may even fall during follow-up.[mayomedicallaboratories.com]
  • Be aware, though, that the c-pep will fall over time as you become fully insulin dependent. Welcome to the club .... #3 Thanks Mark for the quick response, that is what I figured.[diabetesdaily.com]
Malnutrition
  • The mean daily insulin dose, maximum insulin binding capacity and total insulin binding power were significantly higher in type 1 when compared to the malnutrition modulated form of diabetes (36 /-8 vs. 26 /-11 IU/day, P[ncbi.nlm.nih.gov]
Liver Dysfunction
  • The etiology of acute liver dysfunction was unknown, however, we believe that the combination of oral glucocorticoid and lispro insulin was suitable and useful for preventing recurrent liver dysfunction in this patient.[ncbi.nlm.nih.gov]
Suggestibility
  • IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests[ncbi.nlm.nih.gov]
  • These findings suggest that anti-idiotype antibodies may function to regulate the immune response to insulin.[ncbi.nlm.nih.gov]
  • Plasma free insulin, blood glucose and 3-hydroxybutyrate profiles suggest that acid bovine soluble insulin has a significantly more protracted action than neutral human insulin.[ncbi.nlm.nih.gov]
  • FITC-conjugated gamma-globulin showed no significant binding to HepG2 cells by fluorescence microscopy, however, FITC-insulin-antibody conjugates bound extensively, suggesting that FITC-insulin conjugates still retain the ability to bind insulin receptors[ncbi.nlm.nih.gov]
  • The longitudinal change of the k1/b1 population suggests a clonal change of the B cells producing the insulin antibody in insulin autoimmune syndrome.[ncbi.nlm.nih.gov]

Workup

HLA-DR1
  • The results demonstrate that HLA-DR1-positive patients show the highest mean values of insulin antibody, whereas HLA-B18,DR3-positive patients show the lowest.[ncbi.nlm.nih.gov]
HLA-DR3
  • Thus, present observations show that HLA-DR1- and HLA-DR3-linked genes do play opposite roles in the humoral immune response to an exogenous protein, i.e. injected insulin.[ncbi.nlm.nih.gov]
HLA-B8
  • The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity.[ncbi.nlm.nih.gov]

Treatment

  • The failure of oral insulin treatment to provide any measurable clinical benefit may be due to the timing of treatment initiation.[ncbi.nlm.nih.gov]
  • Glycosylated haemoglobin values at the end of four month treatment periods were higher after treatment with human insulin than after treatment with porcine insulin (mean 15.7% (SD 2.3%) v 14.2% (2.3%); p less than 0.01).[ncbi.nlm.nih.gov]
  • Blood samples drawn before or at the beginning of the treatment and after treatment for 3 and 6 months were analyzed for IA affinity and isotype-specific IAs (IgG1-4, IgA, IgM, and IgE).[ncbi.nlm.nih.gov]
  • The highest titers occurred after different lengths of treatment in the two groups of patients. Abl decreased after continuation of treatment particularly in the MC series.[ncbi.nlm.nih.gov]
  • Pre-treatment binding did not correlate with later insulin antibody binding nor metabolic control. In Study 1 we have confirmed previous studies showing abnormally high insulin antibody binding in children with IDDM pre-treatment.[ncbi.nlm.nih.gov]

Prognosis

  • […] insulin, 010475, 抗体, コウタイ, antibody, 011065, 抗体価, コウタイカ, antibody titer, 053092, 診断, シンダン, diagnosis, 029308, 薬物療法, ヤクブツリョウホウ, drug therapy, 023545, グルココルチコイド, グルココルチコイド, glucocorticoid, 033623, ステロイドホルモン, ステロイドホルモン, steroid hormone, 011475, 予後, ヨゴ, prognosis[togodb.biosciencedbc.jp]

Etiology

  • The etiology of acute liver dysfunction was unknown, however, we believe that the combination of oral glucocorticoid and lispro insulin was suitable and useful for preventing recurrent liver dysfunction in this patient.[ncbi.nlm.nih.gov]
  • During the next several weeks, glucose levels remained difficult to control and the endocrinologists became suspicious about other etiologies that caused severe episodes of hypoglycemia.[healio.com]
  • He was referred to our hospital for further survey of etiology of hypoglycemia. During hospitalization, several episodes of disturbed consciousness due to hypoglycemia recurred.[edmcasereports.com]

Epidemiology

  • Type I Diabetes: Molecular, Cellular, and Clinical Immunology, Chapter 9 Epidemiology of Type I Diabetes. Barbara Davis Center for Childhood Diabetes, UCDHSC [On-line information]. Available online at . Eisenbarth, G. (2003 November).[labtestsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • Differential diagnosis of type 1 versus type 2 diabetes Evaluating diabetics with insulin resistance in patients with established diabetes (type 1 or type 2) Investigation of hypoglycemia in nondiabetic subjects Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Colorado State University, Pathophysiology of the Endocrine System [On-line Biomedical Hypertextbook]. Available online through . CSU (1999 June 15, Updated). Glucagon.[labtestsonline.it]

Prevention

  • OBJECTIVE: Despite promising results from studies on mouse models, intranasal insulin failed to prevent or delay the development of type 1 diabetes in autoantibody-positive children with HLA-conferred disease susceptibility.[ncbi.nlm.nih.gov]
  • The etiology of acute liver dysfunction was unknown, however, we believe that the combination of oral glucocorticoid and lispro insulin was suitable and useful for preventing recurrent liver dysfunction in this patient.[ncbi.nlm.nih.gov]
  • This is because the antibody prevents the insulin from working the right way in your cells. As a result, your blood sugar can be unusually high. Many people who are on insulin have detectable antibodies, but these antibodies do not cause symptoms.[medlineplus.gov]
  • Does early detection of anti-insulin antibodies enable prevention of Type I diabetes? Currently, there is no cure for Type I diabetes.[justdoc.com]
  • Immunostaining NOTE : All subsequent incubations should be carried out at room temperature unless otherwise noted in a humid light-tight box or covered dish/plate to prevent drying and fluorochrome fading.[cellsignal.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!