Although deafness has not yet been reported in patients with IGF-I resistance, it is present in some patients with IGF-I deficiency (caused by mutations in the gene encoding the IGF1R ligand, IGFI). [orpha.net]

Values are presented as mean with s.d. or median with interquartile range (IQR), unless stated otherwise. For linear regression analyses, all data are presented as standardised beta. [eje.bioscientifica.com]

Here, a brief paradigm is presented linking testosterone, growth hormone, and IGF-1 to recovery and adaptations to training. [journals.physiology.org]

Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival. [frontiersin.org]

This is demonstrated in Figure 2(a), where the Voc is plotted versus the incident light intensity for the four devices presented in Figure 1. [aip.scitation.org]

• Short Finger

  Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum). [orpha.net]

• Disability

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  Since life expectancy increases, frail or disabled older people will inevitably be more prevalent. The debate about the GH-IGF-1 axis and aging is still ongoing. [eje.bioscientifica.com]

• Short Stature

  Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency. Horm. Res. [frontiersin.org]

• Broad Nasal Bridge

  Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum). [orpha.net]

Management and treatment Management involves nutritional and developmental support. [orpha.net]

Chemo-resistance is a common problem in the treatment of cancer patients, as cancer cells become resistant to chemical substances used in treatment, limiting the efficiency of chemotherapeutic agents (Phi et al., 2018). [frontiersin.org]

This is also supported by findings in studies on the effects of GH treatment in GHD adults or healthy elderly at different ages. [eje.bioscientifica.com]

Prognosis Prognosis varies depending on the underlying molecular anomaly. The documents contained in this web site are presented for information purposes only. [orpha.net]

Studies investigating the association between the IGF system and BC prognosis are limited and controversial. [frontiersin.org]

Etiology IGF-I resistance may be caused by a variety of genetic defects: ring chromosome 15, distal heterozygous 15q deletions encompassing the IGF1R gene (15q26.3), or IGF1R gene mutations. [orpha.net]

Summary Epidemiology Prevalence is unknown. Etiology IGF-I resistance may be caused by a variety of genetic defects: ring chromosome 15, distal heterozygous 15q deletions encompassing the IGF1R gene (15q26.3), or IGF1R gene mutations. [orpha.net]

Later, many epidemiological and prospective studies have reported a positive correlation between circulating IGF-1 levels and BC development. [frontiersin.org]

The exact underlying pathophysiological mechanism for different effects of IGF-1 at different ages is unclear. Serum levels of IGF-1 may not be a good reflection of local effects of IGF-1. [eje.bioscientifica.com]

Thus, strategies that co-target HER-2 and IGF-1R may prevent or postpone development of resistance to trastuzumab (Browne et al., 2012). [frontiersin.org]

Search Google Scholar Export Citation 24↑ The prevention of falls in later life. A report of the Kellogg International Work Group on the Prevention of Falls by the Elderly. Danish Medical Bulletin 1987 34 (Supplement 4) 1–24. [eje.bioscientifica.com]