Symptoma

Intermediate Uveitis

IU

Poor visual acuity at first presentation, snowbanks and vitreoretinal traction were associated with a higher risk for poor BCVA at last presentation. [ncbi.nlm.nih.gov]

  • Facial Mass

    Subsequent treatment with cyclophosphamide, adriamycin, vincristine, prednisone, and rituximab resulted in regressed facial mass and improved visual acuity. [ncbi.nlm.nih.gov]

Laboratory workup has not revealed the inflammation etiology. [eyetube.net]

A detailed discussion of this case along with color photos, laboratory workup, a table of associated diseases, and a schematic for management of intermediate uveitis will be presented in this poster. [aaopt.org]

In all patients, an extensive workup based on clinical suspicion, showed a positive result from the first visit. [meajo.org]

Although most pediatric IU cases are idiopathic, a systemic workup is recommended to evaluate for underlying disorders (see “Possible Etiologies”). [aao.org]

  • Toxocara Canis

    Furthermore, IU has been associated with a number of infectious agents including Borrelia burgdorferi (Lyme disease), Toxocara canis (toxocariasis), syphilis,52 tuberculosis,53 Whipple bacilli (Whipple disease), Epstein-Barr virus, human T-cell lymphotrophic [journals.lww.com]

  • HLA-DR2

    • Sarcoidosis – CT scan lungs, ACE enzymes • Serologic testing for- cat-scratch disease, syphilis (VDRL, FTA-ABS)and Lyme's • HLA DR2 typing • Vitreous tap 28. [slideshare.net]

    HLA-DR2 and HLA-DR15, -DR51 and -DQ6 were closely associated with both pars planitis and MS. [eyewiki.aao.org]

  • HLA-B5

    One patient who was positive for HLA B5 and HLA B51 with history of recurrent oral ulcers and a positive pathergy test was diagnosed as a Bechets disease. [meajo.org]

In case of treatment failure, switching to the other treatment arm was possible. RESULTS: Nineteen patients were included. Ten were randomized to MTX, and 9 were randomized to IFN beta. [ncbi.nlm.nih.gov]

Visual prognosis was good and it was not age-related. Childhood onset was more frequent in boys, adult onset in women. Endocrinal factors could be involved. [ncbi.nlm.nih.gov]

Etiology of IU was idiopathic in 59%. Multiple sclerosis (MS) (20%) and sarcoidosis (10%) were frequent systemic causes of IU. [ncbi.nlm.nih.gov]

Laboratory workup has not revealed the inflammation etiology. [eyetube.net]

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. [ncbi.nlm.nih.gov]

[…] immunosuppressive agents) found that while the steroid implant treatment possibly prevents the recurrence of uveitis, there may be adverse safety outcomes, such as the increased risk for needing cataract surgery and surgery to lower intraocular pressure.[1] Epidemiology [en.wikipedia.org]

Symptoms Onset / Epidemiology Clinical features which can be seen by an ophthalmologist Frequency of complications Tests The diagnosis of intermediate uveitis is on the clinical judgement of the ophthalmologist. There is no specific test. [iritis.co.uk]

Epidemiology of uveitis in the mid-Atlantic United States. Clin Ophthalmol Auckl NZ. 2015;9:889–901. 11. Grajewski RS, Caramoy A, Frank KF, Rubbert-Roth A, Fätkenheuer G, Kirchhof B, et al. [ojrd.biomedcentral.com]

Epidemiology and Etiology IU most often occurs in children and young adults. [entokey.com]

It is evident that genetics plays some role in the pathophysiology of intermediate uveitis, but the importance remains unclear. [en.wikipedia.org]

Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets. [ncbi.nlm.nih.gov]

Pathophysiology There may be an immunogenetic predisposition for the disorder in some cases (see Causes), accounting for family clustering that is seen on occasion, indicating environmental or hereditary associations. [emedicine.medscape.com]

Pathophysiology IU seems to be a T-cell mediated disease, as these cells account for up to 95% of all cell types in the vitreous of patients with IU; most of these cells are CD4 . [eyewiki.aao.org]

An increase awareness of its efficacy is required among paediatricians and ophthalmologists to prevent sight threatening complication of chronic uveitis and its treatment with long term use of steroids. [ncbi.nlm.nih.gov]

Research comparing fluocinolone acetonide intravitreal implants to standard-of-care treatments (prednisolone with immunosuppressive agents) found that while the steroid implant treatment possibly prevents the recurrence of uveitis, there may be adverse [en.wikipedia.org]

Short-acting cycloplegic agents such as hematropine, scopolamine, or cyclopentolate are used during therapy to prevent inflammatory adhesions (posterior synechiae) between the iris and lens. diffuse uveitis Panuveitis. intermediate uveitis Pars planitis [medical-dictionary.thefreedictionary.com]

Related Coverage: Central Foveal Thickness Cut-off Value Identitfied for Corticosteroid Treatment in Intermediate Uveitis Study Shows TNF Inhibitors Prevent Relapse of Uveitis in Most Patients with Ankylosing Spondylitis Assessing Rates of Noninfectious [mdmag.com]

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