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Interstitial Keratitis

Interstitial Keratitis Unspec


  • In an attempt to expand the knowledge of this condition of unknown etiology, we present 3 cases of linear interstitial keratitis. Case series (3 cases are presented) and literature review.[ncbi.nlm.nih.gov]
  • A persistent fall in VDRL titers after treatment provides essential evidence of an adequate response to therapy. Reactive and weakly reactive tests should be confirmed with fluorescent treponemal antibody absorption (FTA-ABS).[emedicine.medscape.com]
  • Abstract Cases of secondary localized corneal amyloidosis have been described in various corneal and ocular inflammations but are believed to occur uncommonly.[ncbi.nlm.nih.gov]
  • .  blunted upper incisor teeth known as Hutchinson's teeth  inflammation of the cornea known as interstitial keratitis  deafness from auditory nerve disease  frontal bossing (prominence of the brow ridge)  saddle nose (collapse of the bony part of[slideshare.net]
  • […] diagnose ocular syphilis by selective serologic testing Prevent visual loss by early recognition and appropriate treatment of stromal keratitis Tertiary prevention Use adequate therapy to reduce sight- threatening complications Correct permanent visual disability[slideshare.net]
Localized Edema
  • .  Tuberculous IK is generally unilateral  Inflammation may involve either the anterior or posterior stroma  Cellular infiltration is often peripheral or quadrantic and is followed by localized edema, and later stromal vascularization may occur with[slideshare.net]
  • Congenital Syphilis Early congenital syphilis occurs in children between 0 and 2 years old After, they can develop late congenital syphilis Symptomatic newborns, if not stillborn, are born  Premature with hepatosplenomegaly  Skeletal abnormalities  Pneumonia[slideshare.net]
Notched Incisors
  • incisors),  Keratitis  Deafness occurs in 63% of cases Treatment (with penicillin) before the development of late symptoms is essential 21.  Stromal Keratitis in Acquired Syphilis Onset  Keratitis is very uncommon in acquired syphilis  Exceptional[slideshare.net]
Skin Lesion
  • Systemic steroids were used to treat the patient's skin lesions and topical steroids to treat his corneal inflammation. He developed posterior uveitis and optic nerve edema both of which were responsive to oral steroids.[ncbi.nlm.nih.gov]
  • .  Signs of disease have been separated into three stages  Stage 1 (Early localisied infection) Flulike illness and the pathognomonic skin lesion Bull’s eye lesion, erythema migrans and follicular conjunctivitis  Stage 2 (Early disseminated infection[slideshare.net]
  • A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching.[ncbi.nlm.nih.gov]
  • Some systemic associations may include life-threatening aortitis (up to 10%), inflammatory bowel disease, pericarditis, abdominal pain, fatigue, weight loss, arthralgia, myalgia, fever, headache, and urticaria.[webeye.ophth.uiowa.edu]
Corneal Opacity
  • METHODS: Five eyes of five patients with congenital syphilitic interstitial keratitis who underwent keratoplasty for corneal opacities and corneal edema were studied.[ncbi.nlm.nih.gov]
  • For the past few years, the parents noted increased corneal opacity. Examination revealed opacity of the anterior stroma with ghost vessels. This is thought to be interstitial keratitis secondary to herpertic keratitis.[sarawakeyecare.com]
  • Some corneal opacity usually remains, causing mild to moderate vision impairment. Corneal opacification and other typical findings on slit-lamp examination Serologic testing to determine etiology The specific etiology must be determined.[msdmanuals.com]
Red Eye
  • A previously healthy 48-year-old man presented with a 1-week history of migrating polyarthropathy preceded by a viral illness, dysuria and bilateral red eyes. Ocular examination revealed anterior and interstitial stromal keratitis.[ncbi.nlm.nih.gov]
  • The Ophthalmology Department, Sarawak General Hospital, Kuching, Sarawak, East Malaysia. a a Interstitial keratitis Photo by Professor Chua chung Nen This 7 year-old had had recurrent right red eye and was treated for herpetic keratitis.[sarawakeyecare.com]
  • Contact lens acute red eye (CLARE) — a non-ulcerative sterile keratitis associated with colonization of Gram-negative bacteria on contact lenses. Treatment [ edit ] Treatment depends on the cause of the keratitis.[en.wikipedia.org]
  • Phlyctenulosis - small pinkish-white nodule with an associated red eye. It occurs as a result of a nonspecific delayed hypersensitivity reaction to bacterial and viral antigens.[patient.info]
Foreign Body Sensation
  • A 45-year-old woman with healed syphilitic interstitial keratitis presented with decreased vision, foreign-body sensation of the right eye, and bilateral conjunctival injection.[ncbi.nlm.nih.gov]
  • Patients tend to be more symptomatic if the lesions are corneal and may present with tearing, irritation, photophobia or foreign body sensation.[clspectrum.com]
  • Presentation - redness, pain, photophobia, foreign body sensation and reduced visual acuity. There will usually be an epithelial defect the presence of white cell infiltrate oedema.[patient.info]
Frontal Bossing
  • .  blunted upper incisor teeth known as Hutchinson's teeth  inflammation of the cornea known as interstitial keratitis  deafness from auditory nerve disease  frontal bossing (prominence of the brow ridge)  saddle nose (collapse of the bony part of[slideshare.net]
  • A previously healthy 48-year-old man presented with a 1-week history of migrating polyarthropathy preceded by a viral illness, dysuria and bilateral red eyes. Ocular examination revealed anterior and interstitial stromal keratitis.[ncbi.nlm.nih.gov]
  • , James Walker Caloundra Hospital, Caloundra, Australia Correspondence to Dr Yi Eve Hsing, hsingeve{at}hotmail.com Summary A previously healthy 48-year-old man presented with a 1-week history of migrating polyarthropathy preceded by a viral illness, dysuria[casereports.bmj.com]
  • It was mainly observed in patients affected by human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis among whom there were 18 cases (15.1%), as opposed to two cases (2.7%) in asymptomatic carriers.[ncbi.nlm.nih.gov]
Neck Stiffness
  • stiffness and photophobia  Stage 3 (Late disseminated infection) Ocular inflammatory signs occur in this stage of the disease and include  Episcleritis  Keratitis  Uveitis  Vasculitis  Exudative retinal detachment  Endophthalmitis 47.  Although[slideshare.net]


  • The patient underwent a systemic workup for interstitial keratitis. All results including RPR and MHA-TP were negative except for Lyme antibody titer (enzyme-linked immunosorbent assay [ELISA]) 178 U/ml (normal, 159 U/ml).[ncbi.nlm.nih.gov]
Trypanosoma Cruzi
  • Infectious causes include syphilis (commonest), followed by other bacterial infections (TB, Leprosy and Lyme disease) and parasitic infections (Acanthamoeba, Onchocerciasis or river blindness, Leishmaniasis, Trypanosoma cruzi or Chagas disease, Trypanosoma[en.wikipedia.org]
  • Trypanosoma cruzi is responsible for the American form or Chagas disease, and Trypanosoma brucei is responsible for the African form, also known as African sleeping sickness.[odlarmed.com]
  • Trypanosoma cruzi is responsible for Chagas disease in the Americas, and Trypanosoma brucei is responsible for trypanosomiasis in Africa; this form of the disease is also known as African sleeping sickness.[emedicine.medscape.com]


  • Treatment was changed from topical 0.5% cyclosporine to topical 0.1% tacrolimus combined with topical acyclovir and betamethasone. After 2 weeks of treatment with topical tacrolimus, the degree of stromal infiltrates decreased.[ncbi.nlm.nih.gov]
  • Treatment & Management Treatment of interstitial keratitis depends on the specific underlying disorder.[emedicine.medscape.com]
  • Treatment The treatment should include topical treatment for keratitis and systemic treatment for syphilis. 1. Local treatment. Topical corticosteroid drops e.g., dexamethasone 0.1% drops every 2-3 hours.[ophthalmologylife.blogspot.com]


  • The prognosis of this secondary glaucoma was very poor, although medical therapy was taken for the wide open angle type, and surgical therapy for the angle closure type.[ncbi.nlm.nih.gov]
  • The prognosis with early diagnosis and treatment is good There are different types of keratitis, which include: Amoebic Keratitis: It is often seen in those who wear contact lenses and is caused by Acanthamoeba, a free-living amoeba Fungal Keratitis caused[dovemed.com]
  • Prognosis Prognosis for interstitial keratitis is good if recognized and treated early before significant corneal scarring has occurred.[eyewiki.aao.org]
  • Outlook (Prognosis) Diagnosing and treating interstitial keratitis and its cause early can preserve the clear cornea and good vision.[ufhealth.org]


  • Linear interstitial keratitis is a rare clinical entity and its histopathologic etiology remains undetermined.[ncbi.nlm.nih.gov]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]


  • Diagnosis: Cogan's Syndrome EPIDEMIOLOGY Predominantly young to middle aged adults Rare SIGNS Interstitial keratitis (limbal stromal opacity or edema, non-inflammed vascular loops in the mid-stroma) Other inflammation of the eye ( episcleritis, scleritis[webeye.ophth.uiowa.edu]
  • […] sensorineural hearing loss Brain tumor (eg, meningioma) Ménière disease Infections Treponema pallidum HIV Vasculitis Microscopic polyangiitis Polyarteritis nodosa Granulomatosis with polyangiitis (GPA) Connective tissue diseases Rheumatoid arthritis Background Epidemiology[arupconsult.com]
  • Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome.[emedicine.medscape.com]
Sex distribution
Age distribution


  • Abstract We studied four patients with the clinical entity of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms to determine whether immunologic abnormalities play a role in its pathophysiology.[ncbi.nlm.nih.gov]
  • A discussion of the causes, pathophysiology, and treatment of interstitial keratitis is also undertaken. The differential diagnosis and appropriate laboratory tests for patients with interstitial keratitis is given.[morancore.utah.edu]
  • Pathophysiology The pathophysiology of interstitial keratitis is unknown, but varies significantly by eitology.The majority of bacterial and parasitic IK is a result of direct invasion of the corneal stroma and the host's allergic/ immune reaction to[eyewiki.aao.org]
  • Pathophysiology By definition, IK is a nonsuppurative inflammation, which is characterized by cellular infiltration of the corneal stroma. In general, no primary involvement of the corneal epithelium or endothelium occurs.[odlarmed.com]
  • […] polyangiitis (GPA) Connective tissue diseases Rheumatoid arthritis Background Epidemiology Incidence – rare; 250 cases reported (Singer, 2015) Age – young adults in 20s-30s A few cases in children and adults 50 years Sex – M:F, equal Ethnicity – none reported Pathophysiology[arupconsult.com]


  • SYSTEMIC - high doses of penicillin to prevent further development of lesions - systemic steroids can be given in refractory cases. 15.[slideshare.net]
  • Prevention Prevention consists of avoiding the infection that causes interstitial keratitis. If you do get infected, get prompt and thorough treatment and follow-up. Images References Ginsberg SP. Corneal problems in systemic disease.[ufhealth.org]
  • Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization[books.google.de]

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