There is a lack of information regarding the impact an emergency presentation has on the timing of postoperative chemotherapy and overall prognosis. [ncbi.nlm.nih.gov]

• Splenomegaly

  However, the presence of extensive retroperitoneal lymphadenopathy and splenomegaly favours lymphoma, whereas adjacent fat infiltration supports adenocarcinoma. [radiopaedia.org]

  Bulky mesenteric or retroperitoneal lymphadenopathy and splenomegaly are findings that support the diagnosis of a lymphoma. Infiltration of the mesenteric fat favours the diagnosis of an adenocarcinoma. [radiologyassistant.nl]

  Diagnosis Examination in patients with low-grade lymphomas may demonstrate peripheral adenopathy, splenomegaly, and hepatomegaly. [emedicine.medscape.com]

• Weight Loss

  Abstract Of 18 patients with small-intestinal lymphoma associated with villous atrophy and crypt hyperplasia of uninvolved mucosa, most presented with acute obstruction or perforation preceded by abdominal pain and weight-loss. [ncbi.nlm.nih.gov]

• Fever

  […] describes a case of multiple location in the small intestine of a non-Hodgkin B-cell in a 53 years old patient, who was initially diagnosed with bilateral pneumonia with pleurisy with E. coli, steeper on the right side, but the persistence of symptoms as fever [ncbi.nlm.nih.gov]

  Other symptoms of both types of lymphoma may include: ongoing fever without infection night sweats, fever, and chills weight loss and loss of appetite unusual itching persistent fatigue, unusual tiredness, or lack of energy pain in lymph nodes after drinking [medicalnewstoday.com]

  Symptoms of these cancers may include weight loss, abdominal pain, enlarged lymph nodes, fatigue, and fever. [beyondceliac.org]

  A : No symptoms (The individual has not had weight loss, fever, or night sweats.) [medicinenet.com]

  Swollen abdomen (belly) Feeling full after only a small amount of food Chest pain or pressure Shortness of breath or cough Severe or frequent infections Easy bruising or bleeding Some people with Non-Hodgkin lymphoma have what are known as B symptoms : Fever [cancer.org]

• Anemia

  Presentation with iron deficiency anemia was associated, in one case, with obvious bleeding and with malabsorption in the second case. Acute abdominal pain was rare and was the presenting feature in one case with intestinal invagination. [annonc.oxfordjournals.org]

  Iron deficiency anemia. Your body needs iron to make red blood cells, which carry oxygen around the body. If you don’t have enough iron and your blood doesn’t have enough oxygen, this can make you tired and short of breath. [webmd.com]

  A general physical examination revealed clubbing and anemia. Abdominal examination revealed a tender, soft, irregular, freely mobile mass of 7 Χ 4 cm size in the right iliac fossa (RIF). Rectal examination results were normal. [dx.doi.org]

  Symptoms of celiac disease, which include diarrhea, weight loss, and iron-deficiency anemia, result from damaged villi. [newsroom.cumc.columbia.edu]

  They may include abdominal discomfort associated with the following: Nausea Bloating Loss of appetite The following symptoms may indicate advanced disease and should be signs to seek medical attention: Fatigue Weight loss Iron deficiency anemia Visible [emedicinehealth.com]

• Malaise

  […] case of multiple location in the small intestine of a non-Hodgkin B-cell in a 53 years old patient, who was initially diagnosed with bilateral pneumonia with pleurisy with E. coli, steeper on the right side, but the persistence of symptoms as fever, malaise [ncbi.nlm.nih.gov]

  RT toxicity In the series reported by Tsang et al toxicity reported included transient anorexia and malaise and occasional nausea or dyspepsia, and were treated conservatively. Late ulceration or hemorrhage was not observed. [slideshare.net]

• Fever of Unknown Origin

  This 28-year-old man was being evaluated for fever of unknown origin. Gallium-67 study shows extensive uptake in the mediastinal lymph nodes due to non-Hodgkin lymphoma (NHL). [emedicine.medscape.com]

• Abdominal Pain

  Sometimes the abdominal pain decreased expelling diarrheal dejections. [ncbi.nlm.nih.gov]

• Diarrhea

  We record the first case of HOA associated with primary intestinal lymphoma in a patient who presented with chronic diarrhea. [ncbi.nlm.nih.gov]

• Intestinal Disease

  Seventy percent of patients with solitary lymphoma and 80% with immunoproliferative small intestinal disease were mulatto. [ncbi.nlm.nih.gov]

  Other intestinal diseases are very important such as immunoproliferative small intestinal disease (IPSID), a prelymphomatous process, and MALT lymphomas, caused by infection of Helicobacter pylori (H. Pylori). [europeanreview.org]

• Abdominal Mass

  Twelve children had Burkitt's lymphoma (BL), presenting most commonly with abdominal masses and/or intestinal obstruction. These patients responded poorly to cyclophosphamide, and the disease disseminated early and extensively. [ncbi.nlm.nih.gov]

  The most common presenting symptoms were abdominal pain (100%), abdominal mass (50%), followed by nausea, vomiting and weight loss (25%), fever (25%) and GI bleeding (15%) as shown in the [Table 1]. [indianjcancer.com]

  Abdominal examination revealed abdominal distension with a palpable, firm, mobile right iliac fossa mass. Biochemistry revealed a haemoglobin of 8.7g/dL and an albumin of 25g/L. She was HIV negative with an ESR of 35mm/h. [ispub.com]

  […] pain 12 Rectal bleeding/maelena 5 Intestinal obstruction 5 Rectal symptoms 4 Diarrhea 3 Flatting 3 Weight loss 2 Iron deficiency anemia 2 Nausea or vomiting 2 Fatigue 1 Steatorrhea 1 Intestinal invagination 1 Perforation 1 Abdominal mass 1 Exsudative [annonc.oxfordjournals.org]

• Loss of Appetite

  An enlarged spleen might press on the stomach, which can cause a loss of appetite and feeling full after only a small meal. Lymphomas in the stomach or intestines can cause abdominal pain, nausea, or vomiting. [cancer.org]

  They may include abdominal discomfort associated with the following: Nausea Bloating Loss of appetite The following symptoms may indicate advanced disease and should be signs to seek medical attention: Fatigue Weight loss Iron deficiency anemia Visible [emedicinehealth.com]

  He showed loss of appetite and weight, and altered bowel habits. A general physical examination revealed that the patient was anemic. [dx.doi.org]

• Hypertension

  Late side effects are expected to be minimal but may include kidney damage and secondary hypertension, or a slightly increased risk of second cancers. Radiotherapy can also be used as an add-on therapy to chemotherapy in aggressive cases. [myvmc.com]

  […] patients who had received > 24 Gy to at least 1/3 rd of the left kidney. ( Mean prescribed dose = 37.9 Gy at 1.5 Gy/ #) 3 patients had persistent, mild elevations of urea and creatinine levels but all had received Cisplatin Only 2 patients developed hypertension [slideshare.net]

• Hepatomegaly

  High Grade Lymphomas 1 Higher frequency of weight loss at presentation Palpable abdominal mass Hepatomegaly Peripheral lymphadenopathy Elevated serum LDH Higher incidence of stage III-IV disease Significantly larger primary tumors Deeper invasion of the [slideshare.net]

  Diagnosis Examination in patients with low-grade lymphomas may demonstrate peripheral adenopathy, splenomegaly, and hepatomegaly. [emedicine.medscape.com]

  […] ref5, ref6, ref7, ref8 : adominal pain (80-100%) diarrhea (70-100%) weight loss (90-100%) vomiting : early stage (10%) advanced stage (30%) low-grade fever (30-50%) abdominal masses early stage (20%) advanced stage (60%) clubbing of fingers (20-60%) hepatomegaly [ufrgs.br]

Workup Routine hematological workup: Hemogram Biochemistry Staging workup UGIE Barium meal & follow through CT scan abdomen Endoscopic USG Chest X ray Bone marrow Optional Immunophenotyping LDH & ß 2 microglobulin CT scan features : Clefts & tracks in [slideshare.net]

Patients who presented with predominant intestinal lesions were classified as having primary intestinal DLBCL according to the definition proposed in previous reports. 13 ⇓ – 15 The imaging studies for staging workup were chest and abdomen-pelvis computerized [bloodjournal.org]

Although a variety of laboratory and imaging studies are used in the evaluation and staging of suspected NHL (see Workup ), a well-processed hematoxylin and eosin (H&E)–stained section of an excised lymph node is the mainstay of pathologic diagnosis. [emedicine.medscape.com]

• Small Bowel Mass

  Carcinoid tumor Small intraluminal mass in the ileum (yellow arrow). Associated spiculated mesenteric mass with adjacent desmoplastic reaction in small bowel carcinoid. Carcinoid tumors are rare neuroendocrine tumors. [radiologyassistant.nl]

• Polyps

  Abstract Turcot's syndrome, the association of brain tumor (usually glioblastoma, medullo-blastoma, or astrocytoma) and colonic polyps, is a very rare condition of which about 20 cases have been reported. [ncbi.nlm.nih.gov]

  While the majority of the polyps removed through colonoscopes are benign, many are precancerous. Removal of precancerous polyps prevents the future development of colon cancer from these polyps. [medicinenet.com]

  Patients with these syndromes often have multiple small bowel polyps. Larger polyps can become malignant and can mimic primary small bowel neoplasms. Here a patient with Peutz-Jeghers, who has multiple polyps in the jejunum. [radiologyassistant.nl]

  Abstract Intestinal mantle cell lymphoma characteristically produces multiple polyps, a finding reported as multiple lymphomatous polyposis. [nature.com]

Treatments were surgery plus chemotherapy (n = 6), surgery alone (n = 3), chemotherapy alone (n = 2), chemotherapy and radiation (n = 1), surgery and radiation (n = 1); two patients died before treatment. [ncbi.nlm.nih.gov]

Thus, the treatment outcomes of 327 patients were compared according to treatment strategy: surgery/chemotherapy versus chemotherapy alone. [bloodjournal.org]

There is a lack of information regarding the impact an emergency presentation has on the timing of postoperative chemotherapy and overall prognosis. [ncbi.nlm.nih.gov]

INTERPRETATION AND CONCLUSIONS: Intestinal lymphomas differ significantly from their gastric counterpart, not only in pathology, but also with regard to clinical features, management and prognosis. [haematologica.org]

However the Odds Ratio was significantly high for the presence of etiological risk factor (OR 7.50) and perforation as presenting symptom (OR 6.67). [ncbi.nlm.nih.gov]

Br J Cancer 60:745–750 Article CAS PubMed Central PubMed Google Scholar Capelle LG, de Vries AC, Looman CW, et al (2008) Gastric MALT lymphoma: epidemiology and high adenocarcinoma risk in a nation-wide study. [link.springer.com]

Epidemiology The disease affects mainly the adult, with male predominance, and it is frequently associated with gluten-sensitive entheropathy. Pathology The disease consists of ulcerated lesions involving the small intestine. Perforation may occur. [atlasgeneticsoncology.org]

Over the past decade, Jonas Ludvigsson, MD, PhD, a pediatrician and professor of clinical epidemiology at the Karolinska Institutet in Stockholm, established a large population-based database using biopsy results from 28 pathology departments in Sweden [newsroom.cumc.columbia.edu]

Epidemiologically, small-bowel adenocarcinomas have a striking resemblance to large-bowel adenocarcinomas. [emedicine.medscape.com]

Pathophysiology [ edit ] The majority of gastric lymphomas are non-Hodgkin's lymphoma of B-cell origin. These tumors may range from well-differentiated, superficial involvements ( MALT ) to high-grade, large-cell lymphomas. [en.wikipedia.org]

Lymphomas of the gastro-intestinal tract - Pathophysiology, pathology, and differential diagnosis. Indian J Pathol Microbiol 2012;55:1-16 How to cite this URL: Cardona DM, Layne A, Lagoo AS. [ijpmonline.org]

Pathophysiology Approximately 64% of all small-bowel tumors are malignant, and approximately 40% of these tumors are adenocarcinomas. Epidemiologically, small-bowel adenocarcinomas have a striking resemblance to large-bowel adenocarcinomas. [emedicine.medscape.com]

Chemotherapy drugs are injected directly into the spinal fluid to prevent the cancer from spreading to the central nervous system. This method of injection is referred to as “intrathecal.” [healthline.com]

Is it possible to prevent colon cancer? The most effective prevention for colorectal cancer is early detection and removal of precancerous colorectal polyps before they turn cancerous. [medicinenet.com]

Early diagnosis may prevent intestinal perforation; however, the diagnosis is often delayed in most cases. [dx.doi.org]

UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. [newsroom.ucla.edu]