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Intestinal Polyp
Intestinal Polyp(s)

Presentation

Some patients will present in infancy. These patients present with rectal prolapse and anemia; occasionally they will present with significant GI bleeding. Hypoproteinemia, malnutrition, and electrolyte imbalances are usually present as well. [ncbi.nlm.nih.gov]

In situations were a hereditary polyposis disorder is suspected, genetic counseling and testing can help to determine what syndrome is present and identify the gene mistake that may be present. [nationwidechildrens.org]

This handbook aims to offer a integrated approach for all physicians (doctors) who deal with these issues, by presenting up-to-date discussion from genetics through treatment, to implications of genetic counseling. [books.google.com]

The fibroblast proliferation of the reaction type presents fusiform and stellate cells intercalated by collagenous matrix 6. [scielo.br]

Gastrointestinal

  • Blood in Stool

    If symptoms do appear, they may include: Changes in bowel habit, including constipation or diarrhea Blood in stools (either dark, tarry stools or bright red stools) Abdominal pain If this combination of symptoms persists for more than a week, make an [verywell.com]

    Both polyps and colorectal cancers can bleed, and FOBT checks for tiny amounts of blood in feces (stool) that cannot be seen visually. (Blood in stool may also indicate the presence of conditions that are not cancer, such as hemorrhoids .) [cancer.gov]

    However, if you do experience symptoms, they may include: blood in the stool or rectal bleeding pain, diarrhea, or constipation that lasts longer than one week nausea or vomiting if you have a large polyp Blood on your toilet tissue or blood-streaked [healthline.com]

    Stool exam. Doctors may also look for the presence of blood in stools or examine the stool DNA. Depending on the results, they may then perform a colonoscopy to investigate further. Treatment Doctors will usually recommend surgery to remove polyps. [medicalnewstoday.com]

    In the event of minor blood loss (bleeding polyp), a fecal occult blood test may confirm a the presence of blood in the stool. This is, however, non-specific for intestinal polyps and other causes of blood in the stool need to be considered. [healthhype.com]

  • Intestinal Disease

    Several studies have indicated that intestinal dysbiosis may impact on the establishment of life-threatening intestinal diseases such as colorectal cancer. [nature.com]

Workup

See Workup for more detail. Management Polypectomy In patients with a solitary or a few pedunculated or sessile polyps, colonoscopic removal can be performed concurrently with the search for other lesions. [emedicine.medscape.com]

Treatment

Pai-1 were significantly reduced in intestinal nonpolyp parts by pitavastatin treatment. [ncbi.nlm.nih.gov]

The diagnosis and treatment of many diseases of the gastrointestinal tract are conducted with the use of high-tech endoscopic techniques. [hmcisrael.com]

Treatments Treatments Polyp removal. If your child has a single polyp, he or she will likely need no other treatment once the polyp is removed. A polyp may be removed during a colonoscopy. [rileychildrens.org]

These situations can fall into a gray area, not only for diagnosis, but also for the correct treatment and follow-up. New developments in pathophysiology and treatment options are leading to new questions. [books.google.com]

Subsequent treatment depends on the histology of the polyp. [merckmanuals.com]

Prognosis

Prognosis Polyps are common. But less than 1% of all polyps ever become cancerous. By removing polyps, the risk is even lower. Survival depends on the stage of cancer. [drugs.com]

Treatment and prognosis Because of the benefits of screening, screening studies (usually colonoscopy) are recommended at age 50 for men and women. The actual screening program depends on the patient's region and risk factors, however. [radiopaedia.org]

PROGNOSIS AFTER TREATMENT Once a colorectal polyp is completely removed, it rarely comes back. However, at least 30% of patients will develop new polyps after removal. [fascrs.org]

Prognosis Although it is estimated that 30% of middle-aged and older people have colon polyps, less than 1% of all polyps ever become cancerous. For people who catch and treat colon cancer early, the 5-year survival rate is over 80%. [womenshealthmag.com]

Etiology

Given their morphological definition, polyps may arise due to a variety of etiologies some of which are non-neoplastic. [pathwaymedicine.org]

[…] epithelial atypia develops ( Cancer 1979;43:1906 ) Second hypothesis: landscaper defect, in which an abnormal stromal environment leads to neoplastic transformation of adjacent epithelium ( Science 1998;280:1036, World J Gastroenterol 2011 ;17:4839 ) Etiology [pathologyoutlines.com]

The IFP etiology remains unknown. Some authors believe that it is caused by an exaggerated allergic reaction, due to a persistent inflammatory stimulus. This can be a result of trauma, bacterial infections or chemical injury 5,7. [scielo.br]

Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology. Scientific reports 6, 34055, https://doi.org/10.1038/srep34055 (2016). 61. Lepage, P. et al. [nature.com]

Etiology Environmental causes Epidemiologic studies suggest that environmental causes contribute to the differences in colonic polyp incidence in geographically distinct populations, but the responsible factors have remained elusive. [emedicine.medscape.com]

Epidemiology

[…] these would likely be called SSA / Ps Terminology HPs have been divided into microvesicular, goblet cell and mucin poor types based on quantity of mucin and the presence or absence of dystrophic goblet cells; however, this has no clinical relevance Epidemiology [pathologyoutlines.com]

There is now considerable experimental and epidemiological evidence that adequate calcium helps to control the rate of growth of colon cells. In addition, certain prebiotic plant fibers enhance the absorption of calcium and magnesium. [prebiotin.com]

“Dietary Magnesium Intake and Risk of Cancer: A Meta-Analysis of Epidemiologic Studies. “ Nutr Cancer. 2014 Jun 9:1-9. [nutritionalmagnesium.org]

Epidemiology United States statistics Population and autopsy studies suggest that about 30% of middle-aged or elderly individuals have colonic polyps. [emedicine.medscape.com]

Pathophysiology

New developments in pathophysiology and treatment options are leading to new questions. [books.google.com]

Juvenile polyposis syndrome: 5 or more juvenile polyps in the colorectum, juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis Sites More common on left side of colon Pathophysiology [pathologyoutlines.com]

Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 126. [medlineplus.gov]

In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed March 18, 2017. Niederhuber JE, et al., eds. [mayoclinic.org]

Prevention

Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? Semin Oncol. 2005 Feb;32(1):24-34. Review. 6. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. [passeportsante.net]

METHODS AND RESULTS: The Apc Min/+ mouse model was used to study the potential preventive effect of LGG on intestinal polyposis, while shotgun metagenomic sequencing was employed to characterize both taxonomic and functional changes within the gut microbial [ncbi.nlm.nih.gov]

View Diet Tips 7 Foods That Help Prevent Colon Polyps There are several natural food remedies for preventing polyps in the colon. [healwithfood.org]

At Marina Del Rey Hospital, our experienced gastroenterologists offer a wide range of treatment options and preventive measures for intestinal polyps. [marinahospital.com]

How can colon polyps be prevented? Doctors do not know of any one sure way to prevent polyps. [drweil.com]

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