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Intestinal Pseudo-Obstruction

Congenital Short Bowel Syndrome


Presentation

  • We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.[ncbi.nlm.nih.gov]
  • The frequencies present were determined by autoregressive modelling using a running spectral analysis method. 6 After running spectral analysis of gastric ECA the dominant frequency was determined if present.[doi.org]
Fatigue
  • Fukuda, K, Strauss, S, Hickie, I, Sharpe, M, Dobbins, J & Komaroff, A ( 1994 ) The chronic fatigue syndrome; a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group.[cambridge.org]
Abdominal Pain
  • A boy aged 2 years and 6 months presented with a 7-day history of fever, coffee-ground vomit, and abdominal pain. Abdominal radiography and ultrasound showed a dilated duodenum.[ncbi.nlm.nih.gov]
  • Clinical features can include abdominal pain, nausea, severe distension, vomiting, dysphagia, diarrhea and constipation, depending upon the part of the gastrointestinal tract involved.[en.wikipedia.org]
Nausea
  • This has led to extensive investigations that have revealed an important role for cannabinoids and their receptors in the regulation of nausea and emesis.[en.wikipedia.org]
  • Symptoms include abdominal pain, nausea, vomiting, diarrhea, constipation, and malnutrition. Vincristine-related pseudo-obstruction has been reported in the literature, but its description in children and recommendations for management are lacking.[ncbi.nlm.nih.gov]
  • Nutrition supplementation is required for many patients with CIP due to symptoms of dysphagia, nausea, vomiting, and weight loss.[doi.org]
  • Symptoms Abdominal distension and discomfort, bloating and nausea are common, particularly after meals.[my.clevelandclinic.org]
Abdominal Distension
  • Although Flomoxef was administered following admission, the boy's fever persisted and abdominal distension gradually worsened. On the 4th day, dry lips, red eyes and a strawberry tongue were noted.[ncbi.nlm.nih.gov]
  • Ten neonates presented with abdominal distension and bilious vomiting and an abdominal x ray suggestive of distal bowel obstruction.[doi.org]
  • CASE REPORT A 60-year-old white male patient had been complaining of abdominal distension and discomfort episodes for 24 years.[scielo.br]
Failure to Thrive
  • As a result, many children suffer from malnutrition, failure to thrive, and weight loss. It is common for doctors to suspect and diagnose this condition soon after birth or before a child’s first birthday in the cases of primary pseudo-obstruction.[childrenshospital.org]
  • The clinical picture tends to be dominated by abdominal distention (98%), vomiting (91%; bilious in 80%), abdominal pain (58–70%), failure to thrive (62%), diarrhea (31–42%), constipation (42–77%), feeding intolerance (39%), and urinary symptoms (11%)[ojrd.biomedcentral.com]
  • These included bloating, abdominal distention and pain, pseudo-obstruction, nausea, vomiting and failure to thrive, and weight loss.[journals.lww.com]
Intestinal Disease
Orthostatic Hypotension
  • Underlying disease Main causes Diseases of central autonomic and enteric nervous systems Stroke, encephalitis, calcification of basal ganglia, orthostatic hypotension, Von Recklinghausen, Hirschsprung Immune-mediated and collagen diseases Paraneoplastic[doi.org]
Hyperhidrosis
  • We describe a 52-years-old man with limbic encephalitis, thymoma, and anti-VGKC antibodies, who presented with autonomic dysfunctions such as severe intestinal pseudo-obstruction, hyperhidrosis and hypertension.[ncbi.nlm.nih.gov]

Workup

  • […] mainly clinical and confirmed by endoscopic or radiological exclusion of mechanical causes as well as by evidence of air-fluid levels in distended bowel loops. 3– 9 Standard or ambulatory intestinal manometry, although not mandatory in the diagnostic workup[doi.org]
Sinus Arrhythmia
  • Evaluation revealed diffuse autonomic dysfunction characterized by intestinal pseudo-obstruction, xerophthalmia, xerostomia, postural hypotension, erectile dysfunction and loss of sinus arrhythmia. Paraneoplastic work-up revealed thymoma.[ncbi.nlm.nih.gov]
Cytoplasmic Inclusion Bodies
  • Sections from these segments showed eosinophilic periodic acid Schiff stain and desmin positive cytoplasmic inclusion bodies in the myocytes.[ncbi.nlm.nih.gov]

Treatment

  • The treatment regimen is discussed in this case report.[ncbi.nlm.nih.gov]
  • Medical treatment [ edit ] Prucalopride, [10] [11] pyridostigmine, [3] metoclopramide, cisapride, and erythromycin may be used, but they have not been shown to have great efficacy. In such cases, treatment is aimed at managing the complications.[en.wikipedia.org]

Prognosis

  • The clinical characteristics, treatments, and prognosis were compared between the 3 groups. There were 57 females and 4 males, with a mean age of 32.0 years.[ncbi.nlm.nih.gov]

Etiology

  • The latter form can be diagnosed early in life due to a genetic etiology or in adulthood when a viral origin may be considered.[ncbi.nlm.nih.gov]
  • Diagnostic studies are needed to confirm the diagnosis, identify the etiology, and search for coexisting motility dysfunction.[ncp.sagepub.com]

Epidemiology

  • OBJECTIVE: To analyze the epidemiology, clinical characteristics, and risk factors for systemic lupus erythematosus-related intestinal pseudo-obstruction (SLE-IPO).[ncbi.nlm.nih.gov]
  • Hidenori Ohkubo, Hiroshi Iida, Hirokazu Takahashi, Eiji Yamada, Eiji Sakai, Takuma Higurashi, Yusuke Sekino, Hiroki Endo, Yasunari Sakamoto, Masahiko Inamori, Hajime Sato, Kazuma Fujimoto and Atsushi Nakajima, An Epidemiologic Survey of Chronic Intestinal[ncp.sagepub.com]
  • Summary Epidemiology The prevalence remains unknown. The male-to-female ratio is about 1.5:1 to 4:1.[orpha.net]
Sex distribution
Age distribution

Pathophysiology

  • We comment on the pathophysiology and on the clinical importance of amyloidosis-associated intestinal pseudo-obstruction.[ncbi.nlm.nih.gov]
  • This article is aimed at reviewing the current knowledge on pathophysiology, clinical features and management of patients affected by CIPO. ETIOLOGY AND PATHOPHYSIOLOGY CIPO is idiopathic in the majority of cases.[doi.org]

Prevention

  • Early recognition of pheochromocytoma with gastrointestinal manifestations will facilitate proper management and prevent possible lethal outcome.[ncbi.nlm.nih.gov]
  • It usually prevents the body from absorbing nutrients. As a result, many children suffer from malnutrition, failure to thrive, and weight loss.[childrenshospital.org]
  • Prevention Many cases of intestinal pseudo-obstruction cannot be prevented. But certain measures can be taken after surgery to help avoid the complication of intestinal pseudo-obstruction.[uvahealth.com]

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