Presentation
A predisposing factor was present in all patients in the form of corticosteroid intake, chronic liver disease and panhypogammaglobulinaemia. [ncbi.nlm.nih.gov]
The present study showed that most patients with Strongyloides infection to be male. [tropicalgastro.com]
Immune System
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Generalized Lymphadenopathy
No generalized lymphadenopathy or edema. Abdominal examination revealed tenderness in the epigastric region. No mass or hepatosplenomegaly. [atmph.org]
Respiratoric
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Persistent Cough
For HIV patients with strongyloidiasis, the most common symptoms were chronic diarrhea, fever, persistent coughing and loss of weight, but only the first three symptoms were significantly different from other immunocompromised hosts. [ncbi.nlm.nih.gov]
Gastrointestinal
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Chronic Abdominal Pain
Conclusion Strongyloides infection should be considered in patients with a clinical presentation of chronic abdominal pain, diarrhea, and failure to thrive (with or without skin rash) and laboratory findings of eosinophilia, elevated inflammatory markers [gastroenterologyandhepatology.net]
Skin
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Cutaneous Manifestation
Larva currens is pathognomonic cutaneous manifestation of Strongyloides infection. [1], [3], [8] The life cycle of this parasite is very complicated. [atmph.org]
manifestation of Strongyloides external autoinfection. 1,9 Few cases of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Strongyloides infection have been reported in the literature. [gastroenterologyandhepatology.net]
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Angioedema
Urticarial skin rashes may occur around the buttocks and hips, and purpuric skin lesions, angioedema and erythroderma have also been reported. [refugeehealthguide.org.au]
Neurologic
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Mydriasis
Hypoalbuminemia is common in HS; the free drug concentration is elevated and hence, the tissue level of ivermectin should be monitored daily, as the drug can be toxic to the central nervous system producing emesis, mydriasis, and ataxia. [14], [15] Uncomplicated [jscisociety.com]
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Responsiveness Decreasing
High fatality rate 400 to 1000 Standard faecal test usually positive Sputum and body fluids likely to be positive for autoinfective larvae Positive, equivocal or negative Immune response decreases and accelerated autoinfection: Autoinfective cycle is [racgp.org.au]
Workup
X-Ray
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Pericardial Effusion
Strongyloides stercoralis infection with bloody pericardial effusion in a non-immunosuppressed patient. Circulation J 2002;66:613–14. Mak DB. Recurrent bacterial meningitis associated with strongyloides hyperinfection. Med J Aust 1993;159:354. [racgp.org.au]
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Cavitary Lesion
lesions on chest X-ray that mimicked tuberculosis but resolved after treatment with anthelmintics. 18 Gastrointestinal: manifestations may include diarrhoea, hypokalaemia, protein-losing enteropathy, malnutrition, wasting, epigastric pain and tenderness [racgp.org.au]
Serum
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Hypochlorhydria
[…] been associated with strongyloidiasis, including immunosuppressive therapy for rheumatic diseases, malignancy (especially lymphomas), human immunodeficiency virus (HIV) infection, human T-cell lymphotropic virus type 1 (HTLV-1) infection, diabetes, hypochlorhydria [jscisociety.com]
Treatment
Because the auto-infective larvae are difficult to eradicate, one regimen dose may be in-sufficient and re-treatment of patients on two occasions, at 1 and 2 months after the initial treatment dose was recommended. [ncbi.nlm.nih.gov]
Follow up Serology is currently the best measure of treatment efficacy available as there is a decline in antibody titre after treatment. [refugeehealthguide.org.au]
Infection may be fatal in immunocompromised patients, even with treatment. [merckmanuals.com]
Management and treatment The treatment of choice is ivermectin. Prophylactic measures revolve around preventing contamination through faeces and wearing shoes. The documents contained in this web site are presented for information purposes only. [orpha.net]
Prognosis
Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Strongyloidiasis from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis [wikidoc.org]
Clinical observations, with special reference to factors influencing prognosis, Rev. Infect. [books.google.de]
Outlook (Prognosis) With proper treatment, the worms can be killed and full recovery is expected. Sometimes, treatment needs to be repeated. [ufhealth.org]
Etiology
Etiology The female nematodes, which measure 2.5 mm in length, live in the small intestine of humans. Eggs laid in the small intestine hatch to release larvae that are normally excreted in the faeces. [orpha.net]
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis, Science, 244, 362, 1989. [books.google.de]
The initial step in the evaluation of the patient with hypoproteinemia is to exclude other more common etiologies such as malnutrition, liver, and renal diseases. [jdeonline.in]
Stercoralis is an uncommon etiology for proximal bowel obstruction, high index of suspicion should be exercised in patients presenting as above and recent travel to areas endemic for S. Stercoralis. [omicsonline.org]
Diagnostic and Statistical Manual of Mental Disorders.Official Full-Text Publication: [Etiology and clinical course of urticaria in hospitalized children.] on ResearchGate, the professional network for scientists.Parasite antigenic determinants of antibody [anyvileq.webcindario.com]
Epidemiology
This review summarizes what is understood about infection by S. stercoralis; its focus will be on the epidemiology, diagnosis, clinical presentation patterns in the immunocompetent and immunocompromised human hosts, and recommended treatment regimens. [ncbi.nlm.nih.gov]
Source: For patient information, click here Strongyloidiasis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Strongyloidiasis from other Diseases Epidemiology and Demographics [wikidoc.org]
Step 1: Define risk category for disseminated strongyloidiasis based on epidemiologic and clinical factors Epidemiologic risk category for Strongyloides exposure/Infection Clinical risk factor for disseminated Strongyloides HTLV-1 Table 1 footnote 1 infection [canada.ca]
This review summarizes what is understood about infection by S. stercoralis ; its focus will be on the epidemiology, diagnosis, clinical presentation patterns in the immunocompetent and immunocompromised human hosts, and recommended treatment regimens [insights.ovid.com]
Pathophysiology
The pathophysiology underlying these risk factors, whether disease-related or iatrogenically induced, is a compromised immune system leading to dysfunction of TH-2 helper cells. [ncbi.nlm.nih.gov]
Source: For patient information, click here Strongyloidiasis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Strongyloidiasis from other Diseases Epidemiology and Demographics [wikidoc.org]
Unlike others on this topic, this text demonstrates how the endoscope incorporates pathophysiology, diagnostic, and treatment modalities into endoscopic practice. [books.google.com]
Prevention
Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies Case Studies Case #1 [wikidoc.org]
Medicines to prevent vomiting or diarrhoea should not be given, especially to children, except when prescribed by a doctor. Prevention Good hygiene and sanitation is the best way to prevent Strongyloidiasis. [nt.gov.au]
Treatment reference Prevention Prevention of primary Strongyloides infections is the same as for hookworms. [merckmanuals.com]
Objective: To provide clinical guidance on the prevention, assessment and management of disseminated strongyloidiasis. [canada.ca]
Prevention and control No public health strategy has been developed to control strongyloidiasis. Strongyloidiasis has almost disappeared in countries where sanitation and human waste disposal have improved. [who.int]