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Intracranial Neoplasm

Intracranial Tumors


Presentation

  • Here we report eight consecutive patients with intracranial neoplasm at different ages clinically presenting with acute esotropia.[ncbi.nlm.nih.gov]
  • […] may be present; If CN VII is affected, facial paresis may be present.[slideplayer.com]
  • We report a unique case of a 42-year-old man who presented with a sudden onset of altered sensorium. Transethmoidal meningocele secondary to an intraventricular epidermoid cyst was detected on imaging.[ncbi.nlm.nih.gov]
  • In contrast to patients with suprasellar craniopharyngiomas, generally presenting with headache and visual disturbance, patients with infrasellar craniopharyngiomas present usually only with nasal obstruction like in the present case.[diagnosticpathology.biomedcentral.com]
  • Three cases are presented to illustrate computed tomographic similarities between intracerebral haematomas and intracranial neoplasms.[ncbi.nlm.nih.gov]
Soft Tissue Mass
Heart Block
  • Maternal connective tissue disease and congenital heart block: Demonstration of immunoglobulin in cardiac tissue. N. Engl. J. Med. ‏[books.google.com]
Xanthoma
  • […] manifestations may result from brain parenchymal metastases or from tumors around the dura (eg, metastatic tumors; meningeal tumors such as meningiomas, sarcomas, or gliomas) or skull lesions (eg, granulomas, hemangiomas, osteitis deformans, osteomas, xanthomas[merckmanuals.com]
Denial
  • […] visual hallucinations, hemianopia or quadrantanopia (contralateral) Astrocytoma Glioblastoma Oligodendroglioma Parietal lobe Deficits in position sensation and in 2-point discrimination (contralateral), anosognosia (no recognition of bodily defects), denial[merckmanuals.com]
Urinary Urgency
  • urgency or incontinence, impaired attention and cognition and apathy (particularly if tumor is bilateral), hemiparesis Expressive aphasia if tumor is in dominant hemisphere Anosmia if tumor is at base of lobe Astrocytoma Glioblastoma Oligodendroglioma[merckmanuals.com]
Confusion
  • Convulsions and seizures Dizziness or loss of balance Vomiting or nausea Difficulty in speaking and thinking Vision changes Hearing changes Disorientation and confusion Personality changes Paralysis or weakness in one part or one side of the body Diagnosis[thebrainandspine.com]
  • When the hypopituitarism is severe episodic confusion occurs and the patient will become drowsy. Pituitary apoplexy results from sudden spontaneous haemorrhage into the pituitary tumour.[surgwiki.com]
  • If it becomes blocked, the symptoms are similar to that of the original condition of hydrocephalus and may include headaches, vomiting, visual problems and/or confusion or lethargy, among others.[aans.org]
  • Sometimes people confuse brain aneurysms with brain tumors. Brain aneurysms are not tumors; they are areas in the brain arteries or veins that are abnormally weak and expand to form a ballooning or expansion of the vessel wall.[emedicinehealth.com]
  • Rhabdoid Tumor Back to top Characteristics Rare Highly aggressive and tends to spread throughout the CNS Often appears in multiple sites in the body, especially the kidneys Difficult to classify; may be confused with medulloblastoma or PNETs Occurs most[braintumor.org]
Neck Stiffness
  • MENINGISMUS Blood in the subarachnoid CSF will cause the features of meningismus (headache, neck stiffness, photophobia and fever or vomiting).[surgwiki.com]
Lhermitte's Sign
  • After radiation therapy to the neck or upper thorax, early-delayed neurotoxicity can result in a myelopathy, characterized by spinal symptoms such as Lhermitte sign (an electric shock-like sensation radiating down the back and into the legs when the neck[merckmanuals.com]
Cognitive Deficit
  • Although there may be less concern over long-term toxicity of full-dose CSI in adults as compared with children, adults treated for medulloblastoma with a mean dose to the whole brain of 35 Gy have been shown to have long-term cognitive deficits (119)[neoadjuvant.wikidot.com]
Frontal Headache
  • Case report We report on a 60-year-old woman with swelling in the left periorbital region and frontal headache at the same side. Her medical history was significant for sinus surgery 9 months before elsewhere.[diagnosticpathology.biomedcentral.com]

Workup

  • […] include incompatibility with certain medical equipment, longer imaging times (increased risk of motion artifact), and poor visualization of the subarachnoid space Neither CT nor MRI can be used to differentiate tumor recurrence from radionecrosis See Workup[emedicine.medscape.com]
  • Any adult who has a recent onset of seizures, particularly focal seizures, is considered a tumor suspect until adequate neurologic workup proves otherwise. Specific Tumor Types There are many types of tumors that develop intracranially.[dartmouth.edu]

Treatment

  • Successful Vemurafenib Treatment of Progressive BRAF V600E–Mutated Anaplastic Pleomorphic Xanthoastrocytoma Editor’s note: Oncologists sometimes suggest a treatment based on specific mutations found in a patient’s tumor.[cancercommons.org]
  • Treatment options icon plus At HCA UK we provide a wide range of specialist and advanced treatments. Your consultant will discuss your diagnosis and treatment options with you in detail and help you make an informed decision about your care.[newmaldendiagnostics.co.uk]
  • However, in order to achieve tumor control, multiple PDT treatments, such as hyper fractionation or metronomic delivery, are required, where the frequency and duration of the treatment are determined by the levels of apoptosis achieved in relationship[osapublishing.org]
  • N Eng J Med 352:997–1003 CrossRef Google Scholar Quang TS, Brady LW (2004) Radioimmunotherapy as a Novel Treatment Regimen: 125I-labeled monoclonal antibody 425 in the Treatment of High-Grade Gliomas.[link.springer.com]
  • Both patients received adjuvant treatment based on chemotherapy and radiation therapy with favorable results. The patients died at 5 and 1.5 years respectively due to renal failure secondary to systemic disease.[ncbi.nlm.nih.gov]

Prognosis

  • There is a high degree of correlation between what the histology shows and the prognosis.[oncolex.org]
  • Patient prognosis and survival was best predicted by tumor histology. Treatment response and outcome did not appear to be influenced by HIV infection. Only the leiomyosarcoma demonstrated evidence of latent EBV infection.[neurology.org]
  • The prognosis of extracranial meningioma is always good if the excision is complete [ 7 ].[diagnosticpathology.biomedcentral.com]
  • Although further studies are needed, especially with bigger cohorts of patients, aMRI showed that we can shed light on the prognosis and response to targeted chemotherapies.[jxym.amegroups.com]
  • Astrocytoma: Glioblastoma Epi: Most common type of primary brain tumor in adults Age of presentation: 40-60, M F Facts: May arise de novo or evolve from a low-grade glioma Tumor infiltrates along white matter tract and can cross corpus callosum Poor Prognosis[slideplayer.com]

Etiology

  • Wegener granulomatosis - Autoimmune etiology and clinical course. Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies.[netdoc.com]
  • Brain abscesses: etiologic categorization with in vivo proton MR spectroscopy. Radiology 2004;230:519-27. [ Crossref ] [ PubMed ] Chang SC, Lai PH, Chen WL, et al.[jxym.amegroups.com]
  • In some instances, however, the symptoms are specific to the etiology. Hemorrhage, which can be parenchymal or extra-axial is the most common cause of intracranial mass lesions and is discussed in Chapter 27.[dartmouth.edu]
  • Inherited diseases associated with brain tumors and history of infections may be indicators of etiology and in the case of hereditary syndromes increase vigilance in surveying for other cancers.[neoadjuvant.wikidot.com]

Epidemiology

  • Rickert CH, Paulus W: Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst 2001;17:503–511. Bleyer WA: Epidemiologic impact of children with brain tumors.[karger.com]
  • Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro-oncology 2002 ; 4 : 278 –299.[cambridge.org]
  • E-mail: alexiougrg@yahoo.gr Received: 19 Aug 2014 Accepted: 30 Sep 2014 Published: 15 Jan 2015 Abstract Aim: Several epidemiological studies have shown an inverse correlation between allergy and brain cancer.[nnjournal.net]
  • […] from Altmetric.com epidemiology incidence elderly intracranial neoplasm Brain tumours are second only to stroke as the leading cause of death from neurological disease.[jnnp.bmj.com]
  • Although few studies had been done on the epidemiology of intracranial tumours in Nigeria and Africa as a whole, the objective of this paper is to provide an ample and detailed perspective on the epidemiological studies of intracranial tumour in a newly[panafrican-med-journal.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Neurologic dysfunction may result from the following: Invasion and destruction of brain tissue by the tumor Direct compression of adjacent tissue by the tumor Increased intracranial pressure (because the tumor occupies space within the[merckmanuals.com]
  • Conclusions Advanced MRI is an essential tool in the study of brain tumors, integrating anatomics informations provided by cMRI with biologic and pathophysiological data of these tumors.[jxym.amegroups.com]
  • The pathophysiology of radiation induced neurocognitive damage is complex and involves inter- and intracellular interactions between vasculature and parenchymal cells, particularly oligodendrocytes, which are important for myelination.[neoadjuvant.wikidot.com]

Prevention

  • This review represents part of a series of papers written to consolidate information about these events and preventive measures as part of an ongoing effort to ascertain the utility of devising system-wide policies and safety tools to improve neurosurgical[ncbi.nlm.nih.gov]
  • Maskless immobilization device may help to prevent movement of head during radiation therapy and immobilize patients with the same accuracy and reliability as the standard thermoplastic mask routinely used for patients receiving radiation therapy.[clinicaltrials.gov]
  • The most common cause in children is diffuse therapy given to prevent leukemia or to treat medulloblastoma.[merckmanuals.com]
  • Radiation can shrink the tumor or help prevent it from growing any larger. Radiation can also be used to kill cancer cells if the tumor is malignant. It may also be used on the parts of a tumor the surgeon was unable to remove.[webmd.com]
  • Prevention The cause of primary brain tumors has not been determined, so there is no known way to prevent them.[medical-dictionary.thefreedictionary.com]

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