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2.1
Ductal Carcinoma in Situ
Noninfiltrating Intraductal Carcinoma

Presentation

[…] initial presenting symptom was a mass in 63% (19/30) of the patients, nipple discharge in 13% (4/30), and mammographic finding in 23% (7/30). [ncbi.nlm.nih.gov]

Entire Body System

  • Inflammation

    Periductal stromal inflammation and multifocality also were seen more frequently in mixed DCIS/IDC than in pure DCIS. [ncbi.nlm.nih.gov]

    Before a definitive cancer diagnosis is established, one must rule out any noncancerous conditions that may cause architectural and cytologic atypia (Box 2).12–16 Benign glands with intense inflammation, especially acute inflammation, can cause both architectural [docksci.com]

    PH1218 Mastitis, Chronic Inflammation of breast tissue usually as a result of bacterial infection, most commonly occurring during lactation. [lifeworkpotential.com]

    Histologically, the wall of the syringocele may be denuded and associated with prominent inflammation as well as fibrosis of the wall. [abdominalkey.com]

    Periductal concentric fibrosis & chronic inflammation. Extensive lesions – palpable as vague nodularity. 19. Noncomedo DCIS Monomorphic cell population – nuclear grades  low to high. [slideshare.net]

  • Swelling

    Symptoms include swelling of the breast (either the entire breast or part), skin irritation, nipple pain, thickening of the nipple skin, discharge from the nipple that is not milk, a lump in the armpit, and breast pain. [healthresearchfunding.org]

    Inflammatory Breast Cancer : Inflammatory breast cancer is a fast-growing form of breast cancer that usually starts with the reddening and swelling of the breast, instead of a distinct lump. [breastcancer.org]

    Her medical history was significant for a swelling of the left parotid gland 6 months before her current presentation. [ejbc.kr]

    […] tenderness; the nipple may also be inverted, or pulled back into the breast Ridges or pitting of the breast; the skin may look like the skin of an orange A change in the way the skin of the breast, areola, or nipple looks or feels [16] such as warmth, swelling [en.wikipedia.org]

  • Sepsis

    […] associated with this congenital abnormality is currently 16 As the prenatal diagnosis of posterior urethral valves may be difficult, most deaths occur in newborns with severe bilateral renal dysplasia, pulmonary hypoplasia, electrolyte imbalances, or sepsis [abdominalkey.com]

  • Infertility

    Additional risk factors include firstdegree relatives with breast cancer, decreased testicular function, exposure to exogenous estrogens, infertility, obesity, prior benign breast disease, exposure to ionizing radiation, and residency in Western countries [quizlet.com]

Respiratoric

  • Pneumonia

    […] urinary incontinence without sensor awareness The main term in in diagnostic statement preoperative fever Icd 9 code for rabies or hydrophobia Punctuation use in icd 10 cm around alternative wordings explanations The main term in actinomycosis with pneumonia [quizlet.com]

Psychiatrical

  • Aggressive Behavior

    Clearly, high-grade metaplastic carcinomas have an aggressive biologic behavior with similar therapy as any other breast carcinoma. [journals.sagepub.com]

    Prostatic Foamy Gland Carcinoma With Aggressive Behavior Clinicopathologic, Immunohistochemical, and Ultrastructural Analysis Thuy T. Tran, etal. [thedoctorsdoctor.com]

Breast

  • Nipple Discharge

    In current clinical practice, the use of nipple discharge cytology as a screening and diagnostic tool for breast carcinoma is largely supplemental; however, this case illustrates the occasional utility of nipple discharge cytology in the diagnosis of [ncbi.nlm.nih.gov]

    PH1216 Intraductal Papillomas Non-cancerous wart-like growths that have grown inside the breast, often involving the large milk ducts near the nipple, causing bloody nipple discharge. [lifeworkpotential.com]

    discharge). 7% of serous and 14% of blood nipple discharges are malignant. [radnotes.co.nz]

    Adenoma an epithelial, papillary mass that grows within a duct that exits the nipple benign, circumscribed lesion that can be a cause of nipple discharge and requires special sonographic technique - rolled nipple - to be imaged well Lipoma represents [quizlet.com]

  • Nipple Retraction

    […] and Areola 197 Inflammatory Carcinoma 199 Skin and Nipple Retraction 203 Ulceration 206 Cutaneous Metastases 207 Lesions That Arise Outside the Ducts and Lobules 213 Skin Tumors 218 Calcifications of the Epidermis and Subcutaneous Tissue 222 Nipple Changes [books.google.com]

    Nipple retraction Lymphatics - involved - block the local area of skin drainage  lymphedema, skin thickening. Tethering of the skin to the breast by Cooper ligaments  peau d'orange. Mammography  Radiodense mass 30. [slideshare.net]

  • Breast Mass

    (primarily breast masses) 14 2/181 (1.1) 1/2 (50) Pijnappel et al., 2004 [ 22 ] Breast mass and calcifications only 14 or 18 8/128 (6.3) 5/8 (62.5) Crystal et al., 2005 [ 21 ] Breast masses 14 6/715 (0.8) 4/6 (66.7) Sauer et al., 2005 [ 20 ] Breast masses [e-ultrasonography.org]

    Recognize US and mammographic features that support or preclude biopsy of an echogenic breast mass. •. Discuss clinical situations in which biopsy of an echogenic breast mass can be safely avoided. •. [pubs.rsna.org]

    Diabetic Mastopathy nonspecific focal region of increased opacity may appear as irregular, speculated mass may be missed in the radiographic dense breast Sonographic Features of Diabetic Mastopathy irregular, ill-defined, or speculated mass markedly [quizlet.com]

    Meanwhile, using MALDI-TOF mass spectrometry to quantify vimentin methylation in breast tumors and breast cancer cell lines, Ulirsch et al. 2013 [9], found that vimentin was differentially methylated in both luminal A and luminal B cell lines and in luminal [scirp.org]

    It occurs in patients in their 30s and 40s who present with a breast mass, and by imaging, they are round, oval or lobulated [ 42 ]. [journals.sagepub.com]

Neurologic

  • Confusion

    Intraductal Carcinoma Intraductal Carcinoma, Noninfiltrating Intraductal Carcinomas Intraductal Carcinomas, Noninfiltrating Noninfiltrating Intraductal Carcinoma Noninfiltrating Intraductal Carcinomas NOTE intraductal refers to mammary ducts only; do not confuse [finto.fi]

    Because of its infiltrative pattern, granular cell tumor may be confused with invasive carcinoma with apocrine features. [pathologyboardreview.com]

    […] characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. intraductal refers to mammary ducts only; do not confuse [reference.md]

    Mammographic imaging can also be confusing as it shows a speculated mass or microcalcifications [ 5 ]. [ejbc.kr]

    Underlying carcinoma - diffusely infiltrative - does not form a discrete palpable mass  confusion with true inflammatory conditions a  delay in diagnosis. Many patients  metastases at diagnosis / recur rapidly. Overall prognosis  poor. 43. [slideshare.net]

Workup

Both patients had negative gastrointestinal endoscopic workups. [thedoctorsdoctor.com]

Treatment

While mastectomy has been the traditional treatment, many now feel it is excessive in most cases. [ncbi.nlm.nih.gov]

Has a known additional malignancy that is progressing or requires active treatment. [clinicaltrials.ucsf.edu]

Prognosis

Lymph node metastases - infrequent.  favourable prognosis ER, PR, HER2 – (triple negative) IncreasedexpressionofICAM-1andp-CADHERIN 30. [slideshare.net]

Either stellate (with focal necrosis, very poor prognosis) or circular/oval (1/3, better prognosis). Molecular classes correlate with prognosis and response to therapy: Luminal A (40-55%) – ER positive and HER2/neu negative. [radnotes.co.nz]

KEYWORDS: diagnostic criteria; intraductal carcinoma of the prostate; prognosis [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

Metastatic breast cancer is harder to treat, and patients with advanced invasive cancers have a poorer prognosis. Some sub-types of IDC have a poorer prognosis than standard IDC, while others have a better prognosis. [diagnosisdelayed.com]

Etiology

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

This case identifies yet another etiology for false-positive sentinel lymph nodes morphologically and by immunohistochemistry. [ncbi.nlm.nih.gov]

[…] the most common benign solid breast tumor noninfiltrative lesion compresses surrounding tissues as it grows within normal tissue planes the pseudocapsule of a fibroadenoma represents the leading edge of compressed breast tissue surrounding the mass Etiology [quizlet.com]

Furthermore, it seems that the connection between these two diseases may not just be etiologic and there may be synergism between the two cancers after tumorigenesis has occurred. [ejbc.kr]

Epidemiology

[…] options Subheadings: analysis anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology [ncbi.nlm.nih.gov]

Expert authors in this issue review this topic in articles such as: Applications for Breast MRI; Lobular Neoplasia; Epidemiology of Breast Cancer; Percutaneous Ablation of Breast Tumors; Triple Negative Breast Cancer and the Basal Breast Cancer Subtype [books.google.ro]

EPIDEMIOLOGY AND CLINICAL FEATURES LCIS is most frequently diagnosed in women aged 40 to 55 years ( 4, 11 ). [oncohemakey.com]

"Epidemiology of ductal carcinoma in situ". Journal of the National Cancer Institute. Monographs. 2010 (41): 139–41. doi : 10.1093/jncimonographs/lgq027. PMC 5161058. PMID 20956818. ^ Kerlikowske, K.; Molinaro, A. M.; Gauthier, M. L.; Berman, H. [en.wikipedia.org]

Pathophysiology

Diagnosis of the two conditions in a single patient is often thought to be coincidental, but there is evidence supporting a possible pathophysiological connection involving a common genetic background or etiologic factor, or possibly, one disease causes [ejbc.kr]

Prevention

[…] imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology genetics history immunology metabolism microbiology mortality nursing organization and administration parasitology pathology physiology physiopathology prevention [ncbi.nlm.nih.gov]

A prominent physician at a San Francisco hospital recommended a course of preventative treatment—just to be safe. But Ms. Adams did not wish to undergo preventative chemotherapy or radiation. [ptreyeslight.com]

[…] high-grade (grade II-III), palpable mass, hormone receptor negative (less than 1%), Her2 positive, young age (less than 45 years old), and large size (greater than 5 cm) Patients with a history of tamoxifen and/or aromatase inhibitor use for treatment or prevention [clinicaltrials.ucsf.edu]

Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 12 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Preventing [clinicaltrials.gov]

It may be argued that those invasive cancers, with their potential for dissemination, could have been prevented had the primary tumor been treated by mastectomy. [nejm.org]

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