CASE REPORT We present a case of a 67-year-old female initially presenting with chest pain at rest, found to have a lung nodule on diagnostic imaging at the time of admission. [ncbi.nlm.nih.gov]

• Inflammation

  Fibrosis and inflammation were seen around the dilated peripheral portal veins embolized with dead S. japonicum eggs. [ncbi.nlm.nih.gov]

• Weight Loss

  Other common symptoms at presentation include abdominal pain, weight loss, and fever. [ncbi.nlm.nih.gov]

  Abstract A 48-year-old Egyptian woman presented with 8 months of sharp right upper chest pain and weight loss. [acgcasereports.gi.org]

  Symptoms of cholangiocarcinoma (bile duct cancer) include: Jaundice Abdominal pain Fever Weight loss Weakness Itching How is cholangiocarcinoma diagnosed? When you see your physician you will have a routine examination. [hopkinsmedicine.org]

  Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor. [icd10data.com]

• Fatigue

  When to see a doctor See your doctor if you have persistent fatigue, abdominal pain, jaundice, or other signs and symptoms that bother you. [mayoclinic.org]

  Patients may have non-specific symptoms including weight loss, abdominal pain, fevers, night sweats and fatigue. [rarediseases.org]

  Many patients with CCA often present with non-specific symptoms such as cachexia, abdominal pain, night sweats, and fatigue which can precede or follow altered hepatocellular and biliar function tests. [omicsonline.org]

  Toxicity Most patients developed fatigue. Six patients had symptomatic nausea requiring medication (18% Grade II toxicity). There were four Grade III adverse effects (12%). [jcancer.org]

• Sepsis

  The main complications are liver failure and sepsis. [em-consulte.com]

• Abdominal Pain

  We present a case of an 83-year-old male patient with abdominal pain who was diagnosed with polypoid intrahepatic cholangiocarcinoma in the left intrahepatic duct (IHD) with peripheral IHD dilatation. He refused to undergo curative surgery. [ncbi.nlm.nih.gov]

• Nausea

  Case Presentation A 30-years-old Caucasian man with no significant medical history was admitted at the Emergency Department with acute upper abdominal pain, nausea and vomiting. [omicsonline.org]

  Six patients had symptomatic nausea requiring medication (18% Grade II toxicity). There were four Grade III adverse effects (12%). Two patients developed duodenal ulceration, one patient had cholangitis and one patient developed a liver abscess. [jcancer.org]

  Symptoms, when present, include abdominal pain, malaise, night sweats, asthenia, nausea and weight loss. [em-consulte.com]

• Vomiting

  A 23-year-old female was noted with intermittent right upper abdominal distension, abdominal pain, and vomiting after eating for more than 1 month. [ncbi.nlm.nih.gov]

  Case Presentation A 30-years-old Caucasian man with no significant medical history was admitted at the Emergency Department with acute upper abdominal pain, nausea and vomiting. [omicsonline.org]

• Jaundice

  He presented with jaundice and computed tomography showed a 4-cm, hypodense tumor in segment VIII of the liver. Microscopically, the resected mass was composed of well-differentiated adenocarcinoma cells. [ncbi.nlm.nih.gov]

• Liver Mass

  Image-guided biopsy is the best diagnostic method for breast cancer with liver mass to avoid misdiagnosis and classify the molecular subtypes to make appropriate treatment. [ncbi.nlm.nih.gov]

  No mediastinal adenopathy or masses were seen, but a 7.1-cm hypodense mass in the right lobe of the liver was found. [acgcasereports.gi.org]

  His tumor markers and liver mass decreased, but after a short time, his tumor markers elevated again (CEA 9.5 ng/mL, CA19-9 9027 U/mL). [surgicalcasereports.springeropen.com]

• Hepatomegaly

  On physical examination, cardiac and pulmonary function was normal; the abdomen was tender in the upper quadrant and revealed hepatomegaly (upon palpation liver inferior margin was 3 cm below the right costal margin on the midclavicular line, the liver [omicsonline.org]

• Pruritus

  BACKGROUND Intrahepatic cholangiocarcinoma is a rare condition which typically occurs in males between 50 and 70 years of age, and presents with symptoms related to biliary obstruction including jaundice, pruritus, and dark urine. [ncbi.nlm.nih.gov]

  Palliative therapy Relief of biliary obstruction is warranted when symptoms such as pruritus and hepatic dysfunction outweigh other symptoms of the cancer. [northshore.org]

  It was also recently demonstrated that the increase in opioidergic tone by the central administration of Morphine, binding to the mu- Opioid Receptor, is associated with pruritus (classical sing of cholestasis) in patients with primary biliary cirrhosis [omicsonline.org]

• Dark Urine

  BACKGROUND Intrahepatic cholangiocarcinoma is a rare condition which typically occurs in males between 50 and 70 years of age, and presents with symptoms related to biliary obstruction including jaundice, pruritus, and dark urine. [ncbi.nlm.nih.gov]

  Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. [2] Symptoms of cholangiocarcinoma may include abdominal pain, yellowish skin, weight loss, generalized itching, and fever. [1] Light colored stool or dark [en.wikipedia.org]

• Hepatocellular Carcinoma

  The pre-operative diagnosis of both cases was hepatocellular carcinoma with metastatic nodule, however, surgical resection pathology revealed that hepatocellular carcinoma and intrahepatic cholangiocarcinoma existed independently in the other side of [ncbi.nlm.nih.gov]

She received oral apatinib treatment since September 30, 2017. Due to related adverse reactions, the patient could not tolerate the treatment, and the subsequent reduction therapy was given. [ncbi.nlm.nih.gov]

The prognosis of sarcomatous ICC is poorly understood. We analyzed the prognosis of sarcomatous ICC by reviewing the previous reports and our own case. Only 15 cases of sarcomatous ICC have been reported in the English-language literature so far. [ncbi.nlm.nih.gov]

These data highlight the relative importance of ICC etiology relative to established clinicopathological factors in the prognosis of patients with ICC. [ncbi.nlm.nih.gov]

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse etiologies, morphologies, and clinical outcomes. [bric.ku.dk]

KEYWORDS: cirrhosis; epidemiology; hepatitis; hepatocellular carcinoma; intrahepatic cholangiocarcinoma [ncbi.nlm.nih.gov]

and the Division of Cancer Epidemiology and Genetics, National Cancer Institute. [journals.plos.org]

We report 2 cases of ICC that presented with a background of hepatitis B virus (HBV) infection and discuss the possible pathophysiological relationships between ICC and HBV infection, with an emphasis on the x gene of HBV. [ncbi.nlm.nih.gov]

In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed Feb. 22, 2016. Rizvi S, et al. [mayoclinic.org]

[…] common in East Asia, due to endemic liver fluke infection More common in older patients (over 75% of patients are older than 65 at initial diagnosis) ( Gastroenterology 2009;136:1134 ) Slightly more common in males than females ( Hepatology 2011;54:173 ) Pathophysiology [pathologyoutlines.com]

[…] dioxide which was used as a radiologic contrast medium, has been linked to the development of cholangiocarcinoma as late as 30–40 years after exposure; Thorotrast was banned in the United States in the 1950s due to its carcinogenicity. [35] [36] [37] Pathophysiology [en.wikipedia.org]

Some of these risk factors are either potentially preventable (eg, alcohol and tobacco use) or are currently treatable (eg hepatitis infection). [ncbi.nlm.nih.gov]

Prevention There's no way to prevent cholangiocarcinoma (bile duct cancer). But you may reduce your risk of the disease if you: Stop smoking. Smoking is linked to an increased risk of cholangiocarcinoma. If you smoke, stop. [mayoclinic.org]

Causes, Risk Factors, and Prevention Learn about the risk factors for bile duct cancer and what you might be able to do to help lower your risk. Early Detection, Diagnosis, and Staging Know the signs and symptoms of bile duct cancer. [cancer.org]