A 54-y-o woman presented to the Emergency Department with shortness of breath and sore throat after intranasal administration of Ecbalium elaterium as a folk remedy for her sinusitis. [ncbi.nlm.nih.gov]

The composite data from individual runs presented in Table 10. [patents.google.com]

Some limitations of the present research should be acknowledged. [journals.plos.org]

• Pain

  RESULTS: Compared with control group, those given preemptive analgesia required significantly less sufentanil during surgery, had less pain at postoperative 6-12 h; those given butorphanol experienced less nausea and vomiting, less pain at postoperative [ncbi.nlm.nih.gov]

  Pain Management A great deal of research has demonstrated that pain control can be obtained through intranasal drug administration in a safe and effective manner with few side-effects. 2 There are a variety of different pain medication choices, including [emsworld.com]

  While intramuscular administration has its disadvantages, it may be favorable for painful or long procedures. [pharmacytimes.com]

  […] ad-min″is-tra´shun ] the giving or application of a pharmacologic or other therapeutic agent. analgesic administration in the nursing interventions classification, a nursing intervention defined as the use of pharmacologic agents to reduce or eliminate pain [medical-dictionary.thefreedictionary.com]

• Falling

  How to recognize a heroin overdose Most overdoses fall into the following categories: Recreational use. Attempt to hide drugs from law enforcement by stuffing them into a body orifice. Deliberate attempt to cause self-harm. [ems1.com]

  First, although the baseline concentrations are statistically similar, the difference does not fall very far short of statistical significance, with OT baseline concentrations being higher than placebo baseline concentrations. [journals.plos.org]

  If the pH lies within the range of pK-1 and pK+1 of the weak acid the buffer capacity is appreciable, but outside this range it falls off to such an extent as to be of little value. [patents.google.com]

• Severe Pain

  An intra-nasal (IN) formulation, SPRIX(®), is approved for the treatment of short term (up to 5 days) acute moderate to moderately severe pain. [ncbi.nlm.nih.gov]

  It is associated with less cardiac instability than morphine, but otherwise functions similarly and has effects on the body nearly identical to morphine and is effective in treating moderate to severe pain. [emsworld.com]

  pain, and is quicker to administer than establishing an IV and administering an IV analgesic. [prehospitalresearch.eu]

• Weakness

  A buffer generally consists of a weak acid and its appropriate salt (or a weak base and its appropriate salt). [patents.google.com]

  Results from our present study also showed weak responses to the Vacc-4x Gag p24 consensus peptides. [journals.plos.org]

• Epilepsy

  Epilepsy Behav 5(2):253–255. doi: 10.1016/j.yebeh.2004.01.003 CrossRef PubMed Google Scholar 25. [link.springer.com]

• Aspiration

  The patient's history included nasal aspiration of the juice of the squirting cucumber (Ecbalium elaterium) for acute maxillary sinusitis. An airway obstruction due to severe uvular angioedema was detected and confirmed by airway X-ray. [ncbi.nlm.nih.gov]

  In the event that the administration is successful, the volume might not be rapidly absorbed and thus drip down the child’s posterior pharynx, where it likely stings and has a terrible taste, causing the child to vomit and risk aspiration. [pharmacytimes.com]

  The fentanyl Oralet™ has been used successfully in oncology patients undergoing painful procedures such as bone marrow aspiration or lumbar punctures. 127, 128 Oral transmucosal administration of morphine (by a buccal tablet) has been considerably less [pediatrics.aappublications.org]

  The manufacturing of such dry powder formulations would include evaluation of feed solution volume (e.g., from about 20 ml to about greater than one liter), inlet and outlet temperatures, aspirator, feed solution flow rate and atomizing pressure, where [patents.google.com]

• Rhinorrhea

  Atropine Intranasal atropine use has been reported in the treatment of organophosphate poisoning (OP) in one animal study (Pravin et al 2001), and is commonly used in humans for treating rhinorrhea and postnasal drip (Baroody et al 1996). [prehospitalresearch.eu]

• Nausea

  Compared with patients given fentanyl, those given butorphanol required significantly less postoperative fentanyl, had less pain at postoperative 18-24 h, less nausea and vomiting, and less POCD. [ncbi.nlm.nih.gov]

  […] names of Imitrex- sumatriptan; Zomig - Zolmitriptan; Migranal - Dihydroergotamine and the OTC nasal spray Sinol-M; are also currently administered by nasal administration because a fast effect is desired and oral administration can be prohibited by nausea [scientiait.com]

  However, Wagner at al (1996) in a double-blind, placebo-controlled evaluation of intranasal metoclopramide in the prevention of postoperative nausea and vomiting (PONV) found that a 20mg dose was ineffective in preventing the occurrence of PONV – they [prehospitalresearch.eu]

• Vomiting

  Compared with patients given fentanyl, those given butorphanol required significantly less postoperative fentanyl, had less pain at postoperative 18-24 h, less nausea and vomiting, and less POCD. [ncbi.nlm.nih.gov]

  In the event that the administration is successful, the volume might not be rapidly absorbed and thus drip down the child’s posterior pharynx, where it likely stings and has a terrible taste, causing the child to vomit and risk aspiration. [pharmacytimes.com]

  However, Wagner at al (1996) in a double-blind, placebo-controlled evaluation of intranasal metoclopramide in the prevention of postoperative nausea and vomiting (PONV) found that a 20mg dose was ineffective in preventing the occurrence of PONV – they [prehospitalresearch.eu]

  A Seattle study of IN naloxone administered by BLS providers cited a 15 percent rate of “naloxone associated violence” which was probably exaggerated as the authors included agitation and vomiting as violent behavior when, in fact, these were probably [ems1.com]

  Scopolamine patches are used to treat motion sickness or to prevent nausea and vomiting. [pediatrics.aappublications.org]

• Hypotension

  Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331:1105-1109. 4. Gross D, Landau EH, Assalia A, Krausz MM. [books.google.it]

  In opioid overdoses, where hypotension and sometimes damaged veins make intravenous administration difficult, nasal naloxone offers a wide margin of safety and reduced risk of infection from vessel puncture while enabling even untrained bystanders to [scientiait.com]

  Physical exam findings in opioid overdose classically include pinpoint pupils (miosis), respiratory and CNS depression, and often flushing, hypotension and decreased bowel sounds. [ems1.com]

• Fracture

  Need a fracture reduced or a large laceration repaired in an uncooperative child? Then intranasal administration might not be the best option. [pharmacytimes.com]

  Kane Guthrie discusses IN drug delivery in a post on Life in the Fast Lane, noting that basal skull fracture is a contraindication, and that some EMS systems avoid this route in anyone with head trauma or an altered GCS. [thepoisonreview.com]

• Epistaxis

  A. copious nasal secretions B. epistaxis C. nasal polyp D. all of the above Question 4 The best absorption of intranasal medication occurs when to a single nostril one delivers volumes less than A. 1 mL. B. 0.5 mL. C. 0.3 mL. D. 0.1 mL. [medium.com]

  Tranexamic Acid While not technically intranasal in the sense we have been discussing, the new kid on the block for many EMS providers, TXA applied to a pledget was better than anterior nasal packing in the initial treatment of idiopathic anterior epistaxis [prehospitalresearch.eu]

• Seizure

  A patient can rapidly become hypoxic during a seizure, and rapid seizure termination is essential. Research now shows there is a faster method to achieve this, and it is important to consider implementing this into prehospital seizure management. [emsworld.com]

  The patient developed respiratory failure, shock, and seizures. When he regained consciousness, the patient had evidence of hypoxic-toxic encephalopathy on neuropsychologic examination. [ncbi.nlm.nih.gov]

  Bhattacharyya (2006) in a randomised study of 46 children (188 seizure episodes) concludes intranasal midazolam is preferable to rectal diazepam in the treatment of acute seizures in children. – ( free full text available here ) – – ( free full text available [prehospitalresearch.eu]

  Arya R, Gulati S, Kabra M et al (2011) Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study. [link.springer.com]

• Agitation

  A Seattle study of IN naloxone administered by BLS providers cited a 15 percent rate of “naloxone associated violence” which was probably exaggerated as the authors included agitation and vomiting as violent behavior when, in fact, these were probably [ems1.com]

  In this case, the homogeneity of the diazepam throughout the suspension can be achieved by maintaining particle buoyancy, for example, in a viscous aqueous solution (e.g., a suspending agent), and/or by agitation of the manufactured product prior to administration [patents.google.com]

RESULTS: During the treatment period the DAS28 decreased similarly for all treatment groups-including placebo-indicating lack of efficacy of intranasal HC gp-39 treatment in the current setting. Safety variables were similar for all study groups. [ncbi.nlm.nih.gov]

Patients with good therapeutic response showed reduction of tumor size and PTBE area, but poor prognosis was associated with lack of response to treatment and persistence of high PTBE. [ncbi.nlm.nih.gov]

Tadao Kishimoto, Takashi Shimazaki, Jun Yoshida, Osamu Isurugi, Koichiro キーワード: Administration, Intranasal Aged Aged, 80 and over Buserelin/administration & dosage/therapeutic use Drug Evaluation Humans Male Middle Aged Multicenter Studies as Topic Prognosis [repository.kulib.kyoto-u.ac.jp]

We reviewed literature pertaining to the etiology, pharmacology, and pathophysiology of neurologic complications resulting from heroin intoxication. [ncbi.nlm.nih.gov]

Clinical and epidemiological research Intranasal administration of recombinant human cartilage glycoprotein-39 as a treatment for rheumatoid arthritis: a phase II, multicentre, double-blind, randomised, placebo-controlled, parallel-group, dose-finding [ard.bmj.com]

A prospective, population-based study of the demographics, epidemiology, management, and outcome of out-of-hospital pediatric cardiopulmonary arrest. Ann Emerg Med. ‎ [books.google.it]

We reviewed literature pertaining to the etiology, pharmacology, and pathophysiology of neurologic complications resulting from heroin intoxication. [ncbi.nlm.nih.gov]

Clinical studies suggest that altered OXT signaling in particular may play a pathophysiological role in mental and developmental disorders characterized by social dysfunction, such as autism, borderline personality disorder, schizophrenia, and social [content.iospress.com]

S-IgA antibodies are highly effective at preventing virus infection. [ncbi.nlm.nih.gov]

Aftercare information Contact information for getting naloxone refills Overdose prevention programs have created many great brochures and educational pamphlets. [harmreduction.org]