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Invasive Ductal Carcinoma


Presentation

  • A 25-year-old woman with a palpable mass in her right breast for three months presented to the presented clinic. On physical examination a mobile, firm mass measuring 2x2 cm was detected in right breast, at a region close to axilla.[ncbi.nlm.nih.gov]
  • We review the literature and discuss possible etiologies for the dual presentation of both cancers.[ncbi.nlm.nih.gov]
  • We present the case of a 20 years old man presenting with a left breast lump. After left mastectomy with level 2 axillary clearance, histopathological examination revealed infiltrating ductal carcinoma.[ncbi.nlm.nih.gov]
  • We report an extraordinary case of a collision tumor consisting of invasive ductal carcinoma with adjacent malignant lymphoma presenting as a single mass in the breast. A 79-year-old woman presented with a breast mass.[ncbi.nlm.nih.gov]
  • The majority of previously reported cases have mainly described the clinicopathological features of the disease, and few have presented cytogenetic data.[ncbi.nlm.nih.gov]
Axillary Lymphadenopathy
  • Examination showed an ulcerating cutaneous mass over the left anterior chest wall, left axillary lymphadenopathy and tenderness over the spine.[ncbi.nlm.nih.gov]
  • Needle biopsy Diff quik Images hosted on other servers: Ductal carcinoma, Figure A Poorly differentiated ductal carcinoma Images hosted on Flickr: 47 year old woman with 3 x 2 cm painless retroareolar mass and ipsilateral axillary lymphadenopathy, courtesy[pathologyoutlines.com]
Swelling
  • Surgeons investigating unilateral breast swellings in young males should not dismiss them simply as gynecomastia, and should be wary of cancer.[ncbi.nlm.nih.gov]
  • The following are possible signs of breast cancer and should immediately be reported to your physician for further evaluation: Lump in the breast Thickening of the breast skin Rash or redness of the breast Swelling in one breast New pain in one particular[hopkinsmedicine.org]
  • Invasive Ductal Carcinoma of Breast (NOS) is mostly observed in women after the age of 40 years The signs and symptoms of Invasive Ductal Carcinoma of Breast (NOS) include lump in the breast, swelling or skin thickening around the region of the lump,[dovemed.com]
  • Symptoms Symptoms of invasive ductal breast cancer include: a lump or thickening of the breast tissue a change of skin texture such as puckering or dimpling of the skin a lump or swelling under the arm changes to the nipple a discharge from the nipple[breastcancercare.org.uk]
  • However, invasive ductal cancer may present with:- A breast lump or breast tumor Swelling Rash or redness of the breast Inverted nipple Nipple discharge Enlarged axillary lymph nodes.[breast-cancer.ca]
Splenectomy
  • The patient underwent laparotomic body-tail pancreatectomy and splenectomy. The histological examination showed mucinous cystoadenoma with associated invasive ductal carcinoma, with ovarian-like stroma and a well delimited fibrous capsule.[ncbi.nlm.nih.gov]
  • Distal pancreatectomy and splenectomy were performed.[ncbi.nlm.nih.gov]
Difficulty Walking
  • He initially presented with a 2-week history of difficulty walking because of bilateral hip and lower back pain.[ncbi.nlm.nih.gov]
Abdominal Mass
  • A 28 year old woman was referred to our service for abdominal mass. She had given birth to her second child two weeks previously.[ncbi.nlm.nih.gov]
Breast Mass
  • Abstract We report a case of a 71-year-old female with a palpable breast mass.[ncbi.nlm.nih.gov]
  • Primary breast lymphoma should always be considered in the differential diagnosis of breast masses. The presence of both malignancies presents a challenge in treatment decisions.[ncbi.nlm.nih.gov]
  • A 79-year-old woman presented with a breast mass. A core biopsy performed at an outside hospital was interpreted as medullary carcinoma.[ncbi.nlm.nih.gov]
  • CASE REPORT We report the case of a 70-year-old presented with right breast mass whose pathology showed benign PT with concomitant IDC and DCIS.[ncbi.nlm.nih.gov]
  • A 57-year-old woman with a left breast mass was referred to our hospital. Mammography revealed only an isodense area with foci of microcalcification in the lateral area of the left breast.[ncbi.nlm.nih.gov]
Flank Pain
  • Pain/etiology Humans Jaundice/etiology Magnetic Resonance Imaging Male Middle Aged Neoplasms, Second Primary/complications Neoplasms, Second Primary/diagnosis* Neoplasms, Second Primary/pathology Neoplasms, Second Primary/surgery Pancreas/pathology*[ncbi.nlm.nih.gov]
Neglect
  • Therefore, the possibility of concomitant breast cancer and endometrial cancer in a younger woman (premenopausal) is often neglected. The reported case is an example of this situation.[ncbi.nlm.nih.gov]
Altered Mental Status
  • We report the first ever case of synchronous ILBCL and invasive ductal carcinoma (IDC) of the breast in a patient presenting with pyrexia of unknown origin and altered mental status who underwent modified radical mastectomy and subsequent chemotherapy[ncbi.nlm.nih.gov]

Workup

  • (See Workup.) Increased public awareness and improved screening have led to earlier diagnosis, at stages amenable to complete surgical resection and curative therapies.[emedicine.medscape.com]
Multilocular Cyst
  • Further examination showed a 7.0 cm multilocular cyst in the pancreatic tail and a solid mass in the thick septum of the cystic tumor. Distal pancreatectomy and splenectomy were performed.[ncbi.nlm.nih.gov]
Hepatocellular Carcinoma
  • Prostate, pancreatic, and hepatocellular carcinomas exhibit consistent marked zinc decrease in situ in the malignant cells, and other cancers (such as kidney, lung, and thyroid) also exhibit decreased tissue zinc levels.[ncbi.nlm.nih.gov]

Treatment

  • This literature review was structured to identify and understand both the positive and negative QOL factors throughout breast cancer treatment, as well as post breast cancer treatment.[ncbi.nlm.nih.gov]
  • Patients with oligometastatic disease may benefit from aggressive treatment including local therapies.[ncbi.nlm.nih.gov]
  • Two months after the myiasis treatment, the breast tissue had healed. The patient had waited ten days from the onset of the myiasis to seek treatment, and that delay interfered negatively in the prognosis of both the neoplasm and the myiasis.[ncbi.nlm.nih.gov]
  • Patient, tumor, and treatment characteristics were collected. Ten-year overall survival (OS) was estimated using the Kaplan-Meier method and Cox proportional-hazards modeling.[ncbi.nlm.nih.gov]
  • Entecavir, a deoxyguanosine analog, offers several advantages over lamivudine for the treatment of HBV reactivation following chemotherapy while exhibiting more potent antiviral activity and a lower resistance rate.[ncbi.nlm.nih.gov]

Prognosis

  • Survival curves showed that the prognosis for ILC became worse than IDC over time.[ncbi.nlm.nih.gov]
  • Clinical characteristics and prognosis of BIDC vary among different molecular subtypes. This study provides valuable input on BIDC therapy.[ncbi.nlm.nih.gov]
  • However, the worse prognosis was diminished after matching for demographic and clinicopathological factors.[ncbi.nlm.nih.gov]
  • IMPC patients showed an unfavorable prognosis for RFS (OR; 2.04; 95% CI: 1.63-2.55) and LRRFS (OR: 2.82; 95% CI: 1.90-4.17) compared with IDC.[ncbi.nlm.nih.gov]
  • In conclusion, Notch1 and EZH2 coexpression contributes to the progression and prognosis of breast invasive ductal carcinoma.[ncbi.nlm.nih.gov]

Etiology

  • Humans Jaundice/etiology Magnetic Resonance Imaging Male Middle Aged Neoplasms, Second Primary/complications Neoplasms, Second Primary/diagnosis* Neoplasms, Second Primary/pathology Neoplasms, Second Primary/surgery Pancreas/pathology* Pancreatectomy[ncbi.nlm.nih.gov]
  • We review the literature and discuss possible etiologies for the dual presentation of both cancers.[ncbi.nlm.nih.gov]
  • Confirming the absence of a common etiology, however, requires further genetic studies.[ncbi.nlm.nih.gov]
  • (Etiology) The exact cause of development of Invasive Ductal Carcinoma of Breast (NOS) is currently not clearly known.[dovemed.com]
  • These data support the evidence that some breast cancers share etiologic factors with ovarian cancer.[emedicine.medscape.com]

Epidemiology

  • METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women who were diagnosed with PD-IDC from 2000 to 2011, comparing baseline demographic and tumor characteristics with those who were diagnosed with IDC alone[ncbi.nlm.nih.gov]
  • The Surveillance, Epidemiology, and End Results database was searched to identify women with non-metastatic IMPC and IDC diagnosed between 2001 and 2013. Comparisons of patient and tumor characteristics were performed using Pearson's chi-square.[ncbi.nlm.nih.gov]
  • Utilizing Surveillance, Epidemiology, and End Results (SEER), we identified 84,764 eligible patients, including 309 MBC and 84,455 IDC.[ncbi.nlm.nih.gov]
  • MATERIALS AND METHODS: With accession to the Surveillance, Epidemiology and End Result (SEER) database, a total of 260,596 patients met the eligibility criteria. Clinicopathological characteristics were compared between groups using Chi-square test.[ncbi.nlm.nih.gov]
  • Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, we enrolled a total of 89,937 eligible patients with an estimated 86 breast-ACC cases and 89,851 invasive ductal carcinoma (IDC) patients.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology The current understanding of breast cancer etiopathogenesis is that invasive cancers arise through a series of molecular alterations at the cell level.[emedicine.medscape.com]

Prevention

  • Since this condition is rarely reported, the correlated risk factors are worthy of our attention and the strategy for prevention is highlighted.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The decreased zinc levels in breast invasive ductal carcinoma is consistent with prostate, pancreatic, and liver carcinomas in which the decrease in zinc is a required event in the development of malignancy to prevent cytotoxicity that would[ncbi.nlm.nih.gov]
  • Though not considered hormone therapy, Herceptin is another drug that helps prevent cancer recurrence. Called a biologic, Herceptin attaches itself to cancer cells and prevents them from receiving growth signals.[healthcentral.com]
  • Both drugs have potential side effects; including being at a higher risk for blood clots Preventative mastectomy: Prophylactic mastectomy, a procedure to surgically remove healthy breasts, is another possible preventative option for women, at a high risk[dovemed.com]
  • Definition Risks & Prevention Diagnosis Treatment Questions to Ask Managing[pennmedicine.org]

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