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Inverse Psoriasis

Intertriginous Psoriasis


Presentation

  • A 65-year-old woman presented to our rheumatology clinic with pain and swelling of multiple joints of her hands. After a thorough evaluation, she was diagnosed with rheumatoid arthritis and was started on hydroxychloroquine therapy.[ncbi.nlm.nih.gov]
  • We present a short case report of inverse psoriasis and a review of the literature on various facets of this disease: epidemiology, histology, clinical presentation, differential diagnosis, and treatment.[ncbi.nlm.nih.gov]
  • Alerts and Notices Synopsis   Inverse psoriasis, also known as intertriginous or flexural psoriasis, is a form of psoriasis that presents in skin folds such as the inframammary areas, the axillae, and the inguinal folds.[visualdx.com]
  • Case Presentation The authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region.[ncbi.nlm.nih.gov]
  • […] involves the folds, recesses, and flexor surfaces such as the ears, axillae, groin folds, inframammary folds, navel, intergluteal cleft, penis, lips, and webspaces. [1] : 193 Diagnosis [ edit ] Differential diagnosis [ edit ] Skin conditions which can present[en.wikipedia.org]
Splenomegaly
  • If you are already a member, please log in here: Username or E-mail Password Remember Me Forgot Password New Case Studies Splenomegaly and Psoriasis—A Case Report September 10, 2018 You must be a Wellspring community member to view this content.[wellspring.digital]
Eruptions
  • Reports showed that 13% of children with psoriasis had psoriatic napkin eruptions with dissemination, whereas 4% had a localized psoriatic napkin eruption [ 32 ], with anogenital psoriasis occurring four-times more often in children over 2 years old than[ncbi.nlm.nih.gov]
  • Another possibility in the differential diagnosis is chronic pityriasis lichenoides, a disease that can be eruptive at onset, while desquamation is really very limited. Finally, there is secondary syphilis.[clinicaldermatology.eu]
  • […] is also a risk factor for cardiovascular disease. 3 As emerging research illustrates its increasing complexity, psoriasis is now considered a systemic inflammatory disorder. 2 Clinically, there are 5 types of psoriasis: plaque psoriasis, guttate or eruptive[clinicaladvisor.com]
  • It is recommended only for chronic or inactive psoriasis, not for acute or inflamed eruptions. People with kidney problems should use anthralin with caution.[pennstatehershey.adam.com]
Keratosis
  • Darier disease (keratosis follicularis) – An inherited acantholytic disorder with characteristic histologic findings; unusual in the genital area.[visualdx.com]
Large Breast
  • If you have large breasts, you may have this skin condition. Wearing a bra makes it worse. This is difficult for large-breasted women to deal with because they, especially, can not go to work and other public places without wearing a bra.[cottonique.com]
Genital Lesions
  • Update on genital lesions. JAMA. 2003; 290 :1001–1005. doi: 10.1001/jama.290.8.1001. [ PubMed ] [ CrossRef ] [ Google Scholar ] 24. Trager JDK. What’s your diagnosis? Well-demarcated vulvar erythema in two girls.[ncbi.nlm.nih.gov]
Pruritus Vulvae
  • Pruritus vulvae. Curr Obstet Gynaecol. 2002; 12 :231–234. doi: 10.1054/cuog.2001.0265. [ CrossRef ] [ Google Scholar ] 39. Camilleri MJ, Calobrisi SD. Skin eruptions in the diaper area.[ncbi.nlm.nih.gov]
Penile Lesion
  • Non-oncological and non-infectious diseases of the penis (penile lesions) EAU-EBU Update Ser. 2006; 41 :13–19. doi: 10.1016/j.eeus.2005.11.004. [ CrossRef ] [ Google Scholar ] 35. MacLean AB, Roberts DT, Reid WMN.[ncbi.nlm.nih.gov]

Treatment

  • Treatments are well tolerated with minimal side effects.[ncbi.nlm.nih.gov]
  • Conventional topical and systemic treatments can be limited in terms of efficacy, acceptability and safety. The 308 nm excimer laser has been shown to be effective in the treatment of psoriatic plaques.[journals.lww.com]
  • If necessary, your doctor may prescribe antibiotic or antifungal treatments. Other treatments may be necessary if your skin becomes infected. It can be difficult to self-diagnose a skin rash.[healthline.com]
  • MacMillan and Champion first reported the use of dapsone as a treatment for psoriasis in an adult with treatment-resistant generalized pustular psoriasis [ 52 ].[ncbi.nlm.nih.gov]
  • In addition, it requires a modified therapeutic approach because it is often less responsive to standard treatment regimens.[ncbi.nlm.nih.gov]

Prognosis

  • Posted : April 10, 2012 Last Update Posted : November 18, 2014 Sponsor: Collaborator: Information provided by (Responsible Party): Tecno Sun SRL Brief Summary: The purpose of this study is to evaluate the efficacy of Aerosal compared to placebo in the prognosis[clinicaltrials.gov]
  • In all these cases, it is recommended to perform a biopsy since a delay in diagnosis may compromise prognosis.[clinicaldermatology.eu]

Etiology

  • The etiology of inverse and genital psoriasis is still unknown and further studies are needed in order to clarify these diseases [ 1 ].[ncbi.nlm.nih.gov]
  • The exact etiology and pathogenesis is unknown but immunologic, genetic, and environmental factors are all are implicated in the development of the disease.[dermatologyadvisor.com]
  • Introduction Psoriasis is a complex, chronic inflammatory skin condition that is common in individuals of European descent, affecting 1%–3% of the population. 1 The disease has a multifactorial etiology; environmental influences, such as infection or[dovepress.com]

Epidemiology

  • We present a short case report of inverse psoriasis and a review of the literature on various facets of this disease: epidemiology, histology, clinical presentation, differential diagnosis, and treatment.[ncbi.nlm.nih.gov]
  • We review current evidence and establish whether inverse psoriasis is a separate disease entity based on characteristics in terms of epidemiology, pathogenesis, clinical and histologic presentation, microbiology, and treatment.[ncbi.nlm.nih.gov]
  • Psoriasis—epidemiology and clinical spectrum. Clin Exp Dermatol. 2001; 26 :314–320. doi: 10.1046/j.1365-2230.2001.00832.x. [ PubMed ] [ CrossRef ] [ Google Scholar ] 3. Myers WA, Gottlieb AB, Mease P.[ncbi.nlm.nih.gov]
  • Epidemiology Bimodal peaks Young adulthood (ages 16 to 22 years old) Older age (late 50s) Prevalence : 1-2% of general population (U.S.) Men and women affected equally III.[fpnotebook.com]
  • Psoriasis – epidemiology and clinical spectrum. Clin Exp Dermatol . 2001;26(4):314–320. 6. Laws PM, Young HS. Topical treatment of psoriasis. Expert Opin Pharmacother . 2010;11(12):1999–2009. 7. Albrecht L, Bourcier M, Ashkenas J, et al.[dovepress.com]
Sex distribution
Age distribution

Pathophysiology

  • We highlight the role of dopamine in the pathophysiology of this dermatosis.[ncbi.nlm.nih.gov]
  • The pathophysiology involves an alteration in the activation of CD4 and CD8 T-cells and an anomalous proliferation and differentiation of keratinocytes.[ncbi.nlm.nih.gov]
  • Pathophysiology Underlying genetic predisposition is common (30% with Psoriasis also have a first degree relative with Psoriasis) Pathogenesis is likely a combination between genetic predisposition and exposure to inciting triggers Autoimmune Viral infection[fpnotebook.com]
  • These Th17 cells pathway are critically important in the pathophysiology of psoriasis.[dermatologyadvisor.com]
  • The pathophysiology of psoriasis. Lancet . 1991;338(8761):227–230. 5. Christophers E. Psoriasis – epidemiology and clinical spectrum. Clin Exp Dermatol . 2001;26(4):314–320. 6. Laws PM, Young HS. Topical treatment of psoriasis.[dovepress.com]

Prevention

  • From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community.[merckmanuals.com]
  • To prevent irritation, wear loose-fitting, absorbent clothes. That will make it easier for your skin to breathe. Inverse psoriasis treatment Inverse psoriasis can be difficult to treat. Your doctor may prescribe topical ointments or steroids.[healthline.com]
  • Good personal hygiene can prevent future cases of jock itch or other fungal infections. Change your undergarments if they become saturated with sweat or water. Shower immediately after participating in any sports.[healthline.com]
  • Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive[jamanetwork.com]
  • Loose clothes will also prevent moisture from getting trapped in the skin folds. Medicated powder can applied to the affected areas to keep the skin dry.[epainassist.com]

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