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Iodide Poisoning

Iodide Toxicity


Presentation

  • Spinal cord lesions producing motor and sensory disturbances were present in one. Late psychiatric disorders were observed in both patients.[ncbi.nlm.nih.gov]
  • Here, we present the case of a 50-year-old man who presented signs of as a stroke mimic. In addition, we briefly discuss the various known causes of stroke mimics.[jmedicalcasereports.biomedcentral.com]
  • This means that the thyroid gland ultimately absorbs a significant fraction of radioiodine present in the human body.[vitanetonline.com]
  • Out of the most common fission products of uranium, iodine is the only one that’s present naturally in our bodies. There are actually fourteen major radioactive isotopes of iodine.[ljkboerner.wordpress.com]
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Myxedema
  • Myxedema is a condition where the individual has dry skin and develops inflammation around the lips and nose. Severe effect is mental retardation. An overdose is the cause of thyroid papillary cancer.[tandurust.com]
  • Thus, iodine toxicity can eventually cause iodide goiter, hypothyroidism, or myxedema. Very large amounts of iodide may cause a brassy taste in the mouth, increased salivation, GI irritation, and acneiform skin lesions.[merckmanuals.com]
  • Amiodarone Induced Hypothyroidism are similar to hypothyroidism symptoms in general: fatigue, lethargy, cold intolerance, mental sluggishness, weakness, constipation, heavy or abnormal periods for women, dry skin, eyes and hair, goiter, and in extreme cases, myxedema[fluoroquinolonethyroid.com]
Lymphadenopathy
  • […] possibility of goitre in infants of mothers taking iodides. 4.7 Effects on ability to drive and use machines 4.8 Undesirable effects May cause allergic reactions, including urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy[medicines.org.uk]
  • Allergic effects Whether iodine is administered topically or systematically, iodine and iodides can give rise to allergic reactions: urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy and eosinophile, acne-form[inchem.org]
Sepsis
Epilepsy
  • Nervous system Epilepsy Todd's palsy presents with postictal confusion, transient focal motor and sensory symptoms, extra-ocular movement deficits; witness and/or history is important and has a resolving course.[jmedicalcasereports.biomedcentral.com]
Productive Cough
Vascular Disease
  • These are primarily non-vascular disease processes producing some of the clinical pictures akin to stroke (Table 1 ). Table 1 Non-vascular disease processes producing some of the clinical picture akin to a stroke A.[jmedicalcasereports.biomedcentral.com]
Psychiatric Symptoms
  • Some patients had purely psychiatric symptoms, while others had neurological deficits as well. Some patients had recovered fully in a course of months, while others had persistent symptoms.[jmedicalcasereports.biomedcentral.com]
  • COPIND – c/f Neurological Symptoms Psychiatric Symptoms 1. Impairment in memory 1. Anxiety 2. Impairment in concentration 2. Dysthymia 3. Impairment in leaning 3. Depression 4. Chronic fatigue 5. EPS : dystonia 6. Resting tremor, bradykinesia 7.[slideshare.net]
Auditory Hallucination
  • He also complained of visual and auditory hallucinations. We discussed our patient's case with the National Poisons Center and they suspected that his symptoms were due to methyl iodide poisoning.[jmedicalcasereports.biomedcentral.com]
Hyperreflexia
  • Encephalopathy Can present with altered behavior, cognition, coma, aphasia, focal motor and sensory deficits, homonymous hemianopia and hemi hyperreflexia.[jmedicalcasereports.biomedcentral.com]
  • , yawning, abdominal cramps, lacrimation, flu-like symptoms, insomnia, vomiting and diarrhea Withdrawal from the following sedating or recreational drugs: Barbiturates Marijuana Opioids Agitation, hallucinations, confusion, disorientation, seizures, hyperreflexia[msdmanuals.com]
Encephalopathy
  • Encephalopathy Can present with altered behavior, cognition, coma, aphasia, focal motor and sensory deficits, homonymous hemianopia and hemi hyperreflexia.[jmedicalcasereports.biomedcentral.com]
  • Consider other causes (eg, CNS infection, head trauma, hypoglycemia, stroke, hepatic encephalopathy, Wernicke encephalopathy) if consciousness is altered, even if poisoning is suspected.[msdmanuals.com]
Slurred Speech
  • Neurological examination showed a Glasgow Coma Scale (GCS) of 14 to 15, a bilateral grade 2 nystagmus, slurred speech, past pointing on the right, and a broad-based ataxic gait.[jmedicalcasereports.biomedcentral.com]
Cognitive Disorder
  • View Article Google Scholar Mangone CA, Genovese O, Abel C: Behavioural-cognitive disorders due to chronic exposure to industrial and environmental toxic substances. Vertex. 2006, 17 (65): 16-22.[jmedicalcasereports.biomedcentral.com]
Aphasia
  • Encephalopathy Can present with altered behavior, cognition, coma, aphasia, focal motor and sensory deficits, homonymous hemianopia and hemi hyperreflexia.[jmedicalcasereports.biomedcentral.com]

Workup

  • Routine blood workup reveals normal serum electrolytes with a raised amylase level of 300. Diagnosis ??? ?? 2. Organophosphorus Poisoning Presenters : Dr Lohit Chauhan : Dr Dhananjay Gupta Moderator : Dr. Gurmeet Kaur 3.[slideshare.net]

Treatment

  • […] technologies for each contaminant Critical concepts of water quality control as applied in water treatment in conventional or chemical treatment plants Disinfection and fluoridation requirements Common problems with water distribution systems, including[books.google.com]
  • These compounds are potent cholinesterase inhibitors and produce symptoms that are due at least partly to this anticholinesterase action.Atropine has long been used in the treatment of intoxication from the organic phosphorus insecticides.[nejm.org]
  • Please find relevant information on First Aid for Iodide (I ) Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • In these cases, prompt identification of intracranial sepsis is important, as any delay in instituting antibiotic or antiviral treatment may produce grave consequences.[jmedicalcasereports.biomedcentral.com]
  • In particular, kelp has long been utilized as a therapeutic treatment that aids the removal of radioactive particles from the body. Grab Some Potassium Iodide today and protect your thyroid![vitanetonline.com]

Prognosis

  • Please find relevant information on First Aid for Iodide (I ) Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • INGESTION: alimentary absorption is very rapid; action during first10-15 min. determines prognosis. Give egg whites, milk, or activated charcoal and induce vomiting; consult physician. EYES: flush with water for at least 15 min.[cameochemicals.noaa.gov]
  • QTc prolongation • Indicates poor prognosis in OP- poisoning 1. Cholinergic stimulation of heart : M2 a. negative ionotropy b. negative chronotropy 2. Oxidative stress causes conduction problems * Shadnia S, Okazi A, et al.[slideshare.net]
  • 9.1.1 Ingestion 9.1.2 Inhalation 9.1.3 Skin exposure 9.1.4 Eye contact 9.1.5 Parenteral exposure 9.1.6 Other 9.2 Chronic poisoning 9.2.1 Ingestion 9.2.2 Inhalation 9.2.3 Skin exposure 9.2.4 Eye contact 9.2.5 Parenteral exposure 9.2.6 Other 9.3 Course, prognosis[inchem.org]

Epidemiology

  • Scientific American spoke with John Boice, a professor at Vanderbilt University's Vanderbilt-Ingram Cancer Center and a cancer epidemiologist with the International Epidemiology Institute in Rockville, Md., to better understand why potassium iodide is[scientificamerican.com]
  • Clinico-Epidemiological Characteristics of Patients Presenting with Organophosphorus Poisoning. N Am J Med Sc. Vol 4(3), JMarch 2012 14. 5. Relative human Toxicity Eddleston M et al.[slideshare.net]
  • Infection Control & Hospital Epidemiology, 10 (10): 447-450. Gommolin IH (1987) Iodated glycerol-induced hypothyroidism. Drug Intell Clin Pharm, 21 : 726-727.[inchem.org]
Sex distribution
Age distribution

Pathophysiology

  • "Pathophysiology: The biological basis for disease in Adults and Children". 5th Edition.[marefa.org]
  • Published on Jan 17, 2016 Pathophysiology and Approach and Management of a case of OP poisoning 1. Clinical Vignette You are posted as a CMO, casualty in the month of June.[slideshare.net]
  • "Pathophysiology: The biological basis for disease in Adults and Children". 5th Edition. Elsievier Publishing [ page needed ] March 23, 2011. "POTASSIUM IODIDE - ORAL (SSKI) side effects, medical uses, and drug interactions". Medicinenet.com.[en.wikipedia.org]

Prevention

  • […] contamination of drinking water requires a multidisciplinary perspective, one that incorporates elements of bacteriology, chemistry, physics, engineering, public health, preventive medicine, and control and evaluation management.[books.google.com]
  • Please find relevant information on First Aid for Iodide (I ) Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • Potassium iodide has long been proven safe and effective in clearing radioiodine from the body over time and preventing mutations of the thyroid.[vitanetonline.com]
  • They don’t prevent your body from taking in the radiation and don’t help prevent radiation damage to other parts of the body. Potassium iodide is available without a prescription as pills or drops. It is also found in radiation exposure kits.[blogs.webmd.com]
  • This effect is useful when we want to prevent unwanted reactions.[www2.uni-siegen.de]

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