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Iodine-induced Hyperthyroidism

Iodide Induced Hyperthyroidism


  • In the present paper, the results of a two-year monitoring (2000-2001) have been summarized.[ncbi.nlm.nih.gov]
  • On initial presentation to his primary care physician, the patient reported losing approximately one pound per day with only a modest reduction in his appetite.[consultant360.com]
  • In the latest article in our Clinical Problem-Solving series , a 51-year-old woman presented to the ER with a 6-month history of intermittent palpitations, which had worsened that day. She described her pulse as fast but regular.[blogs.nejm.org]
Military Personnel
  • personnel who drank water enriched with iodine for purification purposes.[drchainika.wordpress.com]
  • Iodine-induced hyperthyroidism has developed in travelers and military personnel who drank water enriched with iodine for purification purposes. Table 1.[blogs.nejm.org]
  • He was elected a Fellow of the Royal College of Pathologists in 2000. In 1993, he gained a D.Sc. degree for his outstanding contribution to protein metabolism.[books.google.com]
Systolic Murmur
  • Cardiovascular exam was significant for a grade II over VI systolic murmur radiating to the axilla and a soft mid-systolic murmur at the upper-left and -right sternal borders. Respiratory and abdominal examinations were unremarkable.[consultant360.com]
  • Systolic murmur. Bowel disturbance. Failure to gain weight. Emotional upset. Features of Graves' disease may also be seen - for example: Eye signs. Tremor. Weight loss. Pretibial myxoedema.[patient.info]
Scleral Icterus
  • There was no eyelid lag, stare, exophthalmos, or scleral icterus. Oropharynx was clear. There was no palpable thyroid goiter, and the gland was nontender without bruits.[consultant360.com]


  • The diagnostic workup begins with a thyroid-stimulating hormone level test. When test results are uncertain, measuring radionuclide uptake helps distinguish among possible causes.[aafp.org]


  • In the absence of pre-existing cardiac disease, treatment of thyrotoxicosis usually returns cardiac function to normal. Heightened awareness on the part of the health sector will promote early detection and prompt treatment of IIH.[ncbi.nlm.nih.gov]
  • Risk factors:- common in areas where dietary iodine is insufficient. underlying thyroid disease (those with nontoxic nodular goiter, an autonomous nodule, or euthyroid Graves’ disease, especially after treatment with antithyroid drugs), travelers and[drchainika.wordpress.com]
  • Whereas this condition is more common in patients with underlying thyroid disease (those with nontoxic nodular goiter, an autonomous nodule, or euthyroid Graves’ disease, especially after treatment with antithyroid drugs), it also occurs in patients with[blogs.nejm.org]


  • Prognosis The prognosis for AIT may be very poor even though a wide range of antithyroid therapy is available. This prognosis emphasizes the need for careful monitoring of patients receiving amiodarone treatment.[emedicine.medscape.com]
  • Prognosis Good thyroid control is associated with a normal pregnancy with good maternal and fetal health.[patient.info]
  • Prognosis and Follow-up The prognosis for a patient with hyperthyroidism is good with appropriate treatment.[aafp.org]


  • Etiology Underlying causes include: endemic goiter Graves disease toxic multinodular goiter autonomous thyroid nodules in the elderly thyroid adenoma Exogenous sources of iodine include: iodinated contrast oral supplement amiodarone History and etymology[radiopaedia.org]
  • Endemic goiter in Senegal-Thyroid function, etiological factors and treatment with oral iodized oil. Acta Endocrinol 1992, 126: 149–54. PubMed Google Scholar 41. Pharoah PO, Connolly KJ.[link.springer.com]
  • Etiologic diagnosis influences prognosis and therapy.[aafp.org]
  • Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. Indian J Pediatr 2001;68:399-404. 9. Chandra AK, Singh LH, Tripathy S, Debnath A, Khanam J. Iodine nutritional status of children in North East India.[ijem.in]


  • Abstract The occurrence of iodine-induced hyperthyroidism (IIH) has been reported after iodine supplementation from clinics and hospitals, but not following an epidemiologic survey.[ncbi.nlm.nih.gov]
  • Publication Date 1999-11-30 Full Title Iodine-induced hyperthyroidism: occurrence and epidemiology. Authors Stanbury JB, Ermans AE, Bourdoux P, Todd C, Oken E, Tonglet R, Vidor G, Braverman LE, Medeiros-Neto G[populationmedicine.org]
  • This systemic epidemiologic study in an iodine deficient population showed that, following a well-executed iodine supplementation program, the occurrence of IIH is rare.[link.springer.com]
  • Following implementation of an iodine supplementation regimen, there is a shift in the epidemiology of specific thyroid diseases, as reviewed in Thyroid 1998 Dec;8(12):1179-83 Epidemiology of thyroid diseases in iodine sufficiency.[mythyroid.com]
Sex distribution
Age distribution


  • To some extent, these pathophysiologic processes can be reproduced in the animal model.[ncbi.nlm.nih.gov]
  • It may be a side effect of administration of amiodarone, an antiarrhythmic drug (Vaughn-Williams class III) PATHOPHYSIOLOGY:- thyrotoxicosis that may occur when dietary iodine is given to a patient with endemic goiter in an area of environmental iodine[drchainika.wordpress.com]
  • Pathophysiology [ edit ] This phenomenon is thus iodine-induced hyperthyroidism, typically presenting in a patient with endemic goiter (due to iodine deficiency ), who relocate to an iodine-abundant geographical area.[en.wikipedia.org]
  • Int 2008;58:55 ) Epidemiology More frequent in males than in females (3:1) Occurs in 3% of patients treated with amiodarone in North America, increasing to 10% in countries with low iodine dietary intake ( NCBI - Amiodarone Induced Thyrotoxicosis ) Pathophysiology[pathologyoutlines.com]
  • Pathophysiology Amiodarone causes a wide spectrum of effects on the thyroid.[emedicine.medscape.com]


  • Further research to improve the characterization and prevention of IIH is strongly encouraged. The most important conclusion is that IIH, while an issue that needs serious address, is not a reason to stop iodine supplementation in deficient regions.[ncbi.nlm.nih.gov]
  • This up-to-date volume explores both the effects of iodine deficiency as well as the best strategies for IDD prevention.[books.google.com]
  • Iodine-Induced Hyperthyroidism OR Jod–Basedow phenomenon DEFINITION:- Excess iodine resulting in hyperthyroidism among persons whose autoregulatory mechanism fails to prevent an iodine-induced increase in thyroid hormone synthesis (most often, euthyroid[drchainika.wordpress.com]
  • It customarily occurs after an incremental rise in mean iodine intake in the course of programs for the prevention of iodine deficiency, or when iodine-containing drugs such as radiocontrast media or amiodarone are administered.[populationmedicine.org]

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