There is evidence that activated T cells are present in both skin and joint tissue. [clevelandclinicmeded.com]

A variety of tests may be performed in patients presenting with cough and shortness of breath: Pulmonary Function Tests (PFT) (or spirometry) must be performed in all patients presenting with chronic cough. [dictionnaire.sensagent.leparisien.fr]

In small children and adolescents, guttate psoriasis is another distinct presentation and has been reported in up to 44% of patients.[35] Pustularpsoriasis, although rare in children, can present with certain typical morphological patterns such as annular [journals.lww.com]

Atypical presentations associated with non-polyalanine repeat PHOX2B mutations. [gimjournal.org]

The array of symptoms, coupled with the wide range in severity and disease course, presents difficult challenges for treatment [16]. [arthritis-research.biomedcentral.com]

• Weight Loss

  Sadiya Khan MD [Read more…] about #326 NephMadness 2022: Cardiorenal Syndrome Find out whether balanced solutions beat saline in the ICU (fluid wars revisited), how sleep affects weight loss and calorie intake, whether or not Vitamin D can prevent autoimmune [thecurbsiders.com]

• Soft Tissue Swelling

  Joint-space narrowing in the interphalangeal joints, possibly with ankylosis Increased joint space in the interphalangeal joints as a result of destruction Fluffy periostitis Bilateral, asymmetrical, fusiform soft-tissue swelling Unilateral or symmetrical [emedicine.medscape.com]

• Weight Gain

  Associations of Birth Weight and Postnatal Weight Gain With Cardiometabolic Risk Parameters at 5 Years of Age. [uv.es]

• Skin Disease

  Treatment of skin disease associated with PsA can include phototherapy such as ultraviolet B or oral psoralen followed by ultraviolet A (PUVA) [67]. [arthritis-research.biomedcentral.com]

  Risk factors for the development of psoriasis in patients with psoriasis include nail, inverse, and scalp psoriasis; family history of psoriatic arthris, and severity of skin disease. [emedicine.medscape.com]

  Treatment focuses on predominant disease domains and organ involvement—peripheral arthritis, axial disease, dactylitis, enthesitis, and skin and nail disease. [clevelandclinicmeded.com]

  INTRODUCTION Psoriasis is a chronic inflammatory immune-mediated proliferative skin disorder that predominantly involves the skin, nails, and joints. [journals.lww.com]

• Skin Lesion

  See Psoriasis: Manifestations, Management Options, and Mimics, a Critical Images slideshow, to help recognize the major psoriasis subtypes and distinguish them from other skin lesions. [emedicine.medscape.com]

  nail dystrophy, uveitis, and intergluteal/perianal skin lesions.[3,8] The severity and course of PsA varies, ranging from mild symptoms to severe irreversible inflammatory joint destruction. [clevelandclinicmeded.com]

  NSAIDs are effective for relieving musculoskeletal symptoms due to joint inflammation, but have no efficacy on psoriatic skin lesions and are associated with AEs including renal toxicity, gastrointestinal toxicity, and the risk of developing CV events [arthritis-research.biomedcentral.com]

• Hyperkeratosis

  […] current psoriasis defined as psoriatic skin or scalp disease (2 points) Personal history of psoriasis (1 point) A family history of psoriasis in a first- or second-degree relative (1 point) Psoriatic nail dystrophy, such as onycholysis, pitting, or hyperkeratosis [clevelandclinicmeded.com]

  […] frequently is mistaken for dandruff), perineum, intergluteal cleft, and umbilicus Psoriatic nail changes, which may be a solitary finding in patients with psoriatic arthritis, may include the following: Beau lines Leukonychia Onycholysis Oil spots Subungual hyperkeratosis [emedicine.medscape.com]

• Osteophyte

  […] pitting, or hyperkeratosis (1 point) Dactylitis, either present or past, as documented by a rheumatologist (1 point) Negative test result for presence of rheumatoid factor (1 point) Radiographic evidence of juxtaarticular bone formation, distinct from osteophytes [clevelandclinicmeded.com]

• Kidney Failure

  Think you have the bile-acid-stones to start diuretics on a patient requiring pressor support for kidney failure? You have come to the right place! [thecurbsiders.com]

(See Presentation and Workup.) Evidence from one study indicated that psoriatic arthritis is more frequent in patients with severe psoriasis than in those with milder cases. [emedicine.medscape.com]

• Albuminuria

  Website: www.upmynursinggame.com Fri 3/18: BS Medicine – #505: Albuminuria, basketball and the Great White North.. Listen on Apple or Spotify. Website: https://therapeuticseducation.org/ Sat 3/19: Freely Filtered – Animal House Region. [thecurbsiders.com]

  Urinary podocyte-associated molecules and albuminuria in hypertension. [uv.es]

• HLA-Cw6

  […] and psoriatic arthritis is not yet clear) [18, 24, 25, 26, 27, 28, 29, 30] : Early-onset psoriasis: HLA-Cw6, HLA-B57, HLA-DR7, and HLA-B17, with HLA-Cw*0602 variant found to be highly associated Psoriasis: HLA-Cw6 (or psoriasis susceptibility 1 [PSOR1 [emedicine.medscape.com]

As outlined above, this may be achieved by early diagnosis, prevention of disease progression, treatment of PsA-associated physical morbidity, mitigation of treatment-related risk, and treatment of associated medical comorbidity. [arthritis-research.biomedcentral.com]

Table 3: Treatment guidelines for PsA according to disease domains. [clevelandclinicmeded.com]

We review the basic pathophysiology and the standard criteria for diagnosing anaphylaxis, treatment basics, the primary importance of epinephrine, and the utility of adjunctive therapies. [thecurbsiders.com]

Treatment Smoking cessation is of benefit as nicotine paralyzes the cilia comprising the Mucociliary Escalator. Antibiotics Only about 5-10% of bronchitis cases are caused by a bacterial infection. [dictionnaire.sensagent.leparisien.fr]

[…] plan, because patients must be able to manage their symptoms and be comfortable with self-treatment strategies. [emedicine.medscape.com]

An FEV1/FVC ratio below 0.7 that is not fully reversible after bronchodilator therapy indicates the presence of COPD, that requires more aggressive therapy and carries a more severe prognosis than simple chronic bronchitis. [dictionnaire.sensagent.leparisien.fr]

[…] sacroiliitis or limited to only one tract of the spine with or without concomitant peripheral arthritis.[39] Axial psoriatic arthritis may only affect the cervical spine with sparing of other tracts of the axial skeleton.[40] It is characterized by a better prognosis [journals.lww.com]

(See Prognosis.) Psoriatic arthritis occurring in patients over age 60 years (elderly onset psoriatic arthritis) has a more severe onset and more a destructive outcome than does psoriatic arthritis in younger patients. [emedicine.medscape.com]

Prognosis in community-adquired sepsis. BMC Emerg Med. 2021 Dec 18;21(1):161. doi: 10.1186/s12873-021-00532-1. PMID: 34922448; PMCID: PMC8684687. Kotsis V, Martinez F, Trakatelli C, Redon J. Impact of Obesity in Kidney Diseases. [uv.es]

Environmental factors The theory of environmental factors playing a role in the etiology of psoriatic arthritis involves a process of superantigens reacting with autoantigens. [emedicine.medscape.com]

Epidemiology, Etiology, and Risk Factors Estimates of PsA prevalence in the general population vary from 0.3% to 1%, with a higher prevalence of 6% to 42% in patients with psoriasis.[1-3] The prevalence of spondyloarthropathies, of which PsA is a subset [clevelandclinicmeded.com]

Cohen MM Jr (1975) An etiologic and nosologic overview of craniosynostosis syndromes. Birth Defects Orig Artic Ser 11: 137–189. View Article Google Scholar 19. Heller CG, Clermont Y (1963) Spermatogenesis in man: an estimate of its duration. [journals.plos.org]

Etiology of community acquired pneumonia in valencia, spain - a multicenter prospective-study. THORAX. 1991;46:508-511. 10. 1136/thx. 46. 7. 508. [uv.es]

Epidemiology of psoriasis in a clinic from north India Indian J Dermatol Venereol Leprol. 1986;52:208–12 Cited Here | PubMed 6. Bedi TR. [journals.lww.com]

Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 2005; 64(Suppl II):ii14–ii17. Ogdie A, Weiss P. The epidemiology of psoriatic arthritis. Rheum Dis Clin North Am 2015; 41:545–568. [clevelandclinicmeded.com]

Epidemiology and clinical pattern of psoriatic arthritis in Germany: a prospective interdisciplinary epidemiological study of 1511 patients with plaque-type psoriasis. Br J Dermatol. 2009 May. 160(5):1040-7. [QxMD MEDLINE Link]. [emedicine.medscape.com]

Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis. 2005;64 Suppl 2:ii14–7. PubMed PubMed Central Google Scholar Brockbank JE, Stein M, Schentag CT, Gladman DD. [arthritis-research.biomedcentral.com]

Author Summary Epidemiological studies show that the incidence of some genetic diseases increases with the age of the father. [journals.plos.org]

We review the basic pathophysiology and the standard criteria for diagnosing anaphylaxis, treatment basics, the primary importance of epinephrine, and the utility of adjunctive therapies. [thecurbsiders.com]

The pathophysiologic processes underlying anti-LGI-1 antibody production in this context may include epitope exposure as a result of the initial COVID-19 encephalitis or indeed COVID-19-induced molecular mimicry. [ncbi.nlm.nih.gov]

Back to Top Pathophysiology Multiple factors contribute to the pathogenesis of PsA, including genetic, environmental, and immunologic factors. [clevelandclinicmeded.com]

(See Pathophysiology and Etiology.) [7, 8, 9, 10] Peripheral joint disease occurs in 95% of patients with psoriatic arthritis, while in the other 5%, axial spine involvement occurs exclusively. (See Presentation and Workup.) [emedicine.medscape.com]

Back to Top Prevention and Screening Psoriatic skin disease usually precedes the joint symptoms. [clevelandclinicmeded.com]

Sadiya Khan MD [Read more…] about #326 NephMadness 2022: Cardiorenal Syndrome Find out whether balanced solutions beat saline in the ICU (fluid wars revisited), how sleep affects weight loss and calorie intake, whether or not Vitamin D can prevent autoimmune [thecurbsiders.com]

For example, decreased functional status can prevent patients from performing daily activities of living, such as washing and dressing [23]. [arthritis-research.biomedcentral.com]

Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology*. [uv.es]