Edit concept Question Editor Create issue ticket

Iris Atrophy

Atrophy of Iris


Presentation

  • The unusual feature in this case was that, the patient was a 36-year-old male presenting with iris atrophy, corneal oedema and uniocular glaucoma.[ncbi.nlm.nih.gov]

Workup

Ground Glass Appearance
  • The leñ cornea had an irregular epithelium with multiple bullae present, a ground glass appearance to the stroma, and multiple Descemets folds. There were multiple broad peripheral anterior synechiae present.[healio.com]
Hyperviscosity
  • It is postulated that this was related to hyperviscosity of the blood caused by a high white blood cell count (114,000/cu mm).[ncbi.nlm.nih.gov]

Treatment

  • Two cases of acanthamoeba keratitis with almost identical clinical courses developed mature cataract and iris atrophy after prolonged treatment with chlorhexidine 0.02% and propamidine isethionate 0.1%.[ncbi.nlm.nih.gov]
  • A possible mechanism for developing anterior segment ischemia following treatment of ROP can be made by comparing laser treatment in proliferative diabetic retinopathy with laser treatment in ROP.[jamanetwork.com]

Prognosis

  • The patients included in their study were four with Chandler's syndrome and one with essential iris atrophy.12 A study by Chang et al assessing the prognosis of corneal transplantation in ICE syndrome found the overall prognosis good with 75% of eyes[healio.com]
  • Fuchs' heterochromic iridocyclitis (FHI) is a chronic, low grade, usually unilateral, ocular inflammatory disease with a good visual prognosis.[eyewiki.org]
  • The long-term prognosis is guarded, however, in light of the high risk of failure with glaucoma surgery and corneal grafts.[glaucomatoday.com]
  • In some cases these can be treated with a Nd:YAG laser procedure to re-open the fistula. [5] Prognosis Prognosis for patients with ICE syndrome depends on whether the above complications develop.[eyewiki.aao.org]

Etiology

  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • The condition is of unknown etiology but occlusion of the greater vascular circle of the iris is possible. Iris angiography showed an almost total loss of the radial vessels of the iris with some patchy microneovascularization.[ncbi.nlm.nih.gov]
  • Despite numerous studies, the etiology and treatment of this condition remain uncertain.[jamanetwork.com]
  • The etiology and pathogenesis of the disease are unknown.[scielo.br]
  • Various surgical techniques have been devised to avoid intraoperative injury to the iris. 25, 26, 27, 28, 29 Iridocorneal Endothelial Syndrome Etiology Iridocorneal endothelial syndrome (ICE) denotes a spectrum of ocular disorders that includes progressive[entokey.com]

Epidemiology

  • Infection Control and Hospital Epidemiology, 19(6), 401-406. Morrison, C. (2000). Helping patients to maintain a healthy fluid balance. Nursing Times, 96(31), NTplus 7. National Institute for Occupational Safety and Health. (1999).[books.google.com]
  • Epidemiological characteristics of leprosy reactions: years experience from north India. Int J Lepr Other Mycobact Dis 2004 72 125–133. [ PubMed ] [ Google Scholar ][ncbi.nlm.nih.gov]
  • […] endothelium, resulting in its unusual epithelial-like activity. [1] [6] Polymerase Chain Reaction (PCR) testing of corneal endothelial cells from ICE syndrome patients has been found to have high percentages of HSV DNA in comparison to normal controls. [6] Epidemiology[eyewiki.aao.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Add text here Primary prevention Add text here Clinical diagnosis of exclusion based on history and physical findings. Laboratory testing is of no value. History Floaters and visual deterioration.[eyewiki.org]
  • All the ICE syndromes share a common underlying pathophysiology and can all be considered to be primary proliferative endothelial degenerations.5 The corneal endothelium has a fine beaten-silver appearance.[macfarlaneoptometrist.com.au]
  • Now thought of as a syndrome with a common fundamental pathophysiological basis but a spectrum of clinical manifestations, it is historically subdivided into essential (progressive) iris atrophy, Chandler syndrome, and Cogan-Reese (iris-nevus) syndrome[glaucomatoday.com]
  • Pathophysiology Clinically, the corneal endothelium has been described to have a "hammered silver" or "beaten bronze" appearance in ICE syndrome patients, similar to corneal guttae seen in Fuchs Corneal Endothelial Dystrophy. [1] [2] On a pathological[eyewiki.aao.org]

Prevention

  • Footnotes Support Departmental Challenge grant from Research to Prevent Blindness, Inc., New York, New York, and the Research and Education Fund of the Department of Ophthalmology, University of Cincinnati Investigative Ophthalmology & Visual Science[iovs.arvojournals.org]
  • Preventing needlestick injuries in health care settings. Department of Health and Human Services Publication No. 2000-108. ... ‎[books.google.com]
  • Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive[jamanetwork.com]
  • Bacteriological cure does not seem to prevent this from happening, as only three patients were smear positive in our cohort at the end of 2 years of treatment with MDT.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!