Iris melanoma is a rare tumor in clinical practice and its development is primarily associated with increased exposure to ultraviolet radiation. The clinical presentation, apart from unilateral heterochromia, may be asymptomatic, but the unilateral development of glaucomas, as well as cataracts, have been described in the literature. The diagnosis rests on a detailed ophthalmological workup.
Iris melanoma, despite being a very rare occurrence, is the most common malignant disease of the iris  . Although the exact pathogenesis remains unknown, ultraviolet radiation is by far the most important risk factor which may explain (at least in part) why countries like New Zealand (due to the profoundly higher exposure to UV-B light) report higher incidence rates of this tumor  . Solid evidence, however, is yet to be discovered. Conflicting reports exist when it comes to the age of presentation - some authors claim that iris melanoma is most frequently encountered in the first few decades of life , whereas others have documented a mean age of approximately 50 years . Manifestations of iris melanoma are primarily of visual nature  . Most patients present with a pigmented (yellow, brown, or tan-colored) spot on the iris that is often noticed incidentally, and such findings are typical for circumscribed iris melanoma, the most common form  . Unilateral heterochromia of the eye is the characteristic symptom of diffuse iris melanoma     . In up to 30% of patients, additional symptoms and signs are absent, while some of the principal complaints seen in advanced stages of the disease include blurred vision, glaucoma, corectopia, ectropion, hyphema, and anterior chamber inflammation   .
Entire Body System
A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. [ncbi.nlm.nih.gov]
There were no enucleations caused by ocular hypertension. Conclusions Baerveldt shunts were effective in lowering IOP, with few complications, in eyes treated with total anterior segment irradiation for AUM. [bjo.bmj.com]
Aggressive ocular hypertension was observed in the several eyes prior to shunt implantation. Two eyes were enucleated for non-glaucoma related sequelae. [iovs.arvojournals.org]
Anterior Chamber Brain and Optical Pathway Choroid Congenital Syndromes, Malformations and Abnomalities Conjunctiva Cornea Glaucomas, Ocular Hypertension Hypertensive Retinopathy Iris and Ciliary Body Albinism (see: Congenital Syndromes) Anterior Uveitis [atlasophthalmology.net]
Heterochromia iridis was present in all 25 cases (100%), corectopia in 23 (92%), and ectropion iridis in 21 (84%). [ncbi.nlm.nih.gov]
Of 126 patients, 14 (11.1%) had iris heterochromia (ie, heterochromia iridis) (Table 4). The tumors' surface contours were noted to be either smooth in 51 of 130 eyes (39.2%) or irregular in 79 of 130 eyes (60.8%). [jamanetwork.com]
The classic findings of diffuse iris melanoma include acquired hyperchromic heterochromia iridis and ipsilateral glaucoma.49 Ring melanoma of the anterior chamber is a distinct rare variant that manifests as circumferential, flat tumor growth confined [nature.com]
The asymptomatic nature of an iris melanoma may significantly affect the ability of the physician to make the diagnosis, and up to 30 months might pass before the tumor is detected . Having in mind the known risk of metastatic disease (ranging from 5%-13% according to various reports)  , the importance of a properly obtained patient history and a detailed physical examination must be emphasized. If a new lesion on the iris (or a change in eye color) is reported, physicians must include iris melanoma in the differential diagnosis. Because of the fact that this tumor is most often diagnosed while still being very small (2.7mm in average) , a thorough inspection of both eyes is mandatory in order to recognize the lesion. More advanced methods are necessary, however, and techniques such as slit-lamp examination, ultrasound biomicroscopy, fluorescein angiography, and optical coherence tomography (OCT) are recommended in the workup   . Histology and immunohistochemistry have also been described in the literature as valuable tools for differentiation of malignant diseases of the iris  . A viable sample for testing can be obtained through fine needle aspiration biopsy (FNAB), incision biopsy, or a direct approach through the cornea, which might be favored due to the potential risk of seeding malignant cells during the former two procedures   .
Most patients will need treatment for glaucoma and some may require treatment for tear-film instability and/or stem cell failure. [ncbi.nlm.nih.gov]
Prognosis Uveal melanoma Summary Epidemiology Etiology Clinical features Diagnostics Differential diagnoses Treatment Complications Prognosis [amboss.com]
Etiology Despite a large amount of epidemiological and molecular studies, the etiology of uveal melanoma remains largely obscure. [atlasgeneticsoncology.org]
In this case an etiological link between latanoprost and malignancy is unlikely given the brief interval between exposure and clinical melanoma; however, benign melanosis is noted in the pigment epithelial layer of the iris (Figure 2). [ncbi.nlm.nih.gov]
In 3 case-control studies1-3 investigating the role of sunlight in the etiology of melanoma of the uveal tract, those with the disease were more likely than controls to have blue or gray irises. [jamanetwork.com]
Epidemiology References: Epidemiological data refers to the US, unless otherwise specified. Etiology Clinical features Diagnostics Differential diagnoses References: The differential diagnoses listed here are not exhaustive. [amboss.com]
The clinical, epidemiological and pathological characteristics of iris melanomas are summarized and compared to those of other uveal melanomas. [ncbi.nlm.nih.gov]
Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • clinical (human) or epidemiologic studies: outcomes/complications • melanoma 2011, The Association for Research in Vision and Ophthalmology [iovs.arvojournals.org]
Anatomy keywords: published on: 19.2.2012 Riboflavin discipline: Medical Chemistry and Biochemistry keywords: published on: 1.3.2010 Smyslové orgány discipline: Histology, Embryology keywords: published on: 10.4.2017 Zinek discipline: Physiology and Pathophysiology [portal.mefanet.cz]
The exact pathophysiology of raised intraocular pressure remains unclear, but may involve invasion of the iridocorneal angle by tumour cells and by the tumour as well as postirradiation phenomena. [nature.com]
Pathophysiology Perirectal abscesses and fistulas represent anorectal disorders arising predominantly ( 90% of cases) from the obstruction of anal crypts,  possibly involving increased sphincter tone.  Infection of the now static glandular secretions [emedicine.medscape.com]
«Medscape, मई 15» Glaucoma: pathophysiology and diagnosis Aqueous humour is produced by the ciliary body and at an average rate of 2.5 microlitres per minute. It is secreted into the posterior chamber of ... [educalingo.com]
Treatment of slow-growing iris melanoma must be considered to prevent complications. [ncbi.nlm.nih.gov]
The goal of treatment in ocular melanoma is to prevent it from spreading (metastasis). [healthline.com]
Severe lesions can also prevent the iris muscles from functioning properly, thereby making it difficult for the cat to constrict the pupil in response to bright light. [eyespecialistsforanimals.com]
With medial tumours, chloramphenicol ointment was administered instead of drops, to prevent dellen formation. [nature.com]
Footnotes Support Supported in part by NCI R01 CA126557, CA116804, NEI P30 EY06360 and an unrestricted grant from Research to Prevent Blindness, Inc. [iovs.arvojournals.org]
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