Thymomas are cited to be present in 20% of patients with a CASPR2 antibody [3]. [karger.com]

Last updated: 9/17/2015 Treatment Treatment The treatment of Isaacs' syndrome is based on the signs and symptoms present in each person. [rarediseases.info.nih.gov]

Gaines is presently a member of the Greenville County Medical Society, South Carolina Medical Association, South Carolina Gastroenterology Association, and American College of Gastroenterology. [endocenterupstate.com]

Tests may include: Blood tests to identify certain antibodies present in up to half of people with Isaacs’ syndrome. Nerve conduction studies and electromyograms, which measure how your muscles and nerves work. [my.clevelandclinic.org]

• Sweating

  Increased sweating Profuse sweating Sweating Sweating profusely Sweating, increased [ more ] 0000975 Muscle fibrillation 0010546 Muscle spasm 0003394 Muscle stiffness 0003552 Weight loss 0001824 5%-29% of people have these symptoms Distal sensory impairment [rarediseases.info.nih.gov]

  It can also affect your autonomic nervous system, leading to changes in sweating and heart rate. It’s also called: Continuous muscle fiber activity syndrome. Isaacs-Mertens syndrome. Neuromyotonia. Quantal squander syndrome. [my.clevelandclinic.org]

  Sweating may be increased. Carbamazepine or phenytoin (antiseizure drugs) Immune globulin and plasma exchange Symptoms of Isaacs syndrome can be relieved by antiseizure drugs such as carbamazepine or phenytoin. [msdmanuals.com]

  Symptoms, which include progressive muscle stiffness, continuously contracting or twitching muscles (myokymia), cramping, increased sweating, and delayed muscle relaxation, occur even during sleep or when individuals are under general anesthesia. [ninds.nih.gov]

• Muscle Twitch

  The sine qua non is myokymia—continuous muscle twitching described as bag-of-worms movements. [msdmanuals.com]

  Common manifestations of IS are muscle twitching, stiffness hypertrophy, and dysautonomia [Ahmed and Simmons. Muscle Nerve. 2015;52(1):5–12]. [karger.com]

  They can test you for related conditions and help you manage symptoms such as muscle twitching and stiffness. [my.clevelandclinic.org]

  […] that your muscles contract, twitch, or spasm continuously, especially the muscles in your arms and legs. [healthline.com]

• Muscle Weakness

  […] these symptoms Distal sensory impairment Decreased sensation in extremities 0002936 1%-4% of people have these symptoms Muscle weakness Muscular weakness 0001324 Showing of 11 | Last updated: 2/1/2021 Cause Cause The exact cause of Isaacs' syndrome is [rarediseases.info.nih.gov]

• Myokymia

  The sine qua non is myokymia—continuous muscle twitching described as bag-of-worms movements. [msdmanuals.com]

  Myokymia. Medscape Reference. November 2014; http://emedicine.medscape.com/article/1141267-overview. Ahmed A, Simmons Z. Isaacs syndrome: A review. Muscle Nerve. July 2015; 52(1):5-12. Acquired Neuromyotonia. [rarediseases.info.nih.gov]

• Hyperactivity

  IS causes peripheral nerves to become hyperactive and fire continuously. This produces uncontrollable nerve and muscle activity, which causes various symptoms. For example, it might lead to muscle spasms or stiffness. [medicalnewstoday.com]

There was no evidence of malignancy in our case despite an extensive oncological workup. [karger.com]

The symptoms of IS are lifelong, but they are manageable with treatment. This article discusses the symptoms, causes, and treatments for IS. [medicalnewstoday.com]

Isaacs’ syndrome is rarely fatal, and several treatments are available to help manage it. Read on to learn more about the causes, symptoms, and treatments for Isaacs’ syndrome. [healthline.com]

Read More Read Less Treatment Treatment Anticonvulsants, including phenytoin and carbamazepine, usually provide significant relief from the stiffness, muscle spasms, and pain associated with Isaacs' syndrome. [ninds.nih.gov]

Management and Treatment How is Isaacs’ syndrome treated? There’s no cure for Isaacs’ syndrome. Treatment aims to address your symptoms and maximize daily function. [my.clevelandclinic.org]

UK HealthCare’s ALS Multidisciplinary Clinic earned accreditation as a Certified Treatment Center of Excellence from the ALS Association. [ukhealthcare.uky.edu]

Read More Read Less Prognosis Prognosis There is no cure for Isaacs' syndrome. The long-term prognosis for individuals with the disorder is uncertain. Clinical Trials Clinical Trials [ninds.nih.gov]

If there is no response or poor response to plasma exchange, some studies suggest that intravenous infusions of immunoglobulins (IvIg therapy) may be beneficial.[1][3] Last updated: 9/17/2015 Prognosis Prognosis The long-term outlook (prognosis ) for [rarediseases.info.nih.gov]

Outlook / Prognosis What is the outlook for people with neuromyotonia? The outlook for someone with Isaacs’ syndrome varies. [my.clevelandclinic.org]

Differential diagnosis of IS Although the pathophysiology of IS involves the dysfunction of VGKCs by autoantibodies resulting in potassium-ion imbalance that leads to symptoms of muscular hyperexcitability, this case highlights the question of how neuropathic [karger.com]

[…] either hereditary or acquired from another condition, it cannot be prevented. [ukhealthcare.uky.edu]

Treating IS may also prevent further damage to muscles and nerves. The outlook for IS may also depend on the presence of other conditions. [medicalnewstoday.com]