Presentation
Therefore, as is also demonstrated in our case, PPCM may present with predominantly non-cardial symptoms. [link.springer.com]
(See Etiology and Presentation.) [emedicine.medscape.com]
Visual acuity is reduced, and an afferent pupillary defect is present. The optic disk is swollen and elevated, and the swollen nerve fibers obscure the fine surface vessels of the optic nerve. Often hemorrhages surround the optic disk. [msdmanuals.com]
The hand is usually warm, and often a palpable radial pulse or audible Doppler signal is present. [jpgmonline.com]
Liver, Gall & Pancreas
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Protein S Deficiency
The relation between arterial thrombosis and the heritable thrombophilias factor V Leiden mutation, prothrombin G20210A mutation, protein C deficiency, protein S deficiency, and antithrombin deficiency are less well established [ 5 ]. [link.springer.com]
Jaw & Teeth
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Gingival Overgrowth
overgrowth Phonophobia Generalized hirsutism EMG abnormality Borderline personality disorder Truncal ataxia Cardiac arrest Clonus Cerebral visual impairment Hallucinations Abnormality of retinal pigmentation Delusions Anterior hypopituitarism Facial [mendelian.co]
Eyes
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Decreased Lacrimation
lacrimation Angiokeratoma corporis diffusum Shortened QT interval Hyposthenuria Impaired temperature sensation Obstructive lung disease Angiokeratoma Reduced sperm motility Increased blood urea nitrogen Distal renal tubular acidosis Transient unilateral [mendelian.co]
Musculoskeletal
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Numbness of the Feet
Five days before admission she suffered from acute muscle cramps, followed by muscle weakness in both legs and numbness of both feet. [link.springer.com]
Neurotrophic Ulcers With neuropathy being the underlying cause of ulceration, many patients complain of burning, tingling, or numbness of the feet on presentation. [clevelandclinicmeded.com]
Neurologic
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Peripheral Neuropathy
The peripheral neuropathy of necrotizing arteritis: a clinicopathological study / G. Said, C. Lacroix-Ciaudo, H. Fujimura [еt al.] // Ann. Neurol. — 1988. — V. 23(5). — Р. 461-465. Thermann F. [inj.zaslavsky.com.ua]
Diseases related with Peripheral neuropathy and Ischemic stroke In the following list you will find some of the most common rare diseases related to Peripheral neuropathy and Ischemic stroke that can help you solving undiagnosed cases. [mendelian.co]
In conclusion, the unusual combination of rhabdomyolysis and peripheral neuropathy in a patient should urge on doctors to look for a common vascular cause. [link.springer.com]
Unlike sensorimotor components, autonomic peripheral neuropathy requires a more subtle clinical detection and stratification [ 4, 21, 22 ]. [omicsonline.org]
Depending on the disease associated with ischemic neuropathy, a mononeuropathy or a sensory-motor, axonal-demyelinating peripheral neuropathy may be seen as well. The treatment of ischemic neuropathy varies depending on the associated disease. [ncbi.nlm.nih.gov]
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Neuralgia
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280: 1837-1842. 58. Rice AS, Maton S. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo-controlled study. [ge-bu.nl]
(Medical Encyclopedia) Metabolic neuropathies (Medical Encyclopedia) Mononeuritis multiplex (Medical Encyclopedia) Neuralgia (Medical Encyclopedia) Neuropathy secondary to drugs (Medical Encyclopedia) Peripheral neuropathy (Medical Encyclopedia) Radial [icdlist.com]
A prescription patch of 8% capsaicin (Qutenza) is approved for the treatment of postherpetic neuralgia. [medicinenet.com]
such as the facial pain syndrome trigeminal neuralgia. [neuromodulation.com]
Cortical and sub-cortical strokes, traumatic spinal cord injuries, syringo-myelia and syringobulbia, trigeminal and glossopharyngeal neuralgias, neoplastic and other space-occupying lesions are clinical conditions that belong to the former group. [practicalpainmanagement.com]
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Delayed Speech and Language Development
speech and language development Hemeralopia Intellectual disability, mild Crohn's disease Abnormality of the cerebellar vermis Psychotic episodes Tubulointerstitial abnormality Renal Fanconi syndrome Abnormal nerve conduction velocity Auditory hallucinations [mendelian.co]
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Dysmetria
Abnormality of the renal tubule Cerebral ischemia Stroke-like episode Hemianopia Nystagmus Amaurosis fugax Tremor Renal tubular dysfunction Xerostomia Progressive sensorineural hearing impairment Myelodysplasia Bundle branch block Loss of consciousness Dysmetria [mendelian.co]
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Cerebral Calcification
calcification Amenorrhea Hip dysplasia Involuntary movements Memory impairment Increased serum lactate Generalized myoclonic seizures Personality disorder Postural instability Polyneuropathy Hirsutism Lactic acidosis Peripheral axonal neuropathy Ichthyosis [mendelian.co]
Workup
Workup The proper diagnosis of IMN as a vascular lesion can avoid incorrect classification of the injury as a plexus or a root lesion from trauma, as well as avoid incorrect positioning during surgery. [emedicine.medscape.com]
The diagnostic workup includes: Brain Imaging Head CT without contrast should be performed on all patients to exclude intracranial hemorrhage. [cdemcurriculum.com]
Complete electrodiagnostic studies [Nerve conduction studies (NCS) and needle electromyography (EMG)]: Perform if unclear after initial workup or presence of atypical symptoms: asymmetry, motor predominance, non-length dependence, prominent autonomic [clinicaladvisor.com]
Hypertrophy
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Biventricular Hypertrophy
hypertrophy Primary hypothyroidism Microalbuminuria Supraventricular arrhythmia Nephrogenic diabetes insipidus Abnormal cornea morphology Abnormal thrombosis Tubulointerstitial fibrosis Chronic pain Abnormal renal physiology Miosis T-wave inversion Abnormal [mendelian.co]
Treatment
Prompt treatment does not restore lost vision in the affected eye but protects the unaffected eye. Inadequate treatment risks relapses and additional vision loss. [msdmanuals.com]
For example, it is important to exclude the possibility of Temporal Arteritis, which requires urgent treatment to prevent loss of vision in the other eye. [brighamandwomens.org]
Treatment of NA-AION The focus of treatment is on the underlying cardiovascular disease or other risk factors that help trigger and aggravate NA-AION. This can help control the condition and prevent additional loss of vision. [clevelandclinic.org]
The treatment of ischemic neuropathy varies depending on the associated disease. Prognosis can be poor in the case of amyloidosis and the primary vasculitides. [ncbi.nlm.nih.gov]
Diagnosis and treatment of the systemic conditions that cause AION may lessen the risk for vision loss. [lowvision.org]
Prognosis
Prognosis can be poor in the case of amyloidosis and the primary vasculitides. The literature is limited to cross-sectional case series and rare longitudinal studies likely related to the incidence of the diseases. [ncbi.nlm.nih.gov]
Visual prognosis tends to be poor. Give corticosteroids if giant cell arteritis is possible. Click here for Patient Education [msdmanuals.com]
Prognosis Recent studies have suggested that 40% of patients may experience some degree of improvement in central vision or visual acuity weeks to months after the vision or visual field loss. [lowvision.org]
What You Need to Know There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis. Peripheral neuropathy has many different causes. [hopkinsmedicine.org]
What Is the Prognosis for Neuropathy? The outlook for nerve damage depends upon its cause. [emedicinehealth.com]
Etiology
(See Etiology and Presentation.) [emedicine.medscape.com]
They seem to present similar etiologic interactions within the wider group of functional diabetic microangiopathies [ 21 - 23 ]. [omicsonline.org]
The etiology is considered to be an ischemic insult to the proximal limb which results in multiple axonal loss mononeuropathies. [2], [3] It is a devastating complication of AV access which can result in permanent disability even if intervened immediately [jpgmonline.com]
Questions exploring different potential etiology’s as well to discriminate between syndromes: Etiologic questions Duration of symptoms (acute versus sub-acute syndromes). [clinicaladvisor.com]
Epidemiology
Determination of peripheral neuropathy prevalence and associated factors in Chinese subjects with diabetes and pre-diabetes - ShangHai Diabetic Neuropathy Epidemiology and Molecular Genetics Study (SH-DREAMS). [scielo.br]
Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol 2014; 126:3–22. 10. Said G. Examination and clinical care of the patient with neuropathy. Handb Clin Neurol 2013; 115:235–244. 11. Jensen TS, Finnerup NB. [ekjm.org]
The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988;4(2):96-101. Covidien. Endovenous radiofrequency ablation (RFA) catheter (with 3 cm and 7 cm heating elements) instructions for use. [vasculardiseasemanagement.com]
Epidemiology and treatment of neuropathic pain: the UK primary care perspective. Pain. 2006; 122: 156-162. 2. Benarroch EE. Sodium channels and pain. Neurology 2007; 68: 233-236. 3. Richtlijn Polyneuropathie. [ge-bu.nl]
Pathophysiology
The neurophysiologic changes suggest that the underlying pathophysiology is a distal axonopathy affecting nerve fibers of all sizes. [neurology.org]
The pathophysiologic processes and theories underlying neuropathic pain are multiple. [practicalpainmanagement.com]
Lilly, Pathophysiology of Heart Disease, 2007. [pathophys.org]
I hope future research will help to delineate the pathophysiology of chronic ischaemic neuropathy. [webview.isho.jp]
Prevention
Patients should be instructed to care meticulously for their insensate skin areas in order to prevent skin breakdown. (See Treatment.) [emedicine.medscape.com]
How can anterior ischemic optic neuropathy be prevented? Controlling the risk factors associated with NA-AION is an important preventive measure. [clevelandclinic.org]
Finding and treating the problem as soon as possible can help prevent further vision loss from ION. [aao.org]
For example, it is important to exclude the possibility of Temporal Arteritis, which requires urgent treatment to prevent loss of vision in the other eye. [brighamandwomens.org]