Presentation
Therefore, as is also demonstrated in our case, PPCM may present with predominantly non-cardial symptoms. [link.springer.com]
Visual acuity is reduced, and an afferent pupillary defect is present. The optic disk is swollen and elevated, and the swollen nerve fibers obscure the fine surface vessels of the optic nerve. Often hemorrhages surround the optic disk. [msdmanuals.com]
(See Etiology and Presentation.) [emedicine.medscape.com]
The hand is usually warm, and often a palpable radial pulse or audible Doppler signal is present. [jpgmonline.com]
Entire Body System
- Collapse
Some pharmaceuticals as well as vitamin deficiencies can also contribute to collapse of the blood vessels. When cells do not get the oxygen they need from the blood and start to die, this is called ischemia. [texstarchiropractic.com]
The other cases of technical failures were three cases of unsealed arterial perforations, one case of elastic recoil with collapsed extraluminal channel and early thrombosis and three cases of unsuccessful endoluminal angioplasties, due to the presence [omicsonline.org]
- Anorexia
Hepatomegaly Splenomegaly Abdominal pain Optic atrophy Abnormality of the cerebral vasculature Rare Symptoms - Less than 30% cases Ventricular hypertrophy Spontaneous abortion Hypertonia Dystonia Arterial thrombosis Malabsorption Nausea and vomiting Anorexia [mendelian.co]
The most common and initial symptom is migraine (33%) localized in the temporal area, accompanied by fever, malaise, myalgia and anorexia. The temporal artery is often swollen and sensitive to palpation. [ncbi.nlm.nih.gov]
- Hodgkin Lymphoma
Some of secondary systemic vasculitis which lead to peripheral neuropathy are Systemic Lupus Erythematosus (SLE), Sjögren Syndrome and non-Hodgkin lymphoma, etc (3). In Figure1 the classification of peripheral vasculitic neuropathy has been shown. [rcm.mums.ac.ir]
- Whipple Disease
View/Print Table TABLE 2 Distal Symmetric Sensorimotor Polyneuropathies Endocrine diseases Diabetes mellitus Hypothyroidism Acromegaly Nutritional diseases Alcoholism Vitamin B 12 deficiency Folate deficiency Whipple's disease Postgastrectomy syndrome [aafp.org]
Gastrointestinal
- Loss of Appetite
appetite Unexplained loss of weight Fever In a less common form of GCA known as occult giant cell arteritis, no symptoms are present. [clevelandclinic.org]
Skin
- Hirsutism
Generalized-onset seizure Pigmentary retinopathy Cerebral calcification Amenorrhea Hip dysplasia Involuntary movements Memory impairment Increased serum lactate Generalized myoclonic seizures Personality disorder Postural instability Polyneuropathy Hirsutism [mendelian.co]
Eyes
- Blurred Vision
[…] of vision If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Ventricular septal defect and Retinopathy, related diseases and genetic alterations Hepatomegaly and Open mouth, [mendelian.co]
vision Heat intolerance or decreased ability to sweat Hypoglycemia unawareness: Low blood sugar levels (hypoglycemia) are associated with trembling, sweating, and palpitations. [emedicinehealth.com]
Factors to consider in choosing medications in neuropathic pain Medication Starting dosage Maximum dosage Major side effect Precaution Avoid Other benefits TCAs 25 mg at bedtime 150 mg daily Sedation, dry mouth, blurred vision, weight gain, urinary retention [ekjm.org]
Patients with PAN typically demonstrate CNS neurological signs, such as personality and memory disorders, atypical persistent headaches, aphasia, hemiplegia, visual disturbance (blurred vision and hemianopia), seizures, transverse myelitis and subarachnoid [ncbi.nlm.nih.gov]
- Diplopia
[…] vomiting Autistic behavior Ileus Proximal tubulopathy Abnormality of peripheral nerve conduction Speech apraxia Spontaneous hematomas Left ventricular failure Seborrheic dermatitis Apraxia Gait imbalance Reduced consciousness/confusion Intention tremor Diplopia [mendelian.co]
This fatigability is especially present in the eye muscles, causing drooping of the lids on looking upward and to diplopia (double vision). The muscles of the throat, limbs, and respiration may also be involved. [britannica.com]
Musculoskeletal
- Numbness of the Feet
Five days before admission she suffered from acute muscle cramps, followed by muscle weakness in both legs and numbness of both feet. [link.springer.com]
Neurotrophic Ulcers With neuropathy being the underlying cause of ulceration, many patients complain of burning, tingling, or numbness of the feet on presentation. [clevelandclinicmeded.com]
Urogenital
- Kidney Failure
failure Connective tissue disease (e.g., rheumatoid arthritis, lupus, sarcoidosis ) Diabetes mellitus Infectious disease (e.g., Lyme disease, HIV/AIDS, hepatitis B, leprosy) Liver failure Medications Radiculopathy Vitamin deficiencies (e.g., pernicious [healthcommunities.com]
Many other diseases and conditions can cause peripheral neuropathy, for example, drugs, diabetes, shingles, kidney failure, and vitamin deficiency. [medicinenet.com]
Neuropathy may be caused by physical injury, infection, toxic substances, disease (such as cancer, diabetes, kidney failure, or malnutrition), or drugs, including anticancer drugs. [fpnotebook.com]
failure, chronic liver disease and rarely, inherited diseases, like Charcot-Marie-Tooth disease. [verywellhealth.com]
There are numerous causes of peripheral neuropathy, including certain hereditary conditions, viral diseases, liver or kidney failure, and toxins, as well as diseases such as diabetes, vascular disease, and rheumatoid conditions. [6] Peripheral neuropathy [physio-pedia.com]
- Hematuria
[…] than 30% cases Ventricular hypertrophy Spontaneous abortion Hypertonia Dystonia Arterial thrombosis Malabsorption Nausea and vomiting Anorexia Left ventricular hypertrophy Elevated serum creatine phosphokinase Cerebellar hypoplasia Atrial fibrillation Hematuria [mendelian.co]
Neurologic
- Peripheral Neuropathy
Peripheral neuropathy definition and facts Peripheral neuropathy is nerve pain that affects the limbs. Peripheral neuropathy is a condition in which the nerves in the peripheral nervous system become damaged. [medicinenet.com]
Peripheral Neuropathy Prevention Lifestyle choices can play a role in preventing peripheral neuropathy. [hopkinsmedicine.org]
Diagnosis The diagnosis of peripheral neuropathy begins with a neurological examination. [verywellhealth.com]
Home / Conditions / Type 2 Diabetes / Peripheral Neuropathy Associated with CV Disease and Stroke in Type 2 Diabetes Patients Aug 15, 2014 Testing for peripheral neuropathy may provide a way to identify individuals at higher risk of cardiovascular events [diabetesincontrol.com]
Further Reading All Peripheral Neuropathy Content What is Peripheral Neuropathy? Peripheral Neuropathy Types Peripheral Neuropathy Symptoms Peripheral Neuropathy Tremors Last Updated: Aug 23, 2018 Written by Dr. Liji Thomas Dr. [news-medical.net]
- Neuralgia
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280: 1837-1842. 58. Rice AS, Maton S. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo-controlled study. [ge-bu.nl]
(Medical Encyclopedia) Metabolic neuropathies (Medical Encyclopedia) Mononeuritis multiplex (Medical Encyclopedia) Neuralgia (Medical Encyclopedia) Neuropathy secondary to drugs (Medical Encyclopedia) Peripheral neuropathy (Medical Encyclopedia) Radial [icdlist.com]
Trigeminal neuralgia usually affects only one side of the face. The exact cause of trigeminal neuralgia is unknown, but it develops where the trigeminal nerve is compressed, pinched, or irritated. [physio-pedia.com]
A prescription patch of 8% capsaicin (Qutenza) is approved for the treatment of postherpetic neuralgia. [medicinenet.com]
such as the facial pain syndrome trigeminal neuralgia. [neuromodulation.com]
- Cranial Neuropathy
Cranial neuropathy is similar to peripheral neuropathy, except that the cranial nerves are involved. Any of the cranial nerves can be involved. [medicinenet.com]
Cranial neuropathy: Cranial neuropathy occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged. Two specific types of cranial neuropathy are optic neuropathy and auditory neuropathy. [emedicinehealth.com]
Diabetes infrequently causes multifocal neuropathies including the cranial nerves, an asymmetric proximal motor neuropathy (diabetic amyotrophy) or a symmetric proximal motor neuropathy. [aafp.org]
Ischemic optic neuropathy, other isolated cranial nerve palsies and stroke, have been reported due to involvement of the internal carotid artery or its branches. [ncbi.nlm.nih.gov]
- Agitation
— Int Psychogeriatr. 2013 Feb 21:1-11 Neuropsychiatric Symptoms in AD and Functional Connectivity Alterations A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation [practicalneurology.com]
Fasciculations Lymphedema Abnormal myocardium morphology Leukopenia Lupus anticoagulant Pure red cell aplasia Panniculitis Antiphospholipid antibody positivity Erythema nodosum Granulocytopenia Immune dysregulation Hypercoagulability Combined immunodeficiency Agitation [mendelian.co]
In this disorder, individuals lose their orientation in time, space, and person; they may show altered levels of consciousness, emotional instability, physical excitability, agitation, disorderliness, hallucinations, and delusions. [britannica.com]
Workup
Workup The proper diagnosis of IMN as a vascular lesion can avoid incorrect classification of the injury as a plexus or a root lesion from trauma, as well as avoid incorrect positioning during surgery. [emedicine.medscape.com]
The diagnostic workup includes: Brain Imaging Head CT without contrast should be performed on all patients to exclude intracranial hemorrhage. [cdemcurriculum.com]
Complete electrodiagnostic studies [Nerve conduction studies (NCS) and needle electromyography (EMG)]: Perform if unclear after initial workup or presence of atypical symptoms: asymmetry, motor predominance, non-length dependence, prominent autonomic [clinicaladvisor.com]
Treatment
Prompt treatment does not restore lost vision in the affected eye but protects the unaffected eye. Inadequate treatment risks relapses and additional vision loss. [msdmanuals.com]
The medicines will usually be tested against another treatment called a control. This will either be a dummy treatment (a placebo) or a standard treatment already in use. [nhs.uk]
Evaluation and treatment of suspected radiculopathy. Figure 3. Evaluation and treatment of suspected radiculopathy. Figure 4. Evaluation and treatment of suspected polyneuropathy (eg, multifocal mononeuropathy). Figure 4. [jaoa.org]
New treatments for hemorrhagic stroke are becoming available and should improve the range of possible treatments. Get more information on new treatments from the Stroke Association. [urmc.rochester.edu]
How many times should the treatment be applied? Follow-up results let us make a conclusion about how well you’re responding to the treatment and whether you can benefit from a second course. [restore-vision.com]
Prognosis
Prognosis can be poor in the case of amyloidosis and the primary vasculitides. The literature is limited to cross-sectional case series and rare longitudinal studies likely related to the incidence of the diseases. [ncbi.nlm.nih.gov]
What You Need to Know There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis. Peripheral neuropathy has many different causes. [hopkinsmedicine.org]
Visual prognosis tends to be poor. Give corticosteroids if giant cell arteritis is possible. Click here for Patient Education [msdmanuals.com]
What Is the Prognosis for Neuropathy? The outlook for nerve damage depends upon its cause. [emedicinehealth.com]
Prognosis Recent studies have suggested that 40% of patients may experience some degree of improvement in central vision or visual acuity weeks to months after the vision or visual field loss. [lowvision.org]
Etiology
(See Etiology and Presentation.) [emedicine.medscape.com]
Questions exploring different potential etiology’s as well to discriminate between syndromes: Etiologic questions Duration of symptoms (acute versus sub-acute syndromes). [clinicaladvisor.com]
However, muscle cramping may be associated with etiologies other than vascular disease, including neuropathy. [podiatrytoday.com]
Systemic vasculitis is classified as primary (unknown etiology) and secondary (related to other pathological conditions such as connective tissue disease). [rcm.mums.ac.ir]
Epidemiology
Determination of peripheral neuropathy prevalence and associated factors in Chinese subjects with diabetes and pre-diabetes - ShangHai Diabetic Neuropathy Epidemiology and Molecular Genetics Study (SH-DREAMS). [scielo.br]
Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol 2014; 126:3–22. 10. Said G. Examination and clinical care of the patient with neuropathy. Handb Clin Neurol 2013; 115:235–244. 11. Jensen TS, Finnerup NB. [ekjm.org]
The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988;4(2):96-101. Covidien. Endovenous radiofrequency ablation (RFA) catheter (with 3 cm and 7 cm heating elements) instructions for use. [vasculardiseasemanagement.com]
This has important implications when targeting treatments for NP. [8] Screening questionnaires are suitable for identifying potential patients with neuropathic pain, but further validation of them is needed for epidemiological purposes. [physio-pedia.com]
Pathophysiology
The pathophysiologic processes and theories underlying neuropathic pain are multiple. [practicalpainmanagement.com]
The neurophysiologic changes suggest that the underlying pathophysiology is a distal axonopathy affecting nerve fibers of all sizes. [neurology.org]
Lilly, Pathophysiology of Heart Disease, 2007. [pathophys.org]
I hope future research will help to delineate the pathophysiology of chronic ischaemic neuropathy. [webview.isho.jp]
Prevention
Patients should be instructed to care meticulously for their insensate skin areas in order to prevent skin breakdown. (See Treatment.) [emedicine.medscape.com]
You can help prevent mini strokes and these symptoms by talking to your doctor about risk factors, specifically blood clots, and taking the appropriate preventative measures. Success! Your place in line is confirmed. [intermountainhealthcare.org]
How can anterior ischemic optic neuropathy be prevented? Controlling the risk factors associated with NA-AION is an important preventive measure. [clevelandclinic.org]
Peripheral Neuropathy Prevention Lifestyle choices can play a role in preventing peripheral neuropathy. [hopkinsmedicine.org]