A eunuchoid habitus (tall, thin, and with long arms and legs) is generally present. [merckmanuals.com]

• Weight Loss

  Weakness, hypoglycemia, weight loss, and decreased axillary and pubic hair suggest the diagnosis. Blood and urinary steroid levels are low and rise to normal after ACTH replacement. [merckmanuals.com]

• Infertility

  Isolated gonadotropin deficiency occurs in both sexes and must be distinguished from primary hypogonadism; men have low serum testosterone levels and infertility, and women have amenorrhea, low serum estrogen levels, and infertility. [merckmanuals.com]

• Weakness

  Weakness, hypoglycemia, weight loss, and decreased axillary and pubic hair suggest the diagnosis. Blood and urinary steroid levels are low and rise to normal after ACTH replacement. [merckmanuals.com]

• Short Stature

  Isolated growth hormone (GH) deficiency is responsible for many cases of pituitary short stature. [merckmanuals.com]

• Anosmia

  In Kallmann syndrome, the specific lack of gonadotropin-releasing hormone (GnRH) is associated with midline facial defects, including anosmia and cleft lip or palate, and with color blindness. [merckmanuals.com]

• Long Arm

  A eunuchoid habitus (tall, thin, and with long arms and legs) is generally present. [merckmanuals.com]

• Suggestibility

  Weakness, hypoglycemia, weight loss, and decreased axillary and pubic hair suggest the diagnosis. Blood and urinary steroid levels are low and rise to normal after ACTH replacement. [merckmanuals.com]

• Amenorrhea

  Isolated gonadotropin deficiency must also be distinguished from hypogonadotropic amenorrhea secondary to exercise, diet, or mental stress. Although the history may be helpful, differential diagnosis may be impossible. [merckmanuals.com]

Treatment of GH deficiency in adults is discussed elsewhere (see generalized hypopituitarism). [merckmanuals.com]