Signs of a pancreas problem ( pancreatitis ) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up. [drugs.com]

Common side effects may include: red-orange coloration of tears, sweat, saliva, urine, or stools; numbness, tingling, itching, mild rash; drowsiness, dizziness, headache; muscle pain or weakness; heartburn, gas, diarrhea; or mouth pain. [uofmhealth.org]

[…] or tenderness Blurred vision or loss of vision, with or without eye pain Convulsions (seizures) Joint pain Mental depression Mood or other mental changes Common side effects: tingling of hands and feet nausea/vomiting/diarrhea This is not a complete [rxwiki.com]

Seven patients initially experienced excess fatigue, nausea, or abdominal pain, but waited until the onset of jaundice before seeking medical attention. [cdc.gov]

[…] the risk of bleeding) Anemia High blood sugar levels in the blood Gynecomastia (enlargement of the breasts in men) Ringing in the ears Urinary retention (difficulty passing urine) Blood disorders Hypersensitivity reactions Painful joints What is the [medicinenet.com]

A prodromal period characterized by fatigue, weakness, anorexia, and malaise was noted in all patients before the appearance of jaundice. [annals.org]

Seven patients initially experienced excess fatigue, nausea, or abdominal pain, but waited until the onset of jaundice before seeking medical attention. [cdc.gov]

These include any of the following: unexplained anorexia, nausea, vomiting, dark urine, icterus, rash, persistent paresthesias of the hands and feet, persistant fatigue, weakness or fever of greater than 3 days duration and/or abdominal tenderness, especially [rxwiki.com]

These symptoms and signs include: Unexplained loss of appetite Nausea Vomiting Dark urine Yellow skin or a yellowish tinge to the whites of the eyes Persistent fatigue Weakness Fever of greater than 3 days duration Abdominal tenderness or discomfort, [medicinenet.com]

[…] function tests were performed and information was obtained regarding adverse effects, adherence to preventive therapy, and symptoms of hepatotoxicity (at least 2 of the following: jaundice, dark urine, loss of appetite, nausea, vomiting, pruritis, and fatigue [academic.oup.com]

associate pathologist, Peter Bent Brigham Hospital, Boston, for a review of the slides. [nejm.org]

Seven patients initially experienced excess fatigue, nausea, or abdominal pain, but waited until the onset of jaundice before seeking medical attention. [cdc.gov]

Common side effects of Isoniazid include tingling of hands and feet, nausea, vomiting, and diarrhea. Do not drink alcohol while taking isoniazid. Alcohol may increase the risk of liver damage during isoniazid treatment. [rxwiki.com]

Patients should be instructed to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea or vomiting. [rxmed.com]

Adverse Reactions: Peripheral neuropathy (esp. in slow acetylators), elevated serum transaminases (SGOT; SGPT), bilirubinemia, bilirubinuria, jaundice, hepatitis (may be fatal), nausea, vomiting, epigastric distress, pancreatitis, blood dyscrasias, hypersensitivity [clinicaladvisor.com]

Call your doctor right away if you have: nausea, upper stomach pain, loss of appetite, and unusual weakness or tiredness. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking isoniazid and rifampin. [uofmhealth.org]

Abstract A 22-year-old female who was a known case of tubercular meningitis on anti-tubercular therapy, presented to the emergency room with complaints of recurrent vomiting, markedly reduced appetite, yellowish discoloration of eyes, abnormal behaviour [scopemed.org]

Common side effects of Isoniazid include tingling of hands and feet, nausea, vomiting, and diarrhea. Do not drink alcohol while taking isoniazid. Alcohol may increase the risk of liver damage during isoniazid treatment. [rxwiki.com]

excess fatigue, nausea, vomiting, abdominal pain, or jaundice), even before a clinical evaluation has been conducted, and that initial symptoms can be subtle and might not include jaundice. Two of the 17 patients in this series were children. [cdc.gov]

Patients should be instructed to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea or vomiting. [rxmed.com]

Adverse Reactions: Peripheral neuropathy (esp. in slow acetylators), elevated serum transaminases (SGOT; SGPT), bilirubinemia, bilirubinuria, jaundice, hepatitis (may be fatal), nausea, vomiting, epigastric distress, pancreatitis, blood dyscrasias, hypersensitivity [clinicaladvisor.com]

Abstract A 22-year-old female who was a known case of tubercular meningitis on anti-tubercular therapy, presented to the emergency room with complaints of recurrent vomiting, markedly reduced appetite, yellowish discoloration of eyes, abnormal behaviour [scopemed.org]

However, jaundice was notably absent in the patients with enzyme elevations and prompted a further investigation into the possible effect of INH on bilirubin metabolism. Thus, Sprague-Dawley rats were given four daily injections of INH. [ncbi.nlm.nih.gov]

A prodromal period characterized by fatigue, weakness, anorexia, and malaise was noted in all patients before the appearance of jaundice. [annals.org]

ALTHOUGH isoniazid (INH) is thought to be a rare cause of jaundice its precise role is unclear. [nejm.org]

and that initial symptoms can be subtle and might not include jaundice. [cdc.gov]

icterus, or “hepatitis” notation 5300 15 (0.37%) b 1 (.019%) Nolan 6 Jan. 1989 to 1 December 1995 Monthly symptom-based screening AST 5x normal with symptoms, and no other cause 11,141 11 (0.1%) 0 LoBue 7 July 1999 to Nov. 2002 Monthly clinical monitoring [mdedge.com]

Usually, the onset is abrupt, with chills, fever, rash, pruritus, arthralgia, headache, abdominal pain, anorexia, nausea and vomiting. Later, overt evidence of liver damage, such as jaundice, dark urine and an enlarged and tender liver, may develop. [patient.info]

Most clinicians use antihistamines such as diphenhydramine and hydroxyzine for symptomatic pruritus. [gi.org]

On presentation, she complained of fatigue, nausea and dark urine but denied fever, rash or pruritus. She had no previous history of liver disease and did not drink alcohol or take other medications or herbal products. [livertox.nih.gov]

Abstract A 22-year-old female who was a known case of tubercular meningitis on anti-tubercular therapy, presented to the emergency room with complaints of recurrent vomiting, markedly reduced appetite, yellowish discoloration of eyes, abnormal behaviour [scopemed.org]

However, for children with miliary TB, bone or joint TB, or tuberculosis meningitis, treatment should be continued for a minimum of 12 months. [wikidoc.org]

Hepatic toxicity during chemotherapy for severe tuberculosis meningitis. Am J Dis Child 1987; 141: 741-3. [livertox.nih.gov]

Side Effects of Isoniazid If you experience any of the following symptoms of liver damage, call your doctor immediately: excessive tiredness/weakness lack of energy loss of appetite upset stomach, vomiting dark urine yellowing of the skin or eyes Tell [rxwiki.com]

urine for several days 1 146 107 Liver transplant 29 Eczema Rare concurrent alcohol consumption Fatigue, nausea for 2 weeks then icterus, dark urine and jaundice for several days 4 137 16 Death 35 HIV infection, chronic hepatitis C virus infection, eczema [cdc.gov]

Later, overt evidence of liver damage, such as jaundice, dark urine and an enlarged and tender liver, may develop. Two general pathogenic mechanisms are recognised: Predictable or direct: usually promptly follows an exposure to a new medication. [patient.info]

Call your doctor at once if you have: nausea, upper stomach pain, feeling weak or tired, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); vision changes, confusion, hallucinations, unusual thoughts or behavior [uofmhealth.org]

• Instruct patient to report anorexia, nausea, vomiting, jaundice, dark urine, and numbness or tingling of hands or feet. • Tell patient he'll need periodic medical and eye examinations and blood tests to gauge drug effects. • As appropriate, review [medical-dictionary.thefreedictionary.com]

Page 218 - Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. ‎ Page 282 - Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals. A Review. ‎ [books.google.com]

necrosis, acute hepatitis and granulomatous hepatitis Cholestatic injury: bland cholestasis, acute cholestatic hepatitis and chronic cholestatic injury Steatosis and steatohepatitis Vascular lesion: sinusoidal obstruction syndrome, Budd-Chiari syndrome [pathologyoutlines.com]

This damage is caused by hepatic necrosis or death of liver cells, as Isoniazid is metabolized in the liver. The CYP450 family of enzymes play a key role in the metabolism of the drug (see figure 1). [livertoxicity.weebly.com]

Fatal hepatic necrosis secondary to isoniazid therapy. JAMA 1961; 176: 877-9. [livertox.nih.gov]

The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. Aliment Pharmacol Ther 2007;25:1411–1421. 36. Rochon J, Protiva P, Seeff LB et al. [gi.org]