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Isoproterenol
Isoprenaline

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WIKIDATA, Public Domain

Presentation

A series of 12 patients with shock that followed bacteremia due to gram-negative pathogens is presented, and a case is reported. The hemodynamic alterations that occur in such patients are discussed. [ncbi.nlm.nih.gov]

Nearly half of the catecholamine-sensitive patients had inducible AF or pathway-dependent SVT that was present on isoproterenol, but not at baseline. [innovationsincrm.com]

Cardiovascular

  • Tachycardia

    No tachycardias were induced during programmed electrical stimulation. [ncbi.nlm.nih.gov]

    Isoproterenol allowed for tachycardia induction and for more sustained episodes of tachycardia by reversing the effect of flecainide on retrograde accessory pathway conduction. 4) Tachycardia recurred during follow-up in all three patients in whom tachycardia [onlinejacc.org]

    For example, a low-dose isoproterenol infusion is often needed to allow induction of paroxysmal supraventricular tachycardia (PSVT) in a patient with documented tachycardia, but no inducible tachycardia at baseline. [eplabdigest.com]

Skin

  • Dry Skin

    Be alert for signs of hyperglycemia, including confusion, drowsiness, flushed/dry skin, fruit-like breath odor, rapid/deep breathing, polyuria, loss of appetite, and unusual thirst. [fadavispt.mhmedical.com]

Urogenital

  • Polyuria

    Be alert for signs of hyperglycemia, including confusion, drowsiness, flushed/dry skin, fruit-like breath odor, rapid/deep breathing, polyuria, loss of appetite, and unusual thirst. [fadavispt.mhmedical.com]

Workup

Serum

  • Glucose Increased

    Glucose: increased level Patient monitoring • During I.V. administration, monitor ECG and vital signs carefully. • Assess patient's response to drug and adjust I.V. infusion rate accordingly. • Closely monitor arterial blood gas values, urine output, [medical-dictionary.thefreedictionary.com]

Rhythm

  • Sinus Arrhythmia

    The most accurate assessment of CD25 was achieved by using the three shortest R-R intervals of the electrocardiogram to calculate heart rate before and after administration of isoproterenol to eliminate the effect of sinus arrhythmia. [jamanetwork.com]

Treatment

Because of these physiological observations, isoproterenol was used in the acute treatment of certain expressions of circulatory failure. [jamanetwork.com]

We recently utilized continuous infusion intravenous isoproterenol in the treatment of respiratory failure in an 18-yr-old steroid-dependent asthmatic female. [ncbi.nlm.nih.gov]

Prognosis

The prognosis of the patient is essentially determined by the severity in morphological changes, however, high pulmonary vascular resistance in the neonatal period may aggravate tricuspid regurgitation and lead to functional pulmonary atresia. [ncbi.nlm.nih.gov]

Further studies evaluating the long-term prognosis of this intervention in AF ablation must be performed. [bmccardiovascdisord.biomedcentral.com]

Characteristics, prognosis and treatment of the ventricular arrhythmias of right ventricular dysplasia. Eur Heart J. 1989 ; 10 (suppl D):61–67. Crossref Medline Google Scholar 23. Heinze G, Gnant M, Schemper M. [ahajournals.org]

Etiology

The etiology of her electrocardiographic pattern was evaluated by isoproterenol infusion test and was revealed to be an early repolarization. [ncbi.nlm.nih.gov]

Intravenous As a diagnostic agent Adult: For diagnosing etiology of mitral regurgitation: 4 mcg/minute as infusion. For diagnosis of coronary artery disease or lesions: 1-3 mcg/minute as infusion. [ndrugs.com]

As an aid in diagnosing etiology of mitral regurgitation ◇. Adults: I.V. infusion of 4 mcg/minute. As an aid in diagnosing coronary artery disease or lesions ◇. Adults: I.V. infusion of 1 to 3 mcg/minute. [glowm.com]

Epidemiology

"Epidemiologic Studies of Beta Agonists and Asthma Deaths" (PDF). Epidemiologic Studies. 20 (2). PMID 9919437. ^ Jalba, MS (2008). [en.wikipedia.org]

Pathophysiology

This review briefly introduces the pathophysiology of myocardial infarction (MI) and then addresses the progress of natural product research towards its treatment. [ncbi.nlm.nih.gov]

The Journal of pharmacology and experimental therapeutics. 1967 Apr [PubMed PMID: 6023594] [13] Kislitsina ON,Rich JD,Wilcox JE,Pham DT,Churyla A,Vorovich EB,Ghafourian K,Yancy CW, Shock - Classification and Pathophysiological Principles of Therapeutics [statpearls.com]

Prevention

The authors review the possible mechanisms of action of isoproterenol in migraine and present evidence to support the prophylactic use of isoproterenol to prevent transient and possible persistent visual loss in patients with migraine. [ncbi.nlm.nih.gov]

It also decreased the tachycardia cycle length, an effect that was due solely to shortening of AV node conduction time. 3) Flecainide treatment prevented tachycardia induction by affecting retrograde conduction over the accessory pathway. [onlinejacc.org]

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