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Itraconazole


Presentation

  • The presented case shows one of the multiple issues concerning migration between neighboring countries.[ncbi.nlm.nih.gov]
  • We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years.[ncbi.nlm.nih.gov]
  • In the present study, we revisited ITZ metabolism in humans, using a non-targeted metabolomics approach, and identified several novel metabolic pathways including O-dearylation, piperazine oxidation, and piperazine-N,N'-deethylation.[ncbi.nlm.nih.gov]
  • To present two cases of iatrogenic Cushing syndrome caused by the interaction of budesonide, an inhaled glucocorticoid, with ritonavir and itraconazole.[ncbi.nlm.nih.gov]
  • The presented cases suggest a causal relation between itraconazole and pancreatitis.[ncbi.nlm.nih.gov]
Congestive Heart Failure
  • Evidence supporting the association between itraconazole and the onset of congestive heart failure (CHF) is limited and is based on cases reported after drug market release.[ncbi.nlm.nih.gov]
  • At least three of our seven subjects developed either congestive heart failure or hypertension while receiving 400 mg itraconazole, daily.[erj.ersjournals.com]
  • Only few cases have been reported with cardiovascular side effects, especially congestive heart failure (HF), of intraconazole therapy after black box warning by US-FDA (2001).[ncbi.nlm.nih.gov]
  • Congestive Heart Failure, Cardiac Effects and Drug Interactions: Itraconazole should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF[rxwiki.com]
  • Itraconazole has been associated with reports of congestive heart failure.[drugs.com]
Intravenous Administration
  • On day 17 of itraconazole treatment, she developed hypotension and hypoxemia shock after intravenous administration of itraconazole 200 mg, which was eventually reversed by steroid treatment.[ncbi.nlm.nih.gov]
  • ., polymer micelles (IP2K) and albumin nanoparticles (IBSA), to solubilize the extremely hydrophobic and insoluble ITA to allow intravenous administration and pharmacokinetics (PK)/pharmacodynamics (PD) comparisons.[ncbi.nlm.nih.gov]
  • The rapid intravenous administration, insufficient dilution and drug vehicle have been associated with the dysrhythmias caused by imidazole antifungals.[jmedicalcasereports.com]
  • Itraconazole mean total plasma clearance following intravenous administration is 278 mL/min. Itraconazole clearance decreases at higher doses due to saturable hepatic metabolism. Absorption Itraconazole is rapidly absorbed after oral administration.[drugs.com]
Hypoxemia
  • To report a rare but severe adverse effect of intravenous itraconazole, anaphylactic shock with hypotension and hypoxemia, in a female patient with acute lymphoblastic leukemia (ALL).[ncbi.nlm.nih.gov]
Ascitic Fluid
  • Her liver displayed reduced volume and there was a mild accumulation of ascitic fluid in the retroperitoneal cavity. Histologic evaluation showed massive panlobular necrosis.[ncbi.nlm.nih.gov]
Anisocoria
  • Over the next few days, while our patient was stabilized and his renal function improved he developed anisocoria due to a new ischemic stroke on the opposite side, complicated with brain edema.[jmedicalcasereports.com]
Insect Bite
  • We present the case of a 57 year-old male who had a 5 year-history of an irregularly shaped verrucous infiltrative plaque related to and insect bite and posterior trauma due to the manipulation of the lesion.[ncbi.nlm.nih.gov]
Metrorrhagia
  • Abstract We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia.[ncbi.nlm.nih.gov]

Workup

Mycobacterium Avium Complex
  • KEYWORDS: Chronic pulmonary aspergillosis; Itraconazole; Mycobacterium avium complex; Nontuberculous mycobacteria; Rifabutin[ncbi.nlm.nih.gov]
Brain Edema
  • Over the next few days, while our patient was stabilized and his renal function improved he developed anisocoria due to a new ischemic stroke on the opposite side, complicated with brain edema.[jmedicalcasereports.com]
Ischemic Changes
  • An electrocardiogram (ECG) showed atrial fibrillation (AF) with rapid ventricular response; his echocardiogram ejection fraction of 60% with no wall hypokinesia and computed tomography (CT) results confirmed ischemic changes in the area of distribution[jmedicalcasereports.com]

Treatment

  • CONCLUSIONS: For patients with mild or moderate onychomycosis, we recommended a pure medication treatment or combination treatment with medication and laser.[ncbi.nlm.nih.gov]
  • On day 17 of itraconazole treatment, she developed hypotension and hypoxemia shock after intravenous administration of itraconazole 200 mg, which was eventually reversed by steroid treatment.[ncbi.nlm.nih.gov]
  • RESULTS: The mucoadhesive tablets (n 171) did not show inferiority to itraconazole (n 172) in the treatment of OC.[ncbi.nlm.nih.gov]
  • Itraconazole is an antifungal imidazole used for the treatment of aspergillosis.[ncbi.nlm.nih.gov]
  • Co-administration of olaparib with rifampin resulted in a statistically significant decrease in the relative bioavailability of olaparib: C max treatment ratio, 0.29 (90% CI, 0.24-0.33); mean AUC treatment ratio, 0.13 (90% CI, 0.11-0.16).[ncbi.nlm.nih.gov]

Prognosis

  • […] report highlights the importance of a high degree of clinical suspicion in order to diagnose and treat allergic bronchopulmonary aspergillosis in patients with a long-standing history of severe asthma as early as possible as this has a major impact on prognosis[ncbi.nlm.nih.gov]
  • Primary malignant melanoma of the vagina is extremely rare, with a poorer prognosis than cutaneous malignant melanoma.[ncbi.nlm.nih.gov]
  • Tumor expression and circulating levels of angiogenic factors have been correlated with aggressive tumor growth, predilection for metastasis, and prognosis in a wide array of solid tumors, including lung cancer ( 2–4 ).[doi.org]

Etiology

  • This is the second report of this fungus as an etiologic agent of eumycetoma in humans.[ncbi.nlm.nih.gov]
  • The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test.[ncbi.nlm.nih.gov]
  • The etiological agents are in a clinical complex, which includes Sporothrix brasiliensis, Sporothrix schenckii, Sporothrix globosa, and Sporothrix luriei, each of which has specific epidemiological and virulence characteristics.[ncbi.nlm.nih.gov]
  • On the basis of mycological features and the results of the sugar assimilation test, the etiologic agent was identified as Prototheca wickerhamii.[ncbi.nlm.nih.gov]
  • Serologic evaluations on presentation ruled out infectious diseases or other etiological factors. Liver function tests showed alanine aminotransferase 3330 U/L, aspartate aminotransferase 3250 U/L, and bilirubin 21 mg/dL.[ncbi.nlm.nih.gov]

Epidemiology

  • Local epidemiology is vital in guiding prophylaxis strategy.[ncbi.nlm.nih.gov]
  • The etiological agents are in a clinical complex, which includes Sporothrix brasiliensis, Sporothrix schenckii, Sporothrix globosa, and Sporothrix luriei, each of which has specific epidemiological and virulence characteristics.[ncbi.nlm.nih.gov]
  • Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev 2006 ;19: 95 - 110 2. Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T.[nejm.org]
  • Gastrointestinal basidiobolomycosis in Arizona: clinical and epidemiological characteristics and review of the literature. Clin Infect Dis. 2001; 32:1448-55. 106. Pasha TM, Leighton JA, Smilack JD et al.[drugs.com]
  • Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005 ;41: 634 - 653 7. Denning DW, Marinus A, Cohen J, et al.[nejm.org]
Sex distribution
Age distribution

Prevention

  • Author information 1 Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States. 2 Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.[ncbi.nlm.nih.gov]
  • All triazole antifungals except itraconazole capsule were effective in preventing IFIs. Posaconazole was more efficacious in reducing IFIs and all-cause deaths than were fluconazole and itraconazole.[ncbi.nlm.nih.gov]
  • Ketoconazole has been used to prevent relapse, but available information suggests that up to 50 percent of AIDS patients relapse even with ketoconazole treatment. A more effective therapy to prevent recurrence is needed.[clinicaltrials.gov]
  • (via conazole antifungal agent ) (via triazole antifungal agent ) antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals.[ebi.ac.uk]
  • To prevent fungal infections in patients undergoing treatment for hematological malignancies, we investigated the use of oral itraconazole solution as opposed to itraconazole or fluconazole capsules.[ncbi.nlm.nih.gov]

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