The presented case shows one of the multiple issues concerning migration between neighboring countries. [ncbi.nlm.nih.gov]

• Congestive Heart Failure

  At least three of our seven subjects developed either congestive heart failure or hypertension while receiving 400 mg itraconazole, daily. [erj.ersjournals.com]

  CARDIAC RISKS FDA believes that there is a small but real risk of developing congestive heart failure associated with Sporanox® therapy. [web.archive.org]

  Evidence supporting the association between itraconazole and the onset of congestive heart failure (CHF) is limited and is based on cases reported after drug market release. [ncbi.nlm.nih.gov]

  Do not take itraconazole for fungal nail infections if you have had heart failure, including congestive heart failure. [rxwiki.com]

• Fatigue

  Symptoms of heart failure include fatigue, edema (fluid retention), shortness of breath, nausea, abdominal pain, and inability to sleep unless sitting upright. [medicinenet.com]

  Alcohol consumption: toxic reaction, hepatic damage Patient monitoring • In patient with hepatic dysfunction, monitor hepatic enzyme levels. ☞ Monitor for signs and symptoms of hearing loss, pancreatitis, hepatic dysfunction (jaundice, fatigue, nausea [medical-dictionary.thefreedictionary.com]

  Common toxicities included fatigue, nausea, anorexia, rash, and a syndrome of hypokalemia, hypertension, and edema. [ncbi.nlm.nih.gov]

  Adverse reactions CNS: malaise, fatigue, headache, dizziness, somnolence, fever, asthenia, pain, abnormal dreaming, anxiety, depression. CV: edema, hypertension, orthostatic hypotension, heart failure. EENT: rhinitis, sinusitis, pharyngitis. [glowm.com]

• Intravenous Administration

  In the modified antifungal therapy, intravenous administration of itraconazole was replaced by oral administration of voriconazole 200 mg twice daily. Shock did not recur after discontinuation of itraconazole treatment. [ncbi.nlm.nih.gov]

  Heart failure: Negative inotropic effects have been observed following intravenous administration. Discontinue or reassess use if signs or symptoms of heart failure (HF) occur during treatment. [mims.com]

  The rapid intravenous administration, insufficient dilution and drug vehicle have been associated with the dysrhythmias caused by imidazole antifungals. [jmedicalcasereports.com]

• Aspiration

  Following intake of the drug products, gastric and duodenal fluids were aspirated and analyzed for itraconazole concentration, total content and solubilizing capacity. [ncbi.nlm.nih.gov]

• Nausea

  Symptoms of heart failure include fatigue, edema (fluid retention), shortness of breath, nausea, abdominal pain, and inability to sleep unless sitting upright. [medicinenet.com]

  Nausea / vomiting, diarrhea, headache, stomach upset, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. [webmd.com]

  >10% Systemic fungal infections Nausea (11%) 1-10% (Systemic fungal infections) Rash (9%) Vomiting (5%) Edema (4%) Headache (4%) Abnormal liver function test results (3%) Diarrhea (3%) Fever (3%) Fatigue (3%) Hypertension (3%) Pruritus (3%) Abdominal [reference.medscape.com]

• Abdominal Pain

  (8%) Sinusitis, injury (7%) Diarrhea (4%) Dyspepsia (4%) Flatulence (4%) Abdominal pain (4%) Dizziness (4%) Rash (4%) Elevated liver enzymes (4%) Gastrointestinal disorders (4%) Rash (3%) Cystitis (3%) Urinary tract infection (3%) Liver function abnormality [reference.medscape.com]

  Table 3: Clinical Trials of Systemic Fungal Infections: Adverse Events Occurring with an Incidence of Greater than or Equal to 1% Body System/Adverse Event Incidence (%) (N=602) Gastrointestinal Nausea 11 Vomiting 5 Diarrhea 3 Abdominal Pain 2 Anorexia [rxlist.com]

  Tell your doctor right away if you develop symptoms of liver disease, such as: nausea / vomiting that doesn't stop, loss of appetite, stomach / abdominal pain, yellowing eyes / skin, dark urine. [webmd.com]

  Pharmacokinetics: Tmax: 1.5-4 hours; Cmax:10 mcg/ml; Vd: 10.7 L/Kg; Total Clearance: 3.8 ml/min/Kg; Table 2 Adverse Effects: Gastrointestinal: nausea, vomiting, abdominal pain Cardiovascular System: edema, hypertension Dermatologic: skin rashes, pruritus [antimicrobe.org]

• Eczema

  Itraconazole is sometimes used for inflammatory skin diseases such as atopic eczema, seborrhoeic dermatitis or psoriasis, if a fungus or yeast is thought to be contributing to the condition. [dermnetnz.org]

  […] and tapeworms); some contraceptive pills (birth control pills), such as dienogest, ulipristal; reboxetine, venlafaxine (used to treat depression and anxiety); cinacalcet, to treat an over active parathyroid; alitretinoin (oral formulation), to treat eczema [news-medical.net]

• Headache

  >10% Systemic fungal infections Nausea (11%) 1-10% (Systemic fungal infections) Rash (9%) Vomiting (5%) Edema (4%) Headache (4%) Abnormal liver function test results (3%) Diarrhea (3%) Fever (3%) Fatigue (3%) Hypertension (3%) Pruritus (3%) Abdominal [reference.medscape.com]

  1 Malaise 1 Myalgia 1 Vasculitis 1 Vertigo 1 The following adverse events occurred with an incidence of greater than or equal to 1% (N=112): headache: 10%; rhinitis: 9%; upper respiratory tract infection: 8%; sinusitis, injury: 7%; diarrhea, dyspepsia [rxlist.com]

  Adverse reactions CNS: dizziness, headache, fatigue, malaise CV: peripheral edema, tachycardia, heart failure EENT: rhinitis, transient or permanent hearing loss GI: nausea, vomiting, constipation, abdominal pain, flatulence, anorexia, dyspepsia, GI bleeding [medical-dictionary.thefreedictionary.com]

  Side effects such as constipation, upset stomach, headache, sore or bleeding gums, depression, nervousness, sweating and muscle pain have been noted. [aocd.org]

• Coccidioides Immitis

  Coccidioides immitis causes a wide range of disease in humans. Fluconazole and itraconazole are effective treatments. [ncbi.nlm.nih.gov]

  (variable activity) Dimorphic moulds: Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis, Parracoccidioides brasiliensis, Sporothrix schenkii, Penicillium marneffei Zygomycetes: Entomophthorales (variable activity) Dematiaceous moulds [antimicrobe.org]

CONCLUSIONS: For patients with mild or moderate onychomycosis, we recommended a pure medication treatment or combination treatment with medication and laser. [ncbi.nlm.nih.gov]

Treatment of Blastomycosis and Histoplasmosis The recommended dose is 200 mg once daily (2 capsules). [globalrph.com]

[…] report highlights the importance of a high degree of clinical suspicion in order to diagnose and treat allergic bronchopulmonary aspergillosis in patients with a long-standing history of severe asthma as early as possible as this has a major impact on prognosis [ncbi.nlm.nih.gov]

This is the second report of this fungus as an etiologic agent of eumycetoma in humans. [ncbi.nlm.nih.gov]

Local epidemiology is vital in guiding prophylaxis strategy. [ncbi.nlm.nih.gov]

European Journal of Epidemiology 9, 455 –6. 5. Powderly, W. G., Robinson, K. & Keath, E. J. ( 1993 ). Molecular epidemiology of recurrent oral candidiasis in human immunodeficiency virus-positive patients: evidence for two patterns of recurrence. [jac.oxfordjournals.org]

Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev 2006 ;19: 95 - 110 2. Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T. [nejm.org]

All triazole antifungals except itraconazole capsule were effective in preventing IFIs. Posaconazole was more efficacious in reducing IFIs and all-cause deaths than were fluconazole and itraconazole. [ncbi.nlm.nih.gov]

(via conazole antifungal agent ) (via triazole antifungal agent ) antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. [ebi.ac.uk]

Ketoconazole has been used to prevent relapse, but available information suggests that up to 50 percent of AIDS patients relapse even with ketoconazole treatment. A more effective therapy to prevent recurrence is needed. [clinicaltrials.gov]