Jamaican vomiting sickness is a disorder caused by the consumption of the unripe ackee fruit.
The symptoms of this illness are similar to that of Reye’s syndrome. The patient initially complains of severe epigastric pain for 2-6 hours which begins after consuming a meal of ackee fruits followed by an onset of sudden vomiting . Once the sickness begins, the progression is rapid. The symptoms patients experience are as follows: increased sweating, tachypnea, tachycardia, headache, generalized weakness, paresthesia, and disturbed mental state.
After a period of complete prostration which may last as long as 18 hours, a second bout of vomiting may occur . Unless this present condition is treated soon enough, this episode is usually followed by convulsions, coma, and death.
Death is more common in children than in adults. The average time of death is 12.5 hours. The other symptoms that come up in some cases are as follows: tonic-clonic convulsions in 25% of the patients, seizures occur in 85% of all fatal cases and fatty degeneration of the liver. Symptoms of this illness do not include fever or diarrhoea.
Jamaican vomiting sickness comes with its fair share of complications as well. These include: profound hypoglycaemia which may lead to coma and eventually death. There could also be acidosis, hypovolaemia and seizures .
Entire Body System
Acute Intermittent Porphyria
Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria — An epidemiological investigation. 283 ページ - Bressac, B., Kew, M., Wands, J., and Ozturk, M. 1991. [books.google.com]
The children awakened with a high-pitch cry in the early morning, many parents said. Then the youths began having seizures and slipping into comas. In about 40 percent of cases, they died. [nytimes.com]
Patients experience pronounced sweating, tachypnea, tachycardia, headache, and generalized weakness. After a period of prostration, which may last as long as 18 hours, a 2nd bout of vomiting may occur. [tripadvisor.com]
The symptoms patients experience are as follows: increased sweating, tachypnea, tachycardia, headache, generalized weakness, paresthesia, and disturbed mental state. [symptoma.com]
Patients experience pronounced diaphoresis, tachypnea, tachycardia, headache, generalized weakness, paresthesia, and disturbed mental states. After a period of prostration, which may last as long as 18 hours, a second bout of vomiting may occur. [emedicine.medscape.com]
Jamaican vomiting sickness is characterized by a sudden onset of vomiting which follows epigastric discomfort starting 2-6 hours after the consumption of a meal containing ackee. [symptoma.com]
Jamaican vomiting sickness is an acute illness caused by the toxins hypoglycin A and hypoglycin B, which are present in fruit of the ackee tree. [en.wikipedia.org]
We identified methylenecyclopropylacetic acid, a known metabolite of hypoglycin A, in the urine of two patients with Jamaican vomiting sickness. [ncbi.nlm.nih.gov]
vomiting sickness and Reye's syndrome. ( 995147 ) Trauner D.A....Sweetman L. 1976 13 Jamaican vomiting sickness. [malacards.org]
Prevention - Jamaican vomiting sickness Not supplied. Diagnosis - Jamaican vomiting sickness Not supplied. Prognosis - Jamaican vomiting sickness Not supplied. [checkorphan.org]
Natural Remedies Natural Treatments Health Tips Health Fitness Vegans Nutrition Natural Home Remedies Health And Wellness Health And Fitness Forward Stop Nausea With 7 Natural Methods Cara Merawat Ibu dan Janin Trimester Pertama This Site is Currently [pinterest.at]
Nausea was reported by three subjects at doses of 10, 15 and 20mg. One of these patients also experienced a mild episode of emesis. There were no reports of nausea at higher doses. [wallstreet-online.de]
A powerful surge of nausea and dizziness almost knocked him to the ground. He told his wife about it when he got back to their home in Oakland, but he didn’t call his doctor until it happened a third time. [nytimes.com]
The patient initially complains of severe epigastric pain for 2-6 hours which begins after consuming a meal of ackee fruits followed by an onset of sudden vomiting. Once the sickness begins, the progression is rapid. [symptoma.com]
Observed clinical manifestations, listed by degree of severity, are as follows: I - Asymptomatic with normal vital signs II - Dehydration and hypotension as a result of the intense vomiting III - Delirium or coma IV - Seizure (an ominous sign) Author [emedicine.medscape.com]
There were no reports of local irritation or hypotension in any subject treated. A total of 60 doses of APL-130277 were administered to the 16 patients who completed dosing in the CTH-105 study. [wallstreet-online.de]
There could also be acidosis, hypovolaemia and seizures. [symptoma.com]
In severe cases, profound dehydration, seizures, coma, and death may ensue. Children and those who are malnourished are more susceptible to the disease. When ingested, hypoglycin A is metabolized to produce methylenecyclopropylacetic acid (MCPA). [en.wikipedia.org]
Treatment - Jamaican vomiting sickness Depending on poison: airway management, CPR, poison antidote, patient placed on left side, supportive care (I.V. fluid replacement, oxygen therapy, seizure precautions) Resources - Jamaican vomiting sickness Not [checkorphan.org]
In very dire situations,profound dehydration, seizures, coma, and death may ensue. Children and/or those who are malnourished are more susceptible to the disease. [manchestermc.gov.jm]
Treatment may need to be aggressive depending upon the degree of dehydration, hypoglycemia, delirium, and seizures present. [tripadvisor.com]
[…] theatre together. 30 Paul wanted to appear before the crowd, but the disciples would not let him. 31 Even some of the officials of the province, friends of Paul, sent him a message begging him not to venture into the theatre. 32 The assembly was in confusion [biblica.com]
For the rest of the day he felt a little confused. He couldn’t get his mind to focus. But the next day he felt fine, and the rest of his two-week stay in Jamaica was uneventful. [nytimes.com]
Altered Mental Status
CT scan of the head may be indicated to exclude the possibility of structural intracranial pathology in patients with an altered mental status. A patient already suffering from hypoglycaemia may present with a focal neurologic deficit. [symptoma.com]
Clinical manifestations may include profuse vomiting, altered mental status, and hypoglycemia. Severe cases have been reported to cause seizures, hypothermia, coma, and death. [knowledge.statpearls.com]
Focal Neurologic Deficit
A patient already suffering from hypoglycaemia may present with a focal neurologic deficit. A liver biopsy may reveal depleted glycogen stores. There is no standard method of treating Jamaican vomiting sickness. [symptoma.com]
Jamaican vomiting sickness is usually diagnosed by conducting the following tests: a finger prick glucose test in patients with suspected ackee poisoning, a serum chemical test to exclude electrolyte abnormalities which are likely to arise due to vomiting.
Liver function tests to demonstrate an increase in hepatic transaminases is also an indicator for the illness. Elevated levels of ammonia have been reported in cases of Jamaican vomiting sickness .
Urinalysis is usually conducted in order to show whether acidosis is present or no. In ackee fruit poisoning, results show acidosis but no ketosis.
CT scan of the head may be indicated to exclude the possibility of structural intracranial pathology in patients with an altered mental status. A patient already suffering from hypoglycaemia may present with a focal neurologic deficit.
A liver biopsy may reveal depleted glycogen stores.
A liver biopsy may reveal depleted glycogen stores. There is no standard method of treating Jamaican vomiting sickness. Care has been focused on relieving symptoms and providing supportive care. [symptoma.com]
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. 281 ページ - Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanoltreated rabbits. J. Biol. [books.google.com]
There is no standard method of treating Jamaican vomiting sickness. Care has been focused on relieving symptoms and providing supportive care. The traditional way of treating a bout of vomiting would always be to replenish the lost fluids in order to achieve an electrolyte, glucose and pH balance. However, here the mainstay of treatment would be to maintain a normal blood glucose level. It is advisable to administer a bolus of hypertonic dextrose solution followed by an infusion of 10% dextrose solution.
Activated charcoal is usually administered if the patient presents within 4 hours of ingestion. If mental status is altered, consideration should be given to airway protection prior to charcoal use.
The administration of riboflavin and glycine has also been reported to antagonize the effects of hypoglycinA intoxication. It is believed that riboflavin stimulates the de novo synthesis of acyl-CoA dehydrogenases while glycine conjugates with excess dicarboxylic acids produced due to impaired lipid metabolism.
Before various treatments came into picture, the mortality rate was 80%. However, with the introduction of various diagnostic techniques and treatment options available, the patients now have a full recovery.
There were several difficulties encountered by researchers in identifying the causative factor of the illness. The ackee fruit is eaten by many without ill effects. It was therefore not thought to be the likely source of the illness. Hypoglycin A is found predominantly in the immature fruit. The illness is caused due to the consumption of the unripe fruit or consumption of a forcibly opened fruit.
Besides this, consuming water in which an unripe ackee has been cooked also leads to the onset of an acute attack. Undernutrition in an individual also increases the susceptibility towards developing the symptoms of the disease.
The epidemiology of ackee poisoning has not really been understood well and the true incidence and mortality rate are believed to be under-reported. This problem is endemic in Jamaica. In Jamaica, the annual rate of ackee poisoning is 2 cases per 100,000 persons younger than 15 years of age and 0.4 cases per 100,000 persons older than 15 years. It is also frequent in certain other countries in the Caribbean and Western Africa. In contrast, it is rare in France and other Western countries. As ackee is consumed mostly in West Africa and Jamaica; therefore, most cases have occurred in those areas only.
Before treatments were developed, the mortality rate was as high as 80%. In recent years, there have been reported incidences of this illness in Burkina Faso, The Ivory Coast, Togo and Benin. Lethality was 100% in the Burkina Faso epidemic and victims of the illness were all children . Deaths were linked to ackee intoxication due to enhanced concentrations of dicarboxylic acids in the urine of the victims. Suggestions have been made that the ingestion of unripe ackee fruits may be responsible for a substantial number of unexplained deaths in preschool children in West Africa.
Two water-soluble toxins can be extracted from the fruit namely: hypoglycin A and hypoglycin B. Hypoglycin A is found in the aril of the fruit and is also more toxic than hypoglycin B . The unripe fruit contains 20 times more hypoglycin A than a ripe fruit. Both the components are found in the seeds. Hence, the seeds and the membrane covering the base of the seeds are considered poisonous.
The consumption of the ackee fruit leads to toxic hypoglycaemia and inhibition of neoglucogenesis. The hypoglycaemia is caused by the effect of hypoglycin A which is metabolized by means of transamination and oxidative decarboxylation to methylene cyclopropyl acetic acid (MCPA). MCPA forms non-metabolizable carnitine and coenzyme A (CoA) esters. MCPA inhibits beta-oxidation of fatty acids in two ways. Firstly, it interferes with the transport of long chain fatty acids into the mitochondria. Also, it inhibits acyl- CoA dehydrogenases so that only unsaturated fatty acids can be fully oxidized. Therefore, fatty acids accumulate in the liver in a microvesicular pattern. Hence, in the absence of fatty acid metabolism, the body becomes dependent on glucose and glycogen for energy. Hypoglycaemia thus results because both CoA and carnitine are necessary co-factors for long chain fatty acid oxidation and oxidation is a primary requisite for active gluconogeneis  . Once the glycogen stores are depleted, the body cannot synthesize glucose and severe hypoglycemia results.
Children are most susceptible to this illness and there appears to be ignorance with regards to the toxic nature of the unripe fruit. Ongoing educational campaigns are of utmost importance for the prevention and total eradication of this deadly syndrome.
The best way to prevent an attack of this illness is to avoid eating the unripe ackee fruit, avoid eating fruit that has been forcibly opened and totally avoid consuming water in which the ackee fruit has been boiled. It is best to discard such water.
Jamaican vomiting sickness (acute ackee fruit intoxication) is an acute illness caused due to the consumption of the unripe ackee fruit. The ackee fruit is the national fruit of Jamaica and is an integral part of many Jamaican diets.
In 1955 the causative factor of Jamaican vomiting sickness was isolated, a non proteinogenic amino acid, hypoglycin A, so named due to its ability to induce severe hypoglycaemia. Its chemical structure was elucidated in 1958 and scientifically it is referred to as L-alpha-amino-beta-methylene cyclopropane propionic acid.
Jamaican vomiting sickness is an acute illness characterized by the consumption of the unripe ackee fruit that is native to Jamaica. It is also caused by consuming an ackee fruit which has been forcibly opened, or drinking the water in which it has been boiled. Because of the prevalence of this illness more in the Caribbean, it is a must to educate the people about the dangers associated with the consumption of the unripe fruit.
The unripe fruit contains a much higher level of a toxin (hypoglycin A) than the ripe one. The concentration of the toxin is highest in the seeds and the membrane covering them.
A patient suffering with this illness will complain of severe epigastric pain which continues for hours followed by vomiting, convulsions or seizures    . The patient will also present with increased sweating, increased heart rate and pulse rate. There will be profound weakness and fatigue as well. The major complication associated with this illness is that of hypoglycaemia because the toxin interferes with the fatty acid metabolism thus utilizing the glycogen stores from the liver. This results in fatty degeneration of the liver as well. There are some cases which lead to coma and eventually death.
Death is mainly recorded in school children. However, with the introduction of various modes of treatment, the mortality rate has reduced considerable.
It is important to seek medical attention at the right time to prevent complications such as coma and death.
- American Medical Association; American Nurses Association-American Nurses Foundation; Centers for Disease Control and Prevention; Center for Food Safety and Applied Nutrition, Food and Drug Administration; Food Safety and Inspection Service, US Department of Agriculture. Diagnosis and management of foodborne illnesses: a primer for physicians and other health care professionals. MMWR Recomm Rep. Apr 16 2004;53:1-33.
- Dianne E. Grunes, IriniScordi-Bello, Matthew Suh, Sander Florman, et al. Fulminant Hepatic Failure Attributed to Ackee Fruit Ingestion in a Patient with Sickle Cell Trait. Case Rep Transplant. Vol. 2012, Article ID 739238, 4 pages, 2012. doi:10.1155/2012/739238.
- Gaillard Y, Carlier J, Brescht M, Mazover C, et al. Fatal intoxication due to Ackee (Blighia sapida) in Suriname and French Guyana. GC-MS detection and quantification of hypoglycin A. Forensic Sci Int. 2011 Mar 20;206(1-3):e103-7.
- McTague JA, Forney R Jr. Jamaican Vomiting Sickness in Toledo, Ohio. Ann Emergency Medicine, 1994 May;23(5):1116-8..
- Mills J, Melville GN, Bennett C, West M, et al. Effect of hypoglycinA on Insulin Release. Biochem Pharmacol. 1987 Feb 15;36(4):495-7.
- R.A Chalmers, A.M Lawson, A. Whitelaw, P. Purkiss. Organic Acids In Reye’s Like Syndrome: Similarities with Jamaican Vomiting Sickness. Lancet, 1977 May 28;1(8022):1156-7.
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- Ashcroft MT. Some non-infective diseases endemic in the West Indies. Trop Geogr Med. 1978; 30:5-21.
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