METHODS: In the present study, we investigated its molecular mechanism, focusing on the role of a transcription factor, hypoxia inducible factor-1 (HIF-1), which regulates the expression of connective tissue growth factor (CTGF) and vascular endothelial [ncbi.nlm.nih.gov]

Learning issues, if present, can be mild. [ped-rheum.biomedcentral.com]

Vasenius presented the results at the 13th EFORT Congress 2012. He and his colleagues received the Free Paper Silver Award at the meeting for their work. [healio.com]

• Malnutrition

  Severe jaw hypomobility can lead to malnutrition, infection, and serious disability. [aetna.com]

• Feeding Difficulties

  The complications include feeding difficulties, joint contractures, spinal deformities, respiratory compromise, and cardiac involvement. [medical-dictionary.thefreedictionary.com]

• Skin Thickening

  Examination Look for: Early skin changes: skin thickening, dimpling, pitting Firm nodules (the most common site is on the distal palmar crease in line with the ring finger). Cords - longitudinal thickenings. Contractures causing flexion deformity. [patient.info]

• Arthritis

  For arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. [icdlist.com]

  Compared to rheumatoid arthritis, lupus arthritis is less disabling and less likely to cause destruction of the joints. [resources.lupus.org]

  Each of these conditions increases the risk for contractures: Rheumatoid arthritis Tenosynovitis (inflammation of a tendon and its sheath) Polio and other diseases of nerves and muscles Trauma Burns Scarring Prolonged inactivity Symptoms: The primary [knowyourdisease.com]

  Hand Exercises for Rheumatoid Arthritis. 7 hand-stretching exercises to ease rheumatoid arthritis symptoms. Denise Mann, Web MD. The Mayo Clinic's Slide Show: Hand exercises for people with arthritis. [sclero.org]

• Flexion Contracture

  Abstract The most frequent cause of flexion contracture is immobilization, which may occur with or without trauma. Posttraumatic flexion contracture mainly develops from direct injury, intraarticular fluid and the physiological muscle balance. [ncbi.nlm.nih.gov]

  Abstract Various splints are available for the correction of proximal interphalangeal (PIP) joint flexion contracture in patients with hand injuries. This article discusses the mechanics of several splints. [ajot.aota.org]

  This chapter reviews the current methods for evaluating and treating equinus contractures, knee flexion contractures, and knee extension contractures in children. [link.springer.com]

  Complete exercises for a knee flexion contracture only under the supervision of your therapist or doctor. People who sit or lie with their knee flexed for extended periods of time may develop knee flexion contractures. [livestrong.com]

• Ankylosis

  M24.649 Ankylosis, unspecified hand M24.65 Ankylosis, hip M24.651 Ankylosis, right hip M24.652 Ankylosis, left hip M24.659 Ankylosis, unspecified hip M24.66 Ankylosis, knee M24.661 Ankylosis, right knee M24.662 Ankylosis, left knee M24.669 Ankylosis, [icd10coded.com]

  CHAPTER 126 Mark Campbell, MD, MSc Nancy Dudek, MD, MEd Guy Trudel, MD, MSc, FRCPC, DABPMR Synonyms Arthrofibrosis Capsulitis Ankylosis ICD-9 Codes M24.5 Contracture of joint M24.6 Ankylosis of joint M96.0 Arthrodesis ICD-10 Codes M24.50 Contracture, [clinicalgate.com]

  Two types of flexion contracture of the knee can be distinguished: 1) contracture associated with joint destruction and ankylosis and 2) contracture with joint anatomy and mobility are preserved. [4] They can be caused by a piece of bone or other tissue [physio-pedia.com]

  They may also have: Thin, weak (atrophied), stiff or missing muscles Stiff joints due to extra tissue (fibrosis or fibrous ankylosis) Differences in the skin around their joints, such as webbing There’s a wide range of how children are affected, from [seattlechildrens.org]

A 22-year-old male with a PIP joint contraction following replantation failed conventional treatment for release. [ncbi.nlm.nih.gov]

This part of the CORDLESS trial involved the evaluation of 1,080 joints in 643 subjects 3 years after treatment; 58% of joints achieved clinical success after initial treatment with CCH. [healio.com]

You can pass the course of treatment in our rehabilitation center. [medicalcentr.com]

Patients who could comply with the treatment recommendations for DTS treatment did better than those who could not, with an improvement of the MID from 16 mm to 27 mm (p < 0.001) versus 17 mm to 22 mm (p = 0.88). [aetna.com]

Prognosis of Posterior Joint Capsule Contracture Due to advanced medical technology and medical care facilities the prognosis for posterior joint capsule contracture is much better than earlier years. [epainassist.com]

Prognosis Prognosis of contractures will depend upon the cause of the contracture. In general, the earlier the treatment for the contracture begins, the better the prognosis. [medical-dictionary.thefreedictionary.com]

Changes in bone shape are also common and may infl uence prognosis and management. In children, joint contractures pose a particular problem. [link.springer.com]

Prognosis The course of the disease is variable in terms of how fast and how far it will progress. It does not inevitably progress to contracture. Most patients do not require surgery. [patient.info]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

BACKGROUNDS: There have been many reports describing that the capsular fibrosis of the shoulder joint is the main cause of frozen shoulder, whereas others reported the significance of subacromial impingement as an etiological factor. [ncbi.nlm.nih.gov]

Etiology The aetiology remains unknown. There are currently no human genes associated with this disease. Diagnostic methods The features of the hand are especially important for the diagnosis. [orpha.net]

Epidemiology/Etiology Flexion deformities can arise by different causes. [physio-pedia.com]

Arthrogryposis (Multiple Congenital Contractures): Diagnostic Approach to Etiology, Classification, Genetics, and General Principles. Eur J Med Genet 2014;57:464-472. Filges I, Hall JG. [rarediseases.org]

Summary Epidemiology Less than 20 cases have been reported in the literature. Clinical description The fingers are thin with absent knuckles and reduced creases over the joints, and patients show an inability to make a full fist. [orpha.net]

The epidemiology of major joint contractures: a systematic review of the literature. Clinical Orthopaedics & Related Research. 2007:456:22-299. Huckstep RL. Management of neglected joint contractures. [health.cvs.com]

Epidemiological studies indicate a wide range of prevalence of joint contractures in older individuals between 20% and 80% [ 2 – 4 ]. [bmcgeriatr.biomedcentral.com]

Epidemiology/Etiology Flexion deformities can arise by different causes. [physio-pedia.com]

See Epidemiology and Presentation. Although the cause of Dupuytren disease is unknown, a family history is often present. [emedicine.medscape.com]

Since there is no clear understanding of the pathophysiology of posterior joint capsule contracture, both in vitro and animal studies, are required to examine the tissue's cellular and mechanical response to repetitive tensile loads which lead to pathophysiology [epainassist.com]

As with any progressive metabolic disease, early initiation of therapy that addresses the underlying pathophysiology improves outcome, and can prevent or at least delay the development of irreversible disease manifestations. [ped-rheum.biomedcentral.com]

Pathogenesis/Etiology Although the underlying etiology for the development of Dupuytren disease is uncertain, the basic pathophysiology involves fibroblast proliferation, and collagen deposition leading to contractures of the palmar fascia. [emedicine.medscape.com]

Providing frequent changes in position and range of motion exercises is important to prevent contrac- tures. The participation of a physiotherapist in his care is critically important to prevent serious pro- gressive deformity. [endoflifecare.tripod.com]

This will prevent the occurrence of DVT and movement in the ankle joint will alleviate stiffness. [clinicaltrials.gov]

Prevention: Prevention of contractures depends on the cause. [knowyourdisease.com]

Joint contracture is preventable. Once a joint wound has started to heal, the patient can enroll in massage therapy, learning exercises from a professional. Stretches can prevent permanent damage from contracture. [scarfade.com]

These results imply that inflammation and nociception are involved in myogenic contracture formation independently of joint immobilization, and that CBX is effective in preventing joint contracture following immobilization in rats. [ncbi.nlm.nih.gov]