Hence, we have made no changes to the conclusions of this update as presented in the initial review. [cochranelibrary.com]

• Tremor

  Adverse effects often seen with valproate treatment are dyspepsia, weight gain, tremor, transient hair loss and haematological abnormalities (Panayiotopoulos 2001). [cochranelibrary.com]

• Spike-and-Slow-Waves

  EEG, and with diffuse, irregular slow spike and wave as ictal pattern. [cochranelibrary.com]

There were two serious adverse events during the treatment, but they were judged to be unrelated to treatment. In one study (Huang 2009), systemic anaphylaxis rash during lamotrigine treatment led to patients´ withdrawal from the study. [cochranelibrary.com]