Presentation
Abstract An 8-year-old girl presented with bilateral breast masses and was subsequently diagnosed with juvenile myelomonocytic leukemia. [ncbi.nlm.nih.gov]
Entire Body System
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Fatigue
Codes 205.1 Chronic myeloid leukemia Corresponding ICD-10 Codes C92.1 Chronic myeloid leukemia Corresponding ICD-10-CM Codes (U.S. only) C93.3 Juvenile myelomonocytic leukemia (effective October 01, 2015) Signs and Symptoms Easy bruising or bleeding Fatigue [seer.cancer.gov]
The child with leukemia often shows non-specific symptoms of infection such as fever and fatigue. [chop.edu]
Anemia is a condition when there is a low number of red blood cells in the blood which can cause fatigue and shortness of breath. [lls.org]
Anemia is a condition when there is a low number of red cells in the blood which can cause fatigue and shortness of breath. [llscanada.org]
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Turkish
Abstract Here, a case is presented with two rare genetic disorders, biotinidase deficiency and juvenile myelomonocytic leukemia, in a Turkish infant. [ncbi.nlm.nih.gov]
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Dentist
Collaboration between dentist and paediatrician in dealing with patients with a variety of oral lesions and tooth anomalies is important in order to prevent any other possible tooth lesions and ensure correct jaw development. [ncbi.nlm.nih.gov]
Respiratoric
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Respiratory Insufficiency
OBSERVATION: We present 3 children with juvenile myelomonocytic leukemia and suspected pulmonary leukemic cell infiltration who all also suffered from respiratory insufficiency. The differential diagnosis included asthma and infections. [ncbi.nlm.nih.gov]
Gastrointestinal
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Failure to Thrive
Abstract Juvenile myelomonocytic leukemia (JMML) is a distinct myeloproliferative malignancy of early childhood with a varied clinical presentation that may include failure to thrive, malaise, fever, bleeding, pallor, lymphadenopathy, and hepatosplenomegaly [ncbi.nlm.nih.gov]
[…] to thrive, malaise, fever, bleeding, pallor, lymphadenopathy and hepatosplenomegaly; less frequently skin, lung and GI involvement; rarely CNS involvement ( J Pediatr Hematol Oncol 2007;29:770 ) Most patients die of disease, although it may wax and wane [pathologyoutlines.com]
Intervention with chemotherapy is typically only indicated for CBL patients who become symptomatic (splenomegaly, failure to thrive, recurrent infections, etc.). [hematology.org]
Decreased appetite, poor weight gain, irritability, and failure to thrive may also occur in children with JMML. [rarediseases.org]
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Regurgitation
On echocardiography the right ventricular pressure calculated from the velocity of tricuspid regurgitation jet was 55 mmHg with no pulmonary stenosis. [ncbi.nlm.nih.gov]
Jaw & Teeth
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Malocclusion
CONCLUSION: The difficulties of managing and treating these diseases are discussed, with particular focus on tooth anomalies and malocclusion disorders. [ncbi.nlm.nih.gov]
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Microdontia
After treatment, these two different cases showed several similar oral lesions: microdontia, root alterations, numerous tooth ageneses, incomplete calcification, enamel hypoplasia, premature apexification and hypodontia. [ncbi.nlm.nih.gov]
Cardiovascular
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Cardiomegaly
Echocardiography was performed due to cardiomegaly and prominent main pulmonary artery on a chest X-ray film. [ncbi.nlm.nih.gov]
Skin
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Eczema
The patient subsequently developed refractory eczema with undetectable serum IgM, which led to the consideration of Wiskott-Aldrich syndrome (WAS). Lack of WASP expression and a 4-nucleotide deletion mutation in WASP were identified. [ncbi.nlm.nih.gov]
Physical findings include: Skin: eczema, xanthoma, cafe-au-lait spots, macular-papular rash Lymphadenopathy Hepatosplenomegaly Bleeding Respiratory symptoms: chronic tachypnea, cough, wheezing Fever, infection. [78stepshealth.us]
An eczema -like skin rash. The signs and symptoms of TMD may include the following: Swelling all over the body. Shortness of breath. Trouble breathing. Weakness or feeling tired. Pain below the ribs. [northshore.org]
Breast
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Breast Mass
Abstract An 8-year-old girl presented with bilateral breast masses and was subsequently diagnosed with juvenile myelomonocytic leukemia. [ncbi.nlm.nih.gov]
Workup
Clinical Testing and Workup A complete blood count (CBC) can be taken to evaluate the size, number, and maturity of blood cells. In JMML, the CBC frequently reveals high levels of white blood cells and low levels of red blood cells and platelets. [rarediseases.org]
[…] pallor, fever and skin rash, peripheral blood monocyte counts 1x109/L, bone marrow blast counts 20% and the absence of BCR-ABL1 rearrangements are usually indicative of JMML [2], yet diagnosis can be established with certainty only after laboratory workup [clinmedjournals.org]
Microbiology
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Streptococcus Pneumoniae
When a splenectomy is scheduled, JMML patients are advised to receive vaccines against Streptococcus pneumoniae and Haemophilus influenza at least 2 weeks prior to the procedure. [en.wikipedia.org]
Treatment
A suitable treatment after diagnosis and conditioning regimen prior to HSCT are yet to be determined, but several clinical trials have been initiated throughout the world to develop suitable pre- or post-allogeneic HSCT treatments and new targeted therapies [ncbi.nlm.nih.gov]
A suitable treatment after diagnosis and conditioning regimen prior to HSCT are yet to be determined, but several clinical trials have been initiated throughout the world to develop suitable pre‐ or post‐allogeneic HSCT treatments and new targeted therapies [dx.doi.org]
Prognosis
Juvenile myelomonocytic leukemia (JMML) is a rare childhood neoplasm with poor prognosis except in the setting of Noonan syndrome, where prognosis is generally favorable. [ncbi.nlm.nih.gov]
Etiology
MeSH terms Cell Differentiation Child, Preschool Dosage Compensation, Genetic Humans Leukemia, Myelomonocytic, Acute/etiology* Leukemia, Myelomonocytic, Acute/genetics* Leukemia, Myelomonocytic, Acute/pathology Lymphoma, T-Cell/etiology* Lymphoma, T-Cell [ncbi.nlm.nih.gov]
Epidemiology
Resistance, Neoplasm/genetics Female Gene Deletion Genes, p53/genetics* Histone-Lysine N-Methyltransferase Humans Infant Infant, Newborn Leukemia, Myelomonocytic, Juvenile/genetics* Leukemia, Myelomonocytic, Juvenile/therapy Male Myelodysplastic Syndromes/epidemiology [ncbi.nlm.nih.gov]
Clinical trial protocol EWOG-MDS 2006 (2007) Prospective non-randomized multi-center study for epidemiology and characterization of myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) in childhood Google Scholar 6. [doi.org]
[…] bleeding Fatigue Fever Hepatosplenomegaly Infection Lymphadenopathy Pain or a feeling of fullness below the rib s Pale skin Petechiae Shortness of breath Skin rashes Diagnostic Exams Immunocytochemistry Peripheral blood smear Progression and Transformation Epidemiology [seer.cancer.gov]
Pathophysiology
Our studies offer renewable sources of biologically relevant human cells in which to explore the pathophysiology and treatment of JMML. More generally, we illustrate the utility of iPSCs for in vitro modeling of a human malignancy. [ncbi.nlm.nih.gov]
Prevention
Collaboration between dentist and paediatrician in dealing with patients with a variety of oral lesions and tooth anomalies is important in order to prevent any other possible tooth lesions and ensure correct jaw development. [ncbi.nlm.nih.gov]
[…] appears that though the causes are unknown, sporadic or inherited genetic changes in a particular cell in the bone marrow (stem cell), gives rise to a blood type called an immature monocyte which increases uncontrollably in the bone marrow, eventually preventing [nicklauschildrens.org]
It’s important to understand that there’s nothing you could have done or avoided doing that would have prevented your child’s cancer from developing. [danafarberbostonchildrens.org]
After bone marrow transplant, reducing ongoing immunosuppressive therapy has worked successfully to reverse the course of a bone marrow with a dropping donor percentage and to prevent a relapse. [en.wikipedia.org]