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Juvenile Myxedema

Hypothyroidism Juvenile


Presentation

  • Abstract A FREQUENT presenting sign of hypothyroidism in children is short stature. Failure to grow may be a manifestation of hypothyroidism due to pituitary malfunction or to primary thyroid failure.[mdedge.com]
  • Theoretically, the causes of abnormalities present at birth can be listed as of a genetic, germinal or peristatic nature. During the past decades special attention has been paid to both genetic and peristatic factors.[books.google.com]
  • In one a thymoma was present, in three the gland was hyperplastic and in two it was atrophied.[docslide.com.br]
  • Precaution APCA is present in many healthy persons over the age of 60 years. Pathophysiology The parietal cells are present in the proximal portion of gastric mucosa and produce acid ( HCL ) and Intrinsic factor.[labpedia.net]
  • Reproductive system: females present with menstrual irregularities, infertility and anovulation. Males may present with gonadal dysfunctions. Children with juvenile hypothyroidism may present with precocious puberty.[flexikon.doccheck.com]
Goiter
  • MORPHOLOGY OF THE PITUITARY 19 THE OPTIC CHIASM IN ENDOCRINOLOGIC 204 PARANEOPLASTIC ENDOCRINE 223 SEX HORMONES AND HUMAN 219 APPROACH TO THE PATIENT WITH 37 ADVERSE EFFECTS OF IODIDE 360 MORPHOLOGY OF THE THYROID 38 NONTOXIC GOITER 366 SYNTHESIS AND[books.google.com]
  • Iodine Deficiency Goiter: Subiodic goiter; Simple goiter; colloid goiter - pubertal, Adolescent Gestational; Menopausal; Endemic; Sporadic. 4. Hypothyroidism" Adult myxedema; Cretinism; Juvenile myxedema. 5.[homeoint.org]
  • E03 Other hypothyroidism Excludes1 iodine-deficiency related hypothyroidism ( E00 - E02 ) postprocedural hypothyroidism ( E89.0 ) E03.0 Congenital hypothyroidism with diffuse goiter Inclusion term(s): Congenital parenchymatous goiter (nontoxic) Congenital[icd10coded.com]
  • Over 60% presented for goiter, 10% with pain in the thyroid region.[indianpediatrics.net]
  • E04 Other nontoxic goiter E04.0 Nontoxic diffuse goiter E04.1 Nontoxic single thyroid nodule E04.2 Nontoxic multinodular goiter E04.8 Other specified nontoxic goiter E04.9 Nontoxic goiter, unspecified E05 Thyrotoxicosis [hyperthyroidism] E05.0 Thyrotoxicosis[icd10data.com]
Hypothermia
  • American Association of Clinical Endocrinologists (AACE) advocates the use of a high-quality brand preparation of levothyroxine High mortality rate Myxedema coma almost always occurs in the elderly non compliance with hypothyroid treatment *Extreme hypothermia[quizlet.com]
  • […] blood sugar (hypoglycemia), common in insulin-dependent diabetics after an exercise, skipped meal or insulin overdose Blood loss due to external or internal bleeding (in car accidents, shooting or stitch injuries), heavy menstrual bleeding, surgery Hypothermia[ktthebest4u.blogspot.com]
  • Severe cases, requiring hospitalization can exhibit signs of hypothermia, hypoglycemia, hypotension, respiratory depression, and coma. Cause [ edit ] Myxedema is known to occur in various forms of hypothyroidism, and also in Graves' disease.[en.wikipedia.org]
  • Usually occurs in elderly patients and presents with confusion, severe hypothermia, shock and coma.[flexikon.doccheck.com]
Collapse
  • The SLAC wrist: scapholunate advanced collapse pattern of degenerative Arthritis. J Hand Surg [Am] 1984: 9-A:358-65. ‏ الصفحة 308 - Arnett FC, Edworthy SM, Bloch DA. McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS.[books.google.com]
Constipation
  • Since infancy she had had a problem with constipation, which had been controlled with diet. Her skin had always been quite dry. Her medical history and review of systems were otherwise non-contributory.[mdedge.com]
  • Geography of hypothyroidism Incidence is ten times higher than average in iodine-deficient areas *places where there is excessive consumption of goitrogens (e.g. cassava) Symptoms of hypothyroidism Tiredness, weakness Dry skin Feeling cold Hair loss Constipation[quizlet.com]
  • They may have difficulty feeding and experience constipation. If untreated, congenital hypothyroidism can lead to intellectual disability and slow growth.[icdlist.com]
  • Corrosive injury Foreign body ingestion Juvenile polyposis and related syndromes Distal intestinal obstruction syndrome (cystic fibrosis) Roundworm ( Ascaris lumbricoides ) Gastric and intestinal bezoars Colonic volvulus secondary to aerophagia and constipation[unboundmedicine.com]
  • He also reported fatigue, constipation, sleepiness, impaired school performance, and cold intolerance. Figure 1. The patient at diagnosis with apathy, myxedema of the extremities, and sparse-brittle hair.[hormones.gr]
Macroglossia
  • Symptoms Feeding difficulties Somnolence Lethargy Low frequency of crying Constipation Signs Large fontanelles Myxoedema - with coarse features and a large head and oedema of the genitalia and extremities Nasal obstruction Macroglossia Low temperature[patient.info]
  • ORAL MANIFESTATIONS Symptoms  Teeth  Jaw bone  Palate  Macroglossia  Lips Radiological features  Skull changes  Air sinuses  Teeth  Jaw bone 11.    Surgery- trans sphenoidal surgery may result in cure of growth hormone excess especially in[slideshare.net]
Somnolence
  • […] hypothyroidism Depression Cognitive problems Weight gain Fatigue Irregular menstruation Infertility Gastrointestinal disease Hyperlipidemia Coronary artery disease Hypertension Neonatal/congenital hypothyroidism Prolonged jaundice Hoarse cry Constipation Somnolence[quizlet.com]
  • Symptoms Feeding difficulties Somnolence Lethargy Low frequency of crying Constipation Signs Large fontanelles Myxoedema - with coarse features and a large head and oedema of the genitalia and extremities Nasal obstruction Macroglossia Low temperature[patient.info]
  • Signs and symptoms of hypothyroidism include low metabolic rate, tendency to weight gain, somnolence and sometimes myxedema. In the United States, the most common cause of hypothyroidism is hashimoto's thyroiditis, an autoimmune disorder.[icd10data.com]
Apathy
  • The patient at diagnosis with apathy, myxedema of the extremities, and sparse-brittle hair. Bone age was severely delayed (6 years as assessed by the Greulich and Pyle standard).[hormones.gr]
  • Symptoms suggestive of hypothyroidism such as weight gain, growth failure, lassitude, mental apathy, hoarseness, puffiness of eyes, hair loss, poor appetite and constipation were noted in 54% with varying clinical signs of hypothyroidism.[indianpediatrics.net]
Encephalopathy
  • […] white matter, vasculitis, normal pressure hydrocephalus, neuromyelitis optica, Kennedy disease, spinal muscular atrophy, complex regional pain syndrome, disorders of DNA translation, the immune restoration inflammatory syndrome (IRIS), and Hashimoto encephalopathy[books.google.de]
  • .-) Type 1 Excludes superior hemorrhagic polioencephalitis [Wernicke's encephalopathy] ( E51.2 ) Type 1 Excludes: L98.5 ICD-10-CM Diagnosis Code L98.5 Mucinosis of the skin 2016 2017 2018 2019 Billable/Specific Code Applicable To Focal mucinosis Lichen[icd10data.com]

Workup

Delayed Bone Age
  • Children with poor linear growth, delayed bone age, and abnormal GH stimulation tests are considered GH deficient.[nursekey.com]
  • In those presenting with marked growth failure, delayed bone age and other features of hypothyroidism, the thyroid gland is often not palpable due to the aggressive fibrous variant of AITD(2,23).[indianpediatrics.net]
Abnormal Thyroid Function Test
  • THYROID FUNCTION TEST 47 THYROID DISORDERS OF INFANCY 462 P A RT IV CALCIUM AND BONE METABOLISM 473 MORPHOLOGY OF THE PARATHYROID 51 PARATHYROID HORMONE 497 PHYSIOLOGY OF CALCIUM 52 PARATHYROID HORMONERELATED 512 CLINICAL APPLICATION OF BONE MINERAL[books.google.com]

Treatment

  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.com]
  • […] photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment[books.google.de]
  • Primary - Hashimotos thyroiditis Iatrogenic-Hyperthyroid treatment Drugs: iodine excess, contrast, hyperthyroid treatment Congenital hypothyroidism Hypopituitarism: Hypothalamic disorders Associated autoimmune diseases of hypothyroidism Rheumatoid arthritis[quizlet.com]
  • Standard Therapies Treatment Treatment of Graves’ disease usually involves one of three methods, antithyroid drugs (thionamides), use of radioactive iodine, or surgery.[rarediseases.org]
  • Natural treatments for thyroid conditions. Lauren Lehman, Volunteering for CSSDP and Harm Reduction - 13 common mistakes patients make when taking thyroid medication for an underactive thyroid & hypothyroidism.[pinterest.de]

Prognosis

  • Childhood bullous pemphigoid: clinical and immunologic features, treatment and prognosis. Arch Dermatol 1991;127:378-86. 2. Borradori L, Bernard P. Pemphigoid group. In: Bolognia JL, Jorizzo JL, Rapini RP. Dermatology.[degruyter.com]
  • If not, the prognosis remains dismal. [5] History [ edit ] Myxedema was first treated successfully in 1891, when George Redmayne Murray diagnosed a 46-year-old woman with the disease. He prescribed an extract from sheep thyroid.[en.wikipedia.org]
  • Prognosis If CH is detected early in infants and treatment begun, normal development of mental function can occur. [ 11 ] If treatment is delayed, spasticity, gait problems and dysarthria and profound mental disability may result.[patient.info]
  • Treatment and prognosis of Grave’s disease in children and adolescents. UpToDate, Inc. 2014 Jan 10. Available at: Accessed on: November 8, 2015.[rarediseases.org]

Etiology

  • In 183 short chapters, the book provides the essentials clinicians need on symptoms/signs, diagnostic tests, and neurologic disorders of all etiologies. For this edition, Timothy A.[books.google.de]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • Etiology May be congenital (e.g., atresia, duplication), acquired (e.g., neoplastic, inflammatory), or iatrogenic (e.g., adhesions, radiation stricture) Etiology varies by age: Neonates Intestinal atresia (most common cause in neonates) Obstructive meconium[unboundmedicine.com]
  • Etiology:   Autoimmune Infection Drugs 44.[slideshare.net]
  • Rare in the US Remains the most common cause of hypothyroidism worldwide Hypothyroidism In areas of iodine sufficiency Autoimmune disease (Hashimoto's thyroiditis) Iatrogenic causes (treatment of hyperthyroidism) are most common Etiology of hypothyroidism[quizlet.com]

Epidemiology

  • Bullous pemphigoid in infancy: Clinical and epidemiologic characteristics. J Am Acad Dermatol 2008;58(1):41-8. 4. Fisler RE, Saeb M, Liang MG, Howard RM, McKee PH. Childhood bullous pemphigoid: a clinicopathologic study and review of the literature.[degruyter.com]
  • Epidemiology In the UK, 1 in 4,000 live births have CH. The incidence is twice as common in girls. [ 1 ] Areas with iodine deficiency associated with endemic CH are Bangladesh, China, Peru and Zaire.[patient.info]
  • Inoue M, Taketani N, Sato T, Nakajima H (1975) High incidence of chronic lymphocytic thyroiditis in apparently healthy school children: epidemiological and clinical study. Endocrinol Jpn 22:483–489 Google Scholar 11.[link.springer.com]
  • The pituitary secretion is in turn controlled by the releasing hormone TRH that is formed in the hypothalamus. 2 Epidemiology Primary Hypothyroidism is very prevalent worldwide. It can be endemic in regions with severe iodine -deficiency.[flexikon.doccheck.com]
  • Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev. 2008;29:697-725. Jacobson EM, Tomer Y.[rarediseases.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Pathophysiology depends on the mechanism of the obstruction.[unboundmedicine.com]
  • Pathophysiology The parietal cells are present in the proximal portion of gastric mucosa and produce acid ( HCL ) and Intrinsic factor. Intrinsic factor is needed for the absorption of vit B 12.[labpedia.net]
  • Pretibial myxedema can occur in 1–4% of patients with Graves' disease, a cause of hyperthyroidism. [3] Hypothyroidism, including Hashimoto's thyroiditis. [ citation needed ] Pathophysiology [ edit ] Myxedema describes a specific form of cutaneous and[en.wikipedia.org]

Prevention

  • […] respiratory failure Intravenous levothyroxine Parenteral hydrocortisone - prevents adrenal crisis[quizlet.com]
  • Hypothyroidism secondary to autoimmune thyroiditis may develop insidiously with slow and progressive physical changes that may remain unrecognized even to parents. 4 Nevertheless, early recognition of symptoms and signs of hypothyroidism is important to prevent[hormones.gr]
  • Treatment and Prevention Treating hypothyroidism requires replacing hormones with synthetic or natural thyroid hormones. The easiest and most effective thyroid hormone replacement involves a synthetic form of T4 that is taken orally (by mouth).[medbroadcast.com]
  • Dental Management •Postmenopausal osteoporosis can be prevented and treated by sound dietary control adequate levels of dietary calcium.[slideshare.net]
  • A concentration of at least 1 percent of iodine must be maintained in the thyroid gland to prevent goiter.[homeoint.org]

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