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Juxtacortical Osteosarcoma

Juxtacortical Osteogenic Sarcoma


Presentation

  • Thirty-eight patients presented with previously untreated, predominantly low-grade juxtacortical osteosarcoma. There were 12 (32%) men and 26 (68%) women with a mean age of 28.9 years.[miami.pure.elsevier.com]
  • […] is unknown and presently, it is not possible to prevent Parosteal Osteosarcoma occurrence A treatment of this bone tumor may involve surgery, chemotherapy, and radiation therapy.[dovemed.com]
  • Covering pathologic conditions by clinical appearance, Oral Pathology: Clinical Pathologic Correlations, 6th Edition uses an atlas-style format to help you identify, diagnose, and plan treatment for oral disease presentations.[books.google.com]
  • They present as a very dense lobulated mass attached by broad base to the underlying bone. The rarer juxtacortical lesions have a better prognosis than central lesions.[amsjournal.com]
Italian
  • Mario Campa nacci first published three volumes on musculoskeletal neoplasms and other tu mor-like processes in hone and soft parts in Italian in 1981-1985. This book is an update and expansionofthat book, published for the firsttime in English.[books.google.com]
  • English Juxtacortical Osteosarcoma Italian Osteosarcoma iuxtacorticale Last Update: 2014-12-09 Usage Frequency: 11 Quality: Reference: IATE Warning: This alignment may be wrong. Please delete it you feel so.[mymemory.translated.net]
Periodontitis
  • Tumor infiltration along the periodontal ligament space leads to symmetrical widening of the periodontal ligament space of one or several teeth. [10] Case Report A 43-year-old female patient had come with the complaint of pain and swelling in the left[amsjournal.com]
  • Orthopantomograph (OPG) which was taken before extraction [Figure 2] b] showed diffuse radiopaque lesion extending from mandibular canine to canine with displaced anteriors and widening of periodontal ligament space in both mandibular canine with radioapaque[cancerjournal.net]
Trismus
  • Figure 5: Histopathology slide showing highly cellular areas and plump osteoblasts (H&E, 40 ) Click here to view Within 2 weeks of the biopsy, the patient developed trismus and increasing pain in the same region.[amsjournal.com]
Bone Pain
  • Patients usually present with bone pain, occasionally accompanied by a soft-tissue mass or swelling. At times, the first symptoms are related to pathologic fracture.[radiologykey.com]
  • Multiple Myeloma Incidence Accounts for 43% of primary malignant bone tumours Age usually 45 - 65 years (but may occur 25 - 80 years) Male : Female 2:1 Clinically Affects bone containing red marrow (skull, ribs, vertebrae, sternum, pelvis) Weakness, bone[flinders.edu.au]
Knee Pain
  • Because of the location in the popliteal fossa, the patient may note inability to flex the knee. Pain is the second most important symptom, and patients may present with pain without having noted a lump.[musculoskeletalkey.com]
Enthesopathy
  • We discuss the similar radiographic findings between a surface osteosarcoma and florid inflammatory enthesopathy that was found upon biopsy.[ncbi.nlm.nih.gov]
Osteopenia
  • Generalised osteopenia, scleorsis of phalangeal tufts, focal/generalised sclerosis. MRI shows bone marrow granulomas with high T2, intermediate T1, enhancement (DDx mets).[radnotes.co.nz]
Knee Pain
  • Because of the location in the popliteal fossa, the patient may note inability to flex the knee. Pain is the second most important symptom, and patients may present with pain without having noted a lump.[musculoskeletalkey.com]

Workup

  • […] describing patients treated with less than wide margins include only few lesions in this location, indicating the difficulty of making the diagnosis on radiographs when the lesion involves a different bone. [27] MRI should be performed as part of the initial workup[emedicine.medscape.com]
  • Bone lesion workup – If it appears non-aggressive on XR then no further workup required. If appears aggressive, then bone scan (?polyostotic), chest CT (?mets), MRI and biopsy.[radnotes.co.nz]
  • A diagnosis of parosteal osteosarcoma (POS) at the femoral diaphysis was made following a diagnostic workup. Previous reports of long bone diaphyseal POS are rare.[spandidos-publications.com]

Treatment

  • Full-color photomicrographs help you identify pathologic elements and provide correct diagnoses and treatment plans. Boxes and tables offer clear, at-a-glance information on the clinical features, diagnosis, and treatment for many conditions.[books.google.com]
  • DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, TREATMENT, AND AN ANALYSIS OF EIGHTY CASES Archive Abstract Author Information Authors To study the relation of juxtacortical osteosarcoma to intraosseous osteosarcoma and to re-evaluate the treatment of the former,[journals.lww.com]
  • […] of the cases Parosteal Osteosarcoma presents as a mass with signs and symptoms that include pain and decreased joint movement The exact cause of the condition is unknown and presently, it is not possible to prevent Parosteal Osteosarcoma occurrence A treatment[dovemed.com]
  • Journal of Orthopaedics and Traumatology 7(4): 198-200, 2006 Juvenile primary lung cancer in a 17-year-old girl as a 2nd malignant neoplasm after osteosarcoma treatment in childhood. Kyobu Geka.[eurekamag.com]

Prognosis

  • Osteosarcoma is a highly malignant tumour which despite modern surgery and chemotherapy still retains a relatively poor prognosis. This prognosis is, however, much better in the rare variant known as juxtacortical osteosarcoma.[ncbi.nlm.nih.gov]
  • Prognosis Generally good—80% 5-year survival; recurrence with dedifferentiation significantly worsens the prognosis.[medical-dictionary.thefreedictionary.com]
  • The prognosis of Parosteal Osteosarcoma depends on the stage of cancer; higher grade osteosarcomas indicate a poorer prognosis Osteosarcomas are classified in several different ways.[dovemed.com]
  • This prognosis is, however, much better in the rare variant known as juxtacortical osteosarcoma.[semanticscholar.org]

Etiology

  • Expanded sections on etiology, treatment, and diagnosis of oral cancer (HPV) describe how subtypes can play an important role in the development and natural history of some head and neck cancers, most notably those arising in the oropharynx.[books.google.com]
  • .  Definition Introduction and brief history Epidemiology Etiology Pathology Classification 2.  A mesenchymalmalignancy thatdifferentiates toproduce osteoid is anosteosarcoma nomatter how muchosteoid is produced OsteoidDeposition 3.  Malignant[slideshare.net]
  • The etiology is thought to be related to repetitive trauma, similar to tug lesions elsewhere in the body. It is, therefore, also called an avulsive cortical irregularity.[roentgenrayreader.blogspot.com]
  • Pathogenesis Etiology is unknown.[oncohemakey.com]
  • Etiology benign bone-forming osseous tumors enostosis (bone island) exostosis osteochondroma osteoma osteoid osteoma (ICD-O:9191/0) osteoblastoma (ICD-O:9200/0) malignant bone-forming osseous tumors osteosarcomas (osteogenic sarcomas) conventional intramedullary[humpath.com]

Epidemiology

  • Epidemiology Most often found in adults undergoing testing for other reasons, although presumably develops at a younger age during skeletal maturation No gender predilection or inheritance pattern Distribution Found within cancellous bone Preference for[oncohemakey.com]
  • .  Definition Introduction and brief history Epidemiology Etiology Pathology Classification 2.  A mesenchymalmalignancy thatdifferentiates toproduce osteoid is anosteosarcoma nomatter how muchosteoid is produced OsteoidDeposition 3.  Malignant[slideshare.net]
  • […] osteosarcoma Case 127 (HPC:127) : osteoblastic osteosarcoma Case 126 : pulmonary metastase of an osteosarcoma Case 115 : chondroblastic osteosarcoma of the calcaneum UI:323 - Osteosarcoma 1 (NOS) UI:856 - Osteosarcoma 2 (NOS) Images Male 17 y/o Osteosarcoma Epidemiology[humpath.com]
Sex distribution
Age distribution

Pathophysiology

  • […] familial polyposis coli) Osteomas Multiple cutaneous and subcutaneous skin lesions (sebaceous cysts, desmoids, Gardner fibromas) Epidemiology Estimated prevalence: 0.4% Male:female ratio: 2:1 Location: ethmoid and frontal sinuses of the cranium most common Pathophysiology[oncohemakey.com]

Prevention

  • Based on these data, close but negative margins may be adequate in achieving local disease control and preventing metastases in these patients.[miami.pure.elsevier.com]
  • […] distal femur (thigh bone), in approximately 70% of the cases Parosteal Osteosarcoma presents as a mass with signs and symptoms that include pain and decreased joint movement The exact cause of the condition is unknown and presently, it is not possible to prevent[dovemed.com]
  • Expanded section on bisphosphonate-related osteonecrosis of the jaws helps you effectively manage patients taking bisphosphonates to prevent bone loss, including information on oral complications, risk factors, and benefits.[books.google.com]
  • The higher success rate associated with such aggressive surgical resections could be due to two reasons: Wide excision of adjacent bone and periosteum prevents local recurrence by removing small satellite lesions and Overcomes the risk of local spread[amsjournal.com]
  • Wide resection of POS is recommended to prevent local recurrence and the rate of distant metastasis; however, the optimal technique for long bone diaphyseal reconstruction following tumor resection is undecided.[spandidos-publications.com]

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