Kallmann syndrome presents with the following features:

Respiratory: Lack of migration of olfactory neurons from olfactory epithelium leads to complete anosmia. Breathing is rarely affected.

Systemic: Delayed female puberty and secondary sexual characteristics are the chief complaints in Kallmann syndrome.

Urogenital: Delayed menarche and amenorrhea are common presentations of Kallmann syndrome in females and may lead to failure to conceive.

Musculoskeletal: Due to decreased sex hormones which play an important role in bone thickening, growth and muscle mass gain, the bones are usually of decreased density hence easily fractured. Recurring fractures may be a frequent presenting complaint, especially in females. The patients are also usually under weight

Complications

Complications commonly include the following:

Facial deformities: Of these, cleft lip and palate are the most prevalent. This is usually due to faulty migration of neural crest cells during embryonic development.
Auditory defects: In some cases neural hearing defects may also occur. These are rare but occurrence is also due to incomplete or improper migration of the cells of the first pharyngeal pouch.
Renal defects: Anosmin-1 is normally produced by the brain, mesonephros and metanephros. KS may accompany renal agenesis in which the symptoms will be more severe due to complete loss of Anosmin-1. Agenesis if present could be unilateral or bilateral, greatly increasing the mortality rate.
Bone defects: Osteoporosis due to decreased bone density may also be found.

Mortality 

Patients who do not have congenital heart disease or other neurologic manifestations concomitantly with Kallmann syndrome seem to live longer than those who do.

• Male Hypogonadism

  Male hypogonadism is characterized by impaired testicular function, which can affect spermatogenesis and/or testosterone synthesis. [dnatesting.uchicago.edu]

  Establishing the cause of hypogonadism is an important first step to getting appropriate treatment. Causes Male hypogonadism means the testicles don't produce enough of the male sex hormone testosterone. [mayoclinic.org]

  Styne, Delayed Puberty and Hypogonadism, Male☆, Reference Module in Biomedical Sciences, 10.1016/B978-0-12-801238-3.04008-3, (2016). [doi.org]

  Congenital Hypogonadotropic Hypogonadism (CHH) is a developmental disorder caused by gonadotropin-releasing hormone (GnRH) deficiency leading to a lack of production of sex hormones (testosterone in males and oestrogens in females). [endo-ern.eu]

• Delayed Female Puberty

  Systemic: Delayed female puberty and secondary sexual characteristics are the chief complaints in Kallmann syndrome. [symptoma.com]

• Anosmia

  Hypogonadism with anosmia (disorder) Kallman syndrome Kallman's syndrome Familial hypogonadism with anosmia GnRH deficiency Hypogonadism with anosmia de Morsier-Kallman's syndrome de Morsier's syndrome edit Language Label Description Also known as English [wikidata.org]

  This is a contributory factor to the frequent discovery of primary anosmia late in life. [tidsskriftet.no]

  The olfactory test resulted in anosmia. Kallmann syndrome is a developmental disorder which consists of a combination of hypogonadotropic-hypogonadism and anosmia. [knepublishing.com]

  Congenital anosmia: detection thresholds for seven odorant classes in hypogonadal and eugonadal patients. Ann Otol Rhinol Laryngol 1979;88:288-92. 4. Davidson TM, Murphy C. Rapid clinical evaluation of anosmia. The alcohol sniff test. [scielo.br]

  The proband was first seen at 22 years complaining of anosmia and lack of puberty. His brother had puberty at 30 years and a maternal granduncle had anosmia and delayed puberty. [eje.bioscientifica.com]

• Hyposmia

  Associated findings were hyposmia, high pitched voice, absence of puncta and smooth philtrum. Hormonal assay showed hypogonadotropic hypogonadism. He has normal male karyotype. Ultrasonography revealed no renal abnormalities. [casereports.bmj.com]

  Kallmann syndrome (KS) is defined by the association of idiopathic hypogonadotropic hypogonadism and anosmia/hyposmia. [ncbi.nlm.nih.gov]

• Parosmia

  […] detect air-borne chemicals, and an adenovirus was used to implant a working version of the IFT88 gene into defective cells in the nose, which restored the cilia and allowed a sense of smell. [35] [36] See also [ edit ] Phantosmia Hyperosmia Hyposmia Parosmia [en.wikipedia.org]

• Cryptorchidism

  Basal INSL3 levels were lower in both untreated CHH/KS men with cryptorchidism than in those with intrascrotal testes and in patients with testicular volumes below 4 mL. [ncbi.nlm.nih.gov]

  On examination we found cryptorchidism, micropenis and absence of secondary sex characteristics. [endocrine-abstracts.org]

• Amenorrhea

  A 32 yr old woman came to the hospital with a history of treatment for primary amenorrhea once in 2007. Diagnosis of Kallmann syndrome was made based on her complaint of amenorrhea and anosmia. [knepublishing.com]

  These females, aged at 20 and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant clinical signs were observed. Empty sella was observed on MRI in both cases. [ncbi.nlm.nih.gov]

  By contrast, our second patient consulted a doctor at 18 years of age, but the etiology of primary amenorrhea was not investigated at the time, and was simply treated as a symptom. [elsevier.es]

  Characteristic features in males include testicular hypoplasia, gynecomastia, and absent facial hair growth, while females commonly present with amenorrhea. [amboss.com]

• Primary Amenorrhea

  These females, aged at 20 and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant clinical signs were observed. Empty sella was observed on MRI in both cases. [ncbi.nlm.nih.gov]

  By contrast, our second patient consulted a doctor at 18 years of age, but the etiology of primary amenorrhea was not investigated at the time, and was simply treated as a symptom. [elsevier.es]

  A 32 yr old woman came to the hospital with a history of treatment for primary amenorrhea once in 2007. Diagnosis of Kallmann syndrome was made based on her complaint of amenorrhea and anosmia. [knepublishing.com]

  Untreated adult females almost always experience primary amenorrhea with absent, little or normal breast development. [orpha.net]

• Delayed Menarche

  Urogenital: Delayed menarche and amenorrhea are common presentations of Kallmann syndrome in females and may lead to failure to conceive. [symptoma.com]

  Among atypical symptoms of CD, disorders of fertility, such as delayed menarche, early menopause, amenorrhea or infertility, and pregnancy complications, such as recurrent abortions, intrauterine growth restriction (IUGR), small for gestational age (SGA [en.wikipedia.org]

A complete work up is necessary before establishing a diagnosis of Kallmann syndrome. This includes the following:

Imaging

X-rays of upper and lower limbs show decreased bone mass and density indicating a probable underlying hormone deficiency. CT scans may indicate delayed bone age.

Hormone evaluation

For narrowing down the underline cause between probable suspects like hypothalamus, pituitary gland and the gonads themselves, hormone evaluation is vital.

Physical examination

A thorough physical examination may reveal micropenis and lack of pubic hair in males and incomplete breast enlargement in females. CT scans may reveal testicular agenesis or cryptorchidism in males and abnormally small ovaries and an immature uterine tract in females.

• Delayed Bone Age

  This includes the following: Imaging X-rays of upper and lower limbs show decreased bone mass and density indicating a probable underlying hormone deficiency. CT scans may indicate delayed bone age. [symptoma.com]

• Testosterone Decreased

  As testosterone decreases, some men may experience symptoms similar to those of menopause in women. [mayoclinic.org]

The treatment plan includes genetic counselling of affected individuals and the family involved, explaining the disease and the accompanying problems they may face. The second step is hormone replacement therapy which, studies show, has been observed to be beneficial [7]. Complications such as facial deformities may be corrected by surgical means.

The disease is present at birth with progressively evident features. Initially there is agenesis of ovaries in females and testes in males with accompanying hypogenesis of external genitalia. As the individual grows, there is marked increase in height and stature due to delayed closure of epiphyseal plates.

Puberty is late in onset and secondary sexual characteristics are poorly defined, for example, lack of facial and axillary hair, enlargement of larynx and deepening of voice, heavier bone structure and increased muscle mass due to lack of testosterone in males and lack of breast enlargement, growth of axillary and pubic hair, widening of hips and increased subcutaneous fat deposition due to decreased estrogen in females.

As the age progresses, more serious effects are seen like erectile dysfunction and oligospermia in males and amenorrhea and infertility in females.

Mutations in various genes play a vital role in the development of Kallmann syndrome, and as the gene in question varies, so does the pattern of inheritance [1] [2] [3] [4] [5].

KAL1 

The first causative gene is the KAL1 gene on locus Xp22.3 which encodes the synthesis of Anosmin-1 which is a neural cell adhesion molecule. This molecule is necessary for the embryonic migration of two chief factors: olfactory neurons and GnRH synthesizing neurons. A mutation in KAL1 results in incomplete migration of olfactory neurons from the olfactory bulbs to the hypothalamus, a defect which leads to slight or usually, complete loss of smell. The external and internal nares as well as the rest of the anatomical structure of the nasal cavity are normal but a lack of sensory neurons cause significant anosmia in both affected males and females.

The second factor promoted by Anosmin-1 is the migration of GnRH synthesizing neurons to the hypothalamus. A mutation in KAL1 causes a migratory defect causing decreased or in severe cases, absent production of GnRH, which in return presents as hypogonadism, late onset of puberty, diminished libido and infertility. KAL1 mutations are inherited by an X-linked recessive pattern, thus affecting males more.

KAL2 

The second mutation that may cause Kallmann syndrome (KAL2) occurs in the Fibroblast Growth Factor Receptor 1 (FGFR1) gene on chromosome 8. The pattern of inheritance is autosomal dominant. This presentation is rare, evident in only 10% of cases.

KAL3 

Another extremely uncommon autosomal dominant form of Kallmann syndrome (KAL3) is a result of mutations in the Prokineticin receptor-2 gene (PROK2). However, a slight variation in symptoms has been observed in this form.

Others 

Defects in some other ligands like TAC3, LEP, GnRH1 etc have also been indicated in the pathogenesis of Kallmann syndrome.

Kallmann syndrome is a rare genetic disorder which shows a predisposition in male children affecting 1:8000 males and 1:40.000 females. In strictly familial Kallmann syndrome, the male-to-female ratio is 2.5:1.

A decrease in GnRH from the hypothalamus causes diminished synthesis and release of Luteinising hormone and Follicle stimulating hormone from the pituitary gland. A decrease in these hormones cause delayed onset of puberty, small non-functional gonads leading to decreased levels of sex hormones, lack of secondary sexual characters, prolonged and sometimes abnormal growth, decreased bone density and muscle mass. Affected patients are infertile [6].

Kallmann syndrome is the result of a genetic defect. To prevent mutations, life style changes may be advised such as avoidance of harmful radiation, exposure to radioactive substances and in the case of pregnant females, safeguarding against teratogens.

Kallmann syndrome is a congenital disease associated with complete absence or partial decrement of Gonadotropin releasing hormone (GnRH) from the hypothalamus. This isolated GnRH deficiency results in hypogonadism and consequent infertility.

Major symptoms also include partial or complete anosmia. The anosmia is due to a defect in the development of olfactory bulbs leading to progressive decrease in perception of smell. This disease, although present from birth, may not be evident at first but can be suspected in the case of abnormally small genitalia, as observed in male infants.

Definition 

Kallmann syndrome is a genetic disease which results in loss of smell, delayed puberty, bone and muscle weakness and infertility.

Types

Kallmann syndrome is of 3 major types of which the first one, known as KAL1, is the most common. It is inherited from parent to son, having a chance of 1 in 4 children of being affected.

Prevention

As the defect lies in the mutated genes, prevention is essential. Protecting and safeguarding oneself from harmful radiation, radioactive substances, high exposure to ultra violet light and toxic chemicals can prevent the occurrence of Kallmann syndrome.

KS and pregnancy

Special care should be taken by pregnant women to avoid mutations occurring in the fetus. Some drugs like tetracyclines, aminoglycosides, etc should be avoided as well as alcohol intake, exposure to radiation and other toxic substances.

Treatment

The disease itself can be managed with symptomatic treatment. Hormone therapy is initiated to treat the delayed, and often incomplete, attaining of puberty. Administration of sex hormones can reverse the infertility in both males and females, leading to successful conception. Vitamins may be given to strengthen bones and muscles.

Summary

Kallmann syndrome is treatable but not curable. This disease occurs at birth and persists for life. Male infants are especially vulnerable to it. However, its negative effects may be reversed or at least significantly improved by regular treatment and counselling.

1. Dode C, Levilliers J, Dupont JM, et al. Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome. Nat Genet. Apr 2003;33(4):463-5
2. Monnier C, Dode C, Fabre L, et al. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling-activity. Hum Mol Genet. Sep 29 2008
3. Canto P, Munguía P, Söderlund D, et al. Genetic analysis in patients with Kallmann syndrome: coexistance of mutations in prokineticin receptor 2 and KAL1. J Androl. Aug 21 2008
4. Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. Oct 23 2003;349(17):1614-27
5. Trarbach EB, Silveira LG, Latronico AC. Genetic insights into human isolated gonadotropin deficiency. Pituitary. 2007;10(4):381-91
6. Layman LC. The molecular basis of human hypogonadotropic hypogonadism. Mol Genet Metab. Oct 1999;68(2):191-9
7. Hoffman AR, Crowley WF Jr. Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med. Nov 11 1982;307(20):1237-41