In conclusion, the present mutation represents the first mutation in KAL1, the gene responsible for X-linked KS, in a patient presenting reversible KS. [eje.bioscientifica.com]

Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future. Endocrinol Metab (Seoul). 2015 Dec;30(4):456-66. doi: 10.3803/EnM.2015.30.4.456. Review. [medlineplus.gov]

If not enough of these hormones are made, the child will not enter puberty and will not be able to have children of their own without special treatment. [rch.org.au]

Without treatment, most affected men and women are unable to have biological children (infertile). In Kallmann syndrome, the sense of smell is either diminished (hyposmia) or completely absent (anosmia). [medlineplus.gov]

Testosterone replacement (Durateston, Organon do Brasil, São Paulo, Brazil; 250 mg i.m. each 4 weeks) was soon started, but his adherence to treatment and follow-up visits were irregular. [eje.bioscientifica.com]

In addition, periodical interruption of testosterone replacement and reassessment of gonadal function in KS patients may be desirable in order to avoid unnecessary hormone replacement and inappropriate reproductive prognosis. [eje.bioscientifica.com]

Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann’s syndrome): pathophysiological and genetic considerations. Endocrine Reviews 1998 19 521–539. [eje.bioscientifica.com]

Misplacement of GnRH-producing neurons in the brain prevents the production of other sex hormones, which interferes with normal sexual development and causes the characteristic features of hypogonadotropic hypogonadism. [medlineplus.gov]