We are presenting here a case of histoid leprosy presenting with keloid like lesions, probably the rarest presentation of histoid leprosy. [ncbi.nlm.nih.gov]

• Localized Edema

  Only mild local edema and epidermolysis, followed by a short reepithelialization period, were evident. During the 18-month follow-up period, there was no evidence of bleeding, infection, adverse effects, recurrence, or permanent depigmentation. [oadoi.org]

• Plethora

  Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. [ncbi.nlm.nih.gov]

  Despite a plethora of various in vivo and in vitro studies, to date only limited information is available on the exact cause of hypertrophic scar and keloid formation. [doi.org]

• Hyperthermia

  KEYWORDS: Collagen; Fibroblast; Hyperthermia; Keloid; Near-infrared; Water-filtered near-infrared [ncbi.nlm.nih.gov]

• Broad Thumb

  Affected individuals display mainly broad thumbs and toes, a characteristic facies, and mental retardation. [doi.org]

• Liver Fibrosis

  PubMed View Article Google Scholar Dooley S, et al. (2003) Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology. 125:178–91. [doi.org]

• Erythema

  The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively). The keloid color was also evaluated subjectively. [ncbi.nlm.nih.gov]

  Further research is required to determine the mechanism of action for different laser systems and to examine such outcomes as scar erythema, scar texture, degrees of symptom relief, recurrence rates and adverse effects. [ 13 ] One study reported the successful [patient.info]

• Pruritus

  By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. [ncbi.nlm.nih.gov]

  In some studies, the response rate has been as high as 79%, showing substantial reduction in erythema, scar elevation, and pruritus. [13] However, complete resolution has not been noted. [emedicine.medscape.com]

  Keloids present a therapeutic challenge that must be addressed, as these lesions can cause significant pain, pruritus (itching), and physical disfigurement. They may not improve in appearance over time and can limit mobility if located over a joint. [en.wikipedia.org]

As a result, fewer treatment cycles are needed. Because the reepithelialization period is short, treatment intervals, if any, can be shortened to 2 to 3 weeks. [oadoi.org]

Early AMM diagnosis has a very significant effect on prognosis. For some persistent and growing proliferative lesions, obliterative treatments should be avoided before a definitive histopathological diagnosis has been made. [ncbi.nlm.nih.gov]

What is the prognosis for keloids? Small keloids can be effectively treated using a variety of methods. Generally, a series of injections of steroids into the problem area is the simplest and safest approach. [medicinenet.com]

Identification of genetic markers in candidate genes such as the SMAD family may be of significant importance in diagnosis, prognosis and development of new therapies in the management of keloid scarring. [dx.doi.org]

Prognosis Keloids rarely resolve spontaneously; however, with treatment, they may become softer, less tender, less painful, and less pruritic. Following excision treatment alone, keloids frequently recur ( 50%). [emedicine.medscape.com]

Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after a skin injury in genetically susceptible individuals. [ncbi.nlm.nih.gov]

The epidemiology of keloids in general is variable. [doi.org]

Indeed, there has never been a population study to assess the epidemiology of this disorder. [en.wikipedia.org]

The term ' chéloïde ' was coined by Alibert in 1806, from the Greek ' chele ', meaning crab's claw - to describe the lateral growth of tissue into unaffected skin. [ 1 ] Epidemiology [ 2, 3 ] Keloid scars are more common in people with darker skins, especially [patient.info]

In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies. [ncbi.nlm.nih.gov]

The main aim of this review paper is to offer a useful up-to-date guideline to prevent and treat keloids and hypertrophic scars. [ncbi.nlm.nih.gov]

Children may need up to 18 months of prevention. Imiquimod cream may help prevent keloids from forming after surgery. The cream may also prevent keloids from returning after they are removed. Keloid scar; Scar - keloid Habif TP. Benign skin tumors. [nlm.nih.gov]