Only mild local edema and epidermolysis, followed by a short reepithelialization period, were evident. During the 18-month follow-up period, there was no evidence of bleeding, infection, adverse effects, recurrence, or permanent depigmentation. [oadoi.org]

Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. [ncbi.nlm.nih.gov]

Despite a plethora of various in vivo and in vitro studies, to date only limited information is available on the exact cause of hypertrophic scar and keloid formation. [doi.org]

KEYWORDS: Collagen; Fibroblast; Hyperthermia; Keloid; Near-infrared; Water-filtered near-infrared [ncbi.nlm.nih.gov]

Affected individuals display mainly broad thumbs and toes, a characteristic facies, and mental retardation. [doi.org]

PubMed View Article Google Scholar Dooley S, et al. (2003) Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology. 125:178–91. [doi.org]

The erythema and melanin levels in the keloids (Ek and Mk, respectively) were recorded with control data obtained from the flexor aspect of the forearm (Ec and Mc, respectively). The keloid color was also evaluated subjectively. [ncbi.nlm.nih.gov]

Further research is required to determine the mechanism of action for different laser systems and to examine such outcomes as scar erythema, scar texture, degrees of symptom relief, recurrence rates and adverse effects. [ 13 ] One study reported the successful [patient.info]

By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. [ncbi.nlm.nih.gov]

In some studies, the response rate has been as high as 79%, showing substantial reduction in erythema, scar elevation, and pruritus. [13] However, complete resolution has not been noted. [emedicine.medscape.com]

Keloids present a therapeutic challenge that must be addressed, as these lesions can cause significant pain, pruritus (itching), and physical disfigurement. They may not improve in appearance over time and can limit mobility if located over a joint. [en.wikipedia.org]